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What Are The Side Effects Of Pioglitazone Metformin?

Common Side Effects Of Actoplus Met, Actoplus Met Xr (pioglitazone Hcl And Metformin Hcl) Drug Center - Rxlist

Common Side Effects Of Actoplus Met, Actoplus Met Xr (pioglitazone Hcl And Metformin Hcl) Drug Center - Rxlist

The dose of Actoplus MET is individualized on the basis of effectiveness and tolerability. The maximum recommended daily dose is pioglitazone 45 mg/metformin 2550 mg. Hyperglycemia ( high blood sugar ) may result if you take Actoplus MET with drugs that raise blood sugar, such as: isoniazid , diuretics (water pills), steroids, phenothiazines, thyroid medicine, birth control pills and other hormones, seizure medicines, and diet pills, or medicines to treat asthma , colds or allergies. Hypoglycemia (low blood sugar) may result if you take Actoplus MET with drugs that lower blood sugar, such as: alcohol, nonsteroidal anti-inflammatory drugs ( NSAIDs ), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, or probenecid. It may also interact with furosemide , nifedipine , cimetidine or ranitidine , amiloride or triamterene , digoxin , morphine , procainamide, quinidine, trimethoprim , or vancomycin . Tell your doctor all medications you are taking. During pregnancy, Actoplus MET should be used only when prescribed. Your doctor may direct you to use insulin instead during your pregnancy. This medication can promote ovulation and increase the risk of becoming pregnant. Metformin passes into breast milk in small amounts. It is unknown if pioglitazone passes into breast milk. Consult your doctor before breastfeeding. Our Actoplus MET (pioglitazone hydrochloride and metformin hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. This medication may cause lactic Continue reading >>

Side Effects Of Pioglitazone And Metformin Xr

Side Effects Of Pioglitazone And Metformin Xr

Diabetes Home > Side Effects of Pioglitazone and Metformin XR In clinical studies based on the short-acting form of pioglitazone and metformin, common reactions to pioglitazone and metformin XR could include urinary tract infections, signs of the common cold, and fluid retention. Fortunately, adverse reactions, if any, are usually mild and easily treated. Potentially serious pioglitazone and metformin XR side effects that require medical care include signs of liver damage, allergic reactions, and chest pain. An Introduction to Side Effects of Pioglitazone and Metformin XR As with any medicine, side effects are possible with pioglitazone and metformin XR ( Actoplus Met XR). However, not everyone who takes the drug will experience problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. (This article covers many, but not all, of the possible pioglitazone and metformin XR side effects. Your healthcare provider can discuss a more complete list with you.) Serious Pioglitazone and Metformin XR Side Effects Some side effects with pioglitazone and metformin XR, although occurring infrequently, should be reported to your healthcare provider right away. These include but are not limited to: Continue reading >>

Safety And Tolerability Of Pioglitazone, Metformin, And Gliclazide In The Treatment Of Type 2 Diabetes.

Safety And Tolerability Of Pioglitazone, Metformin, And Gliclazide In The Treatment Of Type 2 Diabetes.

Safety and tolerability of pioglitazone, metformin, and gliclazide in the treatment of type 2 diabetes. Takeda Europe R&D Centre, Savannah House, 11-12 Charles II Street, London, UK. [email protected] This analysis compares the safety and tolerability of pioglitazone (a thiazolidinedione), metformin (a biguanide), and gliclazide (a sulfonylurea). Data collected from four 1-year, double-blind studies comparing treatment of over 3700 patients with type 2 diabetes with pioglitazone, metformin, or gliclazide have been combined to provide comparative tolerability and safety profiles. All treatments were well tolerated with approximately 6% of patients withdrawing from treatment because of side-effects. The side-effects profile varied between treatments, with pioglitazone being associated with edema, metformin with gastrointestinal side-effects, and gliclazide with hypoglycemia. Cardiovascular outcome was similar with all treatments, with no excess reports of cardiac failure with pioglitazone treatment. Both pioglitazone and gliclazide resulted in mean weight gain, whilst with metformin there was mean weight loss. Mean liver enzyme values decreased with pioglitazone and to a lesser extent with metformin. With gliclazide, mean liver enzyme values increased. The expected small decreases in mean hemoglobin and hematocrit seen with pioglitazone also occurred with metformin and to a lesser degree with gliclazide. The results show that all three drugs are safe, but that tolerability profiles vary. Each treatment provides an alternative therapy for type 2 diabetes, dependent on the particular needs of individual patients. Continue reading >>

