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Why Is Diabetes Genetic?

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Genetics Of Diabetes

You've probably wondered how you got diabetes. You may worry that your children will get it too. Unlike some traits, diabetes does not seem to be inherited in a simple pattern. Yet clearly, some people are born more likely to get diabetes than others. What leads to diabetes? Type 1 and type 2 diabetes have different causes. Yet two factors are important in both. First, you must inherit a predisposition to the disease. Second, something in your environment must trigger diabetes. Genes alone are not enough. One proof of this is identical twins. Identical twins have identical genes. Yet when one twin has type 1 diabetes, the other gets the disease at most only half the time. When one twin has type 2 diabetes, the other's risk is at most 3 in 4. Type 1 diabetes In most cases of type 1 diabetes, people need to inherit risk factors from both parents. We think these factors must be more common in whites because whites have the highest rate of type 1 diabetes. Because most people who are at risk do not get diabetes, researchers want to find out what the environmental triggers are. One trigger might be related to cold weather. Type 1 diabetes develops more often in winter than summer and is Continue reading >>

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  1. xnikx

    Active Low-Carber Forums

    i been on it almost 3weeks and iv lost aptetite and feelin really low
    and sugestions?? :help:

  2. xnikx

    got weighed at the docs today, have lost 3 kilos in a month and four days :D

  3. xnikx

    takin metformin sucks
    iv been feelin sick for the past 3 days constantly. i cant eat cause the thought of food makes me heave, and then i start to feel the hunger and cause i cant eat it makes me feel even sicker, then feel weak and faint and then get the headache. no wonder people lose alot of weight on it with these kinda side affects
    is this normal sufferin?

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Type-2 Diabetes: A Cocktail Of Genetic Discovery

Type-2 diabetes: a cocktail of genetic discovery Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD To whom correspondence should be addressed. Email: [email protected] Search for other works by this author on: Human Molecular Genetics, Volume 15, Issue suppl_2, 15 October 2006, Pages R202R209, H. Freeman, R.D. Cox; Type-2 diabetes: a cocktail of genetic discovery, Human Molecular Genetics, Volume 15, Issue suppl_2, 15 October 2006, Pages R202R209, Diabetes is one of the most challenging health problems of the 21st century with an alarming increase in the prevalence of type-2 diabetes mellitus (T2DM) and associated conditions such as hypertension, dyslipidemias and obesity. T2DM is a complex genetic disease comprised of many metabolic disorders with a common phenotype of glucose intolerance. Patients with T2DM would have inherited a variety of different genetic factors that together with environmental factors combine as the primary cause. This complicates the genetic study of the disease and means that different methodological approaches are needed if we hope to identify susceptibility genes and genetic variants. The bio Continue reading >>

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  1. louisecochranex

    my names louise, am 17 years old and was diagnosed with PCOS two years ago and have finally been put on metformin and was kinda wondering if its worth my while ? many thanks if someone could help xx

  2. RALH

    Hi,
    I have been on metformin since the beginning of the year for PCOS, I was not ovulating and now am so it must do something x

  3. mamabear85

    I was also on metformin for a few month and i cant really tell it did help me but everyone is differnt.

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Genetics Of Type 1 Diabetes

The HLA region maps to chromosome 6p21.31. The classical HLA loci are encoded in a region of DNA approximately 4 Mb, with the class II loci at the centromeric end of the region and the class I loci at the telomeric end. The region contains >200 identified genes, over half of which are predicted to be expressed. A schematic representation of the HLA region, with T1D-relevant genes indicated, is shown in Figure 1. Only some of the HLA region genes are involved in the immune response; in particular, the genes that encode the classical HLA class I (A, B, and C) and class II (DR, DQ, and DP) antigens. Genes encoding classical HLA class I and class II antigens flank a chromosomal region that is sometimes referred to as the “class III region,” which contains some immunologically relevant genes (e.g., tumor necrosis factor [TNFA]) but no classical HLA genes. Products of loci encoding the six classical class I (A, B, and C) and class II (DR, DQ, and DP) antigens are structurally similar, cell-surface proteins that bind antigenic peptides and present them to T cells. DR-encoding genes differ from those encoding DQ and DP in two important ways. First, the DRA1 gene, which encodes the α c Continue reading >>

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  1. carlabul

    What is the difference between humulin r and humulin n?

    What is the difference between humulin r and humulin n?

  2. PS Psyched

    Carlabul,
    The difference is their reaction times. Humulin R is short acting insulin, regular and it begins to work within 30 minutes of administering it, peaks at 2.5 to 5 hours, and lasts up to 6 hours. Humulin N is intermediate acting insulin in an isophane suspension-it begins working 1.5 to 4 hours after administering it, peaks 4-12 hours, and can last up to 24 hours in the body. Hope this helps.

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