An Overview
Nearly 400 million people worldwide are living with diabetes, and that number is expected to jump to almost 600 million by 2035, according to the International Diabetes Federation. For many people, diabetes can be controlled with diet, exercise and, often, insulin or other drugs. However, complications from diabetes can be serious and include kidney failure, nerve damage, vision loss, heart disease and a host of other health issues. In this section: What is diabetes? How is diabetes treated? How are we using stem cells to understand diabetes? What is the potential for stem cells to treat diabetes? At its most basic, diabetes is a condition in which the body cannot regulate or properly use sugar (called glucose) in the blood. The pancreas, which helps the small intestine digest food, has hundreds of thousands of cell clusters called islets of Langerhans where beta cells live. Beta cells produce insulin, which is released into the bloodstream when blood sugar levels reach a certain threshold. The insulin signals other cells in the body to take up sugar, the primary energy source for all the body’s cells. Type 1, also known as juvenile diabetes. In type 1 diabetes, the body’s immune system attacks the beta cells in the pancreas. When the beta cells are damaged, they don’t produce insulin, or at least not enough insulin. Other cells never get the signal to take up sugar, so they don’t get the energy they need to function properly, and high sugar levels in the blood end up causing damage to the kidneys, eyes, nervous system and other organs. Type 2 diabetes, also called adult-onset diabetes. In type 2 diabetes, cells in the body become resistant to insulin. They don’t respond to the signals insulin sends out, so they don’t take up sugar from the blood. The beta c Continue reading >>
Enhanced Stem Cells For Treating Diabetes Mellitus Type 1 & 2
Updated November 22, 2017 – In the unfortunate event you or perhaps a family member are coping with diabetes you should be aware of its consequences on the body and mind. Diabetes is usually termed the “silent killer” mainly because it strikes the body slowly and without warning. Newly diagnosed diabetic patients are usually not worried about it since their symptoms are often no more severe than recurrent urination and increased thirst. A number of other individuals have no symptoms at all. Treating Diabetics With Stem Cells As time goes by however, the effects of both kinds of diabetes become increasingly serious and may lead to death. These symptoms include heart disease, eye issues, kidney failure, nerve damage and erectile dysfunction, to name a few. Hypoglycemia (acute low blood sugar) and hyperglycemia (high level of blood sugar) are the key contributors to the effects of diabetes. According to recent research, some of the oral diabetes medications can also help contribute to heart malfunction.(Kao and Chen 2012)* That is exactly why it’s important that women and men who are clinically diagnosed as “diabetic” immediately seek treatment to relieve hypoglycemia and hyperglycemia. These conditions often trigger the more harmful, degenerative ailments. The regeneration center can help treat DM with our innovative enriched and expanded Mesenchymal cells treatment for Diabetes safely and without any artificial medicines or need for regular insulin dependency.(Yong Zhao et al. 2013)* Reverse Hyperglycemia with Insulin Producing Beta-Cells Stem Cell treatments for diabetes fights the disease at its origins in the pancreas. Decreasing hyperglycemia as well as associated complications (see above). According to recent research, it can also relieve hypoglycemia or Continue reading >>
Stem Cell Therapy For Diabetes Type 1 And Diabetes Type 2
New treatments and advances in research are giving new hope to people affected by Diabetes Type 1 and Diabetes Type 2. StemGenex Medical Group provides adult stem cell Diabetes therapies to help those with unmet clinical needs achieve optimum health and better quality of life. Mesenchymal stem cell therapy for Diabetes Type 1 & Diabetes Type 2 may help patients who don’t respond to typical drug treatment, want to reduce their reliance on medication, or are looking to try stem cell therapy before starting drug treatment. To learn more about becoming a patient and receiving adult stem cell therapy through StemGenex Medical Group, please contact one of our Patient Advocates at (800) 609-7795. Below are some frequently asked questions about stem cell therapy for Diabetes Type 1 and Diabetes Type 2. Continue reading >>
New Diabetes Treatment Teaches Rogue Immune Cells To Behave
