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Which Type Of Antidiabetic Drugs Is Injected Subcutaneously To Treat Type 2 Diabetes?

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Curcumin Combination With Anti-type 2 Diabetic Drugs For Prevention And Treatment Of Disease Sequelae, Drug-related Adverse Reactions, And Improved Glycemic Control

Compositions and methods for treating type 2 diabetes and its sequelae by intravenous or subcutaneous administration of formulations of synthesized curcumin (diferuloylmethane) and concomitantly one or more anti-diabetic agents to human subjects are disclosed herein. The composition of the present invention may be used to: (i) treat patients with diabetes in advanced stages with evidence of any or all encephalopathy, retinopathy, nephropathy, pancreatitis or neoplasias; (ii) treat patients with diabetic disease status without symptomatic or pathologic evidence of associated sequelae but requiring better glycemic control than that offered by standard of care anti-diabetic; and (iii) patients with objective signs or symptoms of sequelae from diabetes of anti-diabetic drugs. One three-drug combination of the present invention includes a slow release PLGA-curcumin and an oral gliptin (DPP-4)-inhibitor or any incretin-mimetic and metformin. WHAT IS CLAIMED IS: 1. A composition for ameliorating symptoms and/or treating type 2 diabetes and one or more associated pathological conditions (sequelae) in a human subject comprising: a therapeutically effective amount of a formulation comprising

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  1. Gabby PA

    Cleaning Up With Beets

    I received an interesting newsletter today from "The Healing Gourmet" that talked about the great properties of beets. I was thrilled. I love beets, but since being diagnosed, I tend to stay away from them. But the article shared about how beets are of the family of foods that have an enzyme that helps clean the liver.
    "As your liver breaks down and eliminates harmful compounds, dangerous free radicals are formed as a byproduct. Glutathione enzymes are there to neutralize these compounds. However, these enzymes can become depleted. That's why it's critical to consume glutathione-boosting foods - and beets are one of the best."
    Of course you want to watch your glucose levels and beets can be a no-no for some. But with all the drugs we tend to take, this liver cleanser just seems to fit the bill.
    "Harmful compounds can enter your body through diet, alcohol consumption, pharmaceutical drugs, and the application of chemical substances on the skin. In today's world, your liver has a big job to do in neutralizing these damaging substances.
    But the great news is that certain foods can make the load on your liver lighter. And earthy, crimson-hued beets are one of the most powerful liver-protecting foods you can eat."
    So I had beets for dinner tonight!

  2. roses.815

    New to the site glad to hear the good things said here about beets as I love them.

  3. rickster912

    Jaybee I agree with you. Too much of anything is bad for you. Not including sex lol. Anyway I had too much potassium as well from drinking a lot of coconut water and juicing beets. I've calmed down to twice a week now and my body has been so much responsive.

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Liraglutide (subcutaneous Route)

lir-a-GLOO-tide Subcutaneous route(Solution) Dose-dependent and treatment-duration-dependent thyroid C-cell tumors have occurred in rats and mice at clinically relevant exposures. It is unknown whether this risk translates to humans. This drug is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2. Monitoring of serum calcitonin or thyroid ultrasounds for early detection of MTC may not be beneficial . Commonly used brand name(s) In the U.S. Saxenda Victoza Available Dosage Forms: Solution Therapeutic Class: Antidiabetic Pharmacologic Class: Glucagon-Like Peptide-1 Receptor Agonist Uses For liraglutide Liraglutide injection is used to treat a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. Liraglutide is to be used when diet and exercise do not result in good blood sugar control. liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist. Liraglutide injection is also used together with a reduced-calorie diet and proper exercise to help you lose weight and help keep the lost weight from returning. It is may be used in overweight people who may also have diabetes, high b Continue reading >>

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  1. Krysten

    Ingrown toenails and diabetes

    OK so this is probably a very weird question. . But tried researching this and didn't get any kind of definitive answer. . Is there any kind of correlation between diabetes and developing ingrown nails?
    At the same time last year I developed them on both of my big toes. I have never had this happen before, but it has been an issue for the past year.
    I could understand if my feet were swollen but they are not.
    Again apologies for the randomness of this question.

  2. Molly24

    I don't think so and the reason is my husband has had them and my daughter too, both non-diabetics.

  3. PeterPumper

    I don't believe the issue is Getting them, as much as the fact that once you get them, they heal slower (as does nearly everything with us, so they become a larger concern.

