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Can Metformin Extended Release Be Cut In Half

When It's Safe To Split Pills

When It's Safe To Split Pills

It sounds simple enough: Cut your pills in half to cut your prescription costs in half. The do-it-yourself practice of pill splitting is one that many doctors and health plans support. It’s a way to counter rising drug prices and encourage people to take their medications if they’re likely to skip doses and refills because of high costs. And those who have trouble swallowing medicine might find a smaller pill easier to manage. How It Works Your doctor will prescribe a higher dose of medication, often double. (Sometimes the higher dose is the same price as the lower dose.) At home, you cut the pills in half and take one half each day, ending up with two doses for the price of one. But deep discounts aren’t guaranteed, so first ask your pharmacist what you’ll save, advises Barbara Young, Pharm.D., editor of consumer-medication information for the American Society of Health System Pharmacists in Bethesda, Md. Note that the Food and Drug Administration has called pill splitting a “risky practice” and doesn’t encourage it unless a drug’s package insert specifically says it has been approved for splitting. But our medical advisers say it’s safe if you follow the guidelines below. Four Smart Steps 1. Get your doctor (or pharmacist) to OK it first. According to an April 2015 poll by Consumer Reports Best Buy Drugs, 8 percent of consumers trying to save money on medications admitted to cutting their pills in half without a doctor’s or pharmacist’s approval. Many drugs—notably most cholesterol-lowering statins, and those to treat high blood pressure and depression—can be split without losing effectiveness or causing a negative health impact, but it can be dangerous for you to divide others. Your doctor may have other reasons to warn you about splitting p Continue reading >>

Diabetes Drugs: Metformin

Diabetes Drugs: Metformin

Editor’s Note: This is the second post in our miniseries about diabetes drugs. Tune in on August 21 for the next installment. Metformin (brand names Glucophage, Glucophage XR, Riomet, Fortamet, Glumetza) is a member of a class of medicines known as biguanides. This type of medicine was first introduced into clinical practice in the 1950’s with a drug called phenformin. Unfortunately, phenformin was found to be associated with lactic acidosis, a serious and often fatal condition, and was removed from the U.S. market in 1977. This situation most likely slowed the approval of metformin, which was not used in the U.S. until 1995. (By comparison, metformin has been used in Europe since the 1960’s.) The U.S. Food and Drug Administration (FDA) required large safety studies of metformin, the results of which demonstrated that the development of lactic acidosis as a result of metformin therapy is very rare. (A finding that has been confirmed in many other clinical trials to date.) Of note, the FDA officer involved in removing phenformin from the market recently wrote an article highlighting the safety of metformin. Metformin works primarily by decreasing the amount of glucose made by the liver. It does this by activating a protein known as AMP-activated protein kinase, or AMPK. This protein acts much like an “energy sensor,” setting off cellular activities that result in glucose storage, enhanced entry of glucose into cells, and decreased creation of fatty acids and cholesterol. A secondary effect of the enhanced entry of glucose into cells is improved glucose uptake and increased storage of glycogen (a form of glucose) by the muscles. Additionally, the decrease in fatty acid levels brought about by metformin may indirectly improve insulin resistance and beta cell func Continue reading >>

Can Metformin Xr Be Cut In Half 153507

Can Metformin Xr Be Cut In Half 153507

Can You Cut Or Split Metformin ER In Half? PharmacistAnswers Due to this release mechanism, Glucophage XR can not be cut or split. . Glumetza ER uses a mechanism known as gastro-retentive technology (also known as 39;Modified Release 39;). The tablets are designed to remain in the stomach and deliver metformin to the upper GI tract over an extended period nbsp; Can Metformin Be Cut? Diabetes Daily I have seen a variety of opposite answers for this on a google search. I have metformin tablets 500mg. I do not believe that they are extended release as the doctor did not write the prescription that way. I would like to split one in half to take half at lunch and half at dinner times. Can these be cut? Quote nbsp; Glucophage XR Uses, Side Effects amp; Warnings affect Glucophage XR? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Other drugs may interact with metformin, including prescription and nbsp; Metformin Extended Release Tablets FDA prescribing information not produce hypoglycemia in either patients with type 2 diabetes or normal subjects (except in special circumstances, see In patients with decreased renal function, the plasma and blood half-life of metformin is prolonged and the renal clearance is decreased (see Table 1; also see nbsp; Diabetes Update: Metformin vs Metformin ER The problem with breaking Metformin ER in half is this: The Extended Release feature of the drug is caused by it being encapsulated in some kind of matrix that digests slowly as it passes though your digestive tract. If you cut it, it will digest faster, so you no longer get the slower, longer action. If it is working nbsp; quot;Do No Continue reading >>