(Getty Images) A treatment targeting wayward immune cells in people with Type 1 or Type 2 diabetes may help even years later, a new study finds. For the treatment, researchers take blood from a person with diabetes and separate out the immune system cells (lymphocytes). They briefly expose those cells to stem cells from umbilical cord blood from an unrelated infant. Then they return the lymphocytes to the patient's body. The researchers have dubbed this treatment "stem cell educator therapy," because when exposed to the stem cells, the errant lymphocytes seem to re-learn how they should behave. "Stem cell educator therapy is a safe approach" with long-term effectiveness, said the study's lead author, Dr. Yong Zhao, an associate scientist at Hackensack University Medical Center in New Jersey. Type 1 diabetes, an autoimmune disease, occurs when the body's immune system cells mistakenly attack the insulin-producing (beta) cells in the pancreas. This leaves people with Type 1 diabetes with little to no insulin. They need insulin injections to survive. Researchers have long thought that any cure for Type 1 diabetes would have to stop the autoimmune attack, while regenerating or transplanting beta cells. But Zhao and his team developed a new approach to the problem — educating the immune cells that had been destroying beta cells so they stop attacking. In Type 2 diabetes, Zhao said immune cell dysfunction is responsible for chronic inflammation that causes insulin resistance. When someone is insulin-resistant, their body's cells can't properly use insulin to usher sugar from foods into cells for use as energy. Instead, the sugar builds up in the blood. The researchers hoped the stem cell educator would help decrease insulin resistance for people with Type 2 diabetes. In ear Continue reading >>
Diabetes And Stem Cell Research
Stem cell research is in progress for the treatment of diabetes Understanding the root causes of diabetes has eluded researchers for many years now. The way in which the immune system causes the destruction of precious beta islet cells within the pancreas of type 1 diabetics is generally understood to be the key. The ultimate goal, which has so far proved elusive, is a cure for diabetes , which could potentially be available for both types of diabetes through stem cell research. Stem cells are a form of cell that is yet to develop a specific set of traits. However, what stem cells have in abundance is the potential to develop into a number of different forms. Stem cell research covers the scientific study of these stem cells. Stem cell research allows researchers to grow specific varieties of human cells in the lab and research how they behave and interact under different conditions. Stem cells open up a wide spectrum of diabetes research possibilities. In one example of diabetes stem cell research, researchers took cells from human intestine cells and disabled a gene which enabled the cells to produce insulin. Stem cells for the treatment of diabetes are able to come from a variety of sources. Stem cells in the research of type 1 diabetes Within recent years, stem cell research has become a very important part of the scientific understanding of type 1 diabetes. Research has demonstrated that stem cells can be grown in the lab. In 2004, the University of Pittsburgh grew insulin producing beta cells by introducing two genes cdk and cyclin d via a virus. The researchers were able to deactivate the virus and also prevent stem cells from growing further. The research could lead to a better availability of beta cells for future research purposes. Progenitor cells, related t Continue reading >>
Mesenchymal Stem Cell Therapy In Type 2 Diabetes Mellitus
Mesenchymal stem cell therapy in type 2 diabetes mellitus 2Department of Molecular Biology, Institute of Basic Medicine, College of Life Science, Chinese PLA General Hospital, Beijing, 100853 China 2Department of Molecular Biology, Institute of Basic Medicine, College of Life Science, Chinese PLA General Hospital, Beijing, 100853 China 2Department of Molecular Biology, Institute of Basic Medicine, College of Life Science, Chinese PLA General Hospital, Beijing, 100853 China 1Department of Endocrinology, Chinese PLA General Hospital, Beijing, 100853 China 2Department of Molecular Biology, Institute of Basic Medicine, College of Life Science, Chinese PLA General Hospital, Beijing, 100853 China Received 2017 Feb 17; Accepted 2017 May 5. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated. This article has been cited by other articles in PMC. Type 2 diabetes mellitus (T2DM), which is characterized by the combination of relative insulin deficiency and insulin resistance, cannot be reversed with existing therapeutic strategies. Transplantation of insulin-producing cells (IPCs) was once thought to be the most promising strategy for treating diabetes, but the pace from the laboratory to clinical application has been obstructed due to its drawbacks. Mesenchymal stem cells (MSCs) harbor differentiation potential, immunosuppressive properties, an Continue reading >>
Stories Of Hope: A Stem Cell Therapy For Diabetes
