Diabetic Amyotrophy
Diabetic amyotrophy is a nerve disorder complication of diabetes mellitus. It affects the thighs, hips, buttocks and legs, causing pain and muscle wasting. What is diabetic amyotrophy? Diabetic amyotrophy is a nerve disorder which is a complication of diabetes mellitus. It affects the thighs, hips, buttocks and legs, causing pain and muscle wasting. It is also called by several other names, including proximal diabetic neuropathy, lumbosacral radiculoplexus neurophagy and femoral neurophagy. What is diabetic amyotrophy like? The main features of diabetic amyotrophy are: Weakness of the lower legs, buttocks or hip. Muscle wasting, usually in the front of the thigh, which follows within weeks. Pain, sometimes severe, usually in the front of the thigh but sometimes in the hip, buttock or back. Other features which occur in some (but not all) patients are: Altered sensation and tingling in the thigh, hip or buttock, which tends to be mild in comparison to the pain and weakness. About half of patients also have distal neuropathy, meaning that sensation in the nerves of the lower legs and feet may be separately affected by this condition (which is the most common form of diabetic neuropathy). Learn more about diabetic neuropathy. About half of people affected lose weight. Symptoms generally begin on one side and then spread to the other in a stepwise progression. The condition may come on quickly or more slowly and usually remains asymmetrical (ie the two sides of the body are unequally affected) throughout its course. About half of patients also have distal symmetrical polyneuropathy, which means the sensation in their feet and toes on both sides is also affected. The condition tends to go on for several months but can last up to three years. By the end of this time it usuall Continue reading >>
Diabetic Proximal Neuropathy, The Muscle Wasting From Diabetes
Diabetic proximal neuropathy, or amyotrophy, is the muscle weakness and wasting caused by years of high blood sugar. But you can prevent and even reverse it. Diabetic proximal neuropathy is only one of the diabetic neuropathies. Like all the others it is the result of long-term high blood sugar. It is not as well known as the numbness and tingling of fingers and toes that nearly every type 2 diabetic deals with from the beginning of diabetes. That's because not everyone with type 2 diabetes has the symptoms of muscle wasting and weakness of diabetic proximal neuropathy. Also called diabetic amyotrophy (myo- for muscles and -trophy for breaking down), this neuropathy arrives after years and years of too much glucose in your blood. Diabetic peripheral neuropathy starts with pain in the muscles of your thighs, hips, buttocks or legs. In rare cases it also affects your shoulders, too. But wherever it shows up, the pain is usually on only one side, or on one side more than the other. If the cause of the muscle wasting is diabetic nerve disease, it is always in older adults who have had diabetes for a while. Type 2 diabetes has been damaging the blood vessels that supply nerves with oxygen, destroying the nerve pathways slowly over time. The effect is weakness in your legs. You cannot stand up from a chair without help. Your knee and ankle reflexes become weaker and disappear. That's one reason doctors check your reflexes at each physical. They gently tap your knee and ankle joints with a small hammer as they measure your responses. If diabetic proximal neuropathy continues the result is quadriparesis, the medical term for extreme weakness in the arms and legs. That's why it is called muscle wasting. There are other causes for muscle wasting that need to be ruled out, such as Continue reading >>
What Foods Are Good For Building Muscle Mass If You Are Diabetic?
