Metformin, Weight Loss & Pcos – Does It Actually Work?
Did you know that one of the main reasons you can't lose weight with PCOS is because of your hormones? It's true, and that's why many women (and physicians) turn to using Metformin to try and help with weight loss. But just because it works for some people doesn't mean it will necessarily work for YOU. Find out why metformin helps with weight loss, but more important what works better and how to finally lose weight if you have PCOS. Insulin & PCOS: Why It's so Important One of the most common medications prescribed for PCOS is metformin. But, PCOS is a hormonal condition which results in weight gain, hair growth on the face, infertility, acne and estrogen/progesterone imbalances. So why is metformin, a medication used to lower blood sugar and treat insulin resistance, used to treat estrogen/progesterone imbalances in women? The logic is quite simple: Most of the symptoms of PCOS (all those listed above) stem from insulin resistanc e! In fact many physicians recommend that ALL women with PCOS should be treated for insulin resistance regardless of what their fasting insulin and fasting blood sugar levels are. This means that the root cause of PCOS (at least the majority of it) is insulin resistance, and this is why metformin is so commonly used to treat. Insulin resistance causes a block of glucose uptake in your skeletal muscles which results in a lower metabolism (and weight gain), insulin also directly acts on your ovaries and adrenals increasing androgens like testosterone and DHEA. It's also the action of insulin on your pituitary that results in increased LH production which over stimulates your ovaries resulting in the characteristic "cysts" of PCOS. High levels of DHEA and testosterone lead to acne and hair growth (hirsutism). But one simple question r Continue reading >>
How To Take Metformin As A Weight-loss Pill
Metformin, or glucophage, is an oral diabetes medication that is commonly prescribed to control blood sugar levels. This medication makes it easier for your body to absorb available glucose in the bloodstream. Metformin is generally a safe medication; however, some patients may experience lactic acidosis, which results in muscle pain, difficulty breathing, slow or uneven heart rate, weakness, dizziness and stomach pain. In addition, metformin may cause weight loss as a side effect, which can be beneficial if you are trying to lose weight. Video of the Day Schedule and appointment with your physician to determine is metformin is an appropriate medication for control of diabetes and weight loss. Be sure to let your doctor know of other medications you are taking, in particular the medications related to diabetes. Bring in at least a week's worth of before and after-meal blood sugar recordings. Take metformin with a meal, whether it is prescribed once per day or twice per day. Avoid eating high-calorie, fatty foods while taking metformin. Focus on consuming more fruits, vegetables, whole grains and nuts. Check your blood sugar levels after eating. Drink a full glass of water each time you take metformin. It will also make you feel full and reduce your cravings to eat. Continue reading >>
Why Does Metformin Cause Diarrhea
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Metformin: Uses, Action, Dosage, Side Effect And Brand Information
What is metformin used for? Controlling blood sugar levels in adults, adolescents and children aged 10 years and over with type 2 diabetes. Metformin is used when diet alone has failed to fully control blood sugar. It may be used on its own, in combination with other oral antidiabetic medicines, or with insulin. Polycystic ovary syndrome (PCOS). This is an off-licence use of metformin, so you won't find it mentioned in the information leaflets that come with the medicine. However, metformin is a widely used and established treatment option for this condition. How does metformin work? In type 2 diabetes the cells in the body, particularly muscle, fat and liver cells, become resistant to the action of insulin. Insulin is the main hormone responsible for controlling the level of sugar (glucose) in the blood. It makes cells in the body remove sugar from the blood. When the cells are resistant to insulin this makes blood sugar levels rise too high. Metformin hydrochloride is a type of antidiabetic medicine called a biguanide. It works in a number of ways to lower blood sugar levels in people with type 2 diabetes. Firstly, it increases the sensitivity of muscle cells to insulin. This enables these cells to remove sugar from the blood more effectively. Secondly, it reduces the amount of sugar produced by cells in the liver. Finally, it delays the absorption of sugar from the intestines into the bloodstream after eating so that there is less of a spike in blood sugar levels after meals. Metformin is taken regularly every day to help control blood sugar levels both between and directly after meals. In polycystic ovary syndrome or PCOS many women have high insulin levels, and as a result their cells become resistant to the action of insulin. The high insulin levels also cause an Continue reading >>
Could Metformin Actually Make Insulin Resistance Worse?