Home Stories of Hope: A Stem Cell Therapy for Diabetes Stories of Hope: A Stem Cell Therapy for Diabetes The last thing Maria Torres expected was to be diagnosed with type 2 diabetes. She exercised, ate well and kept her weight under control. There had to be some mistake. Maria asked her doctor to repeat the tests, but the results were the same. At 43, for reasons no one could fully explain, she had diabetes, and her life was going to change dramatically. It really scared me, says Maria. I thought I was going to die soon. That Maria doubted her diagnosis is no surprise. Type 2 diabetes is often associated with obesity, and she didnt fit the profile. Most likely, some undiscovered genetic component had made her susceptible to the disease. Regardless, she now had to rework her life to manage the diabetes. Her cells had developed a condition called insulin resistance. Though her pancreas was producing insulin, which tells cells to take in blood sugar, the cells were not cooperating. As a result, glucose was accumulating in her blood, putting her at risk for heart disease, nerve damage, eye issues and a host of other problems. To help her cells absorb glucose, she needs regular insulin injections. Maria injects the hormone five times a day and must often measure her blood sugar levels even more frequently. Faithfully following this regimen has kept her alive for 20 years, but insulin is not a cure. Even with the regular injections, she faces dramatic mood swings and more serious complications as glucose levels rise and fall. One of the most promising strategies to cure diabetes is to transplant beta cells, which sense blood sugar levels and produce insulin to reduce them. Patients with type 1 diabetes would benefit because new beta cells would replace the ones theyd lost t Continue reading >>
Stem Cell Therapy For Type 2 Diabetes Mellitus
You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Stem Cell Therapy for Type 2 Diabetes Mellitus The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. ClinicalTrials.gov Identifier: NCT01142050 Verified June 2010 by Cellonis Biotechnology Co. Ltd.. Recruitment status was: Not yet recruiting Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information The purpose of the study is to evaluate the efficacy and safety in the treatment of Insulin Resistance of Type 2 Diabetes Mellitus with Bone Marrow Mesenchymal Stem Cells. To evaluate the feasibility and safety of transplantation treatment using umbilical cord mesenchymal stem cells in patients with type 2 diabetes mellitus undergoing insulin injection treatments. To assess efficacy of transplantation treatment using umbilical cord mesenchymal stem cells in patients with type 2 diabetes mellitus. A Open Labeled and Self Controlled, Safety/Efficacy Assessed Pilot Study on Transplantation Therapy Using Bone Marrow Mesenchymal Stem Cells for Insulin Resistance of Type 2 Diabetes Mellitus 1.1st transplantation: after finishing all required examines according to protocol in Day 0, ABM-MSCs are transplanted through pancreas artery percutaneously; 2. 2nd transplantation: after finishing all required examines in Day 71, BM-MSCs are transplanted intravenously; 3. 3rd transplantation: after finishing all required examines in Day 142, BM-MSCs are transplanted intravenously. Top of Page Study Description Study Design Ar Continue reading >>
Diabetes Type 2 - Stem Cells Treatment Clinic
Diabetes Type 2 Stem Cell Treatment Diabetes type 2 is a metabolic disorder that is characterized by high blood sugar and lack of insulin, a hormone produced in the pancreas that regulates the metabolism of carbohydrates. It is typically a chronic disease with a ten-year shortened life expectancy and symptoms such as: increased thirst, frequent urination, and constant hunger. There are a number of associated complications including: two to four times the risk of a cardiovascular disease and stroke, a 20-fold increase in lower limb amputations, and increased hospitalizations. Type 2 diabetes is the largest cause of non-traumatic blindness and kidney failure. It is associated with an increased risk of cognitive dysfunction and dementia, such as Alzheimer's disease. Other complications include: sexual dysfunction and frequent infections. Causes of type 2 diabetes: - obesity - poor diet - low activity level - genetics and family history Other diabetes risk factors include old age, high blood pressure, history of gestational diabetes, polycystic ovarian syndrome, impaired glucose intolerance and ethnicity, as African Americans, Hispanic Americans, and Native Americans are prone to an increased incidence of diabetes because of a history of gestational diabetes. With Type 2 Diabetes the body becomes insensitive and less able to produce insulin, which transports glucose from the bloodstream into body tissues. Instead the sugar volume in the blood builds up. The pancreas may increase insulin production but it does not rectify the problem. Other symptoms of this disease include blurred vision, fatigue, increased appetite, thirst and urination, slow-healing or frequent infections and erectile dysfunction. In both forms of diabetes, unless treated, blood sugar will rise uncontrolla Continue reading >>
Combination Of Stem Cell And Drug Therapy Could Reverse Type 2 Diabetes