Proper Use

Proper Use

Drug information provided by: Micromedex This medicine usually comes with a patient information insert. Read the information carefully and make sure you understand it before taking this medicine. If you have any questions, ask your doctor. Carefully follow the special meal plan your doctor gave you. This is a very important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed. Metformin should be taken with meals to help reduce stomach or bowel side effects that may occur during the first few weeks of treatment. Swallow the extended-release tablet whole with a full glass of water. Do not crush, break, or chew it. While taking the extended-release tablet, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about. Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way. You may notice improvement in your blood glucose control in 1 to 2 weeks, but the full effect of blood glucose control may take up to 2 to 3 months. Ask your doctor if you have any questions about this. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the Continue reading >>

Why Not Metformin Er (extended Release)?

Why Not Metformin Er (extended Release)?

Regular metformin and the ER are both available in most areas as a $4 generic. Since the regular often causes GI distress, I don't understand why it's not prescribed initially. I could not take the regular at all. It was awful. ER is fine, no problems. I doubt it's less effective. I think it's greatly improved my sensitivity to my own insulin. D.D. Family Type 2 since June 2014, levemir & metformin In my case, I was prescribed the normal initially so I could safely and easily adjust dosage. For example, I can cut a 1000mg Metforming in half for 500mg or take the whole thing (for 1000mg)... or take a full one and half of another (1500mg), etc. etc. Of course, I could always just get 500mg but my doctor found it easier to prescribe with my insurance company 60 1000mgs versus 120 500mgs. Heck, now it's hard to even get 30 1000mg given changes to policies. If you put an infinite number of monkeys in front of an infinite number of typewriters... the smell would be terrible. Another difference is that the regular is effective in one pop. If the dosage is wrong, it will take longer to wear off. Also, the ER can not be cut in half. Another difference is that the regular is effective in one pop. If the dosage is wrong, it will take longer to wear off. Also, the ER can not be cut in half. I found with the regular, it took about 2-3 hours to start working and would wear off about 5 hours. I would take 3 x 850 a day and would have periods where my bg would go quite high because the metformin had worn off. I find even with a reduced amount of the extended , 1000, I am seeing more stable bgs because it lasts longer before wearing off. 115 pounds, Breast Cancer dx'd 6/16, 6 months of chemo and 6 weeks of radiation 2000 metformin ER, 100 mg Januvia,Glimperide, Prolia, Gabapentin, Melo Continue reading >>

Pill Splitting: When Is It Ok?

Pill Splitting: When Is It Ok?

Dr. Orrange is an Associate Professor of Clinical Medicine in the Division of Geriatric, Hospitalist and General Internal Medicine at the Keck School of Medicine of USC. If you take prescription drugs to treat a chronic illness, its possible to save more than 50% off cost of your medication by simply splitting your pills. Sadly, its not all that easy to know when pill splitting is all right. Not all pills can be split. However, many doctors and insurance companies are advising this strategy with an increasing number of medicines. (Its also worth noting that the American Medical Association, the American Pharmacists Association, and most pharmaceutical companies oppose pill-splitting.) Drugs that should usually not be split include capsules, chemotherapy drugs, birth control pills, seizure-related medications, and any pill that has a coating or other controlled- or extended-release feature. Be sure to check with your doctor prior to splitting any medication. Is it scored?Tablets that are scored can be easily split and have been evaluated by the FDA for safety. Invest in a pill splitter. Pill splitters are very inexpensive and carried by most pharmacies. If youre going to split a pill, spend the $5. Only split once. It is only recommended that you split pills in half, not any smaller. The dose per piece is too likely to be uneven and pills may shatter or crumble. Unequal halves. Even scored tablets can be difficult to split into two perfect halves, and medicine is sometimes distributed unevenly within a single tablet. Buy a pill splitter to help and dont split with a knife. Crumbs. Tablets that are round or too small may crumble easily or unevenly when split and that will affect the dose you are actually getting. Dont forget!Patients who are given a higher dose pill and Continue reading >>

