What Is Long-acting Insulin?
Long-acting insulins are insulin analogs that are steadily released and can last in the body for up to 24 hours. It is often used in the morning or at bedtime as a basal insulin to help control your blood sugar throughout the day. Insulin is made inside the beta cells of the pancreas. It helps regulate the glucose (sugar) in the bloodstream by stimulating the cells to absorb the glucose, which is needed by the cells for energy. Insulin also keeps the liver from producing more glucose. In type 2 diabetes, the body can lose the ability to produce insulin and if insulin is produced, the body isn’t able to use it properly (insulin resistance). Different types of insulin therapies, such as long-acting insulin, enables the body to get the insulin that is needed for optimal glycemic control. Some of the long-acting insulins available in the US include: Levemir contains insulin detemir, which is a long-acting, basal insulin that is used to improve blood sugar control in adults with type 2 diabetes. It can help keep your blood sugar levels within a normal range by moving glucose from the bloodstream into the cells, and it prevents the liver from producing more glucose. Levemir is available in a vial and pre-filled pen called Levemir FlexTouch, each containing 100 units/ml (U-100) of insulin detemir. Once the pen is in use, it is good for 42 days and should not be refrigerated but stored at room temperature (below 86°F). The vial is also good for 42 days after first use, and can be stored in the refrigerator or at room temperature. Levemir is injected under the skin (subcutaneously) in the abdomen, thigh or upper arm once daily, or twice daily depending on your personal requirements. Injection sites should be rotated within the same region from one injection to the next to red Continue reading >>
Compare Levemir Vs. Lantus
Insulin is the most effective blood sugar lowering medication, as it lowers A1c (average blood sugar over time) up to 2 or 3%. When used correctly, it'll prevent the harmful effects of high blood sugar levels on your organs and blood vessels. Levemir (insulin detemir) is a long lasting insulin that provides consistent, all-day blood sugar control with less risk of low blood sugar. Doses can be easily adjusted to make a customized regimen that's tailored to your body's needs. Starting insulin early in the treatment of type 2 diabetes can maintain your body's insulin producing cells and slow down disease progression. Levemir (insulin detemir) can be used in people with liver or kidney problems. Insulin is one of the most effective blood sugar-lowering medication and can lower your A1c (average blood sugar over time) by up to 2-3%. Lantus (insulin glargine) is a long-lasting insulin that provides consistent, all-day sugar control with just once or twice daily dosing. Dose can be easily adjusted to make a customized regimen that's tailored to your body's needs. Lantus (insulin glargine) can be used with liver or kidney problems. 130 reviews so far Have you used Levemir (insulin detemir)? Leave a review 584 reviews so far Have you used Lantus (insulin glargine)? Leave a review Continue reading >>
Lantus And Levemir: What’s The Difference?