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Oral Hypoglycemics for Diabetes Mellitus Type 2 1. Oral Sulfonylureas - Tolbutamide, Acetohexamide, Chlorpropramide, Glyburide, Glipizide, Glimeplide 2. Metfromin - Glucophage 3. Thiazolidindiones - Tioglitazone, Rosiglitazone, Pioglitazone 4. Glucosidase Inhibitors 5. GLP-1 Incretin - Exanetide, Sitagliptin

Oral Hypoglycemics

1. ORAL HYPOGLYCEMICS AND INSULIN Free Powerpoint Templates Page 1 2. DIABETES• A chronic metabolic disorder characterised by a high blood glucose concentration- hyperglycaemia• fasting plasma glucose > 7.0 mmol/l, or plasma glucose> 11.1 mmol/l 2 hours after a meal• caused by – insulin deficiency – insulin resistance Free Powerpoint Templates Page 2 3. PATHOGENESISGENTIC SUSCEPTIBILITY*Concordance in identical twins*susceptibility gene on HLA region in chromosome 6 ENVIRONMENTAL FACTORS *Viral infections *experimental induction with chemicals AUTO IMMUNE FACTORS *Islet antibodies *Insulinitis *CD8+T lymphocyte mediated beta cell destruction TYPE 1 DIABETES MELLITUS Free Powerpoint Templates Page 3 4. PATHOGENESIS GENETIC FACTORS CONSTITUTIONAL DECREASED INSULIN FACTORS SECRETION*conordance in identical twin *obesity *lipotoxicity *both parents diabetic *hypertension *Glucose toxicity of islet 50% risk to child *low physical activity cellsINSULIN RESISTANCE *Receptor & post receptor defects INCREASED HEPATIC GLUCOSE SYNTHESIS HYPERGLYCAEMIA *Impaired glucose utilisation TYPE 2 DIABETES MELLITUS Free Powerpoint Templates Page 4 5. TYPES OF DIABETESFEATURE TYPE1DM TYPE2 DMF Continue reading >>

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  1. wineguy

    Increase Metformin Dosage? A1c Good But Not Good Enough

    Hi All,
    Qualifier - I know the forum is not for medical advice. It's the process I'm trying to grasp.
    Here's the background:
    My A1c, newly dx'd was 9.1 on 2/29/2012. On 6/14/2012 I was 5.9. 500mg Metformin 2x daily. Low carb and exercise of course. OK that is moving in the right direction.
    My family doc suggested taking me off Metformin if my next A1c in September is as low or lower. ???? I thought normal is an avg BG of 85, not 120. My meter is always seems to be at 97-106, lower after exercise, seldom higher; however, I want to be at 85 and no higher than 100. At this point, exercise and diet cannot permanently be improved.
    Is increasing Met dosage a valid discussion? Can anyone share their story on how they approached this? Is this where a philosophical difference with your provider means that you move on? BTW, we have not yet discussed this yet.
    Thanks in advance for your comments.

  2. Miss_Blue

    The ADA recommends <7%, so many doctors are delighted when they see an A1c in the 5% range at all. A 5.9% is a good A1c for a diabetic, but if you feel that you'd like to aim for something closer to normal (low 5% range, maybe even <5%), then that's great. That's my goal, as well.
    Metformin is probably the safest diabetic oral medication on the market. If you're not experiencing any side effects or low blood sugar - which is extremely rare, anyway - on this medication, then I don't see any reason to stop it, especially if it's helping you control your blood sugar right now. You could even go up on your dosage.
    As for my experience, I have a major philosophical difference with my doctor. I lost a bunch of weight, she insisted I'm cured, and wanted to take me off Metformin. When I said I'm not having hypoglycemia, that it's helping my blood sugar, and maybe my weight loss, she could only said, "You shouldn't be using Metformin for weight loss." We had a brawl in her office over this issue and she finally conceded that she'll continue to prescribe it and that I should lower the dose as I feel comfortable over the next few months. I explained that I didn't want to suddenly go off my medication and that I'd test the waters by reducing slowly.
    Maybe you can work out an arrangement with your doctor like that. I don't know. Make sure to show him your BG logs so that he knows you aren't going low. My doctor was so afraid of that. She assumed my A1c (4.9%) was a result of hypoglycemia, as though no one can get that A1c without low blood sugar.

  3. moon

    Where we want our blood sugar is a personal decision, and every body seems capable of different numbers. You're knowledgeable enough about ranges and what your own goal is, so I'll address only my own:
    My A1C is in the high 5's, I'd like it to be in the low 5's but am frankly more concerned about keeping my bs curve during the day as flat as possible. Mostly, I don't want spikes. So my goal is to keep my bs <100 fasting, and I'm most happy when I'm in the 80's though that seems to be only half the time. I don't like being >120 ever and rarely am now.
    I do take 1000 mg metformin daily, but continue considering dropping it to see if I can keep my numbers where they are without it. Why? I'm happiest when I don't need medication at all, and have been dropping any meds in my life that I can - not because metformin is a bad drug, there are many good things about it, but if I can do without a med it's my first choice.
    In this post Daytona gives links to some good info on what the A1C actually is, what it measures and what it doesn't.
    Welcome to the forum.

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