What Are The Genetic And Nongenetic Causes Of Diabetes Insipidus?

Share on facebook

What Are The Early Symptoms Of Diabetes Insipidus?

The kidney filters about 180 liters of fluid from the blood into the glomerular filtrate and then reabsorbs 178.5 liters back into the blood; excreting 1.5 liters or 1500 mL of urine per day. AntiDiuretic Hormone (ADH), made in the pituitary, is responsible for the reabsorption. Without ADH, the body is unable to concentrate the urine and the person will have up to 20 gallons of pale urine; this causes thirst. The blood becomes concentrated and the urine is dilute. The word “diabetes” is Greek for “hollow tube” because the body becomes like a hollow tube- constantly drinking water and urinating. Those are the major symptoms, accompanied by dehydration and hypotension. The word “insipidus” means “lacking character” because the urine has no color or odor. This has nothing to do with sugar. The word “mellitus” is Greek for “sugar” and diabetes mellitus (DM) aka “sugar diabetes” is a different disease. In DM, the high sugar in the blood (from lack of insulin) pulls water from the tissues (by osmosis) and the kidneys excrete water along with the sugar aka osmotic diuresis. The symptoms are also increased urination and thirst , but the cause is different. Urin Continue reading >>

Share on facebook

Popular Questions

  1. Favgrandma

    Hot Flashes after eating

    I experience the feeling of a hotflash after eating. It usually happens anywhere from 15 to 30 min. after eating. Also have them when I am stressed. Would like to know if I am the only one experiencing this and why this occurs. I spend alot of time outside trying to cool down. Sure am not looking forward to the summer season and hot days and nights.

  2. summysd

    I found if you take fish oil 2 to 6 capsules of 1000 mg a day along with vitamin D it really help with the sweating after meals and just in general.

  3. Geoffrey62

    I have them too. I was only recently made aware of the glycemic index. Foods with high glycemic indexes will cause spikes in blood sugar which is not good. Look up the index online and, from what I've heard, you should try to only eat foods with low indexes. But everything in moderation too. I've seen a difference in how I feel, and I have started to take off weight.

  4. -> Continue reading
read more close
Share on facebook

What Are The Types Of Diabetes And What Causes Diabetes?

Types of Diabetes Type 1 Diabetes Type 1 diabetes, once known as juvenile diabetes or insulin-dependent diabetes, is a chronic condition in which the pancreas produces little or no insulin, a hormone needed to allow sugar (glucose) to enter cells to produce energy. The far more common type 2 diabetes occurs when the body becomes resistant to insulin or doesn't make enough insulin. Various factors may contribute to type 1 diabetes, including genetics and exposure to certain viruses. Although type 1 diabetes usually appears during childhood or adolescence, it also can begin in adults. Despite active research, type 1 diabetes has no cure. But it can be managed. With proper treatment, people with type 1 diabetes can expect to live longer, healthier lives than did people with type 1 diabetes in the past. The exact cause of type 1 diabetes is unknown. In most people with type 1 diabetes, the body's own immune system — which normally fights harmful bacteria and viruses — mistakenly destroys the insulin-producing (islet) cells in the pancreas. Genetics may play a role in this process, and exposure to certain environmental factors, such as viruses, may trigger the disease. Type 2 diabet Continue reading >>

Share on facebook

Popular Questions

  1. SweetHeart

    This morning MH went for a full spectrum blood test. He had to fast for 12 hours prior to his 9.40am appointment.
    When he got to the doctors, there was a mix up and they had him booked in for 9.40am tomorrow, not today, even though his appointment card said today. They sent him home and told him to go back at 10.30am. I went with him this time as we were planning to shop afterwards.
    When the nurse took the bloods, MH fainted. Quite a long faint, eyeballs hit the back of his skull, skin was paper white. He was sitting in the chair up against a wall and I had to hold him upright whilst the nurse panicked and told me to fetch the doctor. We got the doctor who administered oral glucose (about 60ml) whilst the nurse did his bloods - 5.2mmol so it wasn't a hypo - when MH had come round enough we moved him to the examination couch so that we could raise his feet above his heart. All told this episode lasted about twenty minutes. We were told to go home, have tea & breakfast. By this time MH had been running on empty for 16 hours. Breakfast was three very small thin slices of brown spelt flour bread (heavily seeded) butter and a thin scraping of half sugar jam and a pint of unsweetened tea.
    It's now nearly 14.30 and MH still feels ill, and getting worse. His bloods climbed steadily from 5.2 to 10.6 mmol half an hour ago. His pulse is about 60 per minute. He says he feels like he's been steamrollered, his legs are really achy and he's incredibly tired. I ought to add that he's no longer on any Metformin - took his last one yesterday morning.
    Why is he still feeling ill?

  2. lucylocket61

    I dont know the answer, but i think you should get medical attention for him asap.
    This may not be anything to do with Diabetes and needs checking out urgently. If your doctors wont come out, ring NHS direct and, if he continues to get worse, ring for help or take him to A & E.
    Is he finding breathing too tiring in any way or feeling sleepy? If so, tell the doctors that too.

  3. SweetHeart

    Lucy, I've been trying to get hold of our DSN but no luck. Latest BG is 8.6, so it's coming down. I've made him walk around a bit and he says his legs are better.
    I want to call the doctor but he won't have it, says I'm making a fuss - but this was scary stuff. I think we have definitely confirmed that he is T2 after the DSN saying she thought he wasn't last Monday. He's being tested for B12 deficiency and all sorts of other things, so his system isn't working as it should be and I wondered if there was an adverse reaction to the glucose.

