The Interaction Between Grapefruit And Metformin (antidiabetic)
The Interaction Between Grapefruit and Metformin (antidiabetic) ........................................................................................................... Metformin is sold with the name Glucophage and it is an oral prescribed antidiabetic that helps to keep the blood sugar levels in check. Metformin can be used by itself or along with other types of medications to treat type2 diabetes . Metformin helps reducing blood sugar levels by reducing the amount of glucose you absorb from your food and the amount of glucose your liver produces. Eating grapefruits could interfere seriously with certain types of medications, but does grapefruit interfere with the absorption of metformin? No Reported grapefruit Interaction with Metformin Some chemicals found in fresh grapefruits or the products containing grapefruits can interact with the absorption and metabolizing of certain drugs leading to concentrated levels of the drug in the blood. However there was no interaction reported or found between grapefruit and metformin. ..................................................................................................... ...................................................................................................... You may experience strong side effects or adverse effects of the medications if they interact with grapefruits. Eating or drinking grapefruit juice at a different time to taking the medication doesnt really help in the interactions. Some cases reported experiencing adverse effects for the medications even one or two days after eating grapefruit. If you are not sure if the drug you are taking could interact with grapefruit, make sire to ask your doctor or pharmacist before eating any grapefruits. Metformin can be found in regular tablets 500mg, e Continue reading >>
Could Grapefruit Juice Protect Against Diabetes?
"Grapefruit juice 'could be the key to weight loss','' is the misleading headline in The Daily Telegraph. It reports on a study in which mice fed a combination of a high-fat diet and grapefruit juice still put on weight – albeit at a lower rate than mice fed a sugary drink. Their blood sugar levels and insulin sensitivity were also better regulated than mice that did not drink grapefruit juice. The mice were given either a high-fat diet or a low-fat diet in a range of experiments. Mice fed a high-fat diet and grapefruit juice had an 18% reduced rate of weight gain compared with mice given sugary water with the same number of calories as the grapefruit juice. They also had 13% lower fasting blood sugar levels. There was no effect on weight gain in mice fed a low-fat diet. Drinking grapefruit juice improved insulin sensitivity in mice, regardless of their diet (in people, reduced insulin sensitivity can be a sign of impending diabetes). Grapefruit juice lowered blood sugar as effectively as metformin, a drug widely used to treat people with type 2 diabetes. However, none of the mice actually had diabetes, so this research has little immediate relevance to humans with the condition. For the time being, people with diabetes should not swap their metformin for grapefruit juice on the basis of this study. Where did the story come from? The study was carried out by researchers from the University of California and was funded by the California Grapefruit Growers Cooperative, although it had no role in the study design, data collection, analysis or decision to publish. The study was published in the peer-reviewed science journal PLOS ONE. This is an open-access journal, so the study is freely available to all. Both the Mail Online and The Daily Telegraph’s headlines incorrec Continue reading >>
Grapefruit, Orange Juices Can Affect Your Medication
Q. I have understood that grapefruit juice generally should not be used to take medicine. My wife believes that orange juice also is dangerous. She is urging me not to take my pills with orange juice. I understand that grapefruit juice contains an ingredient that orange juice does not and that is what interacts adversely with medicine. This is now becoming a major issue for us. Can you resolve it? A. As with most marital disputes, the answer to your question is complicated. Scientists have known for 25 years that grapefruit juice has a special ability to increase blood levels of certain medications, including the hypertension drug felodipine, cholesterol-lowering meds such as atorvastatin and simvastatin and the anti-anxiety agent buspirone. This can make side effects more severe. The only other fruits that act like grapefruit are Seville (sour) oranges and pomelos. Ordinary orange juice and apple juice can affect other medications in a completely different way (Journal of Clinical Pharmacology online, June 10, 2015). Instead of inhibiting the intestinal enzyme (CYP3A) that metabolizes many medicines, these fruit juices inhibit the compounds that help move certain medications into tissues and cells. The affected drugs include aliskiren (Tekturna), fexofenadine (Allegra) and atenolol (Tenormin), most notably. The impact is to lower tissue levels and effectiveness. The grapefruit effect can last for a few days, while orange juice activity disappears within a few hours. Whether or not you need to avoid taking your medication with grapefruit or orange juice depends on which drug you are taking. Q. I have been on metformin since I was diagnosed with diabetes several years ago. About a year ago, I developed debilitating neuropathy. Just going to the store for an hour kept me Continue reading >>
Can I Have Grapefruit While Taking Metformin?