Metformin, Oral Tablet

Metformin, Oral Tablet

Metformin oral tablet is available as both a generic and brand-name drug. Brand names: Glucophage, Glucophage XR, Fortamet, and Glumetza. Metformin is also available as an oral solution but only in the brand-name drug Riomet. Metformin is used to treat high blood sugar levels caused by type 2 diabetes. FDA warning: Lactic acidosis warning This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects. Lactic acidosis is a rare but serious side effect of this drug. In this condition, lactic acid builds up in your blood. This is a medical emergency that requires treatment in the hospital. Lactic acidosis is fatal in about half of people who develop it. You should stop taking this drug and call your doctor right away or go to the emergency room if you have signs of lactic acidosis. Symptoms include tiredness, weakness, unusual muscle pain, trouble breathing, unusual sleepiness, stomach pains, nausea (or vomiting), dizziness (or lightheadedness), and slow or irregular heart rate. Alcohol use warning: You shouldn’t drink alcohol while taking this drug. Alcohol can affect your blood sugar levels unpredictably and increase your risk of lactic acidosis. Kidney problems warning: If you have moderate to severe kidney problems, you have a higher risk of lactic acidosis. You shouldn’t take this drug. Liver problems warning: Liver disease is a risk factor for lactic acidosis. You shouldn’t take this drug if you have liver problems. Metformin oral tablet is a prescription drug that’s available as the brand name drugs Glucophage, Glucophage XR, Fortamet, and Glumetza. Glucophage is an immediate-release tablet. All of the other brands are extended-r Continue reading >>

A Ci= Confidence Interval B Extended-release Metformin Was Clinically Similar To Immediate-release Metformin Based On The Pre-defined

A Ci= Confidence Interval B Extended-release Metformin Was Clinically Similar To Immediate-release Metformin Based On The Pre-defined

Page 1 of 22 Metformin Hydrochloride Extended-Release Tablets 500 mg and 1000 mg Rx only DESCRIPTION Metformin hydrochloride extended-release tablets contain an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N, N- dimethylimidodicarbonimidic diamide hydrochloride) is a member of the biguanide class of oral antihyperglycemics and is not chemically or pharmacologically related to any other class of oral antihyperglycemic agents. The empirical formula of metformin hydrochloride is C4H11N5•HCl and its molecular weight is 165.63. Its structural formula is: Metformin hydrochloride is a white to off-white crystalline powder that is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. Metformin hydrochloride extended-release tablets are designed for once-a-day oral administration and deliver 500 mg or 1000 mg of metformin hydrochloride. In addition to the active ingredient metformin hydrochloride, each tablet contains the following inactive ingredients: ammonio methacrylate copolymer type A, ammonio methacrylate copolymer type B, colloidal silicone dioxide, crospovidone, dibutyl sebacate, hypromellose, magnesium stearate, microcrystalline cellulose and povidone. USP dissolution test for metformin hydrochloride extended-release tablet is pending. SYSTEM COMPONENTS AND PERFORMANCE Metformin hydrochloride extended-release tablet is designed for once-a-day oral administration using the swellable matrix coated with a permeable membrane technology. The tablet is similar in appearance to other film-coated oral administered tablets but it consists of a swellable active core formulation that is coated Continue reading >>

Can You Cut Or Split Metformin (immediate Release) In Half?

Can You Cut Or Split Metformin (immediate Release) In Half?

Can You Cut Or Split Metformin (Immediate Release) In Half? Can You Cut Or Split Metformin (Immediate Release) In Half? Can You Cut Or Split Metformin (Immediate Release) In Half? In our latest question and answer, the pharmacist discusses whether or not metformin (immediate release) can be cut in half. Can Metformin 500mg immediate release pills be cut in half? This is not the extended release pill. Yes, the immediate release metformin 500mg (and other strengths) can be cut in half without negatively affecting the medication. Cutting medications is often necessary for patients who have difficulty swallowing large tablets or need to take 'half' doses. If this is necessary, it is certainly OK and safe to cut your metformin tablets. Most manufactures of metformin tablets do not make the tablet with a 'score' mark (indentation in the middle of the tablet) unfortunately, making it sometimes difficult to successfully cut precisely in half. Due to this, a pill cutter is recommended versus using a knife as designed pill cutters will provide the cleanest cut. It is important that you take both halves of the medication as soon as possible and not store cut tablets for extended periods of time. Although metformin can be cut as mentioned above, split tablets no longer have a protective outer coating that most intact tablets have. This could make them more susceptible to moisture. Be sure to use split tablets as soon as you can and store the unused half in a moisture resistant container. Metformin 500 mg is produced by a variety of manufactures including: Continue reading >>

