The Effect Of Vitamin C And/or E Supplementations On Type 2 Diabetic Adult Males Under Metformin Treatment: A Single-blinded Randomized Controlled Clinical Trial - Sciencedirect
Volume 12, Issue 4 , July 2018, Pages 483-489 The effect of vitamin C and/or E supplementations on type 2 diabetic adult males under metformin treatment: A single-blinded randomized controlled clinical trial Recently, there has been an increasing interest in the influence of antioxidant vitamins on the efficacy of oral hypoglycemic therapy in type 2 diabetic patients (T2DM). This single-blinded randomized controlled clinical trial aimed to investigate the effect of vitamin C and/or E supplementation on the efficacy of oral hypoglycemic therapy in T2DM Palestinian male patients from the Gaza Strip. Forty T2DM male patients aged 4060 years on metformin treatment were randomly divided into four groups, each group received an additional one of the following daily oral supplements for 90days: placebo; vitamin C; vitamin E and vitamin C plus vitamin E. After overnight fasting, venous blood specimens were collected from all individuals into K3-EDTA tubes and serum tubes for measuring the biochemical and hematological parameters of the study at baseline and after 90days of vitamins supplementation. The results revealed that vitamin C and/or E improve fasting blood sugar (FBS), HbA1c, lipid profile, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), reduced glutathione (GSH); and Quantitative Insulin Sensitivity Check Index (QISCI) compared with diabetic patients group that received placebo. This study provided additional evidence on the beneficial effects of supplementing antioxidant vitamins in T2DM which could improve the clinical condition and attenuate or prevent diabetic pathogenesis and complications that, secondly to poor glycemic control, could attribute to the imbalance between the decline in the endogenous antioxidants and increasing production of Continue reading >>
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Type 2 Diabetes: Supplements Overview
Key Points There is limited scientific evidence on the effectiveness of dietary supplements as complementary and alternative medicine (CAM) for type 2 diabetes. The evidence that is available is not sufficiently strong to prove that any of the six supplements discussed in this report have benefits for type 2 diabetes or its complications. A possible exception may be the use of omega-3 fatty acids to lower triglyceridea levels. It is very important not to replace conventional medical therapy for diabetes with an unproven CAM therapy. To ensure a safe and coordinated course of care, people should inform their health care providers about any CAM therapy that they are currently using or considering. The six dietary supplements reviewed in this report appear to be generally safe at low-to-moderate doses. However, each can interact with various prescription medications, affecting the action of the medications. People with type 2 diabetes need to know about these risks and discuss them with their health care provider. Prescribed medicines may need to be adjusted if a person is also using a CAM therapy. aTerms that are underlined are defined in the dictionary at the end of this report. 1. What is diabetes? Diabetes is a chronic condition in which the body cannot properly convert food into energy. Most food that a person eats is eventually broken down into blood glucose (also called blood sugar), which cells need for energy and growth. Insulin is a hormone that helps glucose enter cells. In people with diabetes, the body does not make enough insulin, or it does not respond to insulin properly. This causes glucose to build up in the blood instead of moving into the cells. The most common type of diabetes is type 2 diabetes (formerly called adult-onset diabetes or noninsulin-depen Continue reading >>
Ways To Make Nutritional Progress Against Diabetes