Polycystic Ovarian Syndrome, or PCOS, and Insulin Resistance (IR) often occur simultaneously. While the connection between these two conditions is, as of yet, not entirely clear, researchers have determined that IR can lead to PCOS and diabetes.1 Metformin, or Glucophage, is commonly prescribed for both of these disorders, as it is assumed to reduce IR and improve the symptoms associated with it (such as high blood sugar). Understanding the Fine Print Although Metformin claims to reduce IR, current labeling laws do not require pharmaceutical companies to reveal how their products achieve results, they simply must accurately represent what kind of results can be expected from their medications.2 This pharmaceutical, in particular, lowers blood sugar using less insulin, which has been taken to mean that it reduces IR.2 This may not be the case. How Does Metformin Really Work? Diabetes Update, a blog that reviews diabetes medications and treatment options, has published some interesting findings pertaining to how Metformin actually improves diabetes and PCOS. A study conducted on mice has suggested that the drug lowers blood sugar not by reducing IR, but by activating a gene that does not function properly. This gene, which is located in the liver, stops the production of glucose.2 According to the findings of this study, this pharmaceutical works on a deeper level than simply increasing the sensitivity of the body’s cells to insulin—it actually addresses a genetic issue. While the end result remains the same, blood sugar is lowered; the cells of the body are no more sensitive to insulin than they were before. Although the desired end result is achieved, this doesn’t necessarily heal the body in the same manner as decreasing IR would. Determining Which PCOS Medicine Continue reading >>
Fruit For Diabetes – Is It Actually Safe To Eat?
If you are living with diabetes, you've probably been told to minimize or eliminate your intake of fruit because "fruit is high in sugar." And if this is the case, maybe you refrain from eating fruits because it causes your blood glucose to spike. Attracted by the smell, color and taste, you may find yourself asking a simple question: "Should I avoid fruit in the long-term? And if so, will I ever be able to eat fruit again?” It turns out that this ant-fruit message is a perfect example of pseudoscience at its best. A recent study published in PLOS medicine tracked the health of 512,891 Chinese men and women between the ages of 30 and 79 for an average of 7 years, in order to understand the effect that their diet had on their overall health (1). We like these types of studies because they are: For those who did not have diabetes at the beginning of the study, those who had a higher fruit consumption were 12% less likely to develop diabetes, compared with those who ate zero pieces of fruit per day. The researchers found a dose-response relationship, which means that the more frequently these nondiabetic individuals ate fruit, the lower the risk for developing diabetes. Amongst those living with diabetes at the beginning of the study, those who ate fruit 3 times per week reduced their risk of all-cause mortality (death from any cause) by 17%, compared with diabetic individuals who ate zero pieces of fruit per day. In addition, researchers uncovered that those who ate fresh fruit 3 days per week were 13-28% less likely to experience macrovascular complications (heart disease and stroke) and microvascular damage (kidney disease, retinopathy and neuropathy). Even though this study was observational, the results of the study have profound implications for people living with Continue reading >>
Could Metformin Actually Protect The Kidneys?
The drug metformin is not recommended for people with kidney disease. For this reason, some people think that metformin causes kidney disease. But new evidence suggests that metformin might actually protect the kidneys. For many people with type 2 diabetes, metformin is a very effective drug. In everyone, the liver is a sort of “mother” organ. When blood glucose (BG) levels go down, the liver releases some glucose into the blood to make sure all the other organs get enough glucose energy to work properly. When you eat and your BG levels start going up, the liver is supposed to stop pushing all this glucose out into the bloodstream. But for some reason, in people with type 2 diabetes, like an oversolitous mother, the liver doesn’t stop feeding the bloodstream after meals. “Eat eat” I can hear it say to a bloodstream already stuffed with glucose. And this continued release of glucose into the bloodstream after meals is one reason people with type 2 go high after meals. Metformin helps to stop this process, and this is its main action. But it also reduces insulin resistance. In addition, generic metformin is pretty cheap. So overall, it’s a good drug for type 2s or even for type 1s who have developed insulin resistance. Metformin can also cause side effects, especially gastrointestinal distress. Most people find that these side effects are reduced if they start with a low dose and work up to an effective dose. Taking the drug with meals also helps. Others have found that things like yogurt and milk thistle help with the GI symptoms. The extended-release form seems to cause fewer of these problems. But for those with kidney disease, metformin is not so great. This is because metformin is excreted through the kidneys. If the kidneys aren’t functioning well, the Continue reading >>
Metformin And Diabetes: Trouble In Paradise
Popular Drug Damages Your Cells But Fasting Delivers Energy Jessica came to see me because she had been diagnosed with a condition that is becoming more and more common – PCOS. Polycystic Ovary Syndrome is a problem of the adrenal glands that causes: Irregular menstrual cycles Easy fatiguing And even diabetes Jessica was prescribed a diabetes medication called metformin (tradename Glucophage) that seems to help metabolic problems. It also allows people to burn fat so they stop gaining weight. This drug is a first-line therapy for Type 2 Diabetes (T2D) and has been used for many years. It has the effect of making the body more sensitive to insulin and blocking the liver from putting out more sugar. The net effect of this is to lower blood sugar levels. However, metformin’s specific action reaches deeper into your cells. It blocks the mitochondria, the powerhouse of the cells of your body, from using sugar efficiently. When cells are unable to use sugar, they must switch to fat-burning mode. With the ability to burn fat, the body has lower sugar levels and can actually lose weight! The effect of metformin has been trumpeted for many years. Metformin: Decreases blood glucose Increases fat use Prevents kidney problems Improves PCOS in women Prevents diabetes Lowers cancer rates  Because of these effects metformin is now being considered and used for many conditions including: Type 2 Diabetes Type 1 Diabetes Cancers of all types Polycystic Ovary Syndrome Obesity Indeed, as one of my professors stated, it seems that metformin should be “included in the drinking water.” Everyone would supposedly benefit. Many without diabetes, PCOS, or even pre-diabetes are taking it to prevent diabetes and cancer. Beware of Treating Disease with Metformin All of the symptoms and di Continue reading >>
- Is It Time to Change the Type 2 Diabetes Treatment Paradigm? No! Metformin Should Remain the Foundation Therapy for Type 2 Diabetes
- The Pros and Cons of Metformin for Diabetes
- NZ case study; A citizen scientist controls autoimmune diabetes without insulin, with a low carb diet, a glucose meter, and metformin.