Diabetes is a complex disease that requires knowledge, skill and motivation to control it properly. Diabetes involves managing different food sources, exercise and body systems with careful balance. People with diabetes who want to build muscle mass have special challenges, but they are strongly encouraged to work out and build their muscles, according to "The Journal of the American Dietetic Association," JADA. Video of the Day JADA author Craig Williams is a pharmacist who specializes in diabetes. He reports that the use of muscles has a great deal to do with how well the body uses blood glucose. "When insulin works properly, muscle tissue is the single biggest user of glucose in your body," says Williams. When insulin doesn't work properly and doesn't get used in muscles, it begins to accumulate in your bloodstream, raising glucose levels and contributing to deterioration of multiple body systems, such as nerves, eyesight and circulation. To help control your blood sugar, muscle use and muscle health are essential to people with diabetes. Type 1 diabetes is the insulin-dependent form. Type 2 Diabetes is insulin-resistant, meaning your body is unable to use your own insulin properly. In the United States, Type 2 diabetes is on the rise due to obesity that is near epidemic. Type 2 diabetics can't use insulin to break down glucose as a fuel source. Instead, the muscles seek to use fatty acids, and this worsens insulin resistance and increases the fat levels in the blood, a condition known as elevated fasting triglycerides. This is why it is crucial for people with diabetes to increase their lean protein intake, as well as complex carbohydrates, when building their muscle mass. Because diabetes can also impair kidney function, it is important for diabetics to not overdo Continue reading >>
Type 1 Diabetes Mellitus Clinical Presentation
History The most common symptoms of type 1 diabetes mellitus (DM) are polyuria, polydipsia, and polyphagia, along with lassitude, nausea, and blurred vision, all of which result from the hyperglycemia itself. Polyuria is caused by osmotic diuresis secondary to hyperglycemia. Severe nocturnal enuresis secondary to polyuria can be an indication of onset of diabetes in young children. Thirst is a response to the hyperosmolar state and dehydration. Fatigue and weakness may be caused by muscle wasting from the catabolic state of insulin deficiency, hypovolemia, and hypokalemia. Muscle cramps are caused by electrolyte imbalance. Blurred vision results from the effect of the hyperosmolar state on the lens and vitreous humor. Glucose and its metabolites cause osmotic swelling of the lens, altering its normal focal length. Symptoms at the time of the first clinical presentation can usually be traced back several days to several weeks. However, beta-cell destruction may have started months, or even years, before the onset of clinical symptoms. The onset of symptomatic disease may be sudden. It is not unusual for patients with type 1 DM to present with diabetic ketoacidosis (DKA), which may occur de novo or secondary to the stress of illness or surgery. An explosive onset of symptoms in a young lean patient with ketoacidosis always has been considered diagnostic of type 1 DM. Over time, patients with new-onset type 1 DM will lose weight, despite normal or increased appetite, because of depletion of water and a catabolic state with reduced glycogen, proteins, and triglycerides. Weight loss may not occur if treatment is initiated promptly after the onset of the disease. Gastrointestinal (GI) symptoms of type 1 DM are as follows: Neuropathy affects up to 50% of patients with type 1 D Continue reading >>
- Care of the Athlete With Type 1 Diabetes Mellitus: A Clinical Review
- Women in India with Gestational Diabetes Mellitus Strategy (WINGS): Methodology and development of model of care for gestational diabetes mellitus (WINGS 4)
- The UK Prospective Diabetes Study (UKPDS): clinical and therapeutic implications for type 2 diabetes
Effects Of Type 1 Diabetes Mellitus On Skeletal Muscle: Clinical Observations And Physiological Mechanisms