Stem cell research is heralding a new age of possiblemedical treatments as scientists use them to grow transplantable cells andorgans. Now, it appears those new treatments might include one fortype 2 diabetes. Existing research has already found avenues to treat type 1diabetes. This less-common, early-onset form of diabetes occurs when the body’simmune system attacks and destroys insulin-producing cells in the pancreas,often while fighting an infection elsewhere in the body. By using stem cells,doctors can grow new insulin-producing cells to replace those that the pancreashas lost. However, type 2 diabetes – which makes up 90 percent ofdiabetes cases worldwide – is harder to treat. It typically occurs in adults asa result of excess weight or hormonal imbalances. While people with type 2 diabetes do lose some of theirinsulin-producing cells, their primary problem is elsewhere. Their cells havebecome resistant to insulin. Although insulin is present in the body, the cellscan no longer use insulin to keep blood sugar levels in check. Simply regrowingthe missing insulin-producing cells is not enough to solve the problem. Now, in new research published in StemCell Reports, scientists may have found a way. Read More: Scientists Make Insulin-Producing Cells from Stem Cells to Cure Type 1 Diabetes » A Two-Pronged Approach To create a mouse model of type 2 diabetes, the researchersput mice on a high-fat, high-carb diet. The symptoms of type 2 diabetes soonfollowed. The mice became overweight, intolerant to glucose (blood sugar), andresistant to insulin. Their blood sugar levels skyrocketed. Next came the attempt to reverse the induced diabetic state.The research team cultured human embryonic stem cells and prepared them to besafely implanted into the diabetic mice. Once t Continue reading >>
Stem Cell-based Therapy For Type 2 Diabetes Shows Promise
Stem cell-based therapy for type 2 diabetes shows promise In a new study published in the journal Stem Cell Reports, researchers reveal how a combination of stem cell transplantation and antidiabetic medication successfully treated mice with type 2 diabetes. This image shows the transplanted pancreatic beta cells derived from human embryonic stem cells. Image credit: Jennifer Bruin, University of British Columbia Senior study author Timothy Kieffer, of the University of British Columbia in Canada, and colleagues say the findings could lead the way for the first ever stem cell-based insulin replacement therapy being tested in humans with type 2 diabetes . It is estimated that more than 29 million people in the US have diabetes . Type 2 diabetes accounts for around 90-95% of these cases. The condition occurs as a result of the body being unable to produce enough of the hormone insulin or use it effectively. This leads to high blood glucose levels. In order to manage blood glucose levels, patients with type 2 diabetes are often treated with oral medication - such as metformin - insulin injections, or a combination of both. Kieffer and colleagues note, however, that such treatments can cause gastrointestinal problems, weight gain and low blood glucose levels, and some patients may not even respond to them. With these factors in mind, the team tested a potential alternative treatment approach for patients with type 2 diabetes. Improved glucose metabolism, insulin sensitivity with beta cell transplantation The team created a mouse model of type 2 diabetes by inducing some markers of the disease in the animals - obesity , low response to insulin and high blood glucose levels - by feeding them a high-fat diet. Next, the team transplanted mice with encapsulated pancreatic proge Continue reading >>
Stem Cell Treatment & Therapy For Diabetes Type 2 In Chicago, Il
Why Choose Stem Cell Therapy For Type 2 Diabetes? For people suffering from Type 2 diabetes, stem cell therapy can offer a respite from the symptoms of the disease. Although stem cell therapy cannot cure it, receiving stem cell therapy for diabetes Type 2 from TruStem Cell Therapy has the potential to improve a patients quality of life significantly by reducing symptoms and complications related to Type 2 diabetes, as well as slowing its progression. For patients receiving stem cell diabetes treatment, it is possible to see improvements in any one or multiple disease-related complications such as stabilization of blood sugar levels, lower blood sugar levels, frequent urination, fatigue, poor wound healing, etc. How Does Stem Cell Diabetes Treatment Work? TruStem Cell Therapy provides access to diabetes treatment that utilizes a patients stem cells isolated from his or her own fat tissue. There are multiple benefits afforded by the utilization of adipose-derived stem cells, including their ability to differentiate into a broad variety of cell types (neurons, bone, cartilage, muscle, tendon, etc.), they are present at comparatively much higher levels than other stem cell types; possess higher immunomodulatory capacity; and they do not endanger a patients health the way other stem cells might. There are three steps to the treatment process: Approximately 150 to 250 ccs of a patients own fat tissue is harvested through a minimally invasive procedure. Generally, this fat tissue is collected from around the patients belly region. Process and activate. Harvested fat tissue is taken immediately to the on-site laboratory for processing. At this stage, an optimized protocol is used to isolate the maximum number of stem cells from collected fat tissue. Administer. TruStem Cell Th Continue reading >>
Updates On Harvard’s Diabetes Stem Cell Research From Ada 2015