Metformin Cost In Uk! Online Pill Store

Metformin Cost In Uk! Online Pill Store

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Can Glucophage Xr Be Cut In Half - 249228 - Foodinfo.tv

Can Glucophage Xr Be Cut In Half - 249228 - Foodinfo.tv

Glucophage XR Uses, Side Effects amp; Warnings Glucophage XR used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is sometimes used together with insulin or other medications, but this medicine is not for treating type 1 diabetes. Glucophage XR may also be used for purposes not listed in this medication guide.Can you cut in half Metformin ER? PCOS Message BoardYour siggy says you are on 1000 mg. Are you taking 1000 mg tablets or 500 mg tablets? If you are on 1000 mg tablets, you might ask the dr for 500 mg tablets so that you don 39;t have to break the pill. If you are on 500 mg tablets, they do not need to be cut in half.Can Metformin Be Cut? Diabetes DailyCan Metformin Be Cut I would like to split one in half to take half at lunch and half at dinner times. Can these be cut Metformin vs. Metformin XR.can I cut Metformin 500mg ER in half to take? Yahoo AnswersIt 39;s in their design. Unfortunately, Metformin ER tablets are NOT in that group. You can 39;t chew, crush, cut or break in half. You have to take this tablet whole. If you are not on any other diabetes medications it is very, very, very unlikely that Metformin alone can cause hypoglycemia. Metformin can cause gastritis( unset stomach).Can glucophage be cut in half Metformin (Glucophage, Glucophage XR, Glumetza, Fortamet, Riomet) is a prescription drug used for treating type II diabetes in adults and children.Cutting a 500 mg Metformin pill in 1/2 Type 2 Diabetes Cutting a 500 mg Metformin pill in 1/2. as long as its not the XR metformin, I can 39;t imagine it causing a problem. We cut the 500 in half.Kaufen Glucophage Xr Online Besten Preis ApothekeGlucophage Xr kaufen paypal bezahlen. Xr 1000 mg can a metformin pill be cut in half metformin Continue reading >>

When Do I Take Metformin For My Diet: Morning Or Night?

When Do I Take Metformin For My Diet: Morning Or Night?

Metformin helps control blood sugar and increase your body's sensitivity to insulin. The drug is available only by prescription and sold under several different brand names, including Fortamet, Glumetza, Riomet, Glucophage and Glucophage XR. Your dosage will depend on your normal diet and exercise habits -- too much metformin can lead to low blood sugar and hypoglycemia. Always follow your doctor's directions for taking your medication. Video of the Day Metformin works by limiting your liver's production of glucose and stopping your body from absorbing some of the glucose in your bloodstream. Additionally, metformin increases your body's sensitivity to insulin, allowing your pancreas to produce less insulin. Keeping blood sugar levels stable can decrease hunger and food cravings, leading to weight loss. Metformin is not an appetite suppressant, nor does it boost metabolism; to lose weight, you'll still need to pay close attention to your diet and increase your physical activity. Standard vs. Extended Release Options The amount of metformin you'll take depends on why you are using the medication, how often you take the medicine, other medications you might be taking and the time between doses. The National Institutes of Health explains that metformin is available as a tablet or a liquid solution. Tablets come in an extended release dose -- Glucophage XR -- or in a standard release option. Extended release pills are designed to be taken once daily, with your evening meal. Standard tablet and liquid solutions may be taken once or multiple times daily -- with meals. Metformin should be taken with food. Always follow your doctor's orders. It's typical to start with a 500 milligram dose once daily, then increase both the amount of medication and the frequency. If you're using Continue reading >>

