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Vitamin D Reverse Type 1 Diabetes

Teens With Type 1 May Have Vitamin D Deficiency

Teens With Type 1 May Have Vitamin D Deficiency

A new study suggests nearly 90 percent of teens with Type 1 could use more Vitamin D. In recent years, Vitamin D levels have become a yardstick for researchers to measure everything from heart health to bone density. Now, researchers have found that teens with Type 1 diabetes could be at increased risk of a Vitamin D deficiency. For the study, researchers at the University of Pennsylvania School of Nursing examined blood samples of 200 adolescents treated for diabetes at the Diabetes Center for Children in Philadelphia. They found that 40.6 percent of those tested had a Vitamin D deficiency (levels less than 20 ng/mL). Another 49.2 percent had what researchers considered low levels of Vitamin D (levels less than 35 ng/mL). In the study, only 10.2 percent of teens with Type 1 were found to have adequate or above adequate levels of Vitamin D. There is still some debate about how much Vitamin D one needs. Because of that, it’s difficult to find agreement about what the average level of Vitamin D deficiency is. An oft-cited 2009 study estimates that some 70 percent of U.S. children and teens had a Vitamin D deficiency. If the results of these two studies are accurate, that would mean teens with Type 1 would be at a higher risk of a deficiency. Vitamin D, also called the “sunshine vitamin”, is considered essential for bone health. Researchers also believe it’s an important nutrient for blood pressure maintenance and long-term heart health. Those diagnosed with a Vitamin D deficiency can take a supplement, eat more foods rich in Vitamin D, and get more sun exposure. The University of Pennsylvania researchers say the results show teens with Type 1 should be monitored for Vitamin D deficiency. More study is needed, however, to determine why teens with Type 1 might be mo Continue reading >>

Treating Vitamin D Deficiency In Children With Type 1 Improves Glycemic Control

Treating Vitamin D Deficiency In Children With Type 1 Improves Glycemic Control

Use of cholecalciferol demonstrated reductions in HbA1c. The active form of vitamin D is a very important hormone that works in the body by increasing the absorption of calcium. Vitamin D deficiency has been implicated in a variety of chronic diseases, including bone mineral disease, malignancy, autoimmunity, and diabetes. In recent years, it has been found that beta cells express the vitamin D receptor (VDR) and variations in the genes controlling the vitamin D metabolism and expression of VDR have been associated with a higher risk of diabetes, including type 1 and type 2. Patients with serum concentration of vitamin D below 30 nmol/L and 30-50 nmol/L are categorized as deficient and insufficient, respectively. Daily supplementation of vitamin D in the diet and sunlight exposure in the diet is essential for preventing deficient levels. Some studies have associated vitamin D deficiency with beta cell dysfunction and insulin resistance with a consequent development of type 2 diabetes in the adult population. In children with type I diabetes mellitus (T1DM), the prevalence of vitamin D deficiency has been found to be higher when compared to children without diabetes. Other studies have found the prevalence of vitamin D deficiency is similar between children with and without diabetes. Furthermore, a Finnish study reported that there was a 4-fold increased risk of development of T1DM in children who had rickets, which is a long-term effect of vitamin D deficiency causing weak bones. All these background studies suggest that there is a possible correlation between vitamin D deficiency and the risk of both type 1 and 2 diabetes. However, there is poor evidence related to the effects of vitamin D treatment in children with diabetes and vitamin D deficiency. A retrospective s Continue reading >>

