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Vitamin C And Diabetes Type 1

Taking A Daily Vitamin To Prevent Type 1 Diabetes?

Taking A Daily Vitamin To Prevent Type 1 Diabetes?

Taking a Daily Vitamin to Prevent Type 1 Diabetes? From the Department of Pathology, University of Florida, Gainesville, Florida Corresponding author: Mark A. Atkinson, [email protected] Author information Copyright and License information Disclaimer Copyright 2009, American Diabetes Association Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See for details. See the article " All-trans Retinoic Acid Inhibits Type 1 Diabetes by T Regulatory (Treg)-Dependent Suppression of Interferon-Producing T-cells Without Affecting Th17 Cells " in volume 58 onpage146. This article has been cited by other articles in PMC. Type 1 diabetes is an autoimmune disorder characterized by genetic susceptibility associated with a growing number of loci, including major histocompatibility complex (MHC), which provides a strong influence ( 1 ). While the number of susceptibility genes and loci is numerous, an even larger list of environmental agents has long been noted to influence, in either a positive or negative fashion, the risk for or progression to type 1 diabetes ( 2 ). Unfortunately, studies examining genetic and environmental influences on type 1 diabetes are remarkably complex in terms of study design, performance, and data analysis. Large study populations are also required for identifying minor influences of genetic loci or environmental agents, yet these efforts often result in the identification of candidates with relatively small odds ratios (i.e., a small influence on disease risk). In addition, type 1 diabetes is quite heterogeneous in its presentation, form, and characteristics when examined from either a metabolic or an immunologic perspective. It is also probable that some degree of com Continue reading >>

Effect Of Vitamins C And E On Endothelial Function In Type 1 Diabetes Mellitus

Effect Of Vitamins C And E On Endothelial Function In Type 1 Diabetes Mellitus

Effect of Vitamins C and E on Endothelial Function in Type 1 Diabetes Mellitus Rachel-Marie Cazeau ,1,2 Hong Huang ,3 John A. Bauer ,3and Robert P. Hoffman 1,2,4 1Section of Endocrinology, Metabolism and Diabetes, Nationwide Childrens Hospital, 700 Childrens Drive, Columbus, OH 43205, USA 2Division of Pediatric Endocrinology, Metabolism and Diabetes, Department of Pediatrics, The Clinical Research Center, The Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA 3Department of Pediatrics, University of Kentucky, Lexington, KY 40506, USA 4The Research Institute, Nationwide Childrens Hospital, Columbus, OH 43205, USA Received 1 June 2015; Accepted 14 July 2015 Copyright 2016 Rachel-Marie Cazeau et al. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background/Objectives. Endothelial dysfunction due to hyperglycemia-induced oxidative damage is an important predictor of future cardiovascular risk in patients with type 1 diabetes mellitus (T1DM) and is present in adolescent T1DM. We hypothesized that combined treatment with the antioxidant vitamins C and E might improve endothelial function (EF) and other biochemical risk factors in adolescents with T1DM. Subjects/Methods. Open-label antioxidant supplementation was given for six weeks with endpoint measurements collected at baseline and study completion. Endpoints measured included EF and plasma measurements of biochemical endothelial risk. Results. Two males and 7 females were studied. Mean age was 12.9 0.9 yrs; mean T1DM duration was 5.5 2.5 yrs; mean BMI was 22.1 3.8 kg/m2; and mean hemoglobin A1c was 9.3 1.1%. No differences Continue reading >>