Many medications, such as statins and some antihistamines, have a negative interaction with grapefruit. Metformin is used in treatment of type 2 diabetes. Does having grapefruit while taking metformin lead to adverse side effects? There’s limited research, but here’s what you need to know. Metformin is a drug that’s prescribed to treat type 2 diabetes. People with type 2 diabetes can’t use insulin normally. This means they can’t control the amount of sugar in their blood. Metformin helps people with type 2 diabetes control the level of sugar in their blood in several ways, including: decreasing the amount of sugar your body absorbs from food decreasing the amount of sugar produced by your liver increasing your body’s response to the insulin that it makes naturally Metformin can rarely cause a very serious and life-threatening condition called lactic acidosis. People with liver, kidney, or heart problems should avoid taking metformin. There are more than 85 drugs that are known to interact with grapefruit. Of these drugs, 43 of them can lead to serious adverse effects. All forms of grapefruit — including freshly squeezed juice, frozen concentrate, and the whole fruit — can lead to drug interaction. Some of the chemicals found in grapefruit can bind to and inactivate an enzyme in your body that’s found in your intestines and liver. This enzyme helps break down the medication you take. Normally when you take a drug orally, it’s broken down slightly by enzymes before it reaches your bloodstream. This means that you receive a little less of the drug in your bloodstream than the amount you initially consumed. But when the enzyme is inhibited — as it is when it interacts with the chemicals in grapefruit — there’s a dramatically larger amount of the dr Continue reading >>
Metformin And Grapefruit
Metformin (Glucophage, Glumetza), used to treat people with type 2 diabetes, is an oral medication used to lower blood glucose levels. Like many medications, Metformin is known to have some food and drug interactions that can have a negative effect on the body, but grapefruit is not one of them. Grapefruit and grapefruit juice, in general, are known to have an interaction with many different drugs, but there is no direct evidence of a negative interaction between this substance and Metformin. Chemicals found in grapefruit can affect the absorption and therefore effectiveness of certain medications. In some cases, grapefruit can decrease the levels of drug in the bloodstream making it ineffective; in rare instances, however, it can actually have the opposite effect, increasing the levels of drug in the system andputting patients at risk of having too much of their medication in their bloodstream. The general consensus at this point is that grapefruit juice, however, does not interact with Metformin. Though most studies have found no interaction between Metformin and grapefruit, a study in 2009 produced an unfavourable result when studying a rat population. Dr. Owira, a pharmacologist from the South African University, noted that the combination raised lactic acid in the rat population, which in turn caused low Ph levels in the body, negatively affecting the metabolism. As this result has not been reproduced, Dr. Owira has not recommended people cut grapefruit consumption completely and has instead suggested additional research to see if the phenomenon also applied to humans. The current status of Metformin with grapefruit consumption is that pharmacists and doctors do not acknowledge an association. The FDA does not give any warnings regarding possible negative interact Continue reading >>
Grapefruit & Metformin
Metformin is a drug used to treat Type 2 diabetes, a condition in which the body does not properly process insulin, leading to high blood sugar levels or hyperglycemia. This drug works by decreasing the amount of glucose your body makes and absorbs from food. Additionally, metformin bolsters your body's reaction to insulin, which helps to lower blood sugar. When you take a medication like metformin, it interacts with enzymes and chemicals in your body through a process called metabolism. Other medications or foods such as grapefruit may influence the way your body metabolizes drugs. Metformin Metformin comes in liquid and tablet form and is taken with meals throughout the day. Typically, diabetics begin on a low dose of metformin and monitor their blood sugar to determine how well the medication is working. Your physician will increase your dose as needed. In some rare cases, metformin may cause a life-threatening condition called lactic acidosis. You should call emergency medical services immediately if you experience extreme lethargy, weakness, nausea, vomiting, stomach pain, irregular heartbeat, shortness of breath, flushed skin, rapid or labored breathing, muscle pain, chills or dizziness. Grapefruit and Drug Metabolism Grapefruit and other citrus fruits and juices contain chemicals that impair your body's ability to metabolize some drugs. With metabolism slowed, medications build up in your body and have the potential to reach lethal levels. Unfortunately, it doesn't matter if you eat grapefruit with your medication or consume it at a different time of day. If a drug interacts with grapefruit or other citrus products, you'll need to eliminate them from your diet. Potentially Harmful Interaction Grapefruit juice is rich naringin, an antioxidant compound with blood s Continue reading >>
Grapefruit Juice May Affect Insulin Resistance
