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Can Metformin Help Weight Loss Pcos?

Polycystic Ovarian Syndrome Fertility Treatment With Metformin (glucophage)

Polycystic Ovarian Syndrome Fertility Treatment With Metformin (glucophage)

How Metformin Is Used for Polycystic Ovaries Polycystic ovarian syndrome is a common cause of anovulation and infertility in women. These women do not ovulate (release eggs) regularly and therefore have irregular menstrual periods. The ovaries have many small cysts (2-7 mm diameter) called antral follicles, giving the ovaries a characteristic "polycystic" (many cysts) appearance on ultrasound. A relatively new method of treating ovulation problems in women with polycystic ovarian disease is to use an oral medication called metformin (brand name is Glucophage). Metformin has traditionally been used as an oral drug to help control diabetes. Then, some smart doctor figured out that polycystic ovarian syndrome treatment with metformin can be very effective. If Glucophage alone does not result in ovulation and pregnancy, we often use: If the combination therapy is not effective, we can try: Metformin Use with IVF Treatment We also use Glucophage in women going through in vitro fertilization for PCOS, and for those with very high antral follicle counts - if their ovaries are "polycystic" by ultrasound. We find that some women with polycystic ovaries respond with a "smoother" response to the injectable FSH medication if they have been taking Glucophage. Risks and Side Effects of Metformin / Glucophage In about 25% of women Glucophage causes side effects which may include abdominal discomfort, cramping, diarrhea and nausea. The side effects may be severe enough to make the woman stop the Glucophage medication. We are not aware of any serious complications resulting from Glucophage treatment. Another oral medication used for diabetes called Troglitazone has been associated with liver failure and death in rare cases. This has been publicized on television shows, in newspapers, et Continue reading >>

Must I Increase My Dose Of Metformin To Lose Weight?

Must I Increase My Dose Of Metformin To Lose Weight?

Weight loss is an integral aspect of improving Polycystic Ovarian Syndrome, or PCOS, in women who are overweight. Carrying extra weight can cause the condition’s symptoms to become more severe, and can even increase the level of Insulin Resistance (IR) that a woman experiences.1 IR occurs when the body’s cells become desensitized to insulin, preventing the hormone from turning glucose into energy. This results in high blood sugar and, in some cases, diabetes. For this reason, Metformin, a popular diabetes medication, is also used to improve PCOS. Aside from regulating blood sugar levels, this pharmaceutical, also known as Glucophage, contributes to weight loss. How Metformin Encourages PCOS Weight Loss Insulin is a hormone that triggers both hunger and the production of fat cells. Therefore, by reducing insulin, women can reduce the amount of food they eat as well as the amount of fat cells that their bodies produce.2 Metformin’s primary function is to reduce insulin, so it is only natural that this medication contributes to weight loss. How Much Medication Is Necessary? Dosage is determined by several factors; healthcare professionals consider medical history, body type, and severity of symptoms when coming to the proper dosage. Metformin comes in three different sized pills: 500 mg, 850 mg, and 1,000 mg.2 Generally, individuals are prescribed between 850 and 1,000 mg two times per day, with 850 mg three times per day being the maximum amount of the medication safe to consume.2 Typically, doctors will prescribe a low dose to gauge the body’s reaction to the medication.2 If the body needs more, physicians will alter the dosage until the right amount is achieved. Because so many factors contribute to the proper dosage, many women who are prescribed different amou Continue reading >>

