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What Are The Side Effects Of Stopping Metformin?

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Effects Of Withdrawal From Metformin On The Development Of Diabetes In The Diabetes Prevention Program

Go to: Abstract OBJECTIVE— In the Diabetes Prevention Program (DPP), metformin significantly reduced the risk of diabetes in individuals with impaired glucose tolerance. Diabetes status was assessed by oral glucose tolerance tests (OGTTs) performed while participants were still taking metformin or placebo. To determine whether the observed benefit was a transient pharmacological effect or more sustained, we performed a repeat OGTT after a short “washout” period during which medications (metformin or placebo) were withheld. RESEARCH DESIGN AND METHODS— All participants assigned to medication who had not developed diabetes at the end of the DPP were asked to have a repeat OGTT after discontinuing the study medication for 1–2 weeks. The predesignated outcome was the odds of diabetes in metformin versus placebo comparisons during the trial and washout combined. RESULTS— There were 1,274 participants who participated in the washout study and 529 who did not because they had already developed diabetes. Before the washout, the odds of diabetes in the metformin group was lower than that in the placebo group (odds ratio 0.66, 95% CI 0.54–0.82, P < 0.001). After the washout, di Continue reading >>

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  1. bjcarter

    Side effects of Stopping Metformin

    Hi! I'm new to this forum and regretting not finding this community earlier. I was diagnosed with Type 2 last summer with all the telltale symptoms and an H1Ac of 9.5. I made all the radical changes others have documented throughout this forum. I changed my diet to strict low carb. Started a rigorous exercise regiment. Began taking MetforminXR (500mg). Lost 40 pounds... etc. My numbers plummeted and I felt great. My doctor subsequently asked me to stop taking the metforminXR and I've been off of it for about 20 days now. My BG values as taken with my handheld are fine. Fasting is usually around 95 +/- 10 and my post meal peaks rarely exceed 120 to 130. Still, overall I feel awful. I feel the peaks and valley of normalcy and fatigue that I did before I was diagnosed. I often feel listless and even a little lethargic. I sometimes get cotton mouth and thirst but they don't seem to correspond to peak BG values. My lifestyle remains as it was before I stopped the metformin. This is a little frustrating.
    Has anyone else experienced a similar side effect to coming off metformin? I appreciate any insight.

  2. furball64801

    Hi and welcome to DD I think it might have been better to cut the dose in half and just cut it back a little at a time giving the body a chance to adjust. I am really sorry to hear your having a problem with the metformin, I hope it improves in the future.

  3. The Dutchman

    Hello and welcome to DD,
    I can't remember there were any problems, and I quit at once. Used 2 x 500mg and had always problems with Metformin after I quit the most was gone ...
    I agree with furball, better to cut the dose in half and just cut it back a little....
    And remember, everyone reacts different so stay alert and if you're not sure, contact your Dr

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