Lantus and Levemir have a lot in common. Both are basal insulin formulas, which means that they last for a long time in the body and act as background insulin, with a slow feed that mimics the constant low output of insulin produced by a healthy pancreas. Both are insulin analogues, which means that their insulin molecules are analogous to human insulin, but engineered, or recombined, with slight differences that slow their absorption. Lantus is a clear formula made with glargine, a genetically modified form of human insulin, dissolved in a special solution. Levemir is also a clear formula, but it contains dissolved detemir, a different form of genetically modified insulin. Human insulin is made of two amino acid chains, called A and B, that have two disulfide bonds between them. In glargine, one amino acid has been switched out, and two extra amino acids have been added to one end of the B chain. The modifications make glargine soluble at an acidic pH, but much less soluble at the neutral pH that’s found in the body To make Lantus, first the glargine is produced by a vat of E. coli bacteria. Then it’s purified and added to a watery solution containing a little zinc and some glycerol; a dash of hydrochloric acid is also added to make it acidic, bringing its pH down to about 4. At that degree of acidity, glargine completely dissolves into the watery solution, which is why the vial is clear. After you inject it into your subcutaneous tissue, the acidic solution is neutralized by your body to a neutral pH. Because glargine is not soluble at a neutral pH, it precipitates out into a form that’s not soluble in subcutaneous fat, and there forms a relatively insoluble depot. From that pool, or depot, of precipitated glargine in the tissues, small amounts slowly move back Continue reading >>
Levemir® (insulin Detemir [rdna Origin] Injection) Indications And Usage
Levemir® is contraindicated in patients with hypersensitivity to Levemir® or any of its excipients. Never Share a Levemir® FlexTouch® Between Patients, even if the needle is changed. Sharing poses a risk for transmission of blood-borne pathogens. Dosage adjustment and monitoring: Monitor blood glucose in all patients treated with insulin. Insulin regimens should be modified cautiously and only under medical supervision. Changes in insulin strength, manufacturer, type, or method of administration may result in the need for a change in insulin dose or an adjustment of concomitant anti-diabetic treatment. Administration: Do not dilute or mix with any other insulin or solution. Do not administer subcutaneously via an insulin pump, intramuscularly, or intravenously because severe hypoglycemia can occur. Levemir® (insulin detemir [rDNA origin] injection) is indicated to improve glycemic control in adults and children with diabetes mellitus. Levemir® is not recommended for the treatment of diabetic ketoacidosis. Intravenous rapid-acting or short-acting insulin is the preferred treatment for this condition. Levemir® is contraindicated in patients with hypersensitivity to Levemir® or any of its excipients. Never Share a Levemir® FlexTouch® Between Patients, even if the needle is changed. Sharing poses a risk for transmission of blood-borne pathogens. Dosage adjustment and monitoring: Monitor blood glucose in all patients treated with insulin. Insulin regimens should be modified cautiously and only under medical supervision. Changes in insulin strength, manufacturer, type, or method of administration may result in the need for a change in the insulin dose or an adjustment of concomitant anti-diabetic treatment. Administration: Do not dilute or mix with any other insulin Continue reading >>
Lantus Vs. Levemir
What is Lantus? What is Levemir? 3 How do Lantus and Levemir work? Lantus is a Brand name for a man-made hormone product form called insulin glargine. It works by lowering glucose levels in blood. It is a long-acting form of insulin, a slightly different from other insulin forms that are not man-made. Lantus is used to for the treatment of diabetes type 1 and type 2. Levemir is a Brand name for a man-made hormone product form of insulin called insulin detemir. It works by lowering glucose levels in blood. It is a long-acting form of insulin, a slightly different from other insulin forms that are not man-made. Levemir is used for the treatment of type 2 diabetes in adults. Levemir can be also used to treat type 1for the treatment of diabetes type 1 in adults and children who are at least 2 years old. Lantus and Levemir do have many similarities but they are not the same thing. They are both man-made long-acting form of insulin and they are both used for the treatment of diabetes type 1 and 2, and they are intended for daily management. Studies showed no significant difference in the effectiveness and safety of Lantus and Levemir for the treamtnent of type 2 diabetes. They’re both absorbed slowly over a 24-hour period. Both products are basal insulin formulas, which mean that sugar levels in blood are lowered more slowly but they last much longer. They act as background insulin, with a slow feed that mimics the constant low insulin output produced by a healthy pancreas. They are not used to correct sugar spikes or to treat diabetic ketoacidosis. Ketoacidosis treatment requires short-acting insulin. However, there are some differences. Levemir is an insulin detemir solution, while Lantus is an insulin glargine solution. Insulin glargine -Lantus is made by recombinant DNA Continue reading >>