Metformin For Pcos & Weight Loss

Metformin For Pcos & Weight Loss

Metformin is used for diabetes prevention in women with PCOS.Photo Credit: milosducati/iStock/Getty Images April Khan is a medical journalist who began writing in 2005. She has contributed to publications such as "BBC Focus." In 2012, Khan received her Doctor of Public Health from the University of Medicine and Dentistry of New Jersey. She also holds an Associate of Arts from the Art Institute of Dallas and a Master of Science in international health from University College London. Polycystic ovary syndrome, or PCOS, is a condition caused by an over-production of the luteinizing hormone from the pituitary gland. This over-production causes a hormonal imbalance in estrogen, progesterone and insulin. This results in symptoms such as facial hair growth, weight gain, infertility, ovarian cysts and type 2 diabetes. Although some women dont show these symptoms initially, their physicians may prescribe metformin as a way to prevent diabetes and some may prescribe this medication to treat symptoms of PCOS and aid in weight loss. Metformin is a medication that is usually used to treat type 2 diabetes. Metformin works by controlling the level of glucose in the blood, by minimizing the amount of glucose your blood absorbs from food and the amount your liver produces. Women with PCOS have an increased level of insulin, which puts these women at risk for developing type 2 diabetes or insulin resistance. This risk is increased if a woman with this condition becomes overweight or obese. Women with PCOS may gain weight easily due to the increased insulin level and may also find it very difficult to lose this weight. For this reason, women are usually told to go on a low-glycemic index diet, which shuns foods that cause spikes in blood insulin after consuming them. In addition to dieta Continue reading >>

Role Of Metformin In The Management Of Polycystic Ovary Syndrome

Role Of Metformin In The Management Of Polycystic Ovary Syndrome

Go to: Background Polycystic ovary syndrome (PCOS) is the most common endocrinological disorder affecting 4–12% of women [Diamanti-Kandarakis et al. 1999; Farah et al. 1999; Knochenhauer et al. 1998]. It has also been the most controversial medical condition and every aspect has received a lot of attention from the nomenclature to the management. Several descriptions of similar conditions took place in the 20th century and it was named Stein—Leventhal Syndrome in 1935 after the authors who described polycystic ovarian morphology in patients suffering from hirsutism, amenorrhoea and infertility [Leventhal, 1958; Stein and Leventhal, 1935]. PCOS was also called polycystic ‘ovarian’ syndrome implying that the primary pathology lies in or triggered by the ovary. Others have called it polycystic ovary disease (PCOD), which is the least used term for obvious reasons. Currently, PCOS refers to a disorder with a combination of reproductive and metabolic characteristics. This has evolved over time with controversy over the definition culminating in the latest consensus [ESHRE/ASRM, 2004] which instead of solving the issue created more controversy [Azziz et al. 2006]. In the European Society of Human Reproduction and Embryology/American Society of Reproductive Medicine (ESHRE/ASRM) consensus, at least two of the following features are needed to make the diagnosis; oligo/anovulation, hyperandrogenism, and polycystic features on ultrasound scan [ESHRE/ASRM, 2004]. The Androgen Excess Society, however, recommended that androgen excess should remain a constant feature of PCOS irrespective of the ovulatory status and morphological features of the ovaries [Azziz et al. 2006]. For almost three decades, PCOS has been regarded as a life course disease which besides its reproductiv Continue reading >>

Can You Take Metformin For Weight Loss? A Look At The Numbers

Can You Take Metformin For Weight Loss? A Look At The Numbers

Metformin is a medication said to cause weight loss, but is it true? Should you be worried if you are underweight, or should you use it if you want a slimmer waistline? This article takes a looks at the current evidence and if you can take metformin for weight loss. What is Metformin? Metformin belongs to the class of medications called “oral hypoglycemics.” This means it’s taken by mouth to help reduce blood sugar (glucose) levels. For this reason, metformin is commonly used for the management of type 2 diabetes. How Does Metformin Work? The way metformin works isn’t fully understood yet. However, what is known is that it reduces the production of sugar by liver cells (1). Metformin also improves insulin sensitivity and influences the bacterial community in the gut. It may have anti-inflammatory effects that could be beneficial for metabolic health too (2, 3). Metformin may also cause weight loss by reducing food intake and blocking gastrointestinal absorption of glucose, at least in theory (4). Summary: Commonly prescribed for type 2 diabetes, metformin is a medication that influences the metabolism and absorption of sugar. What is Metformin Used For? Metformin has been approved for treating type 2 diabetes. This medication is also sometimes prescribed for the following: Research continues on other uses for metformin including: Anti-aging or anti-cancer effects (8) Helping manage type 1 diabetes (9) Reducing the risk of heart disease (10). Summary: Metformin has been approved for the management of type 2 diabetes. It is sometimes prescribed for other conditions that involve abnormal blood sugar, such as diabetes during pregnancy. Can You Take Metformin For Weight Loss? Metformin helps manage type 2 diabetes, a health condition associated with being overweight. Continue reading >>