Vitamin C And Vascular Function | Type 1 Diabetes | Life Extension

Vitamin C And Vascular Function | Type 1 Diabetes | Life Extension

Higher vitamin C levels associated with improved vascular function in type 1 diabetes In an article published online on June 24, 2009 in the American Journal of Clinical Nutrition , Scandinavian researchers report that young type 1 diabetic patients with higher vitamin C levels have better vascular function compared to those with lower levels of the vitamin. Vascular function and structure changes can occur early in type 1 diabetes, and are associated with a greater risk of cardiovascular disease and cardiovascular mortality later in life. Petru Liuba and Michael Odermarsky of Lund University Hospital in Sweden, along with Jens Lykkesfeldt of the University of Copenhagen in Denmark, recruited 33 male and 26 female diabetic patients between the ages of 10 and 22 for the current study. Carotid intima-media thickness (cIMT, which measures atherosclerosis), assessments of cutaneous microvascular function, cardiac depolarization and repolarization (evaluated via electrocardiogram as QT interval corrected for heart rate, which, when prolonged, is a predictor of adverse cardiovascular prognosis), lipids, and plasma C-reactive protein, fibrinogen, vitamin C and oxidized vitamin C (dehydroascorbic acid) were assessed. For subjects whose plasma vitamin C levels were among the lowest third of participants, carotid artery intima-media thickness and QT interval duration were greater than those whose vitamin C levels were in the highest third. Additionally, an assessment of cutaneous microvascular response was reduced in those whose vitamin C levels were lowest. Oxidized vitamin C was found to increase as vitamin C levels decreased--a correlation that has been found in smokers. The finding suggests the presence of high oxidative stress levels in type 1 diabetes patients. "It is not Continue reading >>

Stopping Type 1 Diabetes Damage With Vitamin C

Stopping Type 1 Diabetes Damage With Vitamin C

Stopping type 1 diabetes damage with vitamin C Researchers at the Harold Hamm Oklahoma Diabetes Center have found a way to stop the damage caused by Type 1 diabetes with the combination of insulin and a common vitamin found in most medicine cabinets. While neither therapy produced desired results when used alone, the combination of insulin to control blood sugar together with the use of Vitamin C, stopped blood vessel damage caused by the disease in patients with poor glucose control. The findings appear this week in the Journal of Clinical Endocrinology and Metabolism. "We had tested this theory on research models, but this is the first time anyone has shown the therapy's effectiveness in people," said Michael Ihnat, Ph.D., principal investigator and a pharmacologist at the OU College of Medicine Department of Cell Biology. Ihnat said they are now studying the therapy in patients with Type 2 diabetes . The goal of the work being done by Ihnat and British scientists from the University of Warwick led by Dr. Antonio Ceriello is to find a way to stop the damage to blood vessels that is caused by diabetes. The damage, known as endothelial dysfunction, is associated with most forms of cardiovascular disease such as hypertension, coronary artery disease, chronic heart failure, peripheral artery disease, diabetes and chronic renal failure. By reducing or stopping the damage, patients with diabetes could avoid some of the painful and fatal consequences of the disease that include heart disease, reduced circulation and amputation, kidney disease and diabetic retinopathy, which can lead to blindness. Insulin and many other drugs have long been used to control blood sugar, but Ihnat - in an earlier project with scientists in Italy and Hungary - found that cells have a "memory" t Continue reading >>

Vitamin C Stops Blood Vessel Damage In Type 1 Diabetes

Vitamin C Stops Blood Vessel Damage In Type 1 Diabetes

Vitamin C Stops Blood Vessel Damage in Type 1 Diabetes Poor blood glucose control can lead to blood vessel and nerve cell damage in diabetics and the only known way to prevent this is to maintain healthy blood glucose levels, and even this does not always work. A recent research team, however, has found that combining insulin with vitamin C stops blood vessel damage in type 1 diabetics. Type 1 diabetics require insulin to maintain healthy blood glucose levels, which limits the risk of blood vessel damage, but insulin itself does not battle or stop blood vessel damage. In fact, some past research has demonstrated that once blood vessel damage begins in type 1 diabetics, it continues, even when blood glucose is properly controlled. Blood vessel damage, or endothelial dysfunction, results mostly from oxidative stress, and is a major reason that diabetics are at an incredibly high risk for cardiovascular disease. Oxidative stress in diabetics is also closely linked to neuropathy, retinopathy, and resulting pain, amputations and blindness. Vitamin C is an essential nutrient for all humans, and protects against numerous ailments, from common colds, to scurvy. Its anti-oxidant properties are what help in battling oxidative stress. Many citrus fruits, especially oranges, contain large amounts of vitamin C, as well as kiwi, broccoli, papaya, and many other fruits and vegetables. The following conclusions regarding vitamin C mixed with insulin are believed to be applicable to other anti-oxidants as well. Based on past successful research models that showed a combination of insulin and antioxidants helped stop cell and blood vessel damage, the current research applied this treatment to type 1 diabetics with previously poor blood glucose control, and resulting blood vessel damage. Continue reading >>

