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What Is The Antidote For Insulin Overdose?

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Management Of Antidiabetic Medications In Overdose

, Volume 19, Issue5 , pp 411424 | Cite as Management of Antidiabetic Medications in Overdose The drugs used to treat diabetes mellitus are diverse and involve several classes. However, these drugs can be roughly separated into hypoglycaemic agents, such as insulin and the sulphonylureas, and antihyperglycaemic agents, such as the biguanides, the -glucosidase inhibitors and troglitazone. Reports of insulin overdose are rare. The major effects of insulin overdose are secondary to the insult to the CNS produced by hypoglycaemia. The mainstay of insulin overdose management is glucose replacement therapy. Sulphonylureas are the most commonly used oral antihyperglycaemic agents in the management of type 2 (non-insulin-dependent; NIDDM) diabetes mellitus. Sulphonylureas primarily cause serum glucose reduction by stimulating the release of preformed insulin from the pancreatic islets. The mainstay of sulphonylurea overdose management is glucose replacement therapy, and in severe cases, reduction of insulin release. In the large majority of patients intravenous glucose supplementation will be sufficient to maintain euglycaemia. Repaglinide, a meglitinide analogue, is a new nonsulphonylurea Continue reading >>

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  1. loveofrn

    we do not assignment for students without them trying to use google or their textbook to find the answers.

  2. loveofrn

    do you mean magnesium sulfate?

  3. ButterflyRN90, ASN, LPN

    Quote from cwebb
    Can anyone please tell me where I can find out about Insulin antidotes and where & why my professor's answer is D10 & D50? Also the antidote for heparin sodium, and the antidote for Morphine Sulfate (Ms Contin)? To find the answer, figure out what D10 and D50 are. Also, you must know what insulin is and does. Once you find that out,you'll be able to answer.

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A complete description of Glucagon benefits, dosage form, Indications, antidote effects.indications (In hypoglycemia if sugar cant be given by mouth, glucagon can be given by injection Glucagon may be issued to the close relatives of insulin-treated pt. for emergency use in hypoglycemic attack ), dose, administration, precautions, contraindications, overdose, toxicity symptoms, side effects, storage condition, mechanism, indications, and ADR's. Find me: Facebook: https://www.facebook.com/Centreoflear... Instagram: https://www.instagram.com/centre_of_l... Twitter: https://twitter.com/Free_Pptx https://www.youtube.com/channel/UCcnC... Please like and subscribe and keep in touch for every new presentation. Thanks for the support

(dextrose (antidote)) Dosing, Indications, Interactions, Adverse Effects, And More

25-50 g (50-100 mL of D50W solution); administer with thiamine (50-100 mg IV) to prevent Wernicke's encephalitis 10-25 g (40-100 mL of D25W solution or 20-50 mL of D50W solution) IV; may require repeated boluses 400-600 mg of glucose/kg/hr needed for most insulin overdoses Alternatively, administer 25-50 g (D50W) IV; may repeat doses in severe cases; determine glucose levels before injecting dose; in emergencies, may administer promptly before obtaining glucose results 25-50 g (250-500 mL D10W) plus 10 units regular insulin IV over 30-60 min < 6 months: 250-500 mg/kg/dose (1-2 mL/kg/dose D25W) > 6 months: 0.5-1g/kg/dose (2-4 mL/kg/dose D25W) Possibility of intracellular lactic acid production in setting of ischemic brain cells & hyperglycemia Extravasation can result in tissue damage Source of calories and fluid for patients unable to obtain adequate oral intake Substrate for ATP production for aerobic metabolism; promotes glycogen deposition in the liver In hyperkalemia dextrose in combination with insulin stimulates the uptake of potassium by cells (especially in muscle tissue), which in turn lowers serum potassium Onset of action: 10 min (PO; treatement of hypoglycemia) Absorpt Continue reading >>

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  1. loveofrn

    we do not assignment for students without them trying to use google or their textbook to find the answers.

  2. loveofrn

    do you mean magnesium sulfate?

  3. ButterflyRN90, ASN, LPN

    Quote from cwebb
    Can anyone please tell me where I can find out about Insulin antidotes and where & why my professor's answer is D10 & D50? Also the antidote for heparin sodium, and the antidote for Morphine Sulfate (Ms Contin)? To find the answer, figure out what D10 and D50 are. Also, you must know what insulin is and does. Once you find that out,you'll be able to answer.

  4. -> Continue reading
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List Of Antidotes... Download PDF from- http://www.omnursingacademy.weebly.com Join me on Facebook :- https://m.facebook.com/omnursingacademy And Please subscribe My Channel for Hindi Nursing videos....

Antidotes For Overdose: Timely And Effective Counteraction

Antidotes For Overdose: Timely And Effective Counteraction Knowledge of antidotes and how to administer them is necessary for appropriate management of overdose patients presenting to the emergency department. This issue reviews 5 commonly employed antidotes N-acetylcysteine, sodium bicarbonate, glucagon, highdose insulin, and intravenous lipid emulsion including their indications, mechanisms of action, adverse effects, and dosing schedules. N-acetylcysteine, a glutathione precursor, can be used to both prevent and treat hepatotoxicity following acetaminophen overdose. Sodium bicarbonate is useful for urinary and serum alkalinization following salicylate overdose and enhancement of urinary elimination, while also promoting diffusion of salicylate from tissue to the serum. Sodium bicarbonate may also be used to overcome tricyclic antidepressant-mediated sodium-channel blockade. Glucagon activates an intracellular pathway downstream of beta-adrenergic receptors to alleviate hypotension and bradycardia in cases of beta blocker toxicity. High-dose insulin allows greater myocardial glucose utilization and improved microvascular perfusion for treatment of calcium-channel blocker overdos Continue reading >>

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Popular Questions

  1. loveofrn

    we do not assignment for students without them trying to use google or their textbook to find the answers.

  2. loveofrn

    do you mean magnesium sulfate?

  3. ButterflyRN90, ASN, LPN

    Quote from cwebb
    Can anyone please tell me where I can find out about Insulin antidotes and where & why my professor's answer is D10 & D50? Also the antidote for heparin sodium, and the antidote for Morphine Sulfate (Ms Contin)? To find the answer, figure out what D10 and D50 are. Also, you must know what insulin is and does. Once you find that out,you'll be able to answer.

  4. -> Continue reading
read more

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