diabetestalk.net

What Is Drug Induced Diabetes?

Drug Induced Diabetes

Drug Induced Diabetes

RESEARCH SHOWS MANY MEDICATIONS ACTUALLY INDUCE DIABETES A large number of studies are now showing that Many widely prescribed medications can predispose a person to develop type 2 diabetes or can actually precipitate diabetes. This incidence, especially increases when pre-existing risk factors are present. A vast majority of medications may act by increasing insulin resistance, by diminishing the secretion of insulin, or both. Widely Used Medications Linked With Causing Diabetes Thiazide diuretics (HydroDIURIL-hydrochlorothiazide or Lozol-indapamide) are a type of diurectic, used to treat high blood pressure by increasing your water excretion (elimination). They cause the kidneys to pass more fluid into the urine. Along with water, diuretics cause the excretion or loss of many minerals through the urine, especially potassium. These diuretics revolutionized the treatment of hypertension in the 1960s, but were soon noted to increase the risk of diabetes. Research revealed that decreased potassium levels are directly linked with developing Type 2 Diabetes. Beta blockers such as atenolol should no longer be prescribed, according to the guidelines from the National Institute for Clinical Excellence. Medications, like, metoprolol (Lopressor, Toprol XL), Nadolol (Corgard) and atenolol (Tenormin) impair insulin release. Several studies have linked chronic use of -blockers with an increased risk for the development of diabetes. In fact the research revealed that Beta-blockers increase diabetes risk by 50%. Cholesterol lowering medications, like Lipitor, Crestor, Zocor, Simvastatin, Atorvastatin-to name a small few have been linked with causing an increased risk for developing diabetes by 26 times. This risk is even in the absence of any other predisposing factors like obesity. Continue reading >>

Drug-induced Diabetes

Drug-induced Diabetes

DIABETES is a well-known disease these days. It occurs when the sugar or glucose levels rise inside the human body. This rise in blood sugar levels takes place due to abnormal functioning of the cells known as β-cells of pancreas. Under normal conditions, these cells release insulin on requirement to transfer glucose from blood to the tissues/cells for energy. This transfer balances blood sugar levels. The misconduct of these β-cells disturbs the balance of blood sugar levels and causes diabetes. The activity of β-cells can be disturbed due to many reasons. One of those reasons is the consumption of some therapeutic agents. THERAPEUTIC AGENTS can influence the development of diabetes, especially when pre-existing risk factors are present and these may cause glucose control to deteriorate if administered to those with existing diabetes. It has been found that drug-induced diabetes can develop at the age of 20 years but it is more prone at the age between 40-60 years. The chances of development of drug-induced diabetes are found to be more in females (70%) as compared to males (30%). ACTION OF DRUGS INDUCING DIABETES Therapeutic agents causing diabetes may act either by increasing insulin resistance or by affecting the secretion of insulin or both. Drugs that cause diabetes by interfering with insulin production & secretion are: β-receptor antagonist (used in hypoglycemia) Tacrolimus (immunosuppressant used in organ transplant) Priminil (Vacor) (used as rodenticide) Didanosine (used as anti-retroviral therapy) Pentamidine (antimicrobial medication in used in pneumonia) L-asparaginase (as anti-cancer agent) Diphenylhydantoin (used as anticonvulsant or antilepptic drug) Opiates (used as pain reliever) Drugs that cause diabetes by developing insulin resistance: Glucocort Continue reading >>