Diabetes Home WAYS TO MAKE NUTRITIONAL PROGRESS AGAINST DIABETES (Introduction by Abram Hoffer, M.D.: Reading this chapter will report what can be done over and above the use of insulin and classical dietetics. I am very familiar with Type I (insulin dependent diabetes or juvenile diabetes), as two members of my family have it. As this is not a medical text, the author does not describe the symptomatology and treatment using insulin. (By the way, doctors who treat diabetes are practicing orthomolecular medicine without knowing it, for they are using a hormone that is naturally present in the body.) Dr. Saul lists and describes both positive and negative factors in dealing with this condition. Thus for Type I, we have on the positive side the B complex vitamins, especially vitamin B-3, and vitamin C. The negative factors are diets which are too rich in free sugars and not rich enough in the complex carbohydrates. Negative factors also include milk, fluoride, coffee and vaccinations. When it is started at an early age, niacinamide will prevent diabetes from developing in many children born to families prone to the disease. I have also found niacin very helpful in preventing patients from suffering the long term ravages of diabetes, which are not directly due to high blood sugars, but to the side effects involving the vascular system. Niacin lowers total cholesterol, elevates HDL, and prevents the development of arteriosclerosis. Therefore these patients are less apt to become blind and lose their legs. With medical supervision, it may be used safely in dealing with diabetics, but you will need to find a doctor who knows niacin. Dr. Saul provides supporting references to the literature, which physicians will benefit from seeing. I was especially pleased to see that he cite Continue reading >>
(pdf) Role Of Ascorbic Acid In Diabetes Mellitus: A Comprehensive Review
Journal of Medicine, Radiology, Pathology & Surgery (2017), 4, 13 Journal of Medicine, Radiology, Pathology & Surgery Vol. 4:1 Jan-Feb 2017 1 Role of ascorbic acid in diabetes mellitus: Acomprehensive Department of Oral Medicine and Radiology, Dayananda Sagar College of Dental Sciences and Hospital, Bengaluru, Karnataka, India Diabetes mellitus (DM) is a multifactorial disease with no one speci c drug available to treat. e main causes of DM Type2 are insulin resistance and decreased insulin production. Oxidative damage to beta cells due to reactive oxygen species is a trusted cause of DM2. Vitamins are a class of nutrients required in miniscule quantity. Vitamin C is one of the most powerful dietary antioxidant available, closest in structure to carbohydrate. Vitamin C and glucose competitively inhibit each other to penetrate the cell membrane by the tunneling mechanism. Clinical trials have suggested that mega doses of vitamin C reduce the microvascular complications of DM2 such as retinopathy, nephropathy, and diabetic foot. Apart from this, there is another biological signi cance of vitamin C. Vitamin C in higher dose reduces the (glycosylated hemoglobin concentration) levels and low-density lipoproteins. Role of vitamin C as an adjunct in the treatment of DM2, atherosclerosis has been signi cantly contributory. is review paper presents the di erent biological roles of vitamin C, in particular DM2. Diabetes mellitus, oxidative stress, reactive Diabetes mellitus (DM) is clinically and genetically a heterogeneous metabolic disease which is characterized by abnormally elevated blood glucose and dysregulation of carbohydrate, protein and lipid metabolism. e primary cause of DM2 is either insulin resistance or decrease in insulin production. Insulin is the principal regu Continue reading >>
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Vitamin C And Diabetes
D.D. Family Getting much harder to control I am not sure what your trying to do here, I take vitamin C also but am still diabetic. I've taken at least 1 gram (1000mg) a day (usually a lot more, like 3-4 grams) most days for many, many years---like 40 years. Like Fur, I'm still diabetic (but I almost never get colds or flu). D.D. Family T1 since 1966, pumper since '03, transplant '08 First off, it's a study of only 84 people, so pretty much useless. And secondly, while they say they had "significant" decreases in the lipids and bg measurements they took, it's possible that anything over about 3% change or so could be considered "significant". So you really have no idea how helpful the vitamin C really is. You also don't know if these people changed their diets, levels of exercise, or anything else about their routine. They had been, after all, referred to a diabetes research center, so very well may have received help in other areas. So whatever the decreases in markers were, they could very likely have been due to something other than the vitamin C All in all, a very misleading and vague study. Cut back on carbs and you could pretty much get the same results and not spend money. T1 since 1966, dialysis in 2001, kidney transplant in 02 from my cousin, pumping 03 - 08, pancreas transplant Feb 08 Continue reading >>
Dietary Vitamin C Intake Reduces The Risk Of Type 2 Diabetes In Chinese Adults: Homa-ir And T-aoc As Potential Mediators
