Metformin, The Anti-aging Miracle Drug
Metformin, The Anti-Aging Miracle Drug Diabetes Drugs Take A BAD RAP This article is part two of a series, for part one, click here. You probably think of Diabetes Drugs as all lumped together as “Bad Drugs”. For many years , I certainly did. Perhaps it was the Avandia story that gave Diabetes Drugs a Bad Rap and made us think poorly of ALL Diabetes Drugs. Upper Left Image: Photo of French Lilac Plant , the plant origin of Metformin, courtesy of Wikimedia Commons. Avandia, the “BAD Drug” for Diabetes Take the case of Avandia, approved in 1999, it quickly became the world’s best selling diabetes drug. However, 8 years later, the New England Journal reported that Avandia causes increased heart attack rates, and sales were suspended in Europe.(1A) In November 2011, GlaxoSmithKline admitted they withheld safety data on Avandia and agreed to pay the US government 3 billion in civil and criminal penalties related to illegal marketing. The Avandia case gave all diabetes drugs a “Bad Rap”. The reality is that there is one diabetes drug that has stood the test of time, and is in fact a “Good Drug”. This is Metformin. Perhaps the plant origin of the drug makes it a “good drug”. Metformin, the “Good Drug” Is There Anyone Who Should not Take It ? At the May 2012 Orlando A4M Meeting, Terry Grossman, M.D. from Golden Colorado gave an excellent presentation on Metformin. Credit and thanks goes to Terry Grossman MD for sharing his talk at the meeting with all of us. Much of this article comes from Grossman’s PowerPoint slides. Dr Terry Grossman is co-author of the Ray Kurzweil book, Fantastic Voyage. Upper Left Image : Photo of Terry Grossman MD, courtesy of Terry Grossman MD. Metformin by Terry Grossman MD- Metformin Discovery and Approval Discovered in the Continue reading >>
What Is Metformin?
MORE Metformin is a prescription drug used primarily in the treatment of Type II diabetes. It can be used on its own or combined with other medications. In the United States, it is sold under the brand names Fortamet, Glucophage, Glumetza and Riomet. "Metformin is very often prescribed as the first step in a diabetic's regime," said Ken Sternfeld, a New York-based pharmacist. How it works "When you're diabetic you lose the ability to use the insulin you need to offset the food," Sternfeld explained. "If you eat a carb or sugar that can't be metabolized or offset by the insulin you produce, your sugar levels will be higher. Metformin and drugs in that category will help your body better metabolize that food so that insulin levels will be able to stay more in line." Metformin aims to decrease glucose production in the liver, consequently lowering the levels of glucose in the bloodstream. It also changes the way that your blood cells react to insulin. "It makes them more sensitive to insulin," said Dr. Stephen Neabore, a primary care doctor at the Barnard Medical Center in Washington, D.C. "It makes the same amount of insulin work better. It transports the insulin to the cells in a more effective way." Metformin may have a preventive health role, as well. New research presented at the American Diabetes Association 2017 Scientific Sessions showed that long-term use of metformin is particularly useful in preventing the onset of type II diabetes in women who have suffered from gestational diabetes. Because metformin changes the way the body uses insulin, it is not used to treat Type I diabetes, a condition in which the body does not produce insulin at all. Metformin & PCOS Metformin is sometimes prescribed to treat polycystic ovarian syndrome (PCOS), according to Neabore. "I Continue reading >>
Metformin may rarely cause a serious, life-threatening condition called lactic acidosis. Tell your doctor if you have kidney disease. Your doctor will probably tell you not to take metformin. Also, tell your doctor if you are over 65 years old and if you have ever had a heart attack; stroke; diabetic ketoacidosis (blood sugar that is high enough to cause severe symptoms and requires emergency medical treatment); a coma; or heart or liver disease. Taking certain other medications with metformin may increase the risk of lactic acidosis. Tell your doctor if you are taking acetazolamide (Diamox), dichlorphenamide (Keveyis), methazolamide, topiramate (Topamax, in Qsymia), or zonisamide (Zonegran). Tell your doctor if you have recently had any of the following conditions, or if you develop them during treatment: serious infection; severe diarrhea, vomiting, or fever; or if you drink much less fluid than usual for any reason. You may have to stop taking metformin until you recover. If you are having surgery, including dental surgery, or any major medical procedure, tell the doctor that you are taking metformin. Also, tell your doctor if you plan to have any x-ray procedure in which dye is injected, especially if you drink or have ever drunk large amounts of alcohol or have or have had liver disease or heart failure. You may need to stop taking metformin before the procedure and wait 48 hours to restart treatment. Your doctor will tell you exactly when you should stop taking metformin and when you should start taking it again. If you experience any of the following symptoms, stop taking metformin and call your doctor immediately: extreme tiredness, weakness, or discomfort; nausea; vomiting; stomach pain; decreased appetite; deep and rapid breathing or shortness of breath; dizzi Continue reading >>