Too Much Vitamin C Not Good For Diabetics’ Hearts

Too Much Vitamin C Not Good For Diabetics’ Hearts

Too Much Vitamin C Not Good for Diabetics’ Hearts Older women with diabetes who take high doses of vitamin C for the sake of their hearts may be doing more harm than good. The study, which followed nearly 2,000 postmenopausal women with diabetes for 15 years, found that those who took heavy doses of vitamin C supplements — 300 milligrams (mg) a day or more — were roughly twice as likely to die of heart disease or stroke compared with women who took no supplemental C. The researchers did find statistically weak evidence that lower supplement doses — up to 99 mg per day — curbed the risk of cardiovascular death, and high intakes of vitamin C from food were not related to a greater risk of death from cardiovascular causes. According to the researchers, their results suggest that taking supplements to correct the lower blood levels of vitamin C commonly seen in diabetes is not necessarily the right choice. And though the research focused on older women, the findings may apply to men as well, according to the study’s senior author. Dr. David R. Jacobs Jr., of the University of Minnesota in Minneapolis stated that, "Our results, if confirmed by other research, would suggest that diabetics should be more cautious than others about taking supplements." The current recommended dietary intake for vitamin C is 90 mg a day for men and 75 mg per day for women. Vitamin C is an antioxidant, meaning it helps neutralize potentially cell-damaging substances known as oxygen free radicals, which are a normal byproduct of metabolism. While the vitamin is clearly necessary for good health, studies have garnered conflicting results on whether supplements help lower the risk of heart disease and stroke. In addition, Jacobs and his colleagues note in the report, although people with Continue reading >>

Vitamins And Minerals

Vitamins And Minerals

Tweet Depending on the type of treatment regimen you use to control your diabetes, there are some vitamins and minerals that may be beneficial for your condition. Before adding any vitamins or adding dietary supplements to your daily diet, discuss these changes with your healthcare team and doctor to ensure they are safe alongside any prescribed medication you're on. ALA and GLA ALA (alpha-lipoic acid) is a versatile and potent antioxidant, and may function to help diabetic neuropathy and reduce pain from free-radical damage. Also, some studies link ALA to decreased insulin resistance and thus the control of blood sugar. GLA (gamma-lipoic acid) is another naturally occurring antioxidant that is present in evening primrose oil, borage oil and blackcurrant seed oil. GLA may improve the function of nerves damaged by diabetic neuropathy. Biotin Biotin works in synergy with insulin in the body, and independently increases the activity of the enzyme glucokinase. Glucokinase is responsible for the first step of glucose utilisation, and is therefore an essential component of normal bodily functioning. Glucokinase occurs only in the liver, and in sufferers from diabetes its concentration may be extremely low. Supplements of biotin may have a significant effect on glucose levels for both type 1 and type 2 diabetics. Carnitine (L-Carnitine, Acetyl L-Carnitine) Carnitine is required by the body in order to correctly use body fat in the production of energy. It is naturally occurring and derives from hydrophilic amino acids. Diabetics who try carnitine generally respond well, and high levels of fat in the bloodstream (cholesterol and triglycerides) may fall fast. Carnitine helps to break down fatty acids in the body and binds acyl residues. For these reasons, it may be useful to pre Continue reading >>