What Does Metformin Do For Weight Loss
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Uses Metformin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in patients with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Metformin works by helping to restore your body's proper response to the insulin you naturally produce. It also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb. How to use Metformin HCL Read the Patient Information Leaflet if available from your pharmacist before you start taking metformin and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually 1-3 times a day with meals. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Take this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day. If you are already taking another diabetes drug (such as chlorpropamide), follow your doctor's directions carefully for stopping/continuing the old drug and starting metformin. Check your blood sugar regularly a Continue reading >>
Could Grapefruit Juice Protect Against Diabetes?
"Grapefruit juice 'could be the key to weight loss','' is the misleading headline in The Daily Telegraph. It reports on a study in which mice fed a combination of a high-fat diet and grapefruit juice still put on weight – albeit at a lower rate than mice fed a sugary drink. Their blood sugar levels and insulin sensitivity were also better regulated than mice that did not drink grapefruit juice. The mice were given either a high-fat diet or a low-fat diet in a range of experiments. Mice fed a high-fat diet and grapefruit juice had an 18% reduced rate of weight gain compared with mice given sugary water with the same number of calories as the grapefruit juice. They also had 13% lower fasting blood sugar levels. There was no effect on weight gain in mice fed a low-fat diet. Drinking grapefruit juice improved insulin sensitivity in mice, regardless of their diet (in people, reduced insulin sensitivity can be a sign of impending diabetes). Grapefruit juice lowered blood sugar as effectively as metformin, a drug widely used to treat people with type 2 diabetes. However, none of the mice actually had diabetes, so this research has little immediate relevance to humans with the condition. For the time being, people with diabetes should not swap their metformin for grapefruit juice on the basis of this study. Where did the story come from? The study was carried out by researchers from the University of California and was funded by the California Grapefruit Growers Cooperative, although it had no role in the study design, data collection, analysis or decision to publish. The study was published in the peer-reviewed science journal PLOS ONE. This is an open-access journal, so the study is freely available to all. Both the Mail Online and The Daily Telegraph’s headlines incorrec Continue reading >>
The Surprising Truth About Metformin
The “natural” blood-sugar remedy that had been sidelined for far too long What I’m about to tell you may be shocking. And it’s sure to ruffle the feathers of many of the “natural know-it-alls.” But the science is clear, so I’m not afraid to say it: If you have unmanaged Type II diabetes, you should consider the drug metformin as a first line of treatment. And you won’t get the full story anywhere else, since the natural health industry wouldn’t be caught dead recommending a drug. So, please allow me to do the honors here… Think of it as your emergency “get out of jail free card” Diabetes is deadly. High blood sugar coursing through your body destroys your eyes, kidneys, heart, brain, and more. So the sooner you bring it down the better. (Just like high blood pressure, for which I also recommend tried and true medications as a first-line treatment for unmanaged hypertension.) And in this case, the science is clear—the drug metformin has been proven safe and effective for most people. And since it’s now a generic drug, it’s highly cost effective, too. Now don’t get me wrong…I’m not saying diet and exercise isn’t important. In fact, they’re the best means for preventing and even reversing Type II diabetes entirely. Something metformin can’t do. And there are certainly dietary supplements that can help with maintaining healthy blood sugar (like berberine). But Type II diabetes doesn’t develop overnight. And let’s face it, changing the habits and consequences that got us there in the first place isn’t an overnight task either. So if you need additional help, this is one rare instance where you shouldn’t be afraid to look at a mainstream therapy. And when an option this effective comes along to help kick-start your efforts saf Continue reading >>
'can I Take Metformin If I Want To Lose Weight?'