Effects of type 1 diabetes mellitus on skeletal muscle: clinical observations and physiological mechanisms Dept of Pathology & Molecular Medicine, McMaster University, 1200 Main St., W. Hamilton, ON, Canada L8N 3Z5 Muscle Health Research Centre, York University, 4700 Keele St., Toronto, ON, Canada M3J 1P3 Dept of Pathology & Molecular Medicine, McMaster University, 1200 Main St., W. Hamilton, ON, Canada L8N 3Z5 Muscle Health Research Centre, York University, 4700 Keele St., Toronto, ON, Canada M3J 1P3 Thomas J. Hawke, PhD, Department of Pathology and Molecular Medicine, 4N65, Health Sciences Centre, McMaster University, 1200 Main St. W., Hamilton, ON, Canada L8N 3Z5.Tel: (905) 525 9140x22372;fax: 9057777856;email: Dept of Pathology & Molecular Medicine, McMaster University, 1200 Main St., W. Hamilton, ON, Canada L8N 3Z5 Muscle Health Research Centre, York University, 4700 Keele St., Toronto, ON, Canada M3J 1P3 Dept of Pathology & Molecular Medicine, McMaster University, 1200 Main St., W. Hamilton, ON, Canada L8N 3Z5 Muscle Health Research Centre, York University, 4700 Keele St., Toronto, ON, Canada M3J 1P3 Thomas J. Hawke, PhD, Department of Pathology and Molecular Medicine, 4N65, Health Sciences Centre, McMaster University, 1200 Main St. W., Hamilton, ON, Canada L8N 3Z5.Tel: (905) 525 9140x22372;fax: 9057777856;email: Please review our Terms and Conditions of Use and check box below to share full-text version of article. I have read and accept the Wiley Online Library Terms and Conditions of Use. Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. Continue reading >>
- International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #59: Mechanisms of insulin signal transduction Part 3 of 8
- Care of the Athlete With Type 1 Diabetes Mellitus: A Clinical Review
- Effects of Insulin Plus Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) in Treating Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Exercise And Diabetes: Avoiding Type 1 Related Muscle Deterioration
Exercise and Diabetes: Avoiding Type 1 Related Muscle Deterioration Muscle deterioration, and subsequent loss of physical strength, is a possible complication of type 1 diabetes, and one rarely mentioned. The significance of muscle loss is not just in the erosion of strength. Skeletal muscle is the bodys largest insulin-sensitive organ, so muscle loss affects our ability to utilize insulin, and manage blood sugar. Another name for this is insulin resistance, and it contributes to other type 1 diabetes complications such as heart, and kidney disease. Researchers recently discovered that a depletion of muscle stem cells in the early stages of type 1 diabetes may be responsible for diabetes related muscle loss. Their investigation also indicates that taking steps to boost muscle fitness makes a positive, long-term health difference. ...by improving muscle health we can reduce blood sugar levels and improve the response to insulin, said senior research author Thomas Hawke, DeGroote School of Medicine. One means of preventing muscle loss owed to type 1 diabetes is lowering our myostatin levels. Myostatin is a hormone that inhibits muscle growth. The scientists found that blood glucose drops noticeably - even without insulin - when myostatin levels are reduced. Hawkes advice for lowering myostatin is to exercise, and earlier research supports his recommendation. A study published in Medicine and Science in Sports and Exercise concluded that myostatin protein levels are regulated by aerobic exercise and, furthermore, that myostatin is in the causal pathway of acquired insulin resistance with physical inactivity. Here, again, insulin sensitivity is linked to myostatin reduction via exercisespecifically, aerobic activity. Other research, and many fitness experts, also recommend Continue reading >>
Proximal Diabetic Neuropathy
Proximal diabetic neuropathy, more commonly known as diabetic amyotrophy, is a nerve disorder that results as a complication of diabetes mellitus. It can affect the thighs, hips, buttocks or lower legs. Proximal diabetic neuropathy is a peripheral nerve disease (diabetic neuropathy) characterized by muscle wasting or weakness, pain, or changes in sensation/numbness of the leg.[1] Diabetic neuropathy is an uncommon complication of diabetes. It is a type of lumbosacral plexopathy, or adverse condition affecting the lumbosacral plexus. There are a number of ways that diabetes damages the nerves, all of which seem to be related to increased blood sugar levels over a long period of time. Proximal diabetic neuropathy is one of four types of diabetic neuropathy.[2] Proximal diabetic neuropathy can occur in type 2 and type 1 diabetes mellitus patients however, it is most commonly found in type 2 diabetics.[3] Proximal neuropathy is the second most common type of diabetic neuropathy and can be resolved with time and treatment.[4] Signs & symptoms[edit] Signs and symptoms of proximal diabetic neuropathy depend on the region of the plexus which is affected. The first symptom is usually pain in the buttocks, hips, thighs or legs. This pain most commonly affects one side of the body and can either start gradually or come on suddenly. This is often followed by variable weakness in the proximal muscles of the lower limbs. These symptoms, although often beginning on one side, can also spread to both sides.[1] Weakness in proximal diabetic neuropathy is caused by denervation of the specific muscles innervated by regions of the plexus affected and can thus these muscles may start exhibiting fasciculations. Note that diabetic amyotrophy is a condition caused by diabetes mellitus, but sepa Continue reading >>