390 Drugs That Can Affect Blood Glucose Levels

390 Drugs That Can Affect Blood Glucose Levels

Knowing the drugs that can affect blood glucose levels is essential in properly caring for your diabetes patients. Some medicines raise blood sugar in patients while others might lower their levels. However, not all drugs affect patients the same way. 390 Drugs that Can Affect Blood Glucose Levels is also available for purchase in ebook format. 390 Drugs that can affect blood glucose Level Table of Contents: Drugs that May Cause Hyper- or Hypoglycemia Drugs That May Cause Hyperglycemia (High Blood Sugar) (GENERIC NAME | BRAND NAME) Abacavir | (Ziagen®) Abacavir + lamivudine,zidovudine | (Trizivir®) Abacavir + dolutegravir + lamivudine | (Triumeq®) Abiraterone | (Zytiga®) Acetazolamide | (Diamox®) Acitretin | (Soriatane®) Aletinib | (Alecensa®) Albuterol | (Ventolin®, Proventil®) Albuterol + ipratropium | (Combivent®) Aliskiren + amlodipine + hydrochlorothiazide | (Amturnide®) Aliskiren + amlodipine | (Tekamlo®) Ammonium chloride Amphotericin B | (Amphocin®, Fungizone®) Amphotericin B lipid formulations IV | (Abelcet®) Amprenavir | (Agenerase®) Anidulafungin | (Eraxis®) Aripiprazole | (Abilify®) Arsenic trioxide | (Trisenox®) Asparaginase | (Elspar®, Erwinaze®) Atazanavir | (Reyataz ®) Atazanavir + cobistat | (Evotaz®) Atenolol + chlorthalidone | (Tenoretic®) Atorvastatin | (Lipitor®) Atovaquone | (Mepron®) Baclofen | (Lioresal®) Belatacept | (Nulojix®) Benazepril + hydrochlorothiazide | (Lotension®) Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued (GENERIC NAME | BRAND NAME) Betamethasone topical | (Alphatrex®, Betatrex®, Beta-Val®, Diprolene®, Diprolene® AF, Diprolene® Lotion, Luxiq®, Maxivate®) Betamethasone +clotrimazole | (Lotrisone® topical) Betaxolol Betoptic® eyedrops, | (Kerlone® oral) Bexarotene | (Targ Continue reading >>

Drug-induced Diabetes Mellitus

Drug-induced Diabetes Mellitus

Get access/doi/pdf/10.1517/14740338.4.6.1097?needAccess=true Aims: To review the medications that influence glucose metabolism with a focus on hypertensive, transplant and HIV-infected patient populations. Methods: Literature obtained from a MEDLINE search from 1970 to present, including studies published in the English language. The search strategy linked drugs, hyperglycaemia and diabetes mellitus, HIV, transplantation, hypertension and psychiatric patients. Results: Many common therapeutic agents influence glucose metabolism. Multiple mechanisms of action on glucose metabolism exist through pancreatic, hepatic and peripheral effects. The prevalence of hyperglycaemia was higher with the use of thiazide diuretic, -blocker, calcineurin, protease inhibitors and atypical antipsychotic drugs. Conclusions: Patients treated with those drugs appear to be at increased risk for developing diabetes. It is prudent to monitor plasma glucose values when it is not possible to avoid prescription of medication with known effects on carbohydrate metabolism. Continue reading >>

Drug Induced Diabetes

Drug Induced Diabetes

Tweet A number of medications have side effects which include the raising of blood glucose levels. Drug induced diabetes is when use of a specific medication has lead to the development of diabetes. In some cases the development of diabetes may be reversible if use of the medication is discontinued, but in other cases drug-induced diabetes may be permanent. Drug induced diabetes is a form of secondary diabetes, in other words diabetes that is a consequence of having another health condition. Which drugs can induce diabetes? A number of drugs have been linked with an increased risk development of type 2 diabetes. Corticosteroids Thiazide diuretics Beta-blockers Antipsychotics Is diabetes permanent? Diabetes may not be permanent but this can depend on other health factors. With some medications, blood glucose levels may return back to normal once the medication is stopped but, in some cases, the development of diabetes may be permanent. Managing drug induced diabetes If you need to continue taking the medication that has brought on diabetes, it may make your diabetes more difficult to control than would otherwise be the case. If you are able to stop the course of medication, you may find your blood glucose levels become slightly easier to manage. Following a healthy diet and meeting the recommended exercise guidelines will help to improve your chances of managing your blood glucose levels. Can drug induced diabetes be prevented? It may be possible to reduce the risk of developing diabetes by ensuring you to keep to a healthy lifestyle whilst you are on the medication. Being on smaller doses of the medication or shorter periods of time may help to reduce the likelihood of developing high blood sugar levels and diabetes. Doctors will usually try to put you on the smallest e Continue reading >>