How To Switch From Levemir To Lantus
Lantus and Levemir are both types of long-acting insulin known as basal insulin; diabetics on insulin injection therapy typically administer a dose of basal insulin twice daily to provide a small, continuous amount of insulin to the body throughout the day and night. Lantus is composed of dissolved glargine (a synthetic derivative of human insulin), while Levemir contains dissolved detemir. While they both provide long-acting (12 to 24 hour) insulin, they deliver insulin throughout the bloodstream in different ways. Switching between the two for cost or effectiveness purposes is not difficult, but requires extra monitoring and may require adjusting your current insulin regimen. Make an appointment with your doctor to discuss your desire to switch to Lantus. In most states, you will need a new prescription from your doctor to switch from Levemir to Lantus; it is not the same as simply switching from a formulary to a generic drug, or just switching between different manufacturers. Inject the same number of units of Lantus at the same time periods as you were injecting Levemir. The two insulins have a 1:1 ratio. Monitor your blood glucose closely between the 12 and 24 hours after your initial Lantus injection, and discuss any changes with your doctor. Technically, it is suggested that Levemir be administered twice a day but Lantus only be administered once daily; however, many healthcare professionals, like Dr. Richard Bernstein, believe that both should be injected every 12 hours for optimal control. It takes two hours for either Levemir or Lantus to begin working, and each lasts for 18 to 24 hours in the bloodsteam. This can mean you run higher between hours 18 and 24 on a once-daily injection regimen; since different bodies reach to Levemir and Lantus in slightly differ Continue reading >>
Key Facts About Basaglar: A Less Expensive Long-acting Insulin
If you’ve been using a long-acting insulin like Lantus, you might have heard about a friendly competitor called Basaglar which is coming soon to pharmacies. Basaglar is insulin glargine known as a biosimilar (also called a follow-on biologic). Because of the manufacturing process it isn’t considered a generic, but there are no differences from Lantus in regard to safety, purity and potency. To get to know Basaglar better, here are some details you’ll want to be aware of. What is the difference between a biosimilar and a generic? Generic drugs are copies of a brand name drug, and their manufacturing process can be replicated exactly through chemical reactions. Biologics are made using manufacturing processes and living organisms that are unique to each manufacturer. Therefore, it is not really possible to make an exact copy of a biologic. For an in-depth look at the definition of biosimilar, see here. Is Basaglar less expensive than Lantus? The cost of Basaglar is estimated to be about 20% cheaper than Lantus. It is manufactured by Eli Lilly as a KwikPen. Basaglar won’t be sold in a vial form. Will my insurance switch me to Basaglar? In some cases, yes. CVS Health has announced that Basaglar will be on formulary in place of Lantus. Is it really equivalent to Lantus? Yes, the onset, peak and duration of action are almost identical. Will my dose be the same as the insulin I’m currently taking? Your healthcare provider will tell you exactly how to make the switch. In general, Lantus and Basaglar can be interchanged unit for unit. If you were on Levemir, the conversion will also be unit for unit. If you were taking Levemir twice a day, the total number of units will likely be given as one Basaglar injection. If you are switching from Toujeo or NPH, your dose might Continue reading >>
Lantus Vs. Levemir
font size A A A 1 2 Next Are Lantus and Levemir the Same Thing? Lantus (insulin glargine [rdna origin]) and Levemir (insulin detemir [rDNA origin] injection) are man-made forms of a hormone produced in the body used to treat type 1 (insulin-dependent) or on some rare occasions, type 2 (non insulin-dependent) diabetes. What Are Possible Side Effects of Lantus? Side effects of Lantus include: headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). What Are Possible Side Effects of Levemir? Common side effects of Levemir include: injection site reactions (e.g., pain, redness, irritation), swelling of the hands/feet, thickening of the skin where you inject Levemir, weight gain, headache, back pain, stomach pain, flu symptoms, or cold symptoms such as stuffy nose, sneezing, sore throat. Tell your doctor if you experience serious side effects of Levemir including: signs of low potassium level in the blood (such as muscle cramps, weakness, or irregular heartbeat). What is Lantus? Lantus is a long-acting man-made insulin used to control high blood sugar in adults with diabetes mellitus. Lantus is not for use to treat diabetic ketoacidosis. It is not known if Lantus is safe and effective in children less than 6 years of age with type 1 diabetes. It is not known if Lantus is safe and effective in children with type 2 diabetes. What is Levemir? Levemir is a man-made insulin that is used to control high blood sugar in adults and children with diabetes mellitus. Levemir is not meant for use to treat diabetic ketoacidosis. font size A A A Previous 1 2 Lantus vs. Levemir (cont.) Read the detailed Instructions for Use that come with your Lantus SoloStar disposable prefi Continue reading >>
Levemir Vs Lantus: What's The Difference?