Pcos Weight Gain Causes And Treatments

Pcos Weight Gain Causes And Treatments

Many of these conditions can lead to heart disease . In fact, women with PCOS are four to seven times more likely to have a heart attack than women of the same age without the condition. Experts think weight gain also helps trigger PCOS symptoms, such as menstrual abnormalities and acne . What can I do to lose weight if I have polycystic ovary syndrome? Losing weight not only cuts your risk for many diseases, it can also make you feel better.When you have PCOS, shedding just 10% of your body weight can bring your periods back to normal. It can also help relieve some of the symptoms of polycystic ovary syndrome. Weight loss can improve insulin sensitivity. That will reduce your risk of diabetes , heart disease, and other PCOS complications. To lose weight, start with a visit to your doctor. The doctor will weigh you and check your waist size and body mass index. Body mass index is also called BMI, and it is the ratio of your height to your weight. Your doctor may also prescribe medication. Several medications are approved for PCOS, including birth control pills and anti-androgen medications. The anti-androgen medications block the effects of male hormones. A few medications are used specifically to promote weight loss in women with PCOS. These include: Metformin ( Glucophage ). Metformin is a diabetes drug that helps the body use insulin more efficiently. It also reduces testosterone production. Some research has found that it can help obese women with PCOS lose weight. Thiazolidinediones. These should be used with contraception . The drugs pioglitazone ( Actos ) and rosiglitazone ( Avandia ) also help the body use insulin. In studies, these drugs improved insulin resistance. But their effect on body weight is unclear. All patients using Avandia must review and fully un Continue reading >>

Can Metformin Help With Weight Loss?

Can Metformin Help With Weight Loss?

Bottom Line: Yes. About 2 to 9 kg (4 to 20 pounds) according to the studies and this fits my clinical experience. I want to give my patients the best shot possible when trying to lose weight (and keep it off). This may or may not include giving them medicines along the way. Our bodies are working against us so we must work against them (as safely as possible). Most approved weight loss medicines work in the brain to help us control our appetites. They can be pricey (unless generic, which are approved for short-term) and their long-term effects are unknown. There is one medicine that has been prescribed by weight loss doctors and used by bodybuilders for years despite not being approved for weight loss with a very strong safety record. That medicine is metformin. (Or as my Siri has written in the past, Matt Foreman). How to take it: Start with 500 mg tablet with breakfast (some say start with dinner). If you tolerate it after about a week or two, try 500 mg with breakfast and dinner. After another week or two go to 1000 mg with breakfast and dinner. Who takes it?: It is the first-line drug treatment approved for type 2 diabetes. However, it is also commonly used in PCOS (polycystic ovarian syndrome), prediabetes (and those with insulin resistance), those taking antipsychotics looking to minimize weight gain, and adolescents/adults looking to lose weight some weight loss. There are anecdotal reports of athletes and bodybuilders taking it as well. How does it work?: Metformin helps your muscles take in sugar (increases insulin sensitivity) and slows your liver’s sugar production (decreased hepatic gluconeogenesis). The mechanism is likely a peripheral activation of AMPK (AMP-activated protein kinase) and alteration of the gut microbiome and increases in GLP-1. You can re Continue reading >>