Pioglitazone / Metformin

Pioglitazone / Metformin

Prices and Coupons for 60 tablets of pioglitazone / metformin 15mg/850mg Oral route (Tablet;Tablet, Extended Release) May cause or worsen congestive heart failure, is not recommended in patients with symptomatic heart failure, and is contraindicated in patients with established NYHA Class III or IV heart failure. Monitor patients for signs and symptoms of heart failure after initiation or dose increases and if heart failure occurs, consider dose reduction or discontinuing metformin/pioglitazone (immediate and extended-release formulations) and manage according to current standards of care. Lactic acidosis can occur due to metformin accumulation during treatment with metformin/pioglitazone (immediate and extended-release formulations) and may result in death, hypothermia, hypotension, and resistant bradyarrhythmias; risk factors include renal impairment, concomitant carbonic anhydrase inhibitor use (eg, topiramate), age 65 years or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (eg, acute congestive heart failure), excessive alcohol intake, and hepatic impairment. Onset is often subtle with nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain; laboratory abnormalities include elevated blood lactate (greater than 5 mmol/L), anion gap acidosis (without ketonuria or ketonemia), increased lactate:pyruvate ratio, and metformin levels generally greater than 5 mcg/mL. If acidosis is suspected, discontinue treatment, hospitalize the patient immediately, and promptly initiate hemodialysis . Buy Pioglitazone / Metformin for as low as Pioglitazone and metformin combination is used with proper diet and exercise to treat high blood sugar levels caused by type 2 diabetes . Pioglitazone w Continue reading >>

Pioglitazone

Pioglitazone

Pioglitazone and other similar medications for diabetes may cause or worsen heart failure (condition in which the heart is unable to pump enough blood to the other parts of the body). Before you start to take pioglitazone, tell your doctor if you have or have ever had heart failure, especially if your heart failure is so severe that you must limit your activity and are only comfortable when you are at rest or you must remain in a chair or bed. Also tell your doctor if you were born with a heart defect, and if you have or have ever had swelling of the arms, hands, feet, ankles, or lower legs; heart disease; high cholesterol or fats in the blood; high blood pressure; coronary artery disease (narrowing of the blood vessels that supply blood to the heart); a heart attack; an irregular heartbeat; or sleep apnea. Your doctor may tell you not to take pioglitazone or may monitor you carefully during your treatment. If you develop heart failure, you may experience certain symptoms. Tell your doctor immediately if you have any of the following symptoms, especially when you first start taking pioglitazone or after your dose is increased: large weight gain in a short period of time; shortness of breath; swelling of the arms, hands, feet, ankles, or lower legs; swelling or pain in the stomach; waking up short of breath during the night; needing to sleep with extra pillows under your head in order to breathe easier while lying down; frequent dry cough or wheezing; difficulty thinking clearly or confusion; fast or racing heart beat; not able to walk or exercise as well; or increased tiredness. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with pioglitazone and each time you refill your prescription. Rea Continue reading >>

Actoplus Met (pioglitazone,metformin) Dosage, Indication, Interactions, Side Effects | Empr

Actoplus Met (pioglitazone,metformin) Dosage, Indication, Interactions, Side Effects | Empr

Select the drug indication to add to your list Pioglitazone (as HCl), metformin HCl; 15mg/500mg, 15mg/850mg; tabs. Adjunct to diet and exercise to improve glycemic control in type 2 diabetes in patients already on pioglitazone and metformin, or when response to pioglitazone or metformin alone is inadequate. Give in divided doses with meals. Individualize. Previously on pioglitazone and/or metformin: switch on a mg/mg basis. Initially 15mg/500mg twice daily or 15mg/850mg once daily; may titrate gradually as needed; max 45mg pioglitazone/2550mg metformin per day. With CHF (NYHA Class I or II): initially 15mg/500mg or 15mg/850mg once daily. Concomitant strong CYP2C8 inhibitors: max 15mg/850mg daily. Renal impairment (eGFR 3045mL/min/1.73m2): not recommended. If eGFR <45mL/min/1.73m2, assess risk/benefit; discontinue if eGFR <30mL/min/1.73m2. NYHA Class III or IV heart failure. Severe renal impairment (eGFR <30mL/min/1.73m2). Metabolic acidosis. Diabetic ketoacidosis. Symptomatic HF: not recommended. Monitor for signs/symptoms of CHF; discontinue or reduce dose if occurs. Increased risk of metformin-associated lactic acidosis in renal or hepatic impairment, concomitant use of certain drugs (eg, cationic drugs), 65yrs of age, undergoing radiological contrast study, surgery and other procedures, hypoxic states, and excessive alcohol intake; discontinue if lactic acidosis occurs. Discontinue at time of, or prior to intravascular iodinated contrast imaging in patients with eGFR 3060mL/min/1.73m2, history of hepatic impairment, alcoholism, heart failure, or will be given intra-arterial contrast; reevaluate eGFR 48hrs after procedure and restart therapy if renally stable. Suspend therapy if dehydration occurs or before surgery. Avoid if clinical or lab evidence of hepatic diseas Continue reading >>