Drug information provided by: Micromedex This medicine usually comes with a patient information insert. Read the information carefully and make sure you understand it before taking this medicine. If you have any questions, ask your doctor. Carefully follow the special meal plan your doctor gave you. This is a very important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed. Metformin should be taken with meals to help reduce stomach or bowel side effects that may occur during the first few weeks of treatment. Swallow the extended-release tablet whole with a full glass of water. Do not crush, break, or chew it. While taking the extended-release tablet, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about. Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way. You may notice improvement in your blood glucose control in 1 to 2 weeks, but the full effect of blood glucose control may take up to 2 to 3 months. Ask your doctor if you have any questions about this. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the Continue reading >>
Side Effects Of Metformin 500 Mg Tablets
Metformin is a prescription medication used primarily in the management of type 2 diabetes. This pill is sold under brand names such as Glucophage and Riomet. A member of the drug group known as biguanides, this drug’s 500 mg tablet is the smallest available pill -- and a common starting dose for this first-line diabetes medication. This widely used medication is an effective tool to help lower blood glucose levels, used alone or in conjunction with other pills or insulin. However, metformin can also produce adverse effects. Video of the Day The most common side effects from metformin use include gastrointestinal (GI) discomfort, including diarrhea, nausea, vomiting, gas and abdominal pain. A diabetes prevention trial, published in the April 2012 issue of “Diabetes Care,” noted that over a 4-year period, 9.8 percent of metformin users reported GI side effects, while only 1.1 percent of those using placebo had these adverse effects. These side effects usually occur at the beginning of metformin therapy and go away as the body becomes adjusted to the medication. Taking the metformin with food and having the dose gradually increased also helps minimize these adverse effects. Extended-release tablets, such as metformin XR (Glucophage XR, Glumetza or Fortamet) may be easier on the stomach -- and an option for anyone who has these common metformin side effects. Other Less Common Side Effects As with most medications, the potential list of side effects is lengthy. Insight into the adverse reactions experienced by metformin users was noted in an analysis of multiple studies published in the February 2012 issue of “Diabetes Care.” While less common than GI discomfort, other potential metformin side effects include dizziness, headache, palpitations, urinary tract infect Continue reading >>
Uses Metformin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in patients with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Metformin works by helping to restore your body's proper response to the insulin you naturally produce. It also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb. How to use Metformin HCL Read the Patient Information Leaflet if available from your pharmacist before you start taking metformin and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually 1-3 times a day with meals. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Take this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day. If you are already taking another diabetes drug (such as chlorpropamide), follow your doctor's directions carefully for stopping/continuing the old drug and starting metformin. Check your blood sugar regularly a Continue reading >>
Glucophage (metformin) And Diabetes
Tweet Glucophage and Metformin are often mentioned in relation to diabetes treatment. But what exactly is Glucophage and how does Glucophage help control type 2 diabetes? The following guide to Glucophage should help you to understand more about this medication, its side effects and its value. What is Glucophage? Glucophage tablets (and Glucophage SR tablets) each have an active ingredient called Metformin hydrochloride. Metformin is widely used to aid in the control of blood glucose levels amongst people with type 2 diabetes. How does Glucophage help people with type 2 diabetes? Amongst people with type 2 diabetes, the pancreas fails to produce sufficient levels of insulin. Furthermore, the cells in the body may be resistant to any insulin that is present. Normally, insulin would instruct cells to remove sugar from the blood, but in people with diabetes blood sugar levels can climb too high. As we said before, Glucophage contains the ingredient Metformin. Metformin (Metformin hydrochloride) is a type of medicine known as a biguanide. This works to lower the amount of sugar in the blood of people with diabetes. It does this by lowering the amount of sugar produced in the liver, and also increasing the sensitivity of muscle cells to insulin. The cells are therefore more able to remove sugar from the blood. Metformin also slows the absorption of sugars from the intestines. Metformin lowers blood sugar levels between and after meals. Who is Glucophage prescribed to? Glucophage is usually prescribed as a treatment for people with type 2 diabetes who are overweight or obese. When diet and exercise fail to adequately control blood glucose levels, Glucophage is prescribed. Sometimes, this medicine is used in conjunction with other anti-diabetic medication. How often do people Continue reading >>
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Metformin Side Effects
