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What Are The Genetic Causes Of Type 1 Diabetes?

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Genetic Factors In Type 1 Diabetes - The Genetic Landscape Of Diabetes - Ncbi Bookshelf

Location of INS on the human genome. INS maps to chromosome 11, approximately between 2144 and 2148kilobases (kb). Click on the figure or here for a current and interactive view of the locationof INS in the human genome. Note: this figure was created (more...) C-peptide is secreted in equal amounts to insulin, but it has long been thoughtthat it has no biological role. However, in diabetic rats C-peptide has beenshown to reduce the dysfunction of blood vessels and the nervous system that iscommon in diabetes ( 1 ). C-peptidecontains the greatest variation among species, whereas regions of insulin thatbind to the insulin receptor are highly conserved. Several single nucleotide polymorphisms ( SNPs ) have been found within the INS gene, none (at the time ofwriting) of which cause non-synonymous amino acid changes in the mature protein(see the allelic variants that are known to be associated with disease). A BLAST search using human proinsulin precursor as a query findsproteins in 107 different species, which are all metazoans apart from threeplants and one bacterium. However, potential true homologous genes have thus far been identified only in the mouseand rat. IDDM2 and Diabetes: Continue reading >>

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  1. Linnie

    Source(s): Destroy Diabetes Starting Today : http://DiabetesCure.raiwi.com/?TGQI

  2. Comment

    Source(s): The Complete Diabetes Solution : http://DiabetesGoFar.com/?uCLZ

  3. Mary

    Forget anything you have ever been told about Diabetes. And get this - it has nothing to do with insulin, exercise, diet or anything else you've heard in the past. It's all based on latest breakthrough research that Big Pharma is going Stir Crazy to hide from you. Visit here : https://tinyurl.im/aH1RU to find out what all the fuss is about.

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The Genetic Basis of Kidney Cancer: Targeting the Metabolic Basis of Disease Air date: Wednesday, November 20, 2013, 3:00:00 PM Runtime: 01:05:55 Description: NIH Wednesday Afternoon Lecture Annual Astute Clinican Lecture Dr. Linehan has had a long-standing interest in identification of the genetic basis of cancer of the kidney. Kidney cancer is not a single disease. It is made up of a number of different types of cancer, each of which has a different histology, a different clinical course, which respond differently to therapy and are caused by different genes. Studies of the kidney cancer gene pathways have revealed that kidney cancer is fundamentally a metabolic disease. These findings have provided the foundation for the development of targeted therapeutic approaches for patients with advanced forms of this disease. The annual Astute Clinician lecture within the NIH Director's Wednesday Afternoon Lecture Series (WALS) highlights exciting clinical observations that have served as a focus for research. This series has been made possible through the generous gift of the late Dr. Robert W. Miller, Scientist Emeritus, National Cancer Institute and his wife, Haruko (Holly) Miller. For

Genetic Basis For Type 1 Diabetes | British Medical Bulletin | Oxford Academic

Type 1 diabetes (T1D) is characterized by autoimmune destruction of insulin-producing -cells in the pancreas resulting from the action of environmental factors on genetically predisposed individuals. The increasing incidence over recent decades remains unexplained, but the capacity of identifying infants at highest genetic risk has become an increasing requirement for potential therapeutic intervention trials. Literature searches on T1D and genes were carried out, and key papers since the 1970s were highlighted for inclusion in this review. Early genetic studies identified the most important region for genetic susceptibility to T1Dthe human leukocyte antigen genes on chromosome 6; later shown to contribute approximately half of the genetic determination of T1D. The other half is made up of multiple genes, each having a limited individual impact on genetic susceptibility. Historically, there have been many controversial genetic associations with T1D, mostly caused by underpowered casecontrol studies but these are now decreasing in frequency. The functional effect of each gene associated with T1D must be investigated to determine its usefulness both in risk assessment and as a poten Continue reading >>

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  1. xpDiabetes

    Does Gallbladder removal cause diabetes ? Does anyone have found that they got T2 after removing gallbladder ?

  2. cherokee_psh

    I did but I do not believe this was a catalyst to diabetes.

  3. William V

    Mine was removed a few years after Dx. I suspect diet change right after Dx brought it on as next was Fatty liver disease / NAFLD. Heavy Insulin resistance (via liver??) since the beginning.
    BTW -crash diets are known to cause fatty liver in 1/3 and fatty liver leads to diabetes. Edited May 6, 2016 by William V

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Genetic Basis For Type 1 Diabetes | British Medical Bulletin | Oxford Academic

Type 1 diabetes (T1D) is characterized by autoimmune destruction of insulin-producing -cells in the pancreas resulting from the action of environmental factors on genetically predisposed individuals. The increasing incidence over recent decades remains unexplained, but the capacity of identifying infants at highest genetic risk has become an increasing requirement for potential therapeutic intervention trials. Literature searches on T1D and genes were carried out, and key papers since the 1970s were highlighted for inclusion in this review. Early genetic studies identified the most important region for genetic susceptibility to T1Dthe human leukocyte antigen genes on chromosome 6; later shown to contribute approximately half of the genetic determination of T1D. The other half is made up of multiple genes, each having a limited individual impact on genetic susceptibility. Historically, there have been many controversial genetic associations with T1D, mostly caused by underpowered casecontrol studies but these are now decreasing in frequency. The functional effect of each gene associated with T1D must be investigated to determine its usefulness both in risk assessment and as a poten Continue reading >>

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  1. pancreaswanted

    i eat a lowish carb diet, like 100 carbs a day and do exercise every day-running, cycling, just started powerlifting to see if i can get huuuge. so with this kind of diet and exercise i dont expect myself to be making ketones or anything. however, my urine smells like sugared cereal all the time-when i wake up and all through the day. my bg could be normal or high, it doesnt matter. is that weird? what is that?

  2. Pastelpainter

    Just a thought, are you drinking enough water?

  3. kitkat2

    Certain foods can make your urine smell funny too. Not sure about making it smell like sugary cereal, but tuna and asparagus both gives my urine a really strong odor. Also also like posted above....not drinking enough water may be making your urine have more of an odor.

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    Location of INS on the human genome. INS maps to chromosome 11, approximately between 2144 and 2148kilobases (kb). Click on the figure or here for a current and interactive view of the locationof INS in the human genome. Note: this figure was created (more...) C-peptide is secreted in equal amounts to insulin, but it has long been thoughtthat it has no biological role. However, in diabetic rats C-peptide has beenshown to reduce the dysfunction o ...

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