Competact (metformin And Pioglitazone)

Competact (metformin And Pioglitazone)

Competact tablets contain two active ingredients, metformin hydrochloride and pioglitazone hydrochloride. These are both medicines used to help control blood sugar levels in people with type 2 diabetes. Competact is licensed for use in people with type 2 diabetes, particularly overweight people, whose blood sugar is not controlled by the maximum tolerated dose of metformin alone. Competact tablets contain two active ingredients, metformin hydrochloride and pioglitazone hydrochloride. Metformin hydrochloride is a type of antidiabetic medicine known as a biguanide. It works in a number of ways to decrease the amount of sugar in the blood. Firstly, it reduces the amount of sugar produced by cells in the liver. Secondly, it increases the sensitivity of muscle cells to insulin. This enables these cells to remove sugar from the blood more effectively. Finally, it also delays absorption of sugar from the intestines into the bloodstream after eating. Pioglitazone is a type of antidiabetic medicine known as a thiazolidinedione or glitazone. It helps to control blood sugar levels by increasing the sensitivity of liver, fat and muscle cells to insulin. This enables these cells to remove sugar from the blood more effectively. Pioglitazone also reduces the amount of glucose produced by the liver, and preserves the functioning of the cells in the pancreas (beta cells) that produce insulin. This combination of medicines helps control blood sugar levels both directly after meals and between meals. One Competact tablet should be taken twice a day (morning and evening) regularly every day. The tablets can be taken either with or without food, but if you find they upset your stomach this can be minimised by taking the tablets with or just after food. Swallow them with a drink of water. I Continue reading >>

Glimepiride-pioglitazone

Glimepiride-pioglitazone

Glimepiride and pioglitazone is a combination of two oral diabetes medicines that help control blood sugar levels. Glimepiride and pioglitazone is for people with type 2 diabetes. Glimepiride and pioglitazone is sometimes given with other diabetes medications when greater blood sugar control is needed. This medication is not for treating type 1 diabetes. Glimepiride and pioglitazone may also be used for purposes not listed in this medication guide. You should not use this medicine if you have severe or uncontrolled heart failure, active bladder cancer, or diabetic ketoacidosis (call your doctor for treatment with insulin). Glimepiride and pioglitazone is not for treating type 1 diabetes. Glimepiride and pioglitazone can cause or worsen congestive heart failure. Stop using this medicine and call your doctor at once if you have shortness of breath (even with mild exertion), swelling, or rapid weight gain. You should not use this medicine if you are allergic to glimepiride, pioglitazone, or sulfa drugs, or if you have: diabetic ketoacidosis (call your doctor for treatment with insulin). To make sure glimepiride and pioglitazone is safe for you, tell your doctor if you have: congestive heart failure or heart disease; a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency; This medication may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk. Taking glimepiride and pioglitazone may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with this medicine. Follow your doctor's instructions about using this medicine if you are pregnant. Blood sugar control is Continue reading >>

Metformin And Pioglitazone Overview

Metformin And Pioglitazone Overview

Metformin/pioglitazone is a prescription medication used to treat type 2 diabetes. It is a single product containing 2 medications: pioglitazone and metformin. Pioglitazone belongs to a group of drugs called thiazolidinediones. These work by increasing the body’s sensitivity to insulin. Metformin belongs to a group of drugs called biguanides. These work by decreasing the amount of glucose absorbed from food and decreasing the amount of glucose that is produced by the liver. This medication comes in tablet form and is taken one or two times a day, with food. Common side effects of metformin/pioglitazone include upper respiratory tract infection, edema, diarrhea, headache, muscle pain, and weight gain. In combination with other medications to treat diabetes, metformin/pioglitazone can also cause hypoglycemia (low blood sugar), which can cause blurred vision and dizziness. Do not drive or operate heavy machinery until you know how metformin/pioglitazone affects you. Continue reading >>