Dietary Vitamin C Intake Reduces the Risk of Type 2 Diabetes in Chinese Adults: HOMA-IR and T-AOC as Potential Mediators Chunling Zhou ,#1,2 Lixin Na ,#1 Ruiqi Shan ,1 Yu Cheng ,1 Ying Li ,1 Xiaoyan Wu ,1,* and Changhao Sun 1,* 1Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical University, Harbin, P. R. China 2The Second afflicted Hospital of Harbin Medical University, Harbin, P. R. China 1Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical University, Harbin, P. R. China 1Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical University, Harbin, P. R. China 1Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical University, Harbin, P. R. China 1Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical University, Harbin, P. R. China 1Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical University, Harbin, P. R. China 1Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical University, Harbin, P. R. China 1Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical University, Harbin, P. R. China 2The Second afflicted Hospital of Harbin Medical University, Harbin, P. R. China Johns Hopkins University Bloomberg School of Public Health, UNITED STATES Competing Interests: The authors have declared that no competing interests exist. Received 2016 Feb 2; Accepted 2016 Sep 11. This is an open access article distributed under the terms Continue reading >>
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Nutrients | Free Full-text | Inadequate Vitamin C Status In Prediabetes And Type 2 Diabetes Mellitus: Associations With Glycaemic Control, Obesity, And Smoking | Html
Nutrients 2017, 9(9), 997; doi: 10.3390/nu9090997 Inadequate Vitamin C Status in Prediabetes and Type 2 Diabetes Mellitus: Associations with Glycaemic Control, Obesity, and Smoking Department of Medicine, University of Otago, Christchurch 8011, New Zealand Lipid and Diabetes Research Group, Canterbury District Health Board, Christchurch 8011, New Zealand Department of Human Nutrition, University of Otago, Dunedin 9016, New Zealand Department of Pathology, University of Otago, Christchurch 8011, New Zealand Author to whom correspondence should be addressed. Received: 14 July 2017 / Accepted: 6 September 2017 / Published: 9 September 2017 Vitamin C (ascorbate) is an essential micronutrient in humans, being required for a number of important biological functions via acting as an enzymatic cofactor and reducing agent. There is some evidence to suggest that people with type 2 diabetes mellitus (T2DM) have lower plasma vitamin C concentrations compared to those with normal glucose tolerance (NGT). The aim of this study was to investigate plasma vitamin C concentrations across the glycaemic spectrum and to explore correlations with indices of metabolic health. This is a cross-sectional observational pilot study in adults across the glycaemic spectrum from NGT to T2DM. Demographic and anthropometric data along with information on physical activity were collected and participants were asked to complete a four-day weighed food diary. Venous blood samples were collected and glycaemic indices, plasma vitamin C concentrations, hormone tests, lipid profiles, and high-sensitivity C-reactive protein (hs-CRP) were analysed. A total of 89 participants completed the study, including individuals with NGT (n = 35), prediabetes (n = 25), and T2DM managed by diet alone or on a regimen of Met Continue reading >>
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Effects Of Vitamins C And D In Type 2 Diabetes Mellitus
Authors Christie-David D, Girgis C, Gunton J Received 24 September 2014 Accepted for publication 26 November 2014 Checked for plagiarism Yes Peer reviewer comments 3 1Department of Endocrinology and Diabetes, Westmead Hospital, 2Faculty of Medicine, University of Sydney, 3Westmead Millennium Institute, 4Garvan Institute of Medical Research, Sydney, NSW, Australia Abstract: Scurvy and rickets are largely considered historical diseases in developed countries. However, deficiencies in vitamins C and D are re-emerging due to increased consumption of processed foods and reduced fresh foods in the Western diet, as well as to an indoor sedentary lifestyle away from sun exposure. These dietary and lifestyle factors also predispose one to diabetes and metabolic syndrome. Our understanding of the potential roles of vitamin C (an antioxidant) and vitamin D (a biologically active hormone) in disease is increasing. In this review, we present observational, interventional, and mechanistic studies that examine the potential links between vitamins C and D in reversing defects in glucose homeostasis and the prevention of type 2 diabetes. Studies suggest an association between vitamin C deficiency and diabetes. An association between vitamin D and insulin resistance has been well described; however, the role of vitamin C and D supplementation in diabetes and its prevention requires further controlled trials. Keywords: glucose homeostasis, diabetes, insulin resistance, vitamin C, vitamin D Nutrients play essential roles in health and the prevention of disease. Nutrients, including vitamins, are vital to cardiovascular health (ie, vitamin B1), nerve function (ie, vitamins B6 and B12), the production of red blood cells (ie, folate and vitamin B12), and coagulation (ie, vitamin K), among man Continue reading >>