Levemir and Lantus are both long-acting forms of insulin that work for most of the day. Levemir Vs Lantus: Both human insulin analogs Levemir is a brand name for insulin detemir. Levemir takes at least one hour to start working (some sources state up to three hours), and its effects are dependent on the initial dosage given. Dosages of 0.1 units per kg may last only six hours whereas dosages equal to or greater than 0.8 units/kg last approximately 22 to 24 hours. Levemir has a relatively peakless profile but may be more slowly absorbed from the thigh compared to the deltoid (arm) and the abdomen after subcutaneous administration. Lantus is the brand name for insulin glargine. Lantus takes approximately an hour to start working and lasts for an average of 24 hours; however, there is some variability and in some people, it may only act for just over 10 hours, whereas for others it may last longer than 24 hours. Lantus releases consistently, so doesn't really have a peak effect. Levemir Vs Lantus: Differences in formulation account for some differences in action Both Levemir and Lantus are made by modifying human insulin. Both should be clear solutions before they are injected (discard if cloudy). Insulin glargine (Lantus) tends to be absorbed more slowly and for longer than detemir ( Levemir) because it is not as soluble once injected just under the skin. This means it has a longer duration of action and an insignificant peak effect - instead, it delivers consistent blood levels of insulin. Insulin detemir (Levemir) remains soluble after injection but is able to bind to protein in the tissue and bond to itself which gives it a prolonged action. How do Levemir and Lantus compare to NPH insulin? Both Levemir and Lantus were created to improve on NPH insulin, and to better m Continue reading >>
Rapid-Acting Analogues Short-Acting Insulins Intermediate-Acting Insulins Long-Acting Insulins Combination Insulins Drug UPDATES: TRESIBA ®- insulin degludec injection [Drug information / PDF] Click link for the latest monograph Dosing: Click (+) next to Dosage and Administration section (drug info link) Initial U.S. Approval: 2015 Mechanism of Action: The primary activity of insulin, including TRESIBA, is regulation of glucose metabolism. Insulin and its analogs lower blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin also inhibits lipolysis and proteolysis, and enhances protein synthesis. TRESIBA forms multi-hexamers when injected into the subcutaneous tissue resulting in a subcutaneous insulin degludec depot. The protracted time action profile of TRESIBA is predominantly due to delayed absorption of insulin degludec from the subcutaneous tissue to the systemic circulation and to a lesser extent due to binding of insulin-degludec to circulating albumin. INDICATIONS AND USAGE: TRESIBA is indicated to improve glycemic control in adults with diabetes mellitus. Limitations of Use TRESIBA is not recommended for the treatment of diabetic ketoacidosis. Dosing: Individualize dose based on type of diabetes, metabolic needs, blood glucose monitoring results and glycemic control goal. Rotate injection sites to reduce the risk of lipodystrophy. Do not dilute or mix with any other insulin or solution. Administer subcutaneously once daily at any time of day. Do NOT perform dose conversion when using the TRESIBA U-100 or U-200 FlexTouch pens. The TRESIBA U-100 and U-200 FlexTouch pens dose window shows the number of insulin units to be delivered and NO conversion is needed. HOW SUPPLIE Continue reading >>
What Is The Difference Between Levemir Vs Lantus Insulin?
