Which Insulin Has The Fastest Onset Of Action?

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New Faster Aspart Insulin Gives Faster Onset, Earlier Exposure In T1 Kids

Insulin found to provide better control of post-prandial glucose without significantly elevating hypoglycemia risk. Type 1 diabetes is usually detected early in childhood or youth, which prompts them to use daily insulin therapy for life. This is also a period of continuous changes in diet, body weight and insulin sensitivity, and parental assistance. All these factors make their therapy more difficult to adjust. As a result, these young patients seldom meet their HbA1C goals. The use of rapid-acting insulin represents an advantageous therapy approach for reducing post-prandial glucose levels when they are not properly controlled with long-acting basal insulin. Commonly used fast-acting agents include: Lispro (Humalog) and Aspart (Novolog) insulin; however, they may not get absorbed fast enough to achieve the glycemic targets as well as delay the elimination, which may cause post-meal hypoglycemia. The introduction of faster-acting insulin may offer earlier exposure and higher absorption compared to normal fast-acting insulins. Faster-acting insulin Aspart (FIAsp) has already been approved in adults achieving great outcomes controlling the HbA1c when tested versus normal Aspart (I Continue reading >>

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  1. PurpleButterfies

    Conflicting stories about taking metformin - will it help my weight and PCOS?

    My gyno prescribed metformin 500 mg 2 x day for PCOS. He said it was an anti-diabetic but that it is also taken for PCOS. I have had a hard time managing my weight and he thought that it would help. Well I just saw a gastroenterologist for some other issues, and he said I was on a lot of medication, which I agreed, but I take them all because I need to. He asked if I had diabetes because I take metformin, and I said No, that I take it for PCOS and that I was maybe pre-diabetic because I haven't been managing my weight well. He said metformin the purpose of metformin was to utilize sugar by turning it into fat, so it was not going to help me loose weight, it would do the opposite. This thoroughly confused me. I said I was under the impression that it was to keep your sugar leveled... we started to get into a disagreement so I just said ok. Well I am really upset. I have been on it for several months. At first it made me really sick but not so much anymore. But I haven't lost any weight. I am just really confused now. Can anyone offer me their advice, experience, or opinion... it would be appreciated. Thanks.

  2. LA

    The following explain in detail what your gyn is hoping to accomplish:
    Metformin, sold under the trade name Glucophage, is used to treat diabetes, but several studies show that it also helps non-diabetics to lose weight by reducing hunger (1).


  3. PU PurpleButterfies

    Thank you for all the helpful information LaurieShay. Can you please tell me the article you were referencing this information from... I would like to print it out for my gastro. I printed straight from here for me to reference what you were saying, but I'd like the article as well. Thank you so much. I think I've looked at pcossupport.org before and will check it out again. Thanks again.

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Comparative Pharmacokinetics And Insulin Action For Three Rapid-acting Insulin Analogs Injected Subcutaneously With And Without Hyaluronidase

Comparative Pharmacokinetics and Insulin Action for Three Rapid-Acting Insulin Analogs Injected Subcutaneously With and Without Hyaluronidase 1Profil Institute for Clinical Research, Chula Vista, California and 2Halozyme Therapeutics, San Diego, California Corresponding author: Daniel E. Vaughn, [email protected] Received 2012 Apr 26; Accepted 2012 Jul 31. Copyright 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See for details. This article has been cited by other articles in PMC. To compare the pharmacokinetics and glucodynamics of three rapid-acting insulin analogs (aspart, glulisine, and lispro) injected subcutaneously with or without recombinant human hyaluronidase (rHuPH20). This double-blind six-way crossover euglycemic glucose clamp study was conducted in 14 healthy volunteers. Each analog was injected subcutaneously (0.15 units/kg) with or without rHuPH20. The commercial formulations had comparable insulin time-exposure and time-action profiles as follows: 50% exposure at 123131 min and 50% total glucose infused at 183186 min. With rHu Continue reading >>

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  1. Dietbeeties

    Insulin that was left out

    Just curious how long can insulin be left out and still be usable? We went to a birthday party last night (for one of the kids' friends) and it was late when we left. When we got home I grabbed all their treat bags and prizes and totoally forgot about my insulin pouch! (I had put it in the glovebox to kind of hide it from the kiddos). Anyways, when I went to take my shot this morning is when I realized what I did. The cold pack wasn't necessarily cold anymore. I went ahead and opened a new bottle of N, but was out of the R…which I am supposed to pick up a refill tomorrow. I went ahead and took some of the R, and I only need to use it til tomorrow. Just for future reference..how long can it stay out and still be good?

  2. Diabetic Angel

    I left an unopened vile of insulin out is it still good?

  3. Sarhindi

    I am new here, been diabetic type 2, for the past 8 years. Just one query, I am on lantus, i keep my lantus penfil stock refrigrated, living alone and not using refrigerator for quite some time, my refrigerator gave up on me with out me knowing, the temperature inside was moderate and not ideal (between 2 - 8 C) i had roughly 3 packs full of lantus, so are they all gone BAD?

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New Inhaled Insulin Has Rapid Onset Of Action

ADA 2009: New Inhaled Insulin Has Rapid Onset of Action With No Adverse Effect on Lung Function June 8, 2009 (New Orleans, Louisiana) A new formulation of inhaled insulin called technosphere insulin (Afresa, Mannkind Corp) is safe and effective, with an onset of action similar to endogenous insulin. It has an extremely low incidence of hypoglycemia and is associated with some weight loss in patients with type2 diabetes. Importantly, the new formulation appears to have little adverse effect on pulmonary function, unlike its former competitor Exubera (Pfizer, taken off the market in October 2007). Inhaled technosphere insulin is the subject of a large number of presentations here at the American Diabetes Association 69th Scientific Sessions. Elizabeth Potocka, MD, clinical researcher at Mannkind Corporation in Valencia, California, and colleagues conducted a comparison of 45U of inhaled technosphere insulin, 12IU of subcutaneous lispro insulin (Humalog, Eli Lilly), and 4mg of inhaled Exubera insulin with a meal challenge in 18 insulin-treated patients with type2 diabetes and normal pulmonary function. Technosphere insulin had an onset of action that was evident within 10 minutes of Continue reading >>

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  1. petrcvancar

    Glucose Meters Comparison Study

    Plenty of diabetics are not satisfied with the accuracy of their BG meter. Some of them also noticed different BG readings with same blood sample on different BG meters. The reason might be "artificial" systematic bias implemented by manufactures into BG meters.
    There has been made independent research comparing accuracy of 14 BG meters. In case you are interested check the research results on https://blog.gandalf.cz/t1d-en/glucose-meter-comparison-study

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