Drug Induced Diabetes Insipidus

Drug Induced Diabetes Insipidus

Diabetes insipidus is often characterized by excessive thirst and excessive urination. This causes many people to experience dehydration over time, though dipsogenic diabetes insipidus may actually cause excessive hydration. In many instances, ADH suppression is caused by physical changes that have occurred in the central nervous system or the kidneys. It may be caused by a trauma, illness, or tumor in most circumstances. It may also be caused by certain medications that an individual may be taking for an unrelated condition. Drug induced diabetes insipidus will cause the same symptoms as any other form of DI. Over time, if the medication is taken continuously despite the physical symptoms, it is possible for drug induced diabetes insipidus to turn into nephrogenic or central diabetes insipidus. What Drugs Can Cause Diabetes Insipidus? Lithium is the most common medication that causes diabetes insipidus. This is because it affects the flow of sodium through the muscle and nerve cells in the body. It is often used to treat bipolar disorder, especially if an individual suffers from periodic episodes of mania. These additional medications are also known to cause diabetes insipidus as a side effect in some individuals. Amphotericin B: This medication is prescribed for individuals who are suffering from a serious fungal infection. It can also be used to treat leishmaniasis, which is caused by a parasite that is spread by certain biting sandflies. Known as Fungizone or Mysteclin-F, kidney problems are a common side effect with this injectable drug. Cidofovir: Also known as Vistide, this is an antiviral medication that is used to treat CMV retinitis when a patient has been diagnosed with AIDS. It can only be distributed through an intravenous formulation. Demeclocycline: This Continue reading >>

Steroid/drug-induced Hyperglycemia

Steroid/drug-induced Hyperglycemia

OVERVIEW: What every practitioner needs to know Drug-induced hyperglycemia is a more common complication of various treatment regimens than many physicians may realize. - Glucocorticoid (GC) or steroid-induced hyperglycemia has been well described in rheumatology, oncology and transplant literature for several decades. GC-induced hyperglycemia is the most common form of drug-induced hyperglycemia. GC treatment routes include oral, IV, intranasal, inhaled, topical, and localized injections. While all forms of GC administration carry the risk of diabetes, the oral and IV routes are by far the most commonly associated with hyperglycemia and will thus be the only treatment routes described in this chapter. GCs may be the most diabetogenic of all drugs known to induce hyperglycemia. - L-Asparaginase induced hyperglycemia has also been well known to complicate acute lymphocytic leukemia (ALL) induction therapy, particularly in children. - Tacrolimusand cyclosporine (calcineurin inhibitors - CNI) are also diabetogenic. In transplant patients, tacrolimus is more likely to result in hyperglycemia, especially in pediatric transplant recipients and African Americans, and is estimated to be 5 times as diabetogenic as cyclosporine. - In both transplant and oncology patients, GCs, in addition to either L-asparaginase or tacrolimus, has resulted in significantly higher rates of hyperglycemia than seen with any of the agents alone. Because diabetes in transplant patients is unlikely to be due to one factor, the condition has been given a new name, NODAT (New Onset Diabetes After Transplant). - More recently, hyperglycemia has been shown to be associated with a typical or second generation antipsychotic (SGA) use, particularly in conjunction with weight gain. The risk of hyperglycemia Continue reading >>

Medication-induced Diabetes Mellitus

Medication-induced Diabetes Mellitus

Abstract Epidemiological studies and case reports have demonstrated an increased rate of development of diabetes mellitus consequent to taking diverse types of medication. This review explores this evidence linking these medications and development of diabetes and presents postulated mechanisms by which the medications might cause diabetes. Some medications are associated with a reduction in insulin production, some with reduction in insulin sensitivity, and some appear to be associated with both reduction in insulin production and insulin sensitivity. 1 INTRODUCTION A variety of medications have been associated with development of diabetes. Establishing a precise cause and effect relationship between a medication and development of diabetes is challenging for several reasons. Side effects of most medications are rare and clinical studies of medications typically evaluate effectiveness and are not powered to evaluate side effects. Diabetes is a common disease and there is always a question of whether it would have developed if the person had not taken the medication in question. Patients are often taking multiple medications and so it is hard to determine which medication was responsible for the side effect. For example, organ transplant patients may be taking a glucocorticoid and a calcineurin inhibitor, so an epidemiological study has difficulty ascribing the side effect to one or the other or the combination of these medications. There are also covariants such as the weight gain associated with steroids or antipsychotics making it difficult to know if development of diabetes was a primary or secondary effect of the medication. When we turn to deciphering the mechanism by which a medication caused diabetes, there are often multiple plausible molecular mechanisms ident Continue reading >>

Drug-induced Low Blood Sugar

Drug-induced Low Blood Sugar

Low blood sugar (hypoglycemia) is common in people with diabetes who are taking insulin or other medicines to control their diabetes. All of the following can cause blood sugar (glucose) level to drop: Drinking alcohol Getting too much activity Intentionally or unintentionally overdosing on the medicines used to treat diabetes Missing meals Even when diabetes is managed very carefully, the medicines used to treat diabetes can result in drug-induced low blood sugar. The condition may also occur when someone without diabetes takes a medicine used to treat diabetes. In rare cases, non-diabetes-related medicines can cause low blood sugar. Medicines that can cause drug-induced low blood sugar include: Bactrim (an antibiotic) Beta-blockers Haloperidol Insulin MAO inhibitors Metformin when used with sulfonylureas Pentamidine Quinidine Quinine SGLT2 inhibitors (such as dapagliflozin and empagliflozin) Sulfonylureas Thiazolidinediones (such as Actos and Avandia) Continue reading >>