Both levemir and lantus are basal insulins, meaning that once injected, they keep working in the background to keep your blood glucose levels under control during the entire day. They are both used to treat high blood glucose levels in people with diabetes. As long acting insulins, both medications work longer compared to other insulins, and are used to replace the natural hormone in the body. These medicines are not supposed to be used together to treat patients with diabetes. Even though these drugs are both long acting insulins, they should not be used interchangeably without the doctor’s advice. Both drugs have different formula concentrations, meaning that there is a small difference in how they work to control blood sugar levels in people with diabetes. Because of this, they must be prescribed separately and not together. Whether you are prescribed to take levemir or lantus, they should work well in controlling your blood sugar. The medications usually come in regimens that includes short acting insulins or rapid acting insulins. What is Levemir? Levemir or insulin detemir is a man made form of insulin which works by lowering blood glucose levels in people with diabetes. Do not use this medication if it has changed colors. Patients can use this medication once or twice every day. In case it is taken once, it should be administered with the evening meal. If taken twice, you should take the dose with the morning meal and evening meal. The evening dose should be 12 hours after the morning dose. What is Lantus? Lantus or insulin glargine is a long acting acting insulin which works by replacing human insulin, which is produced by the pancreas. Insulin glargine comes in injectible form and is usually administered subcutaneously in the upper arm, stomach or thigh. Simi Continue reading >>
Different Types Of Insulin: What To Use And When?
What’s the difference between the different types of insulin? Long-acting, short-acting, premixed, learn more about all three. You may have a lot of questions as you begin insulin therapy. What are the different types of insulin available? Which should I be using and when? Insulins differ based on 3 key factors: 1 how quickly they work when they peak how long they last (duration) This table compares these factors in the types of insulin available:2 Type Onset (How quickly it starts working) Onset (What it is most effective) Duration (How long it works) Timing of injection (When should it be given) Bolus insulins Rapid acting analogues Apidra/Humalog/NovoRapid 10-15 min 1-2 hours 3-5 hours Given with 1 or more meals per day. To be given 0-15 minutes before or after meals. Short-acting Humulin-R/Toronto 30 min 2-3 hours 6.5 hours Given with one or more meals per day. Should be injected 30-45 minutes before the start of the meal. Basal insulins Intermediate-acting Humulin-N/NPH 1-3 hours 5-8 hours Up to 18 hours Often started once daily at bedtime. May be given once or twice daily. Not given at any time specific to meals. Long-acting analogues Lantus Levemir 90 min Not applicable Lantus: Up to 24 hours Levemir: 16-24 hours Often started once daily at bedtime. Insulin detemir (Levemir) may be given once or twice daily. Not given at any time specific to meals. Premixed insulins Premixed regular insulin Humulin 30/70 and Novolin ge 30/70, 40/60, 50/50 Varies according to types of insulin Contains a fixed ratio of insulin (% of rapid-acting or short-acting insulin to % of intermediate-acting insulin): See above for information about peak actions based on insulin contained Given with one or more meals per day. Should be injected 30-45 minutes before the start of the meal. Pre Continue reading >>
Insulin Detemir Versus Insulin Glargine For Type 2 Diabetes Mellitus.