Generic Name: metformin (met FOR min) Brand Names: Fortamet, Glucophage, Glucophage XR, Glumetza, Riomet What is metformin? Metformin is an oral diabetes medicine that helps control blood sugar levels. Metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Metformin is sometimes used together with insulin or other medications, but it is not for treating type 1 diabetes. Important information You should not use metformin if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking metformin. This medicine may cause a serious condition called lactic acidosis. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. Get emergency medical help if you have signs of an allergic reaction to metformin: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Some people develop lactic acidosis while taking this medicine. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness; numb or cold feeling in your arms and legs; trouble breathing; feeling dizzy, light-headed, tired, or very weak; stomach pain, nausea with vomiting; or slow or uneven heart rate. Common metformin side effects may include: low blood sugar; nausea, upset stomach; or diarrhea. This is not a complete list of side effects and others may occur. Call your doc Continue reading >>
Glumetza Patient Information Including Side Effects
Brand Names: Fortamet, Glucophage, Glucophage XR, Glumetza, Riomet Generic Name: metformin (Pronunciation: met FOR min) What are the possible side effects of metformin (Fortamet, Glucophage, Glucophage XR, Glumetza, Riomet)? What is the most important information I should know about metformin (Fortamet, Glucophage, Glucophage XR, Glumetza, Riomet)? What should I discuss with my healthcare provider before taking metformin (Fortamet, Glucophage, Glucophage XR, Glumetza, Riomet)? What is metformin (Fortamet, Glucophage, Glucophage XR, Glumetza, Riomet)? Metformin is an oral diabetes medicine that helps control blood sugar levels. Metformin is for people with type 2 diabetes. Metformin is sometimes used in combination with insulin or other medications, but it is not for treating type 1 diabetes. Metformin may also be used for purposes not listed in this medication guide. What are the possible side effects of metformin (Fortamet, Glucophage, Glucophage XR, Glumetza, Riomet)? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. This medication may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness; numb or cold feeling in your arms and legs; trouble breathing; feeling dizzy, light-headed, tired, or very weak; stomach pain, nausea with vomiting; or slow or uneven heart rate. Call your doctor at once if you have any other serious side effect such as: feeling short of breath, even with mild exertion; swelling or rapid weight gain; or fever, chills, body aches, flu symptoms. Les Continue reading >>
Can Metformin Help With Weight Loss?
Metformin is a drug prescribed to manage blood sugar levels in people with type 2 diabetes. You may have heard that metformin can also help you lose weight. But is it true? The answer is a resounding maybe. Here’s what you should know about what metformin can do for weight loss, as well as why your doctor may prescribe it for you. According to research, metformin can help some people lose weight. However, it’s not clear why metformin may cause weight loss. One theory is that it may prompt you to eat less by reducing your appetite. It may also change the way your body uses and stores fat. Although studies have shown that metformin may help with weight loss, the drug is not a quick-fix solution. According to one long-term study, the weight loss from metformin tends to occur gradually over one to two years. The amount of weight lost also varies from person to person. In the study, the average amount of weight lost after two or more years was four to seven pounds. Taking the drug without following other healthy habits may not lead to weight loss. Individuals who follow a healthy diet and exercise while taking metformin tend to lose the most weight. This may be because metformin is thought to boost how many calories you burn during exercise. If you don’t exercise, you likely won’t have this benefit. In addition, any weight loss you have may only last as long as you take the medication. That means if you stop taking metformin, there’s a good chance you will return to your original weight. And even while you’re still taking the drug, you may slowly gain back any weight you’ve lost. In other words, metformin may not be the magic diet pill some people have been waiting for. It has been shown to reduce weight in some, but not others. One of the benefits of metformin Continue reading >>
Metformin, Oral Tablet
Metformin oral tablet is available as both a generic and brand-name drug. Brand names: Glucophage, Glucophage XR, Fortamet, and Glumetza. Metformin is also available as an oral solution but only in the brand-name drug Riomet. Metformin is used to treat high blood sugar levels caused by type 2 diabetes. FDA warning: Lactic acidosis warning This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects. Lactic acidosis is a rare but serious side effect of this drug. In this condition, lactic acid builds up in your blood. This is a medical emergency that requires treatment in the hospital. Lactic acidosis is fatal in about half of people who develop it. You should stop taking this drug and call your doctor right away or go to the emergency room if you have signs of lactic acidosis. Symptoms include tiredness, weakness, unusual muscle pain, trouble breathing, unusual sleepiness, stomach pains, nausea (or vomiting), dizziness (or lightheadedness), and slow or irregular heart rate. Alcohol use warning: You shouldn’t drink alcohol while taking this drug. Alcohol can affect your blood sugar levels unpredictably and increase your risk of lactic acidosis. Kidney problems warning: If you have moderate to severe kidney problems, you have a higher risk of lactic acidosis. You shouldn’t take this drug. Liver problems warning: Liver disease is a risk factor for lactic acidosis. You shouldn’t take this drug if you have liver problems. Metformin oral tablet is a prescription drug that’s available as the brand name drugs Glucophage, Glucophage XR, Fortamet, and Glumetza. Glucophage is an immediate-release tablet. All of the other brands are extended-r Continue reading >>