Vitamin D Deficiency

Vitamin D Deficiency

A Finnish study has found that maternal intake of vitamin D via food or supplements during pregnancy was not associated with the development of type 1 diabetes or related autoimmunity in their offspring (Marjamäki et al. 2010). (Note that this study did not actually measure the mothers' levels of vitamin D, it only looked at food and supplement intake, which is not necessarily the same as actual vitamin D levels). Another Finnish study found no difference between pregnant women's vitamin D levels during the first trimester and their children's later risk of type 1 diabetes (Miettinen et al. 2012). This study did test the mothers' actual levels of vitamin D. It found that 70% of all the mothers (those whose children developed type 1, and those whose children did not) were deficient or insufficient in vitamin D, quite a high level. A third Finnish study found that it was the mother's vitamin D-related genes that were associated with the offspring's later risk of type 1 diabetes, instead of the vitamin D levels per se. It is possible that these genetic effects are only important if a mother is vitamin D deficient (Miettinen et al. 2015). A reanalysis found that some genes were more important than others (Miettinen et al. 2017). A Swedish study found that the mothers' use of vitamin D supplements during pregnancy was associated with a reduced risk of autoimmunity in the offspring at 1 year of age, but not by 2.5 years of age (Brekke and Ludvigsson, 2007). Yet another Swedish study found that mothers' use of vitamin D supplements during pregnancy was not associated with the development of type 1 diabetes in the offspring (however, this study was based on questionnaire data, and did not include measurements of vitamin D levels in the mothers) (Granfors et al. 2015). An Itali Continue reading >>

Association Among Vitamin D Deficiency, Type 1 Diabetes Mellitus And Glycemic Control

Association Among Vitamin D Deficiency, Type 1 Diabetes Mellitus And Glycemic Control

1Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia 2Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia 3Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt Citation: Al-Agha AE, Ahmad IA (2015) Association among Vitamin D Deficiency, Type 1 Diabetes Mellitus and Glycemic Control. J Diabetes Metab 6:594. doi:10.4172/2155-6156.1000594 Copyright: © 2015 Al-Agha AE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Visit for more related articles at Journal of Diabetes & Metabolism Abstract Background: Studies have identified that the deficiency of vitamin D is strongly connected with diabetes mellitus type 1. Vitamin D has the capability to control increased blood glucose level. Purpose: The study appraises the association among vitamin D deficiency, type 1 diabetes mellitus, and glycated hemoglobin among children. Methods: Around, 226 diabetic children were selected for this retrospective study from outpatient department of King Abdul Aziz University Hospital. Majority of the participants were female individuals, with the rate of 61.1% and were divided into three categories, based upon the rate of vitamin D deficiency. Every participant of the study was taking intensive insulin therapy. Results: The findings of the study have shown that 77% of the diabetic patients had reduced level of vitamin D in total. The study identified, from the evaluation between HbA1c control and vitamin D status, that 66% of the diabetic and vitamin D deficient participants were poorly controlled (HbA1c>9%). Concl Continue reading >>

Current Research Into Cures For Type-1 Diabetes

Current Research Into Cures For Type-1 Diabetes

Current Research into Cures for Type-1 Diabetes News and updates on potential cures for type-1 diabetes, that are in human (or clinical) trials. This blog posting is discussing the recent news about using Vitamin Das apreventative for type-1 diabetes (not a cure). You can read more about the study here (and many other places on the net): Abstract: More personal and emotional news article: Quick Summary: The researchers measured Vitamin D levels in the blood of people who were later diagnosed with type-1 diabetes, and compared that to levels in the blood of people who were not diagnosed. The levels in the diagnosed group were significantly lower. There was an obvious correlation. Vitamin D was not an absolute preventative. There was not a specific amount of Vitamin D where if you took more than that you would avoid type-1. Rather there is a change inprobabilities. Higher levels of Vitamin D led, on average, to lower levels of type-1 diabetes. Some people with high levels of Vitamin D still got type-1 diabetes, it was just less likely. The reverse was also true: some people with low levels of Vitamin D avoided type-1 diabetes, but it was less likely. A Little Background: It has been well known for decades that people who live near theequatorhave lower rates of type-1 diabetes than people who live nearer the poles. However, it is not known why this is true. Some people believe that a lack of sunlight orVitamin D increases the rate of type-1 diabetes. Other people think it might be wealth, genetics, diet, or any one of a huge number of differences. (In the Americas, for example, Mexico is closer to theequatorand has a lower rate, while USA is farther from the equator and has a higher rate. But there are also large differences in wealth, genetics, diet, and so on.) A Little Continue reading >>