How To Stop Losing Muscle | Diabetic Muscle & Fitness
> HOW TO PREVENT MUSCLE LOSS WITH TYPE 1 DIABETES HOW TO PREVENT MUSCLE LOSS WITH TYPE 1 DIABETES IS IT HARDER FOR PEOPLE WITH DIABETES TO BUILD MUSCLE? However, this is only true when you give diabetes the two fingers and screw controlling your blood sugars. Building muscle with diabetes takes a little more than normal. You need to be smart about it. Really smart. You need to a firm understanding of what to do, and what not to do especially with diet and lifestyle. In this video blog, I go into detail on the complications of poorly controlled diabetes and explain why you must obsess over your blood glucose control if you want to build a healthy, strong and great looking body! This is a must for anyone living with diabetes who wants to get more out of their efforts in the gym! If youre a diabetic bodybuilder or fitness fanatic you need to WATCH THIS VIDEO! If you love reading this kind of stuff and want to know even more about how to build muscle and get as strong as physically possible with diabetes then youre in the right place. Right now, you can join many other like minded individuals in the private Diabetic Muscle and Fitness Facebook group who are following my 112 Day Diabetic MASS transformation plan and also save a MASSIVE 85% OFF with this coupon below. Backed by a full 100% results guarantee you have nothing to lose and, with this coupon, you can access over 112 days of workouts,7-day meal plans supplement guides and personal support from Phil Graham and the rest of the Diabetic Muscle and Fitness team all for $16 (14). Get started here and claim your 85% discount now. Continue reading >>
The Musculoskeletal Effects Of Diabetes Mellitus
Go to: Abstract Diabetes mellitus (DM) is a multi-system disease characterized by persistent hyperglycemia that has both acute and chronic biochemical and anatomical sequelae, with Type-2 DM representing the most common form of the disease. Neuromusculoskeletal sequelae of DM are common and the practicing chiropractor should be alert to these conditions, as some are manageable in a chiropractic office, while others are life and/or limb threatening. This paper reviews the effects of DM on the musculoskeletal system so as assist the chiropractor in making appropriate clinical decisions regarding therapy, understanding contraindications to therapy, referring patients to medical physicians when appropriate and understanding the impact that DM may have on the prognosis for their patients suffering from the myriad musculoskeletal conditions associated with this disease. Keywords: diabetes, musculoskeletal, chiropractic Go to: Introduction Diabetes mellitus (DM) is a multi-system disease characterized by persistent hyperglycemia that has both acute and chronic biochemical and anatomical sequelae. It is thought to affect almost 17 million Americans, only 11 million of whom have been diagnosed according to the American Diabetes Association. In type 1 diabetes, a lack of insulin results in poor carbohydrate, fat, and protein metabolism. Insulin is functionally absent, typically due to immune-mediated destruction of the beta cells of the pancreas, though other etiologies of beta cell destruction have also been implicated, including drugs, chemicals, viruses, mitochondrial gene defects, pancreatectomy and ionizing radiation.1 Type 1 DM (DM1) occurs most commonly in juveniles. It can occur in adults, especially in those in their late 30s and early 40s. Unlike people with Type 2 DM ( Continue reading >>
- The musculoskeletal effects of diabetes mellitus
- Women in India with Gestational Diabetes Mellitus Strategy (WINGS): Methodology and development of model of care for gestational diabetes mellitus (WINGS 4)
- Effects of Insulin Plus Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) in Treating Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
How To Treat Muscle Loss In Diabetics