Steroid Diabetes

Steroid Diabetes

Steroid diabetes (also "steroid-induced diabetes") is a medical term referring to prolonged hyperglycemia due to glucocorticoid therapy for another medical condition. It is usually, but not always, a transient condition. Medical conditions[edit] The most common glucocorticoids which cause steroid diabetes are prednisolone and dexamethasone given systemically in "pharmacologic doses" for days or weeks. Typical medical conditions in which steroid diabetes arises during high-dose glucocorticoid treatment include severe asthma, organ transplantation, cystic fibrosis, inflammatory bowel disease, and induction chemotherapy for leukemia or other cancers. Insulin[edit] Glucocorticoids oppose insulin action and stimulate gluconeogenesis, especially in the liver, resulting in a net increase in hepatic glucose output. Most people can produce enough extra insulin to compensate for this effect and maintain normal glucose levels, but those who cannot develop steroid diabetes. Criteria[edit] The diagnostic criteria for steroid diabetes are those of diabetes (fasting glucoses persistently above 125 mg/dl (7 mM) or random levels above 200 mg/dl (11 mM)) occurring in the context of high-dose glucocorticoid therapy. Insulin levels are usually detectable, and sometimes elevated, but inadequate to control the glucose. In extreme cases the hyperglycemia may be severe enough to cause nonketotic hyperosmolar coma. Treatment[edit] Treatment depends on the severity of the hyperglycemia and the estimated duration of the steroid treatment. Mild hyperglycemia in an immunocompetent patient may not require treatment if the steroids will be discontinued in a week or two. Moderate hyperglycemia carries an increased risk of infection, especially fungal, and especially in people with other risk factors s Continue reading >>

Drug-induced Diabetes Mellitus.

Drug-induced Diabetes Mellitus.

1. Expert Opin Drug Saf. 2005 Nov;4(6):1097-109. Izzedine H(1), Launay-Vacher V, Deybach C, Bourry E, Barrou B, Deray G. (1)Department of Nephrology, Pitie-SalPetriere Hospital, Paris, France. [email protected] AIMS: To review the medications that influence glucose metabolism with a focus onhypertensive, transplant and HIV-infected patient populations.METHODS: Literature obtained from a MEDLINE search from 1970 to present,including studies published in the English language. The search strategy linkeddrugs, hyperglycaemia and diabetes mellitus, HIV, transplantation, hypertensionand psychiatric patients.RESULTS: Many common therapeutic agents influence glucose metabolism. Multiplemechanisms of action on glucose metabolism exist through pancreatic, hepatic and peripheral effects. The prevalence of hyperglycaemia was higher with the use ofthiazide diuretic, beta-blocker, calcineurin, protease inhibitors and atypicalantipsychotic drugs.CONCLUSIONS: Patients treated with those drugs appear to be at increased risk fordeveloping diabetes. It is prudent to monitor plasma glucose values when it isnot possible to avoid prescription of medication with known effects oncarbohydrate metabolism. Continue reading >>

Is Drug Induced Diabetes Reversable?

Is Drug Induced Diabetes Reversable?

Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. I am new to the forum. I was diagnosed with Diabetes Type II several weeks ago and have some questions that I can't seem to get answered from researching myself and my doctor give me conflicting information. I'd appreciate any help. A year ago, I had a A1C of 6.2 and was told that I was insulin resistant but did not get a diagnosis of diabetes...The doctor just said, You are insulin resistant, get this book called Sugar busters and that was it. I should have asked more questions now I think about it, but I didn't. This year was probably the most stressful of my life. I divorced, had to sell my home of 13 years because I was layed off, my father died, I moved into an apt, my daughter had migraine problems, then she got mono....I got pneumonia in one lung, was put on prednisone for four days, clarithromycin, and continued to take a drug called norethindrone which I have been on for going on four months now because of irregular bleeding every two weeks and endometriosis like symptoms. I also have PCOS, Polycystic ovarian syndrome. When in the hospital for pneumonia, the nurse pricked my finger and I had a blood sugar reading of 312. I told her that I had just eaten 2 jelly donuts a half-hour ago but she said that didn't matter. The ER doctor told me I had diabetes and wrote a RX for metformin on the spot, asking me to follow-up with my primary for a blood glucose test. An A1C, now showed 6.9. The night before the blood glucose test, I was depressed and ate a whole pound of ground beef. with taco seasoning, and some taco shells. 10 hours of fasting later, my blood glucose reading turned out to be Continue reading >>