Metformin Vs Metformin Er

Metformin Vs Metformin Er

I'm seeing quite a few posts on BBSes from people who are having problems with metformin because of side effects that could be eliminated if they were taking the extended release form of this drug. For some reason, many family doctors don't seem to be aware that there is a ER version of this drug that has such benefits. This is probably because metformin is a cheap generic and isn't promoted by herds of beautiful ex-cheerleaders turned drug company salespushers who "educate" doctors about far more expensive--and less effective--newer drugs. Here are the facts: Metformin (also sold under the brand name Glucophage) comes in a regular version which is taken at meal time, three times a day, and an extended release form (marketed as ER or XR) which is taken once a day. Almost always, when people report diarrhea or intense heartburn with metformin, they are taking regular version. I experienced the heartburn on the regular drug. It was very disturbing because the pain was localized over my heart and felt just like the description of a heart attack you read in articles. My doctor assured me it was coming from the metformin, but that didn't make it any easier to live with because I kept wondering how, if I were having a real heart attack, I'd know it wasn't a pain from the drug? The ER version releases the drug more slowly and this usually eliminates the gastrointestinal problems. The trade off with taking the ER form is that the amount of blood sugar lowering you see might be a bit less than with the regular form as the drug acts in a slower smoother fashion rather than hitting all at once. But if you can't take the regular at all drug because of the side effects, the slight weakening in effect is a reasonable trade off. Plus, you only have to remember to take one dose rather Continue reading >>

Half Life Of Metformin Extended Release

Half Life Of Metformin Extended Release

Metformin Extended Release Tablets - FDA prescribing ... Metformin Extended Release Tablets official prescribing ... subjects suggest that total plasma clearance of metformin is decreased, the half-life is ... Metformin - Wikipedia, the free encyclopedia Biological half-life: 4-8.7 hours: Excretion: Urine (90%) Identifiers; CAS Number: ... Metformin SR (slow release) or XR (extended release) was introduced in 2004. DailyMed - METFORMIN HYDROCHLORIDE - metformin hydrochloride ... Metformin hydrochloride extended - release tablets ... the plasma and blood half-life of metformin is ... METFORMIN HYDROCHLORIDE - metformin ... Diabetes Update: Metformin vs Metformin ER Metformin vs Metformin ER. ... the metabolic half life of metformin er? ... that might change is if it is an extended release version of Metformin, ... Glucophage, Glucophage XR (Metformin Hcl) Drug ... - RxList Learn about clinical pharmacology for the drug Glucophage, Glucophage XR (Metformin ... metformin is decreased, the half-life ... GLUCOPHAGE XR Extended-Release ... PDF GLUCOPHAGE (metformin hydrochloride) Tablets GLUCOPHAGE (metformin hydrochloride) ... GLUCOPHAGE XR (metformin hydrochloride) Extended-Release ... and blood half-life of metformin is prolonged and the renal ... Steady-state pharmacokinetics of a novel extended-release ... Steady-state pharmacokinetics of a novel extended-release metformin formulation. ... Development of a novel extended-release (XR) formulation of ... Half-Life; Humans ... Steady-State Pharmacokinetics of a Novel Extended-Release ... Steady-State Pharmacokinetics of a Novel Extended-Release Metformin ... metformin extended-release ... half-life. The XR and absorption of metformin from ... Diabetes Drugs: Metformin - Diabetes Self-Management Diabetes Drugs: Metformin. . Continue reading >>

Metformin Extended Release Tablets

Metformin Extended Release Tablets

Generic Name: metformin hydrochloride Dosage Form: tablet, extended release Metformin Extended Release Tablets Description Metformin hydrochloride extended release tablets USP are an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. The structural formula is as shown: Metformin hydrochloride is a white to off-white crystalline compound with a molecular formula of C4H11N5· HCl and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. Metformin hydrochloride extended release tablets USP contain 500 mg of metformin hydrochloride USP as the active ingredient. Metformin hydrochloride extended release tablets USP 500 mg contain the inactive ingredients sodium carboxymethyl cellulose, hypromellose and magnesium stearate. Metformin hydrochloride extended release tablets USP 500 mg meets USP dissolution Test 3. System Components and Performance- Metformin hydrochloride extended release tablets USP comprises a swellable matrix system. In the aqueous gastrointestinal (GI) environment, the dosage form swells remarkably thereby increasing in size and geometry from where drug is released slowly by a process of diffusion through the gel matrix that is essentially independent of pH. The hydrated polymer system is not rigid and is expected to be broken up by normal peristalsis in the GI tract. The biologically inert components of the tablet may occasionally remain intact during GI transit and will be Continue reading >>

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