Vitamin D

Vitamin D

What Is Its Role in Diabetes? What is your vitamin D level? Some day – maybe soon – having your vitamin D level measured may become as routine as having your cholesterol checked. According to some advocates of routine vitamin D testing, the results could prove to be a useful piece of medical information. The importance of adequate vitamin D levels in the body has been recognized for decades. In 1921, scientists proved that exposure to the sun hardens bones and prevents diseases of “rubbery,” weak bones called rickets (in children) and osteomalacia (in adults). It was later discovered that it is the vitamin D produced when the skin is exposed to sun that helps the body absorb calcium and strengthen the skeleton. Around the same time, cod liver oil was found to be a potent food source of vitamin D. Popular and scientific interest in vitamin D waned, however, once these diseases became relatively uncommon, particularly in the United States, where milk and some other foods have been routinely fortified with vitamin D since the 1930’s. Recently, however, new research on the so-called sunshine vitamin has shown that it plays a role in many more bodily systems than just the skeletal system. In fact, a deficiency of vitamin D is thought to possibly play a role in the development of numerous diseases, from cardiovascular disease to multiple sclerosis to complications of pregnancy. All of this new attention has made vitamin D a very popular supplement and the subject of renewed scientific inquiry. Vitamin D in the body The human body was designed to get most of its vitamin D through exposure to the ultraviolet (UVB) rays of the sun – the same rays that cause sunburn and skin damage. “Inactive” vitamin D is derived from cholesterol and “waits” in the skin tissu Continue reading >>

Vitamin D

Vitamin D

Vitamin D can be obtained from the diet or generated in the skin in response to sunlight; its metabolically active form is 1,25(OH)2D3. People with type 1 diabetes have lower circulating levels of this metabolite than controls, and lack of sunlight correlates well with the increased incidence of type 1 diabetes at higher latitudes. Three key genes involved in 1,25(OH)2D3 metabolism are associated with increased risk of type 1 diabetes, and functional studies confirm that this metabolite is under genetic control but set at lower levels than in control populations. 1,25(OH)2D3 receptors are present on pancreatic beta cells and on immunocytes, and vitamin D deficiency is a reversible cause of type 1 diabetes in the non-obese diabetic (NOD) mouse. It has, however, yet to be demonstrated that administration of vitamin D or its analogues can delay the onset of of type 1 diabetes or influence its clinical course. Intervention studies are needed to resolve these issues. Introduction Vitamin D is strictly speaking not a vitamin, since humans can synthesise it for themselves under the influence of UV light; dietary sources are, however, essential under some conditions. In some respects it behaves more like a hormone. Vitamin D is available to the body in two main forms: ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3). These are collectively referred to as vitamin D or calciferol. Vitamin D3 is generated in the skin by sunlight and is present in animal sources, especially fatty fish or their liver oils. Smaller amounts are present in dairy foods, and vitamin D is added to margarines and other products in some countries. Vitamin D2 is not produced by land plants, but is generated by fungi and other unicellular organisms in response to UV light. Vitamin D deficiency, wh Continue reading >>

Reversing The Irreversible

Reversing The Irreversible

The soaring rate of sugar disease comes with a brutal price tag: lives, limbs, poor health and high hospital bills. Celeste McGovern looks at evidence-based ways to put the epidemic in reverse It has been called "the biggest epidemic of the 21st century".1 If you don't have diabetes or know someone with it now, it's likely you eventually will. The prevalence of diabetes, now affecting more than 420 million people across the globe,2 has quadrupled in the past 20 years and continues to soar. It is expected that one person in 10—or 642 million—will be diagnosed with diabetes by 2040. Your body and brain ordinarily run on sugar as fuel for all of their functions, but too much sugar in the bloodstream can be damaging—even fatal. In both forms of diabetes, type 1 and type 2, decreased insulin results in symptoms including increased thirst, frequent urination, weight change, fatigue and blurry vision, among others. But those living with a diabetes diagnosis and symptoms do not need to feel overwhelmed and afraid of their disease forever. The 4.5 million Brits and 20 million Americans with a diabetes diagnosis (and the millions more estimated to have pre-diabetes or undiagnosed diabetes) can take control of their condition. Many type 2 diabetics are living proof that the disease can be reversed, sometimes in under 30 days, and type 1 diabetics are able to dramatically reduce their insulin dependence and cut their risks. In fact, a rare few have even challenged the orthodox medical view that being free of insulin altogether is impossible (see box, page 35). To take control of your blood sugar and put your diabetes in the back seat, here are the top five factors to consider. Your weight Despite all the diabetes diets and conflicting information—eat carbs, don't eat carbs, Continue reading >>

Could Vitamin D Supplements Have Prevented My Daughter’s Type 1 Diabetes?