Diabetes mellitus has many symptoms, including overactive bladder, excessive thirst and hunger, weight loss, a tingling sensation in the digits, and weakened vision. Another lesser known symptom of diabetes is muscle loss. The diabetic mechanism of muscle loss is multifactorial. In other words, diabetes can contribute to muscle loss in several ways. The three main ways muscle loss may occur in diabetics includes: 1. Muscle contracture and disuse It is common for patients with diabetes to suffer from hardened muscles, or muscles that have contracted as a result of thickening soft tissue. This type of general diabetic muscle contracture can be pervasive, and makes it much harder for a patient to move or use their muscles. Movement becomes limited, and muscle disuse that leads to atrophy is the result. 2. Atherosclerosis While atherosclerosis and diabetes are not directly related, diabetes can promote atherosclerosis, or the thickening of arterial walls. This contributes to restricted blood flow, which can cause cramps, pain, or general discomfort. In severe cases, the lack of oxygenated blood to localized areas of muscle can cause infarction, or tissue death caused by restricted blood flow. Infarctions of the heart can lead to heart attacks. 3. Nerve damage Lastly, infarction can cause the death of motor and sensory neurons that are involved in muscle movement and blood supply. The death of these vital neurons can further contribute to muscle disuse and atrophy, and can lead to muscle twitching and pain. An uncomfortable type of muscle atrophy in which the muscles of the shoulders and hips waste away, known as “limb girdle wasting”, is common in diabetics and often referred to as diabetic amyotrophy. In all three cases, muscle loss occurs slowly, but is pervasive and Continue reading >>
My Muscles Are Wasting
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community hi everyone, just wondering if any of you are in the same situation as me. i have muscles wasting in my one arm, calves and now both hands.my doc seems to clam up when i see him about it. is there anyone who has same problem. i would appreciate any feedback. I'm sorry to hear about the wasting musle in your arm, have they offered you any physio to see if they can help to stop it wasting completely. My friend has muscle waste from her Lupus and they have reffered her to see a pain physio at the Royal free, they can't stop what happened but they have given her some gentle exercise to stop it getting any worse. Ask for a second opinion or see another doctor. Tracey is right... don't allow this to be brushed off or ignored, ask to see a specialist. Two thoughts that strike me are: to ask if you are on a statin -- there can be side-effects related to muscle breakdown -- and the other is to wonder about neuropathy? I agree with the contributor if you are on statins. If you are on statins I would suggest you discuss with your GP about stopping or changing them real soon. While for many people they are a good med and don't have side effects e.g. for me, for some they do cause muscle pains and degradation and should be changed to another type or stopped. thank you for your comments, i am on statins and quite a high dose and have stopped them several times,but each time i have been put straight back on them when i have next blood test....when i next see my specialist, i think this will have to be discussed in detail and see if there is any other option...the neuropathy, well, what can i say. i have both peripheral and autonomic, . . Rob, I feel for you, I've go Continue reading >>
Can You Explain Muscle Loss | Diabetic Connect
Muscle loss is an interesting topic because a lot of things can contribute to it. The primary reasons for muscle loss are a lack of exercise, weight loss, and even the aging process itself. To maintain or build muscle, the best type of exercise involves some kind of resistance, such as weight training. Here at Joslin, we recommend aerobic activity (such as jogging, biking or swimming) at least 150 minutes a week with some weight lifting added in. Some believe that eating protein can help build muscle, but there is not a lot of research to substantiate this. When you have diabetes, muscle wasting can sometimes occur when there is not enough insulin in the blood stream. This can happen, for example, with people who have type 1 diabetes, but do not know it yet. Before they are diagnosed, people with type 1 can experience a lot of weight loss, both fat and muscle. Once they start taking insulin, the weight and muscle mass return to normal. This can happen to a person with type 2 diabetes, but it is less common. Continue reading >>
Marked Weight Loss, Muscle Wasting And Fatigueon Administration Of Empagliflozin In A Subject Withtype 2 Diabetes