The Multiple Benefits Of Metformin
Metformin (brand name "Glucophage") has been used in the treatment of type II diabetes for the past 40 years.1 This drug counteracts many of the underlying factors that result in the manifestation of this insidious disease. Metformin also produces helpful side benefits that can protect against the lethal complications of type II diabetes. Frequently prescribed anti-diabetic drugs fail to address the fundamental causes of type II diabetes and can induce serious side effects. Type II diabetes affects between 16 to 19 million Americans. About 75% of type II diabetics will die from a cardiovascular-related disease. Conventional doctors often prescribe drugs for the purpose of lowering blood sugar levels. These drugs do not adequately address the multiple underlying pathologies associated with the type II diabetic state. Type II diabetes is characterized by cellular insulin resistence. The result is excess accumulation of glucose in the bloodstream as cells become resistant to the effects of insulin. Type II diabetes is characterized by cellular insulin resistence. The result is excess accumulation of glucose in the bloodstream because cells become resistant to the effects of insulin and fail to take up glucose As the type II diabetic condition progresses, many people gain weight and develop more fat cells.2 Treating type II diabetes with insulin-enhancing therapy increases the risk of cardiovascular complications, induces weight gain, and fails to correct the underlying cause of the disease. Many type II diabetics produce too much insulin in a futile attempt to drive glucose into insulin-resistant cells. When doctors prescribe insulin-enhancing drugs to these type II diabetics, a temporarily reduction of serum glucose may occur, but the long-term effects of this excess insu Continue reading >>
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Metformin 500 Mg Tablet
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition. Continue reading >>
Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. Limited evidence suggests metformin may prevent the cardiovascular disease and cancer complications of diabetes. It is not associated with weight gain. It is taken by mouth. Metformin is generally well tolerated. Common side effects include diarrhea, nausea and abdominal pain. It has a low risk of causing low blood sugar. High blood lactic acid level is a concern if the medication is prescribed inappropriately and in overly large doses. It should not be used in those with significant liver disease or kidney problems. While no clear harm comes from use during pregnancy, insulin is generally preferred for gestational diabetes. Metformin is in the biguanide class. It works by decreasing glucose production by the liver and increasing the insulin sensitivity of body tissues. Metformin was discovered in 1922. French physician Jean Sterne began study in humans in the 1950s. It was introduced as a medication in France in 1957 and the United States in 1995. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Metformin is believed to be the most widely used medication for diabetes which is taken by mouth. It is available as a generic medication. The wholesale price in the developed world is between 0.21 and 5.55 USD per month as of 2014. In the United States, it costs 5 to 25 USD per month. Medical uses Metformin is primarily used for type 2 diabetes, but is increasingly be Continue reading >>
What Is Metformin?
Commonly Used Brand Name(s)Fortamet, Glucophage, Glucophage XR, Glumetza, Riomet Therapeutic ClassificationsHypoglycemic QUICK LINKS Oral route (Tablet;Tablet, Extended Release;Solution) Death, hypothermia, hypotension, and resistant bradyarrhythmias have been reported due to metformin-associated lactic acidosis. Onset may be subtle and include nonspecific symptoms such as malaise, myalgia, respiratory distress, somnolence, and abdominal distress; laboratory abnormalities include low pH, increased anion gap and elevated blood lactate. The risk of lactic acidosis increases with renal or hepatic impairment, aged 65 years or older, having a radiological study with contrast, surgery, or other procedures, hypoxic states, and excessive alcohol intake. If lactic acidosis is suspected, metformin hydrochloride should be discontinued, supportive measures started in a hospital setting. Prompt hemodialysis is recommended . Save up to 85% on Metformin Find big savings at pharmacies near you with GoodRx discount coupons Average Retail Price: $27.12 Lowest GoodRx Price $4.00 View All Prices Metformin is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes. With this type of diabetes, insulin produced by the pancreas is not able to get sugar into the cells of the body where it can work properly. Using metformin alone, with a type of oral antidiabetic medicine called a sulfonylurea, or with insulin, will help to lower blood sugar when it is too high and help restore the way you use food to make energy. Many people can control type 2 diabetes with diet and exercise. Following a specially planned diet and exercise will always be important when you have diabetes, even when you are taking medicines. To work properly, t Continue reading >>