Could Vitamin D Supplements Have Prevented My Daughter’s Type 1 Diabetes?

A few months ago, our six-year-old daughter, Bisi, was diagnosed with type 1 diabetes. It’s a condition she will have to manage carefully for the rest of her life, to avoid the many terrible potential complications of the disease. Since the diagnosis, my husband and I have often said to one another things like: “What if we had…?” “Maybe if we had …” And the other will respond by (half) jokingly quoting back the text on the box of diabetes information we received at the hospital from the Lilly pharmaceutical company (which makes the insulin Bisi now must take with her meals): “Pause. Take a deep breath. And remember: You couldn’t have prevented what’s happening with your child, so try not to beat yourself up.” The truth is, there is no known way to prevent type 1 diabetes. It is as a disease where our own immune system attacks our pancreas, eventually shutting down its ability to produce insulin. But there are some emerging theories about what makes type 1 diabetes more likely. The most intriguing of these — the one that causes my husband and me to take the most deep breaths — is the theory that links low vitamin D levels to type 1 diabetes. Several studies have shown this link, including one published in September in the journal Diabetologia. In that study, researchers from the Naval Health Research Center in San Diego and from universities in California and Florida compared the vitamin D levels of military servicemembers diagnosed with type 1 diabetes with the vitamin D levels of a control group of servicemembers without diabetes. They found that those servicemembers with the lowest concentration of vitamin D in their blood were 3.5 times more likely to develop diabetes than their peers with the highest vitamin D levels. In 2008, the Archives Continue reading >>

Type I Diabetes

Type I Diabetes

Summary Type 1 diabetes is an autoimmune disease. It is a condition where your own immune system attacks certain cells called beta-cells. Beta-cells help you produce a hormone called insulin. You need insulin to help your body manage glucose you get from food and turn it into energy for your body to use. Researchers don’t know what increases your chances of developing type 1 diabetes. Researchers believe that having a family member who has type 1 diabetes might increase your risk of getting type 1 diabetes. Also, viral infections and environmental factors may increase your chances of developing type 1 diabetes, but we need more research to say for sure or understand which factors play a role. Research shows that there is a link between vitamin D and type 1 diabetes. People with high vitamin D intake during their first year of life are less likely to develop type 1 diabetes later in life. Some research also suggests having high vitamin D levels during pregnancy might help prevent type 1 diabetes in their children later in life. However, this research has been observational, meaning we don’t know for sure if getting enough vitamin D prevents type 1 diabetes. Studies have shown that vitamin D supplementation may help improve insulin sensitivity and help control blood glucose levels in those with type 1 diabetes, though research has been small and inconclusive, so we can’t say for sure if vitamin D helps at all in type 1 diabetes. If you have type 1 diabetes or you are trying to prevent type 1 diabetes and want to take vitamin D, it is unlikely to make your type 1 diabetes worse or cause you any harm, as long as you take less than 10,000 IU per day. However, it’s not proven that it will help your type 1 diabetes. It’s also not proven if taking vitamin D will help Continue reading >>