Twitter Summary: @Harvard #diabetes stem cell lab wows crowd at #2015ADA, plans to produce full pancreatic islets w/ beta + alpha cells. Still early stages. There was a lot of interest this ADA in the Harvard Stem Cell Institute’s diabetes research, which has previously shown the ability to produce mature, insulin-producing beta cells from human stem cells. These beta cells can effectively cure type 1 diabetes in mice. (Normally, beta cells produce insulin and are found in the pancreas). While other groups are also working on stem cell based therapies for diabetes, the Harvard group is unique in that they are able to produce mature beta cells from stem cells. For comparison, the prominent diabetes stem cell research group at ViaCyte is only able to create “parent” cells that, after implantation in the body, could later develop into functional beta cells. Another group called BetaLogics, which is owned by J&J, can produce human “beta-like” cells that, while not identical to human beta cells, would already be mature (i.e. able to produce insulin in response to glucose levels) upon implantation. The Harvard group can also produce an extremely large quantity of cells, which is a critical need given the current deficit of beta cells for the millions of people with type 1 diabetes and type 2 diabetes who can no longer sufficiently produce insulin. Dr. Douglas Melton from Harvard wowed the crowd with his update on the team’s latest discoveries, most notably the announcement that his team can now not only produce beta cells from stem cells, but also alpha cells (which produce glucagon, another important hormone) and delta cells. All of these cells are found together in ‘islets’ in the pancreas, and Dr. Melton believes that his team will in the future be able to Continue reading >>
Type 2 Diabetes Mellitus And Stem Cell Therapy: A Review
Home Diabetes Articles Type 2 Diabetes Mellitus and Stem Cell Therapy: A Review Type 2 Diabetes Mellitus and Stem Cell Therapy: A Review 1. Hematology Department, The Lebanese Canadian Hospital, Sin El-Fil, Lebanon; Notre Dame University Hospital, Jounieh, Lebanon 2. Saint George Hospital, University Medical Center, Balamand Medical School, Beirut, Lebanon The authors have declared no conflicts of interest. The authors would like to thank all diabetic patients who contributed to these studies. Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License . Most public health statistics outline the rapidly exploding burden of Type 2 diabetes mellitus as a chronic endemic disease related to sedentary lifestyle and obesity. Tremendous efforts and resources are being invested in finding new medical treatments and alternative therapies through cell-based replacement strategies among other methods. Several types of cells continue to be under active research, including autologous islet cells, allogeneic cadaveric islet cells, embryonic and induced pluripotent stem cells, bone marrow-derived hematopoietic and mononuclear cells, and mesenchymal stem cells of different sources. The objective of this review is to bring the reader up to speed on the efforts being spent in this field with a clear and critical approach to the difficult and sometimes futile methodology undermining the results obtained. Over the past decade, the potential of stem cells has been explored with amazement, myths, and many more questions than answers. The dream was that we might be able to repair almost any malfunction inflicting our bodies. The promise of taking off-the-shelf cells or even body parts, making better targeted pharmaceutical agents, and even de Continue reading >>
Bone Marrow Derived Stem Cell Therapy For Type 2 Diabetes Mellitus
Bone marrow derived stem cell therapy for type 2 diabetes mellitus 1Hematology Department, the Lebanese Canadian and Notre Dame University Hospitals, Beirut, Lebanon; 2Neurosurgery Department, the Lebanese Canadian Hospital, Beirut, Lebanon; 3Endocrinology Department, Al-Saydet Hospital, Zgharta, Lebanon; 4Endocrinology Department, The Middle East and Notre Dame University Hospitals, Beirut, Lebanon; 5Endocrinology Department, the Lebanese Canadian Hospital, Beirut, Lebanon Correspondence to: Tarek Wehbe, MD. The Notre Dame University Hospital, Notre Dame St., Jounieh, Lebanon. Email: [email protected] . Received 2016 Sep 2; Accepted 2016 Nov 21. Copyright 2016 Stem Cell Investigation. All rights reserved. In this study, 6 patients with type 2 diabetes (T2D) underwent autologous bone marrow mononuclear stem cell (BM-MNSC) infusion into the celiac and superior mesenteric arteries without pretreatment with any myeloablative or immune-suppressive therapy. Five of 6 (83%) showed normalization of their fasting glucose and the glycosylated hemoglobin (HbA1C) with significant reduction of their medication requirements. The HbA1C dropped on average 2.2 points. The three patients with diabetic complications showed improvement or stabilization and most patients reported improved energy and stamina. The durations of response varied between 6 months and 2 years. No patients had any significant adverse effects. Keywords: Type 2 diabetes (T2D), stem cells, bone marrow mononuclear cells, glycosylated hemoglobin Diabetes incidence is on the rise, afflicting 810% of the world population with as many suspected of having pre-diabetes. This incidence will likely double in the next few decades due to the widespread sedentary lifestyles and dietary indiscretions. Ninety-five percent of the Continue reading >>