Metformin Weight Loss – How It Works, Benefits, And Side Effects

Metformin Weight Loss – How It Works, Benefits, And Side Effects

Do you find it extremely difficult to refrain from eating all the time? Have you gained too much weight? Or did your doctor just tell you that you have polycystic ovaries? If you answered “yes” to any one of these questions, chances are your body is resistant to insulin. According to the National Institute of Diabetes and Digestive and Kidney Diseases, insulin resistance can lead to diabetes type 2, prediabetes, and infertility. This can take a toll on your physical and emotional health (1). To counteract these health problems, doctors often prescribe the drug Metformin. This drug has helped many to lose weight and improve insulin sensitivity, and it can definitely help you too. So, read on to find out how Metformin can help you lose weight, the dosage, side effects, and much more. What Is Metformin? Metformin is a drug that helps to control the blood glucose levels. It is a derivative of biguanide (a group of drugs that prevent the production of glucose by the liver) that helps to improve insulin sensitivity, thereby reducing the sugar levels in the blood and the risk of diabetes type 2. It also helps regulate the amount of sugar absorbed in the intestine. Metformin was first synthesized in the 1920s. But only in 1957, it was made available in the market as an effective antidiabetic drug. It is generally sold under the brand name Glucophage and is taken orally. It is taken by people who are obese and at the risk of developing diabetes type 2 and by women who have irregular periods and are at a risk of PCOs and infertility (2). So, how does Metformin aid weight loss? Find out next. Metformin And Weight Loss – How It Works ? In obese individuals, metformin acts by suppressing the production of sugar by the liver. It reduces the rate of gluconeogenesis and glycogeno Continue reading >>

Metformin (glucophage) And Weight Loss

Metformin (glucophage) And Weight Loss

Tweet Metformin, a generic diabetes treatment usually sold under the brand name Glucophage, may help people with diabetes to lose weight by lowering their appetites. Insulin makes people overweight by acting on the brain to cause hunger, making the liver manufacture fat and fill fat cells in the stomach. Avoiding obesity is a matter of avoiding foods high in blood sugar, and taking medication that prevents blood sugar levels from climbing too high. Glucophage function The function of diabetes drug Glucophage is to reduce the release levels of sugar from your liver. This stops blood glucose levels from rising too high, and means that the body does not have to produce as much insulin. Therefore, the patient is not as hungry. Type 2 diabetes drug Metformin (Glucophage) may be used successfully as a medication for type 2 diabetes. Lowers insulin levels It lowers insulin levels, helps to prevent diabetes complications, and helps people with diabetes to lose weight. Losing weight whilst taking Metformin (Glucophage) means also eating a healthy diet. Eating lots of foods that boost blood sugar levels will counteract the effects of Metformin. Most doctors prescribe 500mg of Metformin (Glucophage) before eating. Tweet Type 2 diabetes mellitus is a metabolic disorder that results in hyperglycemia (high blood glucose levels) due to the body: Being ineffective at using the insulin it has produced; also known as insulin resistance and/or Being unable to produce enough insulin Type 2 diabetes is characterised by the body being unable to metabolise glucose (a simple sugar). This leads to high levels of blood glucose which over time may damage the organs of the body. From this, it can be understood that for someone with diabetes something that is food for ordinary people can become a s Continue reading >>

6 Reasons Why Metformin Might Not Be Safe For Pcos

6 Reasons Why Metformin Might Not Be Safe For Pcos

Have you been prescribed metformin for PCOS and are wondering what the side affects are? Metformin is often described as a ‘safe’ drug, but read on to find out why this might not be the case. When I was diagnosed with PCOS, the first thing I asked my GP was what I could take to ‘fix’ it. She gently explained that there was no pill or surgery that could cure my condition. However, there was a drug that could help with the elevated insulin levels caused by it. Metformin, she claimed, was a safe drug with no major side effects that would help with insulin resistance and weight loss. Sign me up. At first, I thought metformin was the wonder drug. I lost about 5kg in 4 months, more than I had ever been able to lose previously. I was ecstatic. I had a quick look online to see whether there were any side effects and initially found that diarrhea, loose stools, fatigue, and muscle soreness were commonly experienced. But I thought that it was small price to pay for finally being able to lose some weight. However, when I investigated further I found that that there are some much more sinister side effects of metformin that aren’t so widely publicised. These include: – Depleting our bodies of essential nutrients. – Increasing the risk of having a baby with a neural tube defect by up to 9 times. – Reducing energy levels by almost 50%. – Killing beneficial gut bacteria. This article is not intended to be a case against metformin for PCOS. There is no doubt that metformin helps to reduce weight, lowers blood glucose levels, and promotes ovulation. My concern is the lack of studies about the safety of long-term use of metformin for PCOS, especially in utero. Drugs can help with the associated symptoms of a disease, but they cannot fix the root cause of it. Metformin i Continue reading >>