Vitamin D And Diabetes

Vitamin D And Diabetes

Renewed interest in vitamin D, the so-called “sunshine vitamin,” has occurred recently because it has been linked to everything from cancer and heart disease to diabetes.1 Research studies continue to pour into the literature stating that vitamin D is a superstar when it comes to health. However, most of the research is based on observational, epidemiological studies, which are important for generating hypotheses but do not prove causality. A PubMed search in 2011 using the term “vitamin D” and selecting articles published in the past 2 years resulted in more than 2,864 hits. The following diseases and conditions have been researched to assess their relationship with vitamin D status: osteomalacia/osteoporosis,2–5 muscle function and falls,6–8 cancer,9–14 multiple sclerosis,15 hypertension,16 type 1 diabetes,17 rheumatoid arthritis,18 tuberculosis,19,20 mental health,21 cardiovascular events,22,23 infection,24,25 seasonal affective disorder,26 obesity,27 aging,28 and overall mortality.23 The challenge for health care providers and nutrition researchers is to determine whether vitamin D deficiency actually causes or increases the incidence of certain diseases or whether, instead, low levels of vitamin D are simply coincidental given that the majority of the general population, regardless of disease, is likely to have insufficient levels of vitamin D. In other words, do people who develop disease states just happen to be deficient in vitamin D, or do low levels of vitamin D cause the disease? Will supplementation with vitamin D prevent diseases, and can it be used to treat diseases such as diabetes? The purpose of this article is to summarize the latest information related to diabetes and vitamin D. For readers who desire further information, Holick29 has wr Continue reading >>

Type 1 Diabetes Can Sometimes Be Reversed With Diet And Common Nutrients

Type 1 Diabetes Can Sometimes Be Reversed With Diet And Common Nutrients

Saving and nurturing cells that make insulin Q: I’m constantly reading about type 2 diabetes treatments. But I have type 1 diabetes. Are there any supplements I can take to prevent type 1 diabetic complications? Dr. Wright: Type 1 diabetes patients are usually surprised to learn that they can use diet and common nutrients to significantly improve their conditions. In fact, they can sometimes even reverse diabetes if caught early. We’ll start with the islet beta cells in the pancreas. These cells produce insulin that transports glucose from the bloodstream to the cells of your body. In Type 1 diabetes, islet cell beta cells (usually just called beta cells) become impaired and die. In recent animal studies, researchers have shown that therapeutic use of an amino acid called GABA may help maintain beta cells and slow, or even reverse, the development of type 1 diabetes. While it’s very likely that GABA in relatively large quantities will have beneficial effects in human type 1 diabetes, complete and permanent reversal of type 1 diabetes in humans also requires strict diet modification, and can be aided by other specific nutrients. The reason beta cells stop working has been traced to an “auto-immune attack” on these cells by lymphocytes (a type of white blood cell) and other cells of the immune system. Cow’s milk protein and gluten have been strongly implicated in “triggering” auto-immune attacks on beta cells. Many years ago, Dr. Christopher Reading pioneered the use of dietary changes to treat auto-immune diseases. He found that dairy products, and especially gluten in grain, interfered with nutrient absorption in the intestine. Dr. Reading advised auto-immune disease patients to eliminate all grains and dairy products from their diets permanently. In dif Continue reading >>

The Search For A Cure Type 1 Diabetes, Vitamin D, & Omega 3s

The Search For A Cure Type 1 Diabetes, Vitamin D, & Omega 3s

Type 1 diabetes (T1D) researchers are ever in search for a cure. Because Type 1 often comes on without easily recognizable warning signs and most commonly affects the young, the search for a cure (or a reliable indicator) is a never-ending pursuit. Incredible New Method for Weight Loss Discovered Though they havent found a cure, researchers have stumbled upon a promising treatment option for Type 1 that does not reverse the effects of Type 1, but may be effective in halting the conditions progression and improving the lives of thosediagnosed with Type 1 diabetes, young or old. Vitamin D is a pivotal ingredient, if you will, in the human body. Unfortunately today, most people suffer from a vitamin D deficiency, whether that is due to a lack of vitamin D in theirdiet or a lack of sun exposure.Vitamin D deficiencies can cause cognitive impairment, fatigue, asthma, brittle bones, depression, and recurring cases of tuberculosis. Indeed, this sunshine vitaminis vital to the development of strong bones, optimal cognitive function, and mood and hormonal regulation. Omega 3s are another important puzzle piece in thebodys health. Deficiencies in omega 3s can lead to dry hair and skin, fatigue, poor memory, heart problems, poor circulation, and mood swings. Although each of these symptoms would be problematic on their own, they can be further aggravated by the presence of diabetes. Omega 3s are essential to effective circulation, optimal cognitive function, stable moods, and even the performanceof therespiratory system.These fatty acids are most commonly found in fish and oils. A study developed in Italy has suggested that high doses of vitamin D and omega 3s, both proven safe and effective for minimizing inflammation and promoting optimal health, have the ability to halt the pro Continue reading >>