Abstract BACKGROUND: Chronically elevated blood glucose levels are associated with significant morbidity and mortality. Many diabetes patients will eventually require insulin treatment to maintain good glycaemic control. There are still uncertainties about the optimal insulin treatment regimens for type 2 diabetes, but the long-acting insulin analogues seem beneficial. Several reviews have compared either insulin detemir or insulin glargine to NPH insulin, but research directly comparing both insulin analogues is limited. OBJECTIVES: To assess the effects of insulin detemir and insulin glargine compared with each other in the treatment of type 2 diabetes mellitus. SEARCH STRATEGY: We searched MEDLINE, EMBASE, The Cochrane Library, online registries of ongoing trials and abstract books. Date of last search was January 2011. SELECTION CRITERIA: All randomised controlled trials comparing insulin detemir with insulin glargine with a duration of 12 weeks or longer were included. DATA COLLECTION AND ANALYSIS: Two authors independently selected the studies and extracted the data. Pooling of studies by means of random-effects meta-analysis was performed. MAIN RESULTS: This review examined four trials lasting 24 to 52 weeks involving 2250 people randomised to either insulin detemir or glargine. Overall, risk of bias of the evaluated studies was high. Insulin glargine was dosed once-daily in the evening. Insulin detemir was initiated once-daily in the evening with the option of an additional dose in the morning in three studies and initiated twice-daily in one study. Of randomised patients 13.6% to 57.2% were injecting insulin detemir twice-daily at the end of trial.Glycaemic control, measured by glycosylated haemoglobin A1c (HbA1c) and HbA1c equal to or less than 7% with or with Continue reading >>
Levemir Vs. Lantus: Similarities And Differences
Levemir and Lantus are both long-acting injectable insulins that can be used for long-term management of diabetes. Insulin is a hormone that is naturally produced in the body by the pancreas. It helps convert the glucose (sugar) in your bloodstream into energy. This energy is then distributed to cells throughout your body. With diabetes, your pancreas produces little or no insulin or your body is unable to use the insulin correctly. Without insulin, your body can’t use the sugars in your blood and can become starved for energy. The excess sugar in your blood can also damage different parts of your body, including your blood vessels and kidneys. Everyone with type 1 diabetes and many people with type 2 diabetes must use insulin to maintain healthy blood sugar levels. Levemir is a solution of insulin detemir, and Lantus is a solution of insulin glargine. Both are basal insulin formulas. That means that they work slowly to lower your blood sugar levels. They’re both absorbed into your body over a 24-hour period. They keep blood sugar levels lowered for longer than short-acting insulins do. Although the formulations are slightly different, Levemir and Lantus are very similar drugs. There are only a few differences between them. Children and adults can use both Levemir and Lantus. Specifically, Levemir can be used by people who are 2 years or older. Lantus can be used by people who are 6 years or older. Levemir or Lantus can help with daily management of diabetes. However, you may still need to use short-acting insulin to treat spikes in your blood sugar levels and diabetic ketoacidosis (a dangerous buildup of acids in your blood). Learn more: All about diabetic ketoacidosis » Administration Both Levemir and Lantus are given through injection in the same way. You can gi Continue reading >>
Ada: Once-daily Dosing With Lantus And Levemir Similar For Type 2 Diabetes But Different For Type 1
WASHINGTON, June 13 â€” Long-acting insulin analogs Levemir (insulin detemir) and Lantus (insulin glargine) appear equal for once-daily use in type 2 diabetes, yet Lantus may have an edge for type 1 diabetes. The two head-to-head comparisons of the metabolism activity of the long-acting insulins, presented at the American Diabetes Association meeting here, are virtually the first reports of their kind for these drugs. Both agents are FDA-approved. "We do not have any pharmacodynamic studies in type 2 diabetes for either insulin," said Tim Heise, M.D., CEO of clinical science at Profil Institute for Metabolic Research in Neuss, Germany, "and up to this conference we had no direct comparison between these two long-acting agents at all." In an oral presentation, Dr. Heise reported the results of a study that randomized 13 patients with type 2 diabetes to Levemir and 14 to receive Lantus. Both agents were given at 0.4, 0.8, and 1.4 U/kg doses to "cover the dose range" used by clinicians, with periodic 24-hour glucose monitoring under glucose clamp conditions. "There is no difference in the time-action profiles between glargine and detemir with regard to the duration of action and mean metabolic impact," he said. The groups had similar baseline characteristics with an average body mass index (BMI) of about 30 kg/m and an HbA1c of about 7.6%. The researchers included only patients with fasting C-peptide levels below 1 nmol/L to eliminate endogenous insulin production as a confounding factor. Also, all participants were male, which Dr. Heise said was to control for the differences in glucose metabolism that occur during the menstrual cycle. The researchers found that "there is really no difference" in glucose infusion rates between the Lantus and Levemir. The only differe Continue reading >>