Januvia Side Effects
Januvia is the brand name of the drug sitagliptin, which is used to treat type 2 diabetes. Type 2 diabetes is a disease in which the body doesn't make or use the hormone insulin normally, so it can't properly control your blood sugar levels. Januvia belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing levels of substances in the body that help lower blood sugar. Januvia may be taken alone or with other diabetes medications. It's often prescribed as a combination medicine called Janumet (which contains the drugs sitagliptin and metformin). Taking Januvia, along with adopting a healthy lifestyle, can reduce your risk of developing serious or life-threatening complications from diabetes, which may include heart disease, stroke, nerve damage, kidney problems, or eye problems. The U.S. Food and Drug Administration (FDA) approved Januvia in 2006. It's manufactured by Merck & Co. Januvia Warnings Januvia shouldn't be taken by people with type 1 diabetes (a disease in which the body doesn't produce any insulin) or diabetic ketoacidosis (a dangerous condition that can occur if high blood sugar is untreated). Before taking Januvia, tell your doctor if you have, or have ever had: Kidney disease Angioedema (swelling of the face, lips, tongue, throat, arms, or legs) Januvia may increase the risk of developing pancreatitis (swelling and inflammation of the pancreas). Be sure to tell your doctor if you've ever had any problems with your pancreas, or if you experience any of the following symptoms while taking Januvia: Severe pain in your upper stomach that spreads to your back Loss of appetite Fast heartbeat Severe nausea and vomiting Also, tell your doctor you're taking this medicine before having any type of surgery, including a dental Continue reading >>
What Is Januvia®?
JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA. IMPORTANT SAFETY INFORMATION Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. Before you start taking JANUVIA, tell your doctor if you've ever had pancreatitis. Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis. Before you start taking JANUVIA, tell your doctor if you have ever had heart failure (your heart does not pump blood well enough) or have problems with your kidneys. Contact your doctor right away if you have increasing shortness of breath or trouble breathing (especially when you lie down); swelling or fluid retention (especially in the feet, ankles, or legs); an unusually fast increase in weight; or unusual tiredness. These may be symptoms of heart failure. Do not take JANUVIA if you are allergic to any of its ingredients, including sitagliptin. Symptoms of serious allergic reactions to JANUVIA, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have any symptoms of a serious allergic reaction, stop taking JANUVIA and call your doctor right Continue reading >>
Fda Approves Combo Of Januvia Plus Metformin In Once A Day Dosage
The FDA approved JANUMET® XR (sitagliptin and metformin hydrochloride (HCl) extended-release) tablets, a treatment for type 2 diabetes that combines sitagliptin, which is the active component of JANUVIA® (sitagliptin), with extended-release metformin…. JANUMET XR provides a convenient once-daily treatment option for patients who need help to control their blood sugar. JANUMET XR is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes when treatment with both sitagliptin and extended-release metformin is appropriate. JANUMET XR should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. JANUMET XR has not been studied in patients with a history of pancreatitis. It is unknown whether patients with a history of pancreatitis are at increased risk for the development of pancreatitis while using JANUMET XR. The FDA approved JANUMET XR based upon a clinical bioequivalence study that demonstrated that administration of JANUMET XR was equivalent to co-administration of corresponding doses of the two individual medications, sitagliptin and metformin HCl extended- release. Extended-release metformin was as effective as immediate-release metformin. The labeling for JANUMET XR contains a boxed warning for lactic acidosis, a rare, but serious complication that can occur due to metformin accumulation. JANUMET XR is contraindicated in patients with renal impairment (e.g., serum creatinine levels ≥1.5 mg/dL for men, ≥1.4 mg/dL for women or abnormal creatinine clearance), which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction, and septicemia; hypersensitivity to metformin HCl; acute or chronic metabolic acidosis, including diabetic ketoacid Continue reading >>
Januvia And Janumet
Januvia (sitagliptin) is an oral Type 2 diabetes medication manufactured by Merck & Co. The U.S. Food and Drug Administration (FDA) approved the drug in 2006, and it is one of the most popular Type 2 diabetes drugs on the market. In 2007, the FDA approved a variation of Januvia called Janumet, which is a combination of sitagliptin and metformin. Janumet also comes in an extended-release formula called Janumet XR. Januvia and Janumet are known as dipeptidyl peptidase 4 (DPP-4) inhibitors that work by helping the body produce more insulin. Both Januvia and Janumet belong to a class of drugs called dipeptidyl peptidase 4 (DPP-4) inhibitors that work by helping the body produce more insulin. Januvia was the first DPP-4 approved by the FDA and is the top-selling brand in its class. Two million prescriptions were written for Januvia in 2011. Januvia brought in about $6 billion in 2014. Merck stands to benefit from the patent on the drug until 2022. In clinical trials, Januvia proved effective in controlling blood-sugar levels. However, some studies reported rare and serious side effects, including acute pancreatitis, severe joint pain, pancreatic cancer and thyroid cancer. How Do Januvia and Janumet Work? Januvia is designed to work with other Type 2 diabetes medications, like Byetta, to increase their effectiveness. It helps lower blood sugar in two ways. It helps the body increase insulin to stabilize blood sugar and decrease sugars that are made in the liver. It is a part of the class of diabetes medications called DPP-4 inhibitors. DPP-4 is a protein made by the body that plays a role in glucose metabolism. The process works like this: After a person eats and blood sugar rises, intestinal cells release hormones called incretin hormones. Incretin stimulates pancreatic cell Continue reading >>
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How Does Januvia Work In Your Body?
JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA. Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. Before you start taking JANUVIA, tell your doctor if you've ever had pancreatitis. Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis. Before you start taking JANUVIA, tell your doctor if you have ever had heart failure (your heart does not pump blood well enough) or have problems with your kidneys. Contact your doctor right away if you have increasing shortness of breath or trouble breathing (especially when you lie down); swelling or fluid retention (especially in the feet, ankles, or legs); an unusually fast increase in weight; or unusual tiredness. These may be symptoms of heart failure. Do not take JANUVIA if you are allergic to any of its ingredients, including sitagliptin. Symptoms of serious allergic reactions to JANUVIA, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have any symptoms of a serious allergic reaction, stop taking JANUVIA and call your doctor right away. Kidney problems, somet Continue reading >>
Januvia (sitagliptin)
Tweet Januvia (Sitagliptin) is an oral gliptin drug used to lower blood glucose levels amongst people with type 2 diabetes. Sitagliptin is the first of a class of drugs to be approved that mimics the actions of the dipeptidyl peptidase-4 (DPP-4) enzyme. How does Januvia work? Sitagliptin works by inhibiting the DPP-4 enzyme that destroys GLP and GIP hormones, allowing both to function more effectively. Both glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are released by the intestine and affect blood glucose levels. When more of these hormones are released blood sugar levels are reduced. Who is Januvia prescribed to? Sitagliptin is prescribed to people with type 2 diabetes, and is usually taken alongside a healthy diet and regular, appropriate exercise to help control diabetes. Furthermore, Sitagliptin is often prescribed alongside other diabetes drugs such as (trade name first, generic name in brackets): Avandia (Rosiglitazone) Metformin (Metformin Hydrochloride) Actos (Pioglitazone) What side effects are associated with Januvia? Common side effects relating to sitagliptin include: Infections of the upper respiratory tract Headaches More infrequently, Sitagliptin is associated with abdominal pain, nausea and diarrhoea. I want to know more about Sitagliptin, what should I do? If your question is urgent, you should contact your doctor or diabetes healthcare professional immediately. Please use the Diabetes forum to get an independent perspective from the community. Tweet Type 2 diabetes mellitus is a metabolic disorder that results in hyperglycemia (high blood glucose levels) due to the body: Being ineffective at using the insulin it has produced; also known as insulin resistance and/or Being unable to produce enough insulin Type 2 Continue reading >>
Important Safety Information
WHAT IS JANUVIA®? JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA. Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. Before you start taking JANUVIA, tell your doctor if you've ever had pancreatitis. Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis. Before you start taking JANUVIA, tell your doctor if you have ever had heart failure (your heart does not pump blood well enough) or have problems with your kidneys. Contact your doctor right away if you have increasing shortness of breath or trouble breathing (especially when you lie down); swelling or fluid retention (especially in the feet, ankles, or legs); an unusually fast increase in weight; or unusual tiredness. These may be symptoms of heart failure. Do not take JANUVIA if you are allergic to any of its ingredients, including sitagliptin. Symptoms of serious allergic reactions to JANUVIA, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have any symptoms of a serious allergic reaction, stop taking JANUVIA and call your doctor right away. Kid Continue reading >>
What Is Januvia
JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA. IMPORTANT SAFETY INFORMATION Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. Before you start taking JANUVIA, tell your doctor if you've ever had pancreatitis. Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis. Before you start taking JANUVIA, tell your doctor if you have ever had heart failure (your heart does not pump blood well enough) or have problems with your kidneys. Contact your doctor right away if you have increasing shortness of breath or trouble breathing (especially when you lie down); swelling or fluid retention (especially in the feet, ankles, or legs); an unusually fast increase in weight; or unusual tiredness. These may be symptoms of heart failure. Do not take JANUVIA if you are allergic to any of its ingredients, including sitagliptin. Symptoms of serious allergic reactions to JANUVIA, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have any symptoms of a serious allergic reaction, stop taking JANUVIA and call your doctor right Continue reading >>