Drinking grapefruit juice daily can lead to weight loss and help control blood glucose… Grapefruit juice is considered to be high in nutrients while remaining relatively low in calories when compared to other fruit juices. These diets often rely on daily low calorie commitment, which calls into question the true weight loss effect of grapefruit juice. Also, previous studies have shown mixed results. The purpose of this study was to determine the impact of using grapefruit juice while maintaining a diet that was high in fat which is typical of many Americans. These results would be compared to those given a low fat diet. The study was performed on mice. The mice were randomized into groups that were given a diluted grapefruit juice or water sweetened with glucose and saccharin. Grapefruit juice use was also compared to water sweetened with glucose and saccharin that contained metformin. Weight and blood glucose samples were collected three times per week. An insulin ELISA was used to monitor insulin concentrations. Results showed that mice fed the high fat diet receiving grapefruit juice weighed 18.4% less than the controls after 100 days (31.4+0.7g vs 38.5+2.8g, P<0.05). This group also saw fasting blood glucose that was 13% lower compared to controls (P<0.05). Fasting serum insulin levels were 72% lower compared to controls (P<0.05). Finally, triglycerides in the liver were reduced by 38% in this group compared to the control group. Those mice on the low fat diet saw a decrease in fasting insulin, but none of the other effects as seen in the high fat diet group. Grapefruit juice use compared favorably to those receiving metformin. Weight loss was seen in both groups with no statistically significant difference noted. Both groups also saw lowered fasting blood glucose Continue reading >>
Who Knew Grapefruit And Metformin Don't Go Together!!!!
Who knew grapefruit and metformin don't go together!!!! Yesterday on facebook I was telling Karen to get some grapfruit to go with her diet. I read in the internet that just the smell of grapefruit helps curb your appetite~~~well she replied that grapefruit and metformin are no nos and she hasn't eaten the fruit in 8 years. Meantime my sis neighbor has three trees we raid every year and I eat tons of grapefruit and love it. Take metformin 750 mg. in the am and pm. Have never noticed any differences in bloodsugar but I don't test that closely probably to tell. I'm posting this msg I saw on internet. It gives a little more explanation. The interaction between grapefruit and some medications was discovered by accident when researchers were looking for an interaction between a particular blood pressure medicine and alcohol. Grapefruit juice was used as a vehicle to mask the taste of the alcohol. While the alcohol did not affect the amount of the drug circulating in the body, the grapefruit juice greatly increased the levels of the medication. It is thought that one or more of the chemicals (most likely flavonoids) in grapefruit juice alter the activity of specific enzymes (such as CYP3A4 and CYP1A2) in the intestinal tract. These enzymes decrease the amount of certain drugs which enter the systemic circulation. This could allow a larger amount of these drugs to reach the bloodstream, resulting in increased Some of the drugs which interact with grapefruit have a narrow therapeutic index. This means that the amount needed for the desired effects are not much lower than the amount that can cause toxicity. In this type of medication even a moderate increase in blood levels could cause harm. Well I'm truly disappointed about this news since I have 10 grapefruits in the fridge. Continue reading >>
Grapefruit Juice And Metformin
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community Can anyone tell me if it's OK to drink grapefruit juice shortly after taking Metformin. I have been doing this occasionally and found that my blood sugar goes up to higher than normal 2 hours later when doing glucose test. This was the only reason I could think of as to why my blood sugar was higher than normal after breakfast. I Googled this and low and behold I have just read that you should not combine the two and I have also read that it does not matter. Suffice to say, I won't be combining them any more! I would also like to take apple cider vinegar every day. Does anyone know if this affects Metformin? I don't know about the combination of metformin and grapefruit juice but have never heard it could be a problem. Carbs in general will raise your bg. There is a lot of sugar in grapefruit juice and possible in other of the food items you have for breakfast like bread or milk so a rise in BG is to be expected. I usually have eggs and such for breakfast and it doesn't move my BG at all. Pretty sure it's fine. I think you may be getting confused with grapefruit juice and statins. The leaflets that come with my metformin tablets (and I've had several different brands!) don't have any warnings about not taking them with grapefruit. As dannyw says, if you take statins then you definitely must not eat grapefruit - and the information leaflet do warn against doing so. Your pharmacist or doctor should be able to give you a definitive answer, so check with them. All fruit juice is high in sugar and will raise blood glucose. It's a big myth that fruit juice is healthy, it's worse than the actual fruit because it's more highly concentrated and doesn't have th Continue reading >>
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Grapefruit Juice And Some Drugs Don't Mix