Top 5 Vitamins For Type 1 Diabetes

Top 5 Vitamins For Type 1 Diabetes

The high blood sugar level in the body occurring because of the malfunctioning of the pancreas is a condition known as diabetes, which can further be divided into two types. The type 1 diabetes is a condition, where there is no insulin secreted by the pancreas whereas the type 2 diabetes is a condition, where the insulin secreted by the pancreas is very insufficient in amount because of some kinds of abnormal conditions within the people’s body that do not enable them to take in the insulin properly. Both the types of diabetes can be cured with the help of medication, diet and exercise but it is also important to include several vitamins in the diet in order to get the maximum help in diabetes. There are insulin injections needed to be taken by people suffering from type 1 diabetes because it is a condition, where there is no insulin secreted by the pancreas. Apart from the injections, there are several vitamins that also help in controlling diabetes to a large extent. The vitamins for type 1 diabetes are as follows: Vitamins For Type 1 Diabetes Vitamin D The richest sources of vitamin D like eggs, cheese, salmon, tuna and fishes should be taken by people suffering from type 1 diabetes because the deficiency of this vitamin can lead to the creation of diabetic problems in people. Source: For people, who are vegetarians, they can get enough of this vitamin by exposing themselves to the sun early in the morning because sunlight is a rich source of vitamin D. Vitamin C Vitamin C is also known to be one of the best vitamins for type 1 diabetes because it is said to lower the levels of sorbitol in a person, which is a very harmful sugar and can affect the blood level of a person and is found in large numbers in people suffering from type 1 diabetes. 3 Foods to Remove from Continue reading >>

Best Vitamins For Diabetics

Best Vitamins For Diabetics

Eating a varied diet rich in natural sources of vitamins is a good idea for diabetics. Nutritional support is critical for diabetics because diabetes tends to drain nutrients. When levels of glucose are high in the blood, the body tries to ‘wash’ the excess sugar out. This is why diabetics need to use the washroom frequently. Unfortunately, diabetics also lose nutrients via their urine. Research studies show that diabetics are repeatedly found to be deficient in important water-soluble vitamins and minerals. What’s more, the loss of these vitamins worsens the body’s ability to manage blood sugar, creating a vicious cycle. Combining a healthy diabetes diet plan and a daily exercise routine with the best vitamin supplements for diabetics goes a long way in achieving stable blood sugar levels. What Vitamins Are Diabetics Deficient In? The term vitamin is short for “Vital Amino Acid”. This means that these are vital for the proper functioning of hundreds of chemical processes in the body which the body cannot manage by itself. Proper blood sugar control is one such function for which vitamins are critical. There are 13 essential vitamins that the human body requires and they must be obtained from an external source — through food and/or supplements. Diabetics need two kinds of vitamins: Water Soluble – Vitamins B1, B2, B3, B6, B12, C, Biotin, and Folate are water-soluble and cannot be stored in the body for longer periods of time. Diabetics are often deficient in these vitamins since they pass greater amounts of urine daily. As their body tries to get rid of extra sugar, diabetics lose more water-soluble vitamins than most others. That’s why diabetics need to to get these vitamins daily in doses larger than what normal people need. Luckily, you can get all Continue reading >>

Type I Diabetes

Type I Diabetes

Summary Type 1 diabetes is an autoimmune disease. It is a condition where your own immune system attacks certain cells called beta-cells. Beta-cells help you produce a hormone called insulin. You need insulin to help your body manage glucose you get from food and turn it into energy for your body to use. Researchers don’t know what increases your chances of developing type 1 diabetes. Researchers believe that having a family member who has type 1 diabetes might increase your risk of getting type 1 diabetes. Also, viral infections and environmental factors may increase your chances of developing type 1 diabetes, but we need more research to say for sure or understand which factors play a role. Research shows that there is a link between vitamin D and type 1 diabetes. People with high vitamin D intake during their first year of life are less likely to develop type 1 diabetes later in life. Some research also suggests having high vitamin D levels during pregnancy might help prevent type 1 diabetes in their children later in life. However, this research has been observational, meaning we don’t know for sure if getting enough vitamin D prevents type 1 diabetes. Studies have shown that vitamin D supplementation may help improve insulin sensitivity and help control blood glucose levels in those with type 1 diabetes, though research has been small and inconclusive, so we can’t say for sure if vitamin D helps at all in type 1 diabetes. If you have type 1 diabetes or you are trying to prevent type 1 diabetes and want to take vitamin D, it is unlikely to make your type 1 diabetes worse or cause you any harm, as long as you take less than 10,000 IU per day. However, it’s not proven that it will help your type 1 diabetes. It’s also not proven if taking vitamin D will help Continue reading >>

Diabetes Mellitus Is Controlled By Vitamin C Treatment.