Can You Take Metformin And Januvia Together
What type of drug is Metformin Metformin is a Generic name for a drug with antihyperglycemic properties that is used for treating non – insulin – dependent diabetes mellitus. This drug can improve glucose levels in blood by decreasing the production of glucose in liver, decreasing intestinal absorption of glucose and increasing insulin-mediated glucose uptake. Therapy with metformin may also decrease the risk of having a stroke, heart attack, or other diabetes-related complications. Metformin can induce weight loss and that’s why it is the drug of choice for obese patients with diabetes type two. When it is used alone, this drug doesn’t cause hypoglycemia as side effect; but, it may potentiate the hypoglycemic effects of sulfonylureas drugs and insulin if they are used together. Metformin is available in the form of tablet in following dosage forms: 500, 750, 850 and 1000 mg. It is usually taken during meals. Common Brand names on the market containing metformin as an active ingredient are: Glucophage, Glumetza, Glucophage XR, Fortamet, Metformin Sandoz, Diabex, Diaformin, Siofor, Metfogamma and Riomet. What is Januvia Januvia is a Brand name for a drug containing sitagliptin as an active ingredient. It is an oral diabetes drug that is used to control sugar levels in blood. Januvia works by regulating insulin levels that body produces after eating. This drug is used for the treatment of patints with type 2 diabetes. Januvia can be used in combination with other diabetes medicines, but is not used for treating type 1- diabetes. Patients with diabetic ketoacidosis should not use Januvia. Januvia is available in tablet and film-coated tablet form in following strenghts: 25, 50 and 100 mg. Common Brand names on the market containing sitagliptin as an active ingredie Continue reading >>
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Sitagliptin; Januvia
are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>
What Is Januvia?
Januvia is a prescription medication used to treat adults with type 2 diabetes. When used as part of a healthy lifestyle plan encompassing exercise and diet, Januvia helps patients control their blood sugar levels. Januvia, a type 2 diabetes medication manufactured by Merck & Co., generates an estimated $6 billion in sales each year. The FDA approved Januvia for treating type 2 diabetes in 2006. Since hitting the market, it has become one of the most commonly prescribed medications to reduce blood sugar levels in patients with type 2 diabetes. By managing blood sugar, Januvia lessens the risk of other medical conditions caused by type 2 diabetes such as heart disease, kidney damage and eye problems. Unfortunately, there are several long-term risks associated with Januvia that can impact a person’s life forever. Numerous reports have linked Januvia to different cancers including pancreatic cancer and thyroid cancer. Even with new, stricter label requirements, Merck & Co. has been sued over their negligence to inform consumers about life-threatening side effects. SIDE EFFECTS of JANUVIA While there are many benefits of taking Januvia to help control your type 2 diabetes, some people may experience adverse side effects. Many side effects are minor and not harmful to your health. However, if you experience severe side effects that do not go away, you should seek medical attention immediately. Pancreatic cancer, thyroid cancer and acute pancreatitis are several of the most dangerous side effects of Januvia. Because of this, let your health provider know if you have a medical history of pancreatitis, gallstones or kidney problems. Januvia may also cause changes in your blood sugar levels. High or low blood pressure makes you susceptible to various complications such as a he Continue reading >>
Sitagliptin, Oral Tablet
Sitagliptin oral tablet is available as a brand-name drug. It’s not available as a generic drug. Brand name: Januvia. Sitagliptin only comes as a tablet you take by mouth. Sitagliptin is used to treat high blood sugar levels caused by type 2 diabetes. Pancreatitis warning: Sitagliptin may increase your risk of pancreatitis (inflammation of the pancreas). This can be severe and sometimes fatal. Before you start taking this drug, tell your doctor if you’ve ever had: pancreatitis gallstones (stones in your gallbladder) alcoholism high triglyceride levels kidney problems Joint pain warning: This drug may cause severe and disabling joint pain. Tell your doctor right away if you have joint pain while taking this drug. Your doctor may switch you to another medication to control your diabetes. Sitagliptin is a prescription drug. It comes as an oral tablet. Sitagliptin