Subscribe: FDA Consumer Health Information Download PDF (190 K) Grapefruit juice and the actual grapefruit can be part of a healthy diet. Grapefruit has vitamin C and potassium—nutrients your body needs to work properly. But it isn’t good for you when it affects the way your medicines work, especially if you have high blood pressure or arrhythmia (irregular or abnormal heart beat). This food and drug interaction can be a concern, says Shiew Mei Huang, PhD, of the U.S. Food and Drug Administration. The FDA has required that some prescription and over-the-counter (OTC) drugs taken by mouth include warnings against drinking grapefruit juice or eating grapefruit while taking the drug, Huang says. Here are examples of some types of drugs that grapefruit juice can cause problems with (interact): Some statin drugs to lower cholesterol, such as Zocor (simvastatin) and Lipitor (atorvastatin). Some drugs that treat high blood pressure, such as Procardia and Adalat CC (both nifedipine). Some organ-transplant rejection drugs, such as Sandimmune and Neoral (both cyclosporine). Some anti-anxiety drugs, such as buspirone. Some corticosteroids that treat Crohn’s disease or ulcerative colitis, such as Entocort EC and Uceris (both budesonide). Some drugs that treat abnormal heart rhythms, such as Pacerone and Nexterone (both amiodarone). Some antihistamines, such as Allegra (fexofenadine). Grapefruit juice does not affect all the drugs in the categories above. The severity of the interaction can be different depending on the person, the drug, and the amount of grapefruit juice you drink. Talk to your doctor, pharmacist or other health care provider and read any information provided with your prescription or OTC drug to find out: If your specific drug may be affected. How much, if a Continue reading >>
Grapefruit With Some Medications: Risky Business
Nov. 27, 2012 -- The number of drugs that can be risky when taken with grapefruit is on the rise, largely due to the influx of new medications and chemical formulations, a new study shows. As it stands, there are now more than 85 drugs that may interact with grapefruit. The number of drugs that may result in potentially fatal side effects when mixed with grapefruit increased from 17 to 43 during the past four years. This equates to more than six new potentially risky drugs a year. The list includes some statins that lower cholesterol (such as atorvastatin , lovastatin , and simvastatin ), some antibiotics, cancer drugs, and heart drugs. Most at risk are older people who use more prescriptions and buy more grapefruit. Heres what happens: Grapefruit contains furanocoumarins, which block an enzyme that normally breaks down certain medications in the body. When it is left unchecked, medication levels can grow toxic in the body. Its not just grapefruits, either. Other citrus fruits such as Seville oranges (often used in marmalade), limes, and pomelos also contain the active ingredients (furanocoumarins), but have not been as widely studied. Grapefruit and Some Medications: Risky Business Researchers searched the medical literature for articles on grapefruit and drug interaction using key terms. They also looked at prescribing information for recently approved drugs in Canada. Their findings appear in the Canadian Medical Association Journal. Drugs that interact with grapefruit are taken by mouth. The degree of the grapefruit effect can vary. With some drugs, just one serving of grapefruit can make it seem like a person is taking multiple doses of the drug. This interaction can occur even if grapefruit is eaten many hours before taking the medication. For example, simvastati Continue reading >>
Grapefruit Juice May Be As Effective As Diabetes Drugs
TIME Health For more, visit TIME Health. A new mice study suggests that grapefruit juice might be just as effective as the type 2 diabetes drug, metformin, at lowering blood glucose. The research, which was funded by the California Grapefruit Growers Cooperative, was published Wednesday in the journal PLOS ONE. Regarding the funding, study co-author Joseph Napoli, PhD, professor and chair of nutritional sciences and toxicology at the University of California, Berkeley, said this: “I understand the skepticism.” But the funders had nothing to do with the experiment, he says, besides providing some money and grapefruits. “We were very clear in telling them, you’re going to get the data we get,” Napoli says. “We can’t guarantee you’re going to like what you see. It might be nothing.” What they found was not nothing. The researchers fed different groups of mice a range of liquids: sweetened diluted grapefruit juice, sweetened water, and water that contained metformin, a diabetes drug. The mice who were fed a high-fat diet typical of the average American and drank the grapefruit juice lost 18% more weight than those drinking sweetened water, and they had a 13-17% drop in blood glucose levels and threefold decrease in insulin levels. (Mice on a low-fat diet had far less dramatic effects.) But one of the biggest findings was that mice drinking grapefruit juice had glucose-lowering effects that were just as potent as the mice who sipped on metformin. “It was very surprising,” says Napoli. You might have to drink a lot to get those prescription-level effects, however. The amount of grapefruit juice used in mice equates about four cups a day in people, the study says. But the researchers were so encouraged by the results that they plan to next look at if lowe Continue reading >>
Can U Eat Grapefruits With Taking Metformin 500mg?