Diabetes Mellitus Is Controlled By Vitamin C Treatment.

Diabetes mellitus is controlled by vitamin C treatment. Kodama Research Institute of Preventive Medicine, Nagoya, Japan. The present study was started to investigate the question of whether or not vitamin C administration may help control diabetes mellitus (DM) by stimulating the insulin mechanism of a DM patient. We were motivated to take up the above thesis by the anticipation that vitamin C, being detectable in abundance in endocrine cells, may play a cardinal role in the production of hormones. In the preliminary experiment, we investigated the relation between glucose, insulin and vitamin C in the plasma of a non-diabetic male volunteer in whom vitamin C was introduced intravenously either by injection or by infusion, and with or without concomitant administration of glucose. In the follow-up study of 3 DM patients, the effect of the vitamin C infusion therapy on DM was assessed by summing up multiple clinical information. Results obtained are as follows: 1) the drip infusion system was superior to the ordinary injection system for maintaining plasma concentration of vitamin C at a high level and for a long period. 2) The plasma concentration of insulin, when tested in the vitamin C infusion system, followed a bimodal curve--a finding to suggest that vitamin C may stimulate the insulin mechanism in 2 distinct ways. The early mode was glucose-dependent at its height, but the late mode was independent of glucose charge. 3) The praxis of vitamin C infusion produced clinical improvements in 3 DM patients. The therapeutic efficacy of the treatment varied from patient to patient. In all cases, control of DM was started by combined use of the vitamin C infusion treatment and the insulin injection treatment.(ABSTRACT TRUNCATED AT 250 WORDS). Continue reading >>

Vitamin C And Diabetes

Vitamin C And Diabetes

A new study has added to the growing amount of research showing that vitamin C- as well as a high intake of vegetables and fruits- may have protective effects against diabetes. This makes more than a little intuitive sense- after all Diabetes is a disease marked by a good amount of oxidative damage- damage done to your cells and DNA by rogue molecules called free radicals. Antioxidants- like vitamin C- can help protect against this. A cornerstone of the Atkins program has always been a diet high in antioxidants such as vitamin C, vitamin E, zinc and selenium, precisely because of their multiple protective benefits. In the current study, published in the July 28 edition of the Archives of Internal Medicine, researchers collected food questionnaires from over 21,000 subjects. The researchers also measured blood levels of vitamin C in all the participants. The subjects were then followed up for 12 years during which 735 individuals were diagnosed with diabetes (about .4% of the population studied). There was a significant inverse association between vitamin C levels in the blood and the risk of getting diabetes. In other words those patients with the highest blood levels of vitamin C at the beginning of the study were the least likely to be among those who developed diabetes. Since vitamin C is often a “marker” for fruit and vegetable intake- after all, we get 90% of our vitamin C from vegetables and fruits- the researchers decided to investigate the effect of fruit and vegetable consumption independently from blood levels of vitamin C. Using the questionnaires, they determined that indeed, fruit and vegetable consumption did protect against diabetes to some degree. But surprisingly, the protection was not nearly as dramatic as the protection obtained by high blood lev Continue reading >>

Interference Of Intravenous Vitamin C With Blood Glucose Testing

Interference Of Intravenous Vitamin C With Blood Glucose Testing

Self-monitoring of blood glucose (SMBG) is an integral component in the management of diabetes. However, it is important to understand the limitations of SMBG due to presence of interfering substances (1). We present a patient with diabetes and malignancy, who had falsely elevated blood glucose readings following administration of intravenous ascorbic acid (AA). A 56-year-old woman with type 1 diabetes was diagnosed with metastatic pancreatic neuroendocrine tumor. She administered insulin glargine and insulin aspart before meals. After three cycles of chemotherapy, due to poor response, she decided to stop further traditional therapies. She consulted a naturopath, who started her on intravenous AA at a dose of 75 g twice weekly. Following this, she noted that her SMBG levels were consistently elevated after intravenous AA. She presented to the University of Washington where her SMBG downloads were reviewed. On the days she received intravenous AA infusion, the average blood glucose was 26.9 ± 4.8 mmol/L, compared with an average of 12.36 ± 2.7 mmol/L on other days. She was using glucose oxidase (GOD)−based strips (OneTouch, LifeScan, Inc., Milpitas, CA) for her SMBG. We suspected interference with AA in the measurement of blood glucose using GOD-based strips and recommended that she measure her blood glucose using glucose dehydrogenase-flavin adenine dinucleotide (GDH-FAD)−based strips (Bayer Contour, Tarrytown, NY). She was advised not to change her insulin doses. A written log comparing the two chemistries with the same blood sample confirmed significantly higher glucose levels with the GOD strips. Unfortunately, the patient died before we could download the meter or compare blood results with a hospital laboratory. AA is used as an alternate or adjuvant to chem Continue reading >>