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Faq : Vitamin Raises Blood Sugar? | Hoffman Center
Q:I am a type 2 diabetic who takes 4,000 mg of vitamin C each day. I recently heard that C can raise your blood sugar. Is this true? A:Vitamin C is an important antioxidant for maintaining optimal health as well as managing infection and disease. It is hard to imagine such an important vitamin could cause adverse effects in anybody. I believe the conundrum of vitamin C raising blood sugar has several sources. A study in 2004 (Am J Clin Nutr 2004;80:1194-200) concluded a high vitamin C intake from supplements (just 300 mg or more) is associated with an increased risk of death from cardiovascular disease (CVD) in older women with diabetes. I have to take issue with this conclusion because it was extrapolated from the Iowa Womens Health Study which was designed to examine diet and lifestyle factors and the incidence of cancer and mortality, not vitamin C and its relationship to blood sugar. Fortunately, the authors responsibly note that their study had several limitations, one being there was only one diet and health assessment at the beginning of the study and secondly, the subjects in the study were self-reported diabeticsresearchers did not validate this important criteria. Fueling the conundrum are foods containing vitamin C, such as citrus fruit and juices. They can and will raise blood sugarespecially among diabetics. Fruit intake, let alone juice, has to be kept in check so as not to increase blood sugar. In this setting, high blood sugar is created by the fructose in fruit rather than any vitamin C contained in it. At the other end of the spectrum are reports that vitamin C in doses of 1,000 mg per day decrease blood sugar and improve Hemoglobin A1c in diabetes, while doses of only 500 mg did not significantly reduce blood sugar or HgbA1c (Indian J Med Res 2007;12 Continue reading >>
High Doses Of Vitamin C Supplement Increase Blood Glucose Levels
According to the July issue of Diabetes Care, high doses of supplementary vitamin C may cause an unexpected elevation of blood sugar levels and false diagnosis of type 2 diabetes. Donald R. Branch, PhD, reports the case of a 49-year-old, slightly obese man who took high levels of vitamin C, causing high fasting (121 mg/dl) and after-meal (220 mg/dl) blood sugar levels. The man, who had earlier been diagnosed as a potential candidate for type 2 diabetes based on his age, obesity and repeat elevated blood sugar readings, had taken 4,500 mg. per day of a synthetic, unsweetened vitamin C product for the past five years. The patient was asked to discontinue the supplement and, after seven days, morning blood sugar averages dropped to 99 mg/dl. He then restarted vitamin C supplements in dosages of 4,500 mg. per day, and morning blood sugars rose to 110 mg/dl. He discontinued the supplement again and, after one week, blood sugars dropped to 79 mg/dl. Branch says that elevated blood sugars, as a result of taking such a high dose of vitamin C, “…could result in a misdiagnosis of diabetes and/or additional, unnecessary testing, as in this case.” He adds that “..vitamin C-induced production of glucose may interfere in the glucose monitoring of true diabetic patients.” Branch says that the man reduced his vitamin C intake to 1,500 mg. per day, and his blood sugars returned to the normal range. He says that vitamin C, taken in dosages of 1,500 to 2,000 mg. per day, has been proven to effectively reduce blood sugar and HbA1c levels. Also, research suggests it prevents kidney injury in diabetic rats. This time of year, I always like to look back at the previous year and reflect on the people and the events that shaped me; giving thanks for what I have learned and reflecting Continue reading >>
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Effect Of Vitamin C On Blood Glucose, Serum Lipids & Serum Insulin In Type 2 Diabetes Patients.