  4. -> Continue reading
read more close
Share on facebook

Holoprosencephaly: A Guide To Diagnosis And Clinical Management

Go to: Abstract Holoprosencephaly affects 1 in 8,000 live births and is the most common structural anomaly of the developing forebrain, resulting in facial dysmorphism, neurologic impairment, and additional clinical sequelae. Given the increasing relative contribution of genetic diseases to perinatal morbidity and mortality in India, proper recognition and management of holoprosencephaly can improve care for a significant number of affected Indian children. We used the PubMed database (search terms: “holoprosencephaly,” “HPE,” “holoprosencephaly India”) and cross-referenced articles regarding holoprosencephaly, using our research group’s extensive experience as a guide for identifying seminal papers in the field. Holoprosencephaly is classified into four types based on the nature of the brain malformations as seen on neuroimaging and/or pathologic examination, with typically recognizable craniofacial phenotypes. Despite the identification of several genetic loci and other etiologic agents involved in pathogenesis, additional causes are elusive. Moreover, satisfactory explanations for phenomena such as incomplete penetrance and variable expressivity are lacking. For ea Continue reading >>

Share on facebook

Popular Questions

  1. SerotoninSurfer

    Starting Metformin; how long until I see benefits?

    Started on metformin last night, 500mg x2 daily. Until now, I can never get below 100 without a liver dump shooting it back up into the 120s-130s. When I am at work under stress, it can go into the 190s.
    Any idea how long before I should be able to see some effect on my base bg level? Kinda hoping it could lower my "bounce" level about 20 points or so...

  2. Shanny

    Met often takes 3-4 weeks to reach full strength blood levels, but that doesn't mean it isn't working in the interim. You may see changes in just a few days. Your dose is a good starting level, and if you get by without gastric side effects, my guess would be you could increase your dosage gradually over time, if you don't see as much improvement as you hoped for. What did your doc say about future increases?

  3. SerotoninSurfer

    He said nothing about future increases yet, I almost had to twist his arm to get met to start with. It wasn't until I started mentioning the 190s from stress that he prescribed it.

  4. -> Continue reading
read more close

No more pages to load

Related Articles

  • What Are The Genetic And Nongenetic Causes Of Diabetes Insipidus?

    There are four themes in this teaching exercise for Professor McCance. The first challenge was to explain how a premature infant with Bartter's syndrome could survive despite having such a severe degree of renal salt wasting. Second, the medical team wanted to know why there was such a dramatic decrease in the natriuresis in response to therapy, despite the presence of a permanent molecular defect that affected the loop of Henle. Third, Professor ...

    diabetes Jan 4, 2018
  • What Are The Genetic Causes Of Type 1 Diabetes?

    Abstract BACKGROUND: Type 1 diabetes, a multifactorial disease with a strong genetic component, is caused by the autoimmune destruction of pancreatic β cells. The major susceptibility locus maps to the HLA class II genes at 6p21, although more than 40 non-HLA susceptibility gene markers have been confirmed. CONTENT: Although HLA class II alleles account for up to 30%–50% of genetic type 1 diabetes risk, multiple non-MHC loci contribute to dise ...

    diabetes May 1, 2018
  • Dipsogenic Diabetes Insipidus Causes

    Dipsogenic diabetes insipidus is similar to other manifestations of this disorder, especially in regards to neurogenic versions. It causes extreme thirst, which creates an increased fluid intake. This creates an excessive need to urinate because of the high fluid levels. It is characterized by low levels of vasopressin within the blood plasma and high levels of plasma osmolality. Treating dipsogenic diabetes insipidus usually involves a diuretic ...

    diabetes Apr 30, 2018
  • Central Diabetes Insipidus Vs Nephrogenic Diabetes Insipidus

    Print Overview Diabetes insipidus (die-uh-BEE-teze in-SIP-uh-dus) is an uncommon disorder that causes an imbalance of water in the body. This imbalance leads to intense thirst even after drinking fluids (polydipsia), and excretion of large amounts of urine (polyuria). While the names diabetes insipidus and diabetes mellitus sound similar, they're not related. Diabetes mellitus — which can occur as type 1 or type 2 — is the more common form of ...

    diabetes May 1, 2018
  • What Are The Causes And Symptoms Of Diabetes Insipidus?

    During the day, your kidneys filter all your blood many times. Normally, most of the water is reabsorbed, and only a small amount of concentrated urine is excreted. DI occurs when the kidneys cannot concentrate the urine normally, and a large amount of dilute urine is excreted. The amount of water excreted in the urine is controlled by antidiuretic hormone (ADH). ADH is also called vasopressin. ADH is produced in a part of the brain called the hy ...

    diabetes Apr 23, 2018
  • Diabetes Insipidus Causes

    INTRODUCTION Nephrogenic diabetes insipidus (DI) refers to a decrease in urinary concentrating ability that results from resistance to the action of antidiuretic hormone (ADH). This problem can reflect resistance at the ADH site of action in the collecting tubules, or interference with the countercurrent mechanism due, for example, to medullary injury or to decreased sodium chloride reabsorption in the medullary aspect of the thick ascending limb ...

    diabetes Apr 23, 2018

Popular Articles

More in diabetes