Relation Between Intake Of Vitamins C And E And Risk Of Diabetic Retinopathy In The Atherosclerosis Risk In Communities Study

Relation Between Intake Of Vitamins C And E And Risk Of Diabetic Retinopathy In The Atherosclerosis Risk In Communities Study

Relation between intake of vitamins C and E and risk of diabetic retinopathy in the Atherosclerosis Risk in Communities Study From the Department of Ophthalmology and Visual Sciences (AEM, RK, and JAM) and the Departments of Population Health and Biostatistical Medical Informatics (MP), University of Wisconsin Medical School, Madison; the Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis (ARF); and the Department of Nutrition, University of North Carolina, Chapel Hill (JS) Search for other works by this author on: From the Department of Ophthalmology and Visual Sciences (AEM, RK, and JAM) and the Departments of Population Health and Biostatistical Medical Informatics (MP), University of Wisconsin Medical School, Madison; the Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis (ARF); and the Department of Nutrition, University of North Carolina, Chapel Hill (JS) Search for other works by this author on: From the Department of Ophthalmology and Visual Sciences (AEM, RK, and JAM) and the Departments of Population Health and Biostatistical Medical Informatics (MP), University of Wisconsin Medical School, Madison; the Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis (ARF); and the Department of Nutrition, University of North Carolina, Chapel Hill (JS) Search for other works by this author on: From the Department of Ophthalmology and Visual Sciences (AEM, RK, and JAM) and the Departments of Population Health and Biostatistical Medical Informatics (MP), University of Wisconsin Medical School, Madison; the Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis (ARF); and the Department of Nutrition, University of North Carolina, Chap Continue reading >>

Effects Of Vitamins C And D In Type 2 Diabetes Mellitus

Effects Of Vitamins C And D In Type 2 Diabetes Mellitus

Authors Christie-David D, Girgis C, Gunton J Received 24 September 2014 Accepted for publication 26 November 2014 Checked for plagiarism Yes Peer reviewer comments 3 1Department of Endocrinology and Diabetes, Westmead Hospital, 2Faculty of Medicine, University of Sydney, 3Westmead Millennium Institute, 4Garvan Institute of Medical Research, Sydney, NSW, Australia Abstract: Scurvy and rickets are largely considered historical diseases in developed countries. However, deficiencies in vitamins C and D are re-emerging due to increased consumption of processed foods and reduced fresh foods in the Western diet, as well as to an indoor sedentary lifestyle away from sun exposure. These dietary and lifestyle factors also predispose one to diabetes and metabolic syndrome. Our understanding of the potential roles of vitamin C (an antioxidant) and vitamin D (a biologically active hormone) in disease is increasing. In this review, we present observational, interventional, and mechanistic studies that examine the potential links between vitamins C and D in reversing defects in glucose homeostasis and the prevention of type 2 diabetes. Studies suggest an association between vitamin C deficiency and diabetes. An association between vitamin D and insulin resistance has been well described; however, the role of vitamin C and D supplementation in diabetes and its prevention requires further controlled trials. Keywords: glucose homeostasis, diabetes, insulin resistance, vitamin C, vitamin D Nutrients play essential roles in health and the prevention of disease. Nutrients, including vitamins, are vital to cardiovascular health (ie, vitamin B1), nerve function (ie, vitamins B6 and B12), the production of red blood cells (ie, folate and vitamin B12), and coagulation (ie, vitamin K), among man Continue reading >>

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