Polycystic Ovary Syndrome (pcos) And Weight Gain

Polycystic Ovary Syndrome (pcos) And Weight Gain

Most women at some point have to contend with weight gain. But for women with polycystic ovary syndrome (PCOS), losing weight can become a constant struggle. PCOS is the most common hormonal disorder in women of childbearing age and can lead to issues with fertility. Women who have PCOS have higher levels of male hormones and are also less sensitive to insulin or are "insulin-resistant." Many are overweight or obese. As a result, these women can be at a higher risk of diabetes, heart disease, sleep apnea, and uterine cancer. If you have PCOS, certain lifestyle changes can help you shed pounds and reduce the disease's severity. Why does polycystic ovary syndrome cause weight gain? PCOS makes it more difficult for the body to use the hormone insulin, which normally helps convert sugars and starches from foods into energy. This condition -- called insulin resistance -- can cause insulin and sugar -- glucose -- to build up in the bloodstream. High insulin levels increase the production of male hormones called androgens. High androgen levels lead to symptoms such as body hair growth, acne, irregular periods -- and weight gain. Because the weight gain is triggered by male hormones, it is typically in the abdomen. That is where men tend to carry weight. So, instead of having a pear shape, women with PCOS have more of an apple shape. Abdominal fat is the most dangerous kind of fat. That’s because it is associated with an increased risk of heart disease and other health conditions. What are the risks associated with PCOS-related weight gain? No matter what the cause, weight gain can be detrimental to your health. Women with PCOS are more likely to develop many of the problems associated with weight gain and insulin resistance, including: Endometrial cancer Many of these condit Continue reading >>

Metformin And Weight Loss In Obese Women With Polycystic Ovary Syndrome: Comparison Of Doses

Metformin And Weight Loss In Obese Women With Polycystic Ovary Syndrome: Comparison Of Doses

Context: Metformin treatment of women with polycystic ovary syndrome (PCOS) is widespread, as determined by studies with diverse patient populations. No comparative examination of weight changes or metabolite responses to different doses has been reported. Objective: The aim of this study was to determine whether different doses of metformin (1500 or 2550 mg/ d) would have different effects on body weight, circulating hormones, markers of inflammation, and lipid profiles. Design: The study included prospective cohorts randomized to two doses of metformin. Setting: The study was performed at a university teaching hospital with patients from gynecology/endocrinology clinics. Patients: The patients studied were obese (body mass index, 30 to <37 kg/m2; n = 42) and morbidly obese (body mass index, ≥37 kg/m2; n = 41) women with PCOS. Intervention: Patients were randomized to two doses of metformin, and parameters were assessed after 4 and 8 months. Main Outcome Measures: The main outcome measures were changes in body mass, circulating hormones, markers of inflammation, and lipid profiles. Results: Intention to treat analyses showed significant weight loss in both dose groups. Only the obese subgroup showed a dose relationship (1.5 and 3.6 kg in 1500- and 2550-mg groups, respectively; P = 0.04). The morbidly obese group showed similar reductions (3.9 and 3.8 kg) in both groups. Suppression of androstenedione was significant with both metformin doses, but there was no clear dose relationship. Generally, beneficial changes in lipid profiles were not related to dose. Conclusion: Weight loss is a feature of protracted metformin therapy in obese women with PCOS, with greater weight reduction potentially achievable with higher doses. Additional studies are required to determine wh Continue reading >>

Metformin Weight Loss – Does It Work?

Metformin Weight Loss – Does It Work?