Abstract BACKGROUND & OBJECTIVE: Diabetes mellitus is one of the most common metabolic disorders that causes micro- and macro-vascular complications. Because of additive effects of hyperglycaemia and hyperlipidaemia for cardiovascular diseases, lipid abnormalities should be evaluated in diabetes. As vitamin C is known for its beneficial effects on serum lipids and glycated haemoglobin (HbA1c), we evaluated the effect of different doses of vitamin C on blood glucose, serum lipids and serum insulin in individuals with type 2 diabetes mellitus. METHODS: A total of 84 patients with type 2 diabetes referred to Yazd Diabetes Research Center, Iran, were included in the study. They received randomly either 500 mg or 1000 mg daily of vitamin C for six weeks. Fasting blood sugar (FBS), triglyceride (TG), total cholesterol (TC), low and high density lipoprotein (LDL, HDL), glycated haemoglobin HbA(Ic) and serum insulin were measured before and after vitamin C consumption and the results were analyzed. RESULTS: A significant decrease in FBS, TG, LDL, HbA1c and serum insulin was seen in the group supplemented with 1000 mg vitamin C. The dose of 500 mg vitamin C, however, did not produce any significant change in any of the parameters studied. INTERPRETATION & CONCLUSION: Our results indicate that daily consumption of 1000 mg supplementary vitamin C may be beneficial in decreasing blood glucose and lipids in patients with type 2 diabetes and thus reducing the risk of complications. Continue reading >>
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The Cure For Type Ii Diabetes
If you are already on insulin, absolutely do not stop taking insulin, and do not stop measuring your glucose levels, without your doctor's permission. Surprisingly, medical researchers, such as from Medical News Today, consider Type 2 diabetes to be an immune problem whereby the immune system attacks the body's own cells. Type 2 diabetes is in the process of being redefined as an autoimmune disease rather than just a metabolic disorder, said an author of a new study published in Nature Medicine this week, the findings of which may lead to new diabetes treatments that target the immune system instead of trying to control blood sugar. … The researchers believe that insulin resistance, the hallmark of type 2 diabetes (unlike type 1 diabetes where it is the insulin-producing cells that are destroyed), is the result of B cells and other immune cells attacking the body's own tissues. This discovery is nothing new to some natural medicine researchers. Treatments that do the things necessary to build the immune system have been curing type 2 diabetes for years. Some of these treatments are “electromedicine” treatments which use gentle electrical waves to do the things necessary to rebuild the immune system. But these gentle electrical waves do not directly build the immune system, rather they remove the “root cause” of why the immune system is dysfunctional in the first place. Think of the school bully. Instead of fixing the students he beats up every week, the school might just kick the bully out of school. By doing this the school is not dealing with the “symptoms” of the bully (i.e. the injured students) they are dealing with the “root cause” of the injuries (i.e. the bully). So what is the “root cause” of why the immune system is weak? To understand th Continue reading >>
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Too Much Vitamin C Not Good For Diabetics’ Hearts
Too Much Vitamin C Not Good for Diabetics’ Hearts Older women with diabetes who take high doses of vitamin C for the sake of their hearts may be doing more harm than good. The study, which followed nearly 2,000 postmenopausal women with diabetes for 15 years, found that those who took heavy doses of vitamin C supplements — 300 milligrams (mg) a day or more — were roughly twice as likely to die of heart disease or stroke compared with women who took no supplemental C. The researchers did find statistically weak evidence that lower supplement doses — up to 99 mg per day — curbed the risk of cardiovascular death, and high intakes of vitamin C from food were not related to a greater risk of death from cardiovascular causes. According to the researchers, their results suggest that taking supplements to correct the lower blood levels of vitamin C commonly seen in diabetes is not necessarily the right choice. And though the research focused on older women, the findings may apply to men as well, according to the study’s senior author. Dr. David R. Jacobs Jr., of the