Metformin / Pioglitazone Side Effects

Metformin / Pioglitazone Side Effects

For the Consumer Applies to metformin / pioglitazone: oral tablet, oral tablet extended release Along with its needed effects, metformin / pioglitazone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking metformin / pioglitazone: More common Bladder pain bloody or cloudy urine difficult, burning, or painful urination frequent urge to urinate lower back or side pain swelling of the face, fingers, feet, or lower legs weight gain Less common Pain or swelling in the arms or legs without any injury pale skin troubled breathing with exertion unusual bleeding or bruising unusual tiredness or weakness Rare Abdominal or stomach discomfort anxiety blurred vision chills cold sweats coma confusion cool, pale skin decreased appetite depression diarrhea dizziness fast heartbeat fast, shallow breathing general feeling of discomfort headache increased hunger muscle pain or cramping nausea nightmares seizures shakiness sleepiness slurred speech Some side effects of metformin / pioglitazone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Body aches or pain cough ear congestion fever, sneezing, or sore throat loss of voice runny nose stuffy nose For Healthcare Professionals Applies to metformin / pioglitazone: oral tablet, oral tablet extended release Cardi Continue reading >>

Common Side Effects Of Actos (pioglitazone Hydrochloride) Drug Center - Rxlist

Common Side Effects Of Actos (pioglitazone Hydrochloride) Drug Center - Rxlist

Actos is available as tablets in strengths of 15, 30 or 45 mg. Dose is dependent on patient response and the prescribing doctor's clinical judgment; glucose tests may help determine doses. Actos and other similar drugs may exacerbate symptoms of congestive heart failure (dyspnea, edema , weight gain) and these symptoms may be serious. Patients with congestive heart failure classified as III or IV (NY Heart Association) should not take this Actos. Other serious side effects of Actos include nausea, vomiting , jaundice , and vision changes or loss; it may also cause hypoglycemia . There are no good studies in pregnant or breastfeeding women. Use of Actos in these patients should weigh risks versus benefits. There are no studies of safety or effectiveness of Actos on pediatric (under 18 years old) patients. Our Actos Drug Center provides a comprehensive view of available drug information as well as related drugs, user reviews, supplements , and diseases, and conditions. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Fractures [see WARNINGS AND PRECAUTIONS ] Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Over 8500 patients with type 2 diabetes have been treated with ACTOS in randomized, double-blind, controlled clinical trials, including 2605 patients with type 2 diabetes and macrovascular disease treated with ACTOS in the PROactive clinical trial. In these trials, over 6000 patients have been treated with ACTOS for six months or lon Continue reading >>

Pioglitazone-metformin

Pioglitazone-metformin

Nausea , vomiting , stomach upset, diarrhea , weakness , sore throat , muscle pain , weight gain, tooth problems or a metallic taste in the mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If stomach symptoms return later (after taking the same dose for several days or weeks), tell your doctor right away. Stomach symptoms that occur after the first days of your treatment may be signs of lactic acidosis . Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: new/worsening vision problems (such as blurred vision ), bone fracture, reddish-colored urine, urgent need to urinate, pain while urinating. Pioglitazone may rarely cause liver disease. Tell your doctor right away if you develop symptoms of liver disease, including: dark urine, yellowing of eyes / skin , persistent nausea / vomiting , stomach/ abdominal pain . This medication usually does not cause low blood sugar ( hypoglycemia ). Low blood sugar may occur if this drug is prescribed with other diabetes medications (such as insulin or a sulfonylurea). Low blood sugar is more likely if you drink large amounts of alcohol, do unusually heavy exercise , or do not consume enough calories from food. To help prevent low blood sugar , eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal. Symptoms of low blood sugar include sudden sweating , shaking, fast heartbeat, hunger , blurred vision , dizziness , or tingling hands/feet. It is a good habit t Continue reading >>