Drug Or Chemical Induced Diabetes Mellitus W/o Complications

Drug Or Chemical Induced Diabetes Mellitus W/o Complications

ICD-10: E09.9 Short Description: Drug or chemical induced diabetes mellitus w/o complications Long Description: Drug or chemical induced diabetes mellitus without complications This is the 2018 version of the ICD-10-CM diagnosis code E09.9 Valid for Submission The code E09.9 is valid for submission for HIPAA-covered transactions. Code Classification Endocrine, nutritional and metabolic diseases (E00–E90) Diabetes mellitus (E08-E13) Drug or chemical induced diabetes mellitus (E09) Convert to ICD-9 Synonyms Diabetes mellitus caused by drug without complication Diabetes mellitus caused by non-steroid drugs Diabetes mellitus caused by non-steroid drugs without complication Drug-induced diabetes mellitus Drug-induced diabetes mellitus Steroid-induced diabetes Steroid-induced diabetes mellitus without complication Diabetes Also called: DM, Diabetes mellitus Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. Glucose comes from the foods you eat. Insulin is a hormone that helps the glucose get into your cells to give them energy. With type 1 diabetes, your body does not make insulin. With type 2 diabetes, the more common type, your body does not make or use insulin well. Without enough insulin, the glucose stays in your blood. You can also have prediabetes. This means that your blood sugar is higher than normal but not high enough to be called diabetes. Having prediabetes puts you at a higher risk of getting type 2 diabetes. Over time, having too much glucose in your blood can cause serious problems. It can damage your eyes, kidneys, and nerves. Diabetes can also cause heart disease, stroke and even the need to remove a limb. Pregnant women can also get diabetes, called gestational diabetes. Blood tests can show if you have diabetes. One t Continue reading >>

Drug-induced Diabetes.

Drug-induced Diabetes.

Abstract The only drugs which commonly cause diabetes during therapeutic use are the anti-hypertensive vasodilator diazoxide, and corticosteroids in high doses such as those used to palliate intracranial tumours. Thiazide diuretics have in the past been used in higher doses than necessary to treat hypertension, and the lower doses now used probably carry only a slight risk of inducing diabetes. The risk from beta-blockers is also quite small, but there is some evidence that thiazides combined with beta-blockers may be more likely to cause diabetes than either drug alone. The combination is probably best avoided in patients with a family history of non-insulin-dependent diabetes. The effect of the low-oestrogen combined oral contraceptive pill seems to be slight, and it presents a risk only to women who have had gestational diabetes. Bodybuilders who take enormous doses of anabolic-androgens can develop impaired glucose tolerance. Several drugs, including theophylline, aspirin, isoniazid and nalidixic acid can cause transient hyperglycaemia in overdosage, but only streptozotocin, alloxan and the rodenticide Vacor are likely to cause permanent diabetes. Continue reading >>

Medicationinduced Diabetes Mellitus

Medicationinduced Diabetes Mellitus

Department of Pediatrics, University of Virginia, Charlottesville Corresponding Author: David R. Repaske, Department of Pediatrics, University of Virginia, Charlottesville, VA ( Department of Pediatrics, University of Virginia, Charlottesville Corresponding Author: David R. Repaske, Department of Pediatrics, University of Virginia, Charlottesville, VA ( Please review our Terms and Conditions of Use and check box below to share full-text version of article. I have read and accept the Wiley Online Library Terms and Conditions of Use. Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. Epidemiological studies and case reports have demonstrated an increased rate of development of diabetes mellitus consequent to taking diverse types of medication. This review explores this evidence linking these medications and development of diabetes and presents postulated mechanisms by which the medications might cause diabetes. Some medications are associated with a reduction in insulin production, some with reduction in insulin sensitivity, and some appear to be associated with both reduction in insulin production and insulin sensitivity. A variety of medications have been associated with development of diabetes. Establishing a precise cause and effect relationship between a medication and development of diabetes is challenging for several reasons. Side effects of most medications are rare and clinical studies of medications typically evaluate effectiveness and are not powered to evaluate side effects. Diabetes is a common disease and there is always a question of whether it would have developed if the person had not taken the medication in question. Patients are often taking multiple medications and so it is hard to determine w Continue reading >>

More in diabetes