oral tablet is available as the brand-name drug Januvia. It’s not available as a generic drug. Sitagliptin may be used as part of a combination therapy. That means you may need to take it with other drugs. Why it's used Sitagliptin is used to treat high blood sugar levels caused by type 2 diabetes. It’s used along with lifestyle changes such as improved diet and exercise, and avoiding smoking. How it works Sitagliptin belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Insulin is a chemical in your body that helps remove sugar from your blood and moves it to cells, where it can be used for energy. Hormones in your body called incretins regulate the production and release of insulin. Sitagliptin works by protecting incretin hormones so they aren’t broken Continue reading >>
Sitagliptin
Sitagliptin is used along with diet and exercise and sometimes with other medications to lower blood sugar levels in patients with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Sitagliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing the amounts of certain natural substances that lower blood sugar when it is high. Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. Sitagliptin comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take sitagliptin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sitagliptin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Sitagliptin helps to control high blood sugar but does not cure diabetes. Continue to take sitagliptin even if you feel well. Do not stop taking sitagliptin withou Continue reading >>
Januvia Side Effects Center
Januvia (sitagliptin) is an oral diabetes medicine for people with type 2 diabetes (non-insulin-dependent) diabetes. Januvia is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Many people using Januvia do not have serious side effects. Side effects that may occur with Januvia include: headache, joint or muscle pain, nausea, stomach pain, diarrhea, or constipation. Although Januvia by itself usually does not cause low blood sugar (hypoglycemia), low blood sugar may occur if Januvia is prescribed with other anti-diabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Tell your doctor if you have serious side effects of Januvia including pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate), urinating less than usual or not at all, swelling, weight gain, shortness of breath, or severe skin reaction (fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads [especially in the face or upper body] and causes blistering and peeling). The recommended dose of Januvia is 100 mg once daily. Januvia may interact with digoxin, probenecid, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), or beta-blockers. Tell your doctor all prescription and over-the-counter medications you use. During pregnancy Januvia should be used only when prescribed. Pregnancy may cause or worsen diabetes. Your doctor may change your diabetes treatment during pregnancy. It is unknown if this drug passes into breast milk. Cons Continue reading >>
Sitagliptin
Sitagliptin (INN; /sɪtəˈɡlɪptɪn/ ( listen), previously identified as MK-0431 and marketed as the phosphate salt under the trade name Januvia) is an oral antihyperglycemic (antidiabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. It was developed, and is marketed, by Merck & Co. This enzyme-inhibiting drug is used either alone or in combination with other oral antihyperglycemic agents (such as metformin or a thiazolidinedione) for treatment of diabetes mellitus type 2.[2] Adverse effects[edit] Side effects are as common with sitagliptin (whether used alone or with metformin or pioglitazone) as they were with placebo, except for rare nausea and common cold-like symptoms, including photosensitivity.[3] No significant difference exists in the occurrence of hypoglycemia between placebo and sitagliptin.[3][4][5] In those taking sulphonylureas, the risk of low blood sugar is increased.[6] The existence of rare case reports of renal failure and hypersensitivity reactions is noted in the United States prescribing information, but a causative role for sitagliptin has not been established.[7] Several postmarketing reports of pancreatitis (some fatal) have been made in people treated with sitagliptin and other DPP-4 inhibitors,[8] and the U.S. package insert carries a warning to this effect,[9] although the causal link between sitagliptin and pancreatitis has not yet been fully substantiated.[2] One study with lab rats published in 2009 concluded that some of the possible risks of pancreatitis or pancreatic cancer may be reduced when it is used with metformin. However, while DPP-4 inhibitors showed an increase in such risk factors, as of 2009, no increase in pancreatic cancer has been reported in individuals taking DPP-4 inhibitors.[10] The updated (August 20 Continue reading >>