Glycemic Changes After Vitamin D Supplementation In Patients With Type 1 Diabetes Mellitus And Vitamin D Deficiency

Glycemic Changes After Vitamin D Supplementation In Patients With Type 1 Diabetes Mellitus And Vitamin D Deficiency

Glycemic changes after vitamin D supplementation in patients with type 1 diabetes mellitus and vitamin D deficiency From the Division of Endocrinology, Department of Medicine, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia Correspondence: Dr. Khalid Aljabri, Division of Endocrinology, Department of Internal Medicine, King Fahad Armed Forces Hospital, Jeddah, PO Box 6572, Makkah, Saudi Arabia T: +966-590-008035 F: +966-2-576-0665 [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC. A prospective, nonblinded and nonrandomized controlled trial was conducted to test the hypothesis that vitamin D supplementation would improve glycemic control in patients with type 1 diabetes mellitus who have vitamin D deficiency. Eighty patients with type 1 diabetes mellitus who had 25-hydroxyvitamin D levels less than 50 nmol/L were assigned to receive 4000 IU of vitamin D3. Calcium supplements were provided to ensure a total calcium intake of 1200 mg/d. Glycosylated hemoglobin and 25-hydroxyvitamin D levels were measured at baseline and at 12 weeks. There was a significant difference in mean (SD) glycosylated hemoglobin level (%) between the groups that achieved 25-hydroxyvitamin D levels of <35.4 nmol/L, 35.4-51 nmol/L and >51 nmol/L at 12 weeks (P=.02). There was a significant difference in glycosylated hemoglobin change from baseline between the groups that achieved 25-hydroxyvitamin D levels of <35.4 nmol/L, 35.4-51 nmol/L and >51 nmol/L at 12 weeks (P=.04). There was a significant difference in 25-hydroxyvitamin D level betwe Continue reading >>

Type 1 Diabetes: Vitamin D Deficiency Occurs In Early Stage

Type 1 Diabetes: Vitamin D Deficiency Occurs In Early Stage

Follow all of ScienceDaily's latest research news and top science headlines ! Type 1 diabetes: Vitamin D deficiency occurs in early stage Helmholtz Zentrum Mnchen - German Research Center for Environmental Health Low levels of vitamin D are commonly found in people with type 1 diabetes. But even children who have multiple positive islet autoantibodies without manifest type 1 diabetes have lower levels of vitamin D in their blood. This does not appear, however, to influence the progression of the disease from pre-diabetes to diabetes, according to scientists. "Vitamin D deficiency precedes the onset of type 1 diabetes. This may be a consequence of an immune response," one author says. "In the case of prediabetic children, we must therefore be mindful of the risk of vitamin D deficiency and consider recommending vitamin D supplementation at an early stage of type 1 diabetes." Vitamin D is known as a major regulator of calcium levels and bone metabolism. Furthermore, it also influences the immune system. Previous studies have shown that patients with recently diagnosed type 1 diabetes have significantly lower vitamin D levels. Scientists from the Institute of Diabetes Research (IDF) and the Helmholtz Zentrum Mnchen, a member of the German Center for Diabetes Research (DZD), as well as from the Diabetes Research Group at the Technische Universitt Mnchen (TUM) examined whether a vitamin D deficiency occurs during an early stage of type 1 diabetes, defined by the presence of multiple diabetes-specific islet autoantibodies. Furthermore they also determined whether vitamin D deficiency influences the progression to type 1 diabetes in children with multiple islet autoantibodies. Vitamin D deficiency already exists in prediabetes Children who had not yet developed clinical type Continue reading >>

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