Metformin is a drug designed to treat patients with Type 2 diabetes, but it comes with an interesting side effect: weight loss. And Reddit is filled with stories from people who have lost weight on the drug. “Was trying to lose weight for a long time with no success,” one person wrote of being prescribed metformin. “I’m on 1000 mg a day and am down 10 pounds.” “I saw weight loss at first with 500 mg twice per day,” another wrote. “The difference was almost immediate.” While some people say the drug didn’t do much for them, others swear by it—even those that don’t have Type 2 diabetes, says Fatima Cody Stanford, M.D., an instructor of medicine and pediatrics at Harvard Medical School and obesity medicine physician at Massachusetts General Hospital. In fact, Cody Stanford says that she often prescribes the medication to overweight or obese people who don't have Type 2 diabetes. Here’s what you need to know about the drug. (Hit the reset button—and burn fat like crazy with The Body Clock Diet!) How It Works Metformin causes a decrease in the release of glucose from a person’s liver. This helps to lower a person’s blood sugar when it’s too high and restore the way someone uses food to make energy, according to the Mayo Clinic. "Weight loss can occur because it decreases appetite in some people who take it," says women's health expert Jennifer Wider, M.D. In order for the prescription to work effectively, the amount of metformin you take must be balanced against your diet and exercise because it helps level out your blood sugar, the clinic says. For that reason, if you change your diet or exercise, you doctor may need to change the amount of metformin you take. Check out these moves that can help you light those calories up! Can It Help You Continue reading >>
Metformin: Get The Whole Story
Many people look for alternatives to diabetic pharmaceutical drugs like Metformin™. At Liver Medic, we receive many inquiries regarding drug interaction of alternatives with Metformin as a common concern. Americans filled 76.9 million prescriptions for Metformin in 2016. By The Numbers In the United States, approximately 26 Million people are diabetic, and of that 95% are Type II diabetics, a condition influenced by lifestyle not genetics. This is actually good news. Before one starts blaming the diabetic victims, please review articles on GMOs and addictive processed foods. Many of the health hazards of these foods are deliberately hidden from consumers and short of having a degree in chemistry it’s difficult for the individual to determine danger levels.. Metformin is the generic name, but is also found in brand names such as; Glucophage™, Glucophage XR™, Glumetza™, Fortamet™ and Riomet™. Metformin is an oral medication that lowers blood glucose (sugar) by influencing the body’s sensitivity to insulin and is used for treating Type II diabetes. Metformin and the Liver Metformin has even been used to treat liver disease. The problem with this application is that the liver is responsible for breaking down drugs. That Metformin is a drug that the body needs to detoxify makes us wonder about the effectiveness of this application as a drug versus a clearly more effective alternative. The connection physicians make with Metformin, diabetes and liver disease does have a common thread.. The liver is responsible for regulating the insulin cycles. The work of the liver is to signal the pancreas to secrete insulin, breaking down insulin and storing much of the glycogen in the body. The Root of the Problem Mainstream medicine and the drug industry have historic Continue reading >>
Metformin (glucophage) Side Effects & Complications
The fascinating compound called metformin was discovered nearly a century ago. Scientists realized that it could lower blood sugar in an animal model (rabbits) as early as 1929, but it wasn’t until the late 1950s that a French researcher came up with the name Glucophage (roughly translated as glucose eater). The FDA gave metformin (Glucophage) the green light for the treatment of type 2 diabetes in 1994, 36 years after it had been approved for this use in Britain. Uses of Generic Metformin: Glucophage lost its patent protection in the U.S. in 2002 and now most prescriptions are filled with generic metformin. This drug is recognized as a first line treatment to control blood sugar by improving the cells’ response to insulin and reducing the amount of sugar that the liver makes. Unlike some other oral diabetes drugs, it doesn’t lead to weight gain and may even help people get their weight under control. Starting early in 2000, sales of metformin (Glucophage) were challenged by a new class of diabetes drugs. First Avandia and then Actos challenged metformin for leadership in diabetes treatment. Avandia later lost its luster because it was linked to heart attacks and strokes. Sales of this drug are now miniscule because of tight FDA regulations. Actos is coming under increasing scrutiny as well. The drug has been banned in France and Germany because of a link to bladder cancer. The FDA has also required Actos to carry its strictest black box warning about an increased risk of congestive heart failure brought on by the drug. Newer diabetes drugs like liraglutide (Victoza), saxagliptin (Onglyza) and sitagliptin (Januvia) have become very successful. But metformin remains a mainstay of diabetes treatment. It is prescribed on its own or sometimes combined with the newer d Continue reading >>