Home Q & A Questions Can u eat grapefruits with... Can u eat grapefruits with taking metformin 500mg? Yes, it is fine to eat grapefruit while taking metformin. There are no known interactions between them. Still looking for answers? Try searching for what you seek or ask your own question . The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Subscribe to receive email notifications whenever new articles are published. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated Feb 28th, 2018), Cerner Multum (updated Mar 1st, 2018), Wolters Kluwer (updated Mar 1st, 2018) and others. To view content sources and attributions, please refer to our editorial policy . Continue reading >>
Grapefruit And Metformin May Have Ill Effects On The Bodys Ph Levels
Grapefruit and Metformin May Have Ill Effects on the Bodys pH Levels A South African university pharmacologist has found that simultaneous consumption of metformin and grapefruit juice raises lactic acid to dangerous levels in rats (and conceivably in people) with type 2 diabetes. Too much acid in the blood can cause low pH levels that interfere with the bodys metabolic functions. Conceivably, says Dr. Peter Owira, a pharmacologist at the University of KawZulu-Natal, such low levels could be fatal. Dr. Owiras research involved three groups of non-diabetic rats, each of which received a different dose of grapefruit juice. While two groups ingested juice only, a third group ingested both grapefruit juice and metformin. Results showed that all three groups experienced lowered glycemic levels. The group receiving both juice and metformin, however, also developed what Dr. Owira calls metformin-induced lactic acidosis, a condition in which lactic acid levels climb to very high, and potentially dangerous, levels. Dr. Owira notes that grapefruit juice is a popular drink among South Africans with type 2 because it assists in weight control and helps lower blood glucose levels. By itself, he says, grapefruit juice is fine. The problem arises when it is consumed in combination with metformin-a common occurrence because in South Africa, as in the United States, metformin is the number-one oral drug consumed by type 2s. Given the differences between rat and human metabolism, however, Dr. Owira does not directly recommend that type 2s curb their consumption of grapefruit juice. He will publish his findings in Methods and Findings in Experimental and Clinical Pharmacology for 2009, an international scientific journal. Your email address will not be published. Required fields are mark Continue reading >>
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Grapefruit: Uses, Side Effects, Dosage, Interactions & Warning
Bioflavonoid Complex, Bioflavonoid Concentrate, Bioflavonoid Extract, Bioflavonoids, Bioflavonodes, Bioflavonodes d'grumes, Citrus Bioflavones, Citrus Bioflavonoid, Citrus Bioflavonoid Extract, Citrus Bioflavonoids, Citrus Flavones, Citrus Flavonoids, Citrus Grandis Extract, Citrus paradisi, Citrus Seed Extract, Cold-Pressed Grapefruit Oil, Complexe Bioflavonode, Complexe Bioflavonode de Pamplemousse, Concentr de Bioflavonode, CSE, Expressed Grapefruit Oil, Extrait de Bioflavonode, Extrait de Bioflavonodes d'Agrumes, Extrait de Graines de Pamplemousse, Extrait de Pamplemousse, Extrait Normalis de Pamplemousse, Flavonodes d'Agrumes, Grapefruit Bioflavonoid Complex, Grapefruit Extract, Grapefruit Oil, Grapefruit Seed Extract, Grapefruit Seed Glycerate, GSE, Huile de Pamplemousse, Huile de Pamplemousse Presse Froid, Pamplemousse, Pamplemousse Rose, Paradisapfel, Pink Grapefruit, Pomelo, Red Mexican Grapefruit, Shaddock Oil, Standardized Extract of Grapefruit, Toronja. Grapefruit is a citrus fruit. People use the fruit, oil from the peel, and extracts from the seed as medicine. Grapefruit seed extract is processed from grapefruit seeds and pulp obtained as a byproduct from grapefruit juice production. Vegetable glycerin is added to the final product to reduce acidity and bitterness. Grapefruit juice is used for asthma, high cholesterol, "hardening of the arteries" (atherosclerosis), cancer, improving levels of red blood cells, a skin disease called psoriasis, and for weight loss and obesity. It is also used to reduce stomach complaints in people with eczema (atopic dermatitis). Grapefruit seed extract is taken by mouth for bacterial, viral, and fungal infections including yeast infections. Grapefruit oil is applied to the skin for tired muscles, hair growth, toning the ski Continue reading >>