1Central Iowa Veterans Health Care System, Des Moines, Iowa, USA. 2University of Iowa, Iowa City, Iowa, USA. Background: Weight loss, fatigue and decreased quality of life are frequently reported at the time of initial diagnosis by subjects with Diabetes Mellitus of both types although far more frequently with type 1 and are attributed to fluid and electrolyte losses due to persistent glycosuria as well as decline in adipose tissue secondary to lipolysis. However, muscle wasting and weakness as initial manifestations are noted almost exclusively in subjects with type 1 diabetes. Case Report: A man with history of type 2 diabetes about 10 years reported onset of general fatigue, polyuria, nocturia, polydipsia as well as profound progressive weight loss, muscle wasting and weakness within 2 weeks after initiation of Empagliflozin. He had been receiving glimepiride 8 mg and metformin 2000 mg daily for about 5.5 years. Resolution of polyuria, nocturia and polydipsia was attained promptly within a week after discontinuation of Empagliflozin and initiation of insulin glargine. Weight gain and improvement in fatigue began by 2 weeks, continued until achieving desirable glycemic control over next 4 months and then stabilized. However, muscle mass and strength have not yet returned to the level prior to initiation of Empagliflozin during the follow up period of 12 months. Conclusion: Empagliflozin is responsible for induction of transient weight loss as well as persistent muscle weakness and wasting in this subject. Type 2 diabetes; empagliflozin; muscle wasting; myopathy; osteopenia. Continue reading >>
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"muscle Wasting In Type 2 Diabetes": Diabetes Community - Support Group
That seemed to be what was happening to me when I was diagnosed with prediabetes. I was 18 years old, 5'7", and about 118 lbs. I was continually losing weight, and I felt weak. I was also really thirsty all of the time--I drank about 20 cups of water per day. And my roommate and friends commented that I acted drunk when I ate sweets (which wasn't often). Of course, I still never expected the prediabetes diagnosis. My doctor ordered the glucose tolerance test to see if I had hypoglycemia. Right now I weight about 126 lbs. I feel much stronger. Some days I still feel really weak, but on my best days I am much stronger than I was when I was first diagnosed. I definitely gained weight when I started Metformin, and I suspect that a lot of the weight is muscle. I'm a woman, and your name suggests that you're a woman too. I think we have to work really hard to maintain muscle mass. If I even skip lifting weights for a week, I start to lose tone. Also, if you had an easier time maintaining muscle tone as a teen, it's probably because your testosterone levels were higher. Testosterone levels drop in women during their early 20s. There is a different school of thought that you must be aware of. The body can use either sugar or fat as its primary fuel. When the default fuel source is sugar (which is not the preferred fuel source), then the body can burn down muscle and bones and convert them to sugar which is used as a fuel. That is why it is important to switch over to fat as the default fuel source for your body. Muscles in type 2 diabetes typically look and work similarly to the muscles of otherwise healthy people of the same body weight and exercise level. 90% of people with type 2 diabetes are overweight or obese, and there is lots of fat "marbled" in these muscles. Under th Continue reading >>
Unexplained Weight Loss With Diabetes
You might be aware that as a metabolic disorder, some forms of diabetes come with excessive weight. But diabetes might also cause a sudden drop in weight too. In fact, many patients who are ultimately diagnosed with diabetes first go to their doctor with concerns about unexplained weight loss. Several mechanisms are behind this symptom. Weight loss can occur as a consequence of high blood sugar, dehydration, muscle breakdown and problems with your thyroid. Video of the Day Although both type 1 and type 2 diabetes can involve fairly dramatic weight loss over several days at the onset of the disease, it tends to be more common among people with type 1. In both cases, the cause is that your body fails to adequately deal with insulin. The job of insulin is to transport glucose from the foods you eat into your cells to provide energy for all the work that’s required to keep you alive. However, most type 1 diabetics don’t produce insulin. Type 2 diabetics either don’t produce enough insulin or their bodies don’t respond to it properly. Consequently, even if you eat normally, that blood sugar simply builds up and gets excreted in your urine. This causes weight loss, but it could also damage your organs if you don't receive treatment. If you experience an unexplained weight loss, surpassing 5 percent of your body weight within days, see your health care provider as soon as possible. Another symptom of diabetes associated with weight loss is frequent urination. When you urinate more frequently and don’t drink enough to replace the lost fluid, you become dehydrated. Urination increases in diabetes, because your kidneys have to work harder to filter the excess glucose building up in your system. The increased glucose in the urine draws fluid from your tissues. When you l Continue reading >>