Pioglitazone/metformin

Pioglitazone/metformin

Pioglitazone/metformin (also known by the brand names Actoplus Met, Piomet and Politor) is combination of two oral diabetes medications pioglitazone and metformin. The two oral antihyperglycemic agents with different mechanisms of action are used to improve glycemic control in patients with diabetes mellitus type 2. Mechanisms[edit] Pioglitazone is a member of the thiazolidinedione class, it decreases insulin resistance in the periphery and in the liver resulting in increased insulin dependent glucose disposal and decreased hepatic glucose output. Metformin is a member of the biguanide class, improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Indication[edit] Pioglitazone/metformin is indicated as an adjunct to diet and exercise: To improve glycemic control in patients with type 2 diabetes, or For patients who are already treated with a separate combination of pioglitazone and metformin, For patients whose diabetes is not adequately controlled with metformin alone, or For patients who have initially responded to pioglitazone alone and require additional glycemic control. Dosage and administration[edit] Recommended dose[edit] Use of antihyperglycemic agents in the management of type 2 diabetes should be individualized on the basis of effectiveness and tolerability. Pioglitazone/metformin should be given with meals; the initial starting dose is either the 15 mg/500 mg or 15 mg/850 mg tablet strength once or twice daily, and gradually titrated after assessing adequacy of therapeutic response, while not exceeding the maximum recommend Continue reading >>

Actoplus Met, Actoplus Met Xr (metformin And Pioglitazone) Drug Side Effects, Interactions, And Medication Information On Emedicinehealth.

Actoplus Met, Actoplus Met Xr (metformin And Pioglitazone) Drug Side Effects, Interactions, And Medication Information On Emedicinehealth.

oval, white, imprinted with 4833M, 15/850 What are the possible side effects of metformin and pioglitazone (Actoplus Met, Actoplus Met XR)? This medication may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or irregular heart rate, dizziness , or feeling very weak or tired. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any other serious side effects, such as: stomach pain, blood in your urine, painful urination; feeling short of breath, especially when lying down; pale skin, feeling light-headed, rapid heart rate, trouble concentrating; sudden unusual pain in your hand, arm, or foot; or nausea, stomach pain, low fever , loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). sneezing, runny nose, cough or other signs of a cold. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about metformin and pioglitazone (Actoplus Met, Actoplus Met XR)? You should not use this medication if you are allergic to metformin (Glucophage) or pioglitazone (Actos), or if you have kidney problems, severe heart failure, active bladder cancer , or metabolic acidosis. Do not use metformin and pioglitazone if you are in a state o Continue reading >>

Actoplus Met (metformin Hydrochloride/pioglitazone) Dose, Indications, Adverse Effects, Interactions... From Pdr.net

Actoplus Met (metformin Hydrochloride/pioglitazone) Dose, Indications, Adverse Effects, Interactions... From Pdr.net

Thiazolidinediones/Glitazone and Other Oral Antidiabetic Combinations Oral combination of metformin, a biguanide, and pioglitazone, a thiazolidinedione, for type 2 DM; rare but serious risk of lactic acidosis. Actoplus Met XR Oral Tab ER: 15-1000mg, 30-1000mg Actoplus Met/Pioglitazone Hydrochloride, Metformin Hydrochloride/Pioglitazone, Metformin Hydrochloride Oral Tab: 15-500mg, 15-850mg For the treatment of type 2 diabetes mellitus in combination with diet and exercise and when treatment with both metformin and pioglitazone is appropriate. NOTE: Metformin; pioglitazone is not for use in patients with type 1 diabetes or diabetic ketoacidosis. NOTE: When metformin; pioglitazone is used in combination with insulin or an insulin secretagogue, a lower dose of the insulin or insulin secretagogue may be needed in order to reduce the risk of hypoglycemia. In patients taking insulin and metformin; pioglitazone who experience hypoglycemia, reduce the dose of insulin by 10 to 25%. Individualize any further adjustments based on glycemic response. NOTE: When adding pioglitazone to metformin in patients with or without symptomatic heart disease and diabetes, monitor closely for signs of weight gain, peripheral edema, or congestive heart failure. In general, pioglitazone should be initiated at the lowest dose and increased gradually after at least three months of therapy. The risk of these symptoms is increased when higher doses of pioglitazone are used in combination with insulin in patients at risk of congestive heart failure. Pioglitazone should not be used in patients with New York Heart Association Class III or IV heart failure; metformin should not be used in patients with congestive heart failure requiring pharmacological therapy. Metformin; pioglitazone should be discontinu Continue reading >>

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