Metformin weight loss claims are something that are often talked about by health professionals to be one of the benefits of commencing metformin therapy, but are they true? At myheart.net we’ve helped millions of people through our articles and answers. Now our authors are keeping readers up to date with cutting edge heart disease information through twitter. Follow Dr Ahmed on Twitter @MustafaAhmedMD Metformin is possibly one of the most important treatments in Type II Diabetes, so the question of metformin weight loss is of the utmost importance, as if true it could provide a means to lose weight as well as control high sugar levels found in diabetes. What is Metformin? Metformin is an oral hypoglycemic medication – meaning it reduces levels of sugar, or more specifically glucose in the blood. It is so effective that the American Diabetes Association says that unless there is a strong reason not to, metformin should be commenced at the onset of Type II Diabetes. Metformin comes in tablet form and the dose is gradually increased until the maximum dose required is achieved. How Does Metformin Work & Why Would it Cause Weight Loss? Metformin works by three major mechanisms – each of which could explain the “metformin weight loss” claims. These are: Decrease sugar production by the liver – the liver can actually make sugars from other substances, but metformin inhibits an enzyme in the pathway resulting in less sugar being released into the blood. Increase in the amount of sugar utilization in the muscles and the liver – Given that the muscles are a major “sink” for excess sugar, by driving sugar into them metformin is able to reduce the amount of sugar in the blood. Preventing the breakdown of fats (lipolysis) – this in turn reduces the amount of fatt Continue reading >>

Metformin, Weight Loss & Pcos – Does It Actually Work?

Metformin, Weight Loss & Pcos – Does It Actually Work?

Did you know that one of the main reasons you can't lose weight with PCOS is because of your hormones? It's true, and that's why many women (and physicians) turn to using Metformin to try and help with weight loss. But just because it works for some people doesn't mean it will necessarily work for YOU. Find out why metformin helps with weight loss, but more important what works better and how to finally lose weight if you have PCOS. ​ Insulin & PCOS: Why It's so Important One of the most common medications prescribed for PCOS is metformin. But, PCOS is a hormonal condition which results in weight gain, hair growth on the face, infertility, acne and estrogen/progesterone imbalances. So why is metformin, a medication used to lower blood sugar and treat insulin resistance, used to treat estrogen/progesterone imbalances in women? The logic is quite simple: Most of the symptoms of PCOS (all those listed above) stem from insulin resistanc e! In fact many physicians recommend that ALL women with PCOS should be treated for insulin resistance regardless of what their fasting insulin and fasting blood sugar levels are. This means that the root cause of PCOS (at least the majority of it) is insulin resistance, and this is why metformin is so commonly used to treat. Insulin resistance causes a block of glucose uptake in your skeletal muscles which results in a lower metabolism (and weight gain), insulin also directly acts on your ovaries and adrenals increasing androgens like testosterone and DHEA. It's also the action of insulin on your pituitary that results in increased LH production which over stimulates your ovaries resulting in the characteristic "cysts" of PCOS. ​ High levels of DHEA and testosterone lead to acne and hair growth (hirsutism). ​ But one simple question r Continue reading >>

3 Things You Need To Know About Metformin

3 Things You Need To Know About Metformin

September 30, 2015 by Dr. Brooke in Be Better , Eat Better , pcos 3 Things You Need To Know About Metformin Metformin is recommended by doctors for women with PCOS that want to loose weight or otherwise manage their PCOS and insulin resistance. But there are 3 very important things that you need to know about it including the fact that it's not the only option! Let me first say, I dont hate Metformin for women with PCOS . For some women it really does help spur ovulation, control blood sugar and help with some weight management but.its not without its share of issues. And its definitely not the magic bullet for weight loss although its usually presented that way. How Metformin (or its generic form: Glucophage) Works Metformin is typically given with meals throughout the day, or more commonly now the extended release version is given once with dinner or at bedtime. While only having to pop a pill one time per day is always appealing, this once a day dosing (especially at bedtime) is where I see the most problems with my patients. It lowers both fasting and post meal glucose levels by decreasing the glucose absorption in your intestines after a meal; as well as decreasing the amount of glucose your liver makes for later use. It also does help improve insulin sensitivity by increasing glucose movement into a cell. All sounds good so far right? Not so fast, here are the most common issues I see in women using Metformin: Metformin is notorious for causing sometimes severe digestive issues including stomach pain or upset, nausea, vomiting, diarrhea and even a sense of body weakness or metallic taste in the mouth in some. And it is touted as not causing low blood sugar as many older blood sugar lowering drugs did, however I see it every day in my practice that Metformin can m Continue reading >>

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