University of Minnesota in Minneapolis stated that, "Our results, if confirmed by other research, would suggest that diabetics should be more cautious than others about taking supplements." The current recommended dietary intake for vitamin C is 90 mg a day for men and 75 mg per day for women. Vitamin C is an antioxidant, meaning it helps neutralize potentially cell-damaging substances known as oxygen free radicals, which are a normal byproduct of metabolism. While the vitamin is clearly necessary for good health, studies have garnered conflicting results on whether supplements help lower the risk of heart disease and stroke. In addition, Jacobs and his colleagues note in the report, although people with Continue reading >>
Antioxidant Effects Of Vitamins In Type 2 Diabetes: A Meta-analysis Of Randomized Controlled Trials
Vitamins are essential micronutrients with antioxidant potential that may provide a complementary treatment for patients with chronic diseases. Our aim was to assess the effect of vitamin supplementation on the antioxidant status and glycemic index of type 2 diabetes mellitus patients. We performed a systematic review with meta-analyses. Electronic searches were conducted in PubMed, Scopus, and Web of Science (December 2017). Randomized controlled trials evaluating the effect of any vitamin or vitamin complex supplementation on antioxidant status as primary outcome were included. The outcomes considered were: reduction of malondialdehyde (MDA); augmentation of glutathione peroxidase (GPx); changes in total antioxidant capacity (TAC), enhance in superoxide dismutase enzymeSOD, and thiobarbituric acid reactive substances (TBARS). Outcomes of glycemic control were also evaluated. Pairwise meta-analyses were performed using software Review Manager 5.3. Thirty trials fulfilled the inclusion criteria, but only 12 could be included in the meta-analyses of antioxidant outcomes. The most commonly studied vitamins were B, C, D and E. Vitamin E was related to significant reduction of blood glucose as well as glycated hemoglobin compared to placebo, while both vitamins C and E were mainly associated with reducing MDA and TBARS and elevating GPx, SOD and TAC, compared to placebo. However, outcome reports in this field are still inconsistent (e.g. because of a lack of standard measures). Supplementation of vitamin E may be a valuable strategy for controlling diabetes complications and enhancing antioxidant capacity. The effects of other micronutrients should be further investigated in larger and well-designed trials to properly place these complementary therapies in clinical practic Continue reading >>
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Relation Between Intake Of Vitamins C And E And Risk Of Diabetic Retinopathy In The Atherosclerosis Risk In Communities Study
Relation between intake of vitamins C and E and risk of diabetic retinopathy in the Atherosclerosis Risk in Communities Study From the Department of Ophthalmology and Visual Sciences (AEM, RK, and JAM) and the Departments of Population Health and Biostatistical Medical Informatics (MP), University of Wisconsin Medical School, Madison; the Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis (ARF); and the Department of Nutrition, University of North Carolina, Chapel Hill (JS) Search for other works by this author on: From the Department of Ophthalmology and Visual Sciences (AEM, RK, and JAM) and the Departments of Population Health and Biostatistical Medical Informatics (MP), University of Wisconsin Medical School, Madison; the Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis (ARF); and the Department of Nutrition, University of North Carolina, Chapel Hill (JS) Search for other works by this author on: From the Department of Ophthalmology and Visual Sciences (AEM, RK, and JAM) and the Departments of Population Health and Biostatistical Medical Informatics (MP), University of Wisconsin Medical School, Madison; the Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis (ARF); and the Department of Nutrition, University of North Carolina, Chapel Hill (JS) Search for other works by this author on: From the Department of Ophthalmology and Visual Sciences (AEM, RK, and JAM) and the Departments of Population Health and Biostatistical Medical Informatics (MP), University of Wisconsin Medical School, Madison; the Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis (ARF); and the Department of Nutrition, University of North Carolina, Chap Continue reading >>
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