Type 1 Diabetes Linked To Increased Dementia Risk
Type 1 Diabetes Linked to Increased Dementia Risk WASHINGTON, DC Older patients with type 1 diabetes (T1D) have more than an 80% increased risk for dementia compared with those without diabetes, a new study suggests. Previous research showed that older people with type 2 diabetes (T2D) have about a two-fold greater risk for dementia compared with people without diabetes, but the current study is the first to look at dementia risk in elderly adults with T1D. "There has been a paucity of work in type 1 diabetes because only recently have they been living longer, and living long enough to be at risk for an age-related neurocognitive dysfunction," Rachel Whitmer, PhD, senior scientist, Division of Research, Kaiser Permanente, Oakland, California, told Medscape Medical News. Dr Whitmer presented the results here at the Alzheimer's Association International Conference (AAIC) 2015. The study included 490,344 persons aged 60 years and older who were members of Kaiser Permanente Northern California, none of whom had dementia. Of these, 334 had T1D. Over a 12-year period, 16% of the patients with T1D were diagnosed with dementia compared with 12% of those without T1D. Compared with participants without T1D, those with T1D were 83% more likely to get dementia (hazard ratio [HR], 1.83; 95% confidence interval [CI], 1.3 - 2.5) after adjustment for differences in age, sex, race, and vascular risk factors. After adjustments for stroke, peripheral artery disease, and hypertension, the HR was 1.61. Another analysis excluded participants with T2D, which resulted in a somewhat larger dementia risk for those with T1D (HR, 1.93; 95% CI, 1.3 - 2.6). This fell to an HR of 1.73 (95% CI, 1.2 - 2.3) when fully adjusted. Patients with T1D are now living longer, in large part because of changes i Continue reading >>
Diabetic Retinopathy And Dementia In Type 1 Diabetes.
Diabetic Retinopathy and Dementia in Type 1 Diabetes. Rodill LG, et al. Alzheimer Dis Assoc Disord. 2017. Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands. Department of Epidemiology & Biostatistics, University of California, San Francisco, CA. Alzheimer Dis Assoc Disord. 2017 Dec 19. doi: 10.1097/WAD.0000000000000230. [Epub ahead of print] OBJECTIVE: Retinopathy impacts over one-third of those with diabetes mellitus and is associated with impaired cognitive performance and cerebrovascular lesions in middle-aged adults with type 1 diabetes. However, the association between diabetic retinopathy (DR) and risk of dementia in type 1 diabetes is unknown. We investigated the association between DR and incident dementia in a large, elderly population with type 1 diabetes. METHODS: A cohort of 3742 patients with type 1 diabetes aged 50 years and above was followed from January 1, 1996 to September 30, 2015 for incident dementia. DR diagnoses were identified from electronic medical records. Age as timescale Cox proportional hazard models evaluated associations between time-updated DR and dementia risk. Models were adjusted for demographics, severe glycemic events, glycosylated hemoglobin, and vascular comorbidities. RESULTS: Among 3742 patients with type 1 diabetes (47% female, 21% nonwhite), 182 (5%) were diagnosed with dementia during a mean follow-up of 6.2 years. No significant association was found between DR and incident dementia in the main analyses [adjusted Hazard Ratio=1.12; 95% confidence interval, 0.82-1.54), nor among subgroup restricted to those aged 60 years and above or 70 years and above. CONCLUSIONS: DR was not associated with risk of dementia, suggesting that pathophysiological processes underlying d Continue reading >>
Type 1 Diabetes Linked To Higher Risk Of Dementia
MONDAY, July 20, 2015 (HealthDay News) -- People with type 1 diabetes may face a greater risk of developing thinking and memory problems as they age compared to the general population, new research suggests. The study found that people with type 1 diabetes were 83 percent more likely to develop dementia as seniors. "Our study found a modestly higher risk of all-cause dementia in people with type 1 diabetes . The next step is to figure out what that means, and how we can help people with type 1 diabetes age successfully," said study author Rachel Whitmer, a senior scientist in the division of research at Kaiser Permanente in Oakland, Calif. However, Whitmer also noted that the study doesn't prove that type 1 diabetes caused dementia, only that the two diseases were linked. "This is an observational study that shows association, not causation. We don't have tissue from these people's brains," she added. Whitmer plans to present the findings Monday at the Alzheimer's Association International Conference, in Washington D.C. Findings presented at meetings are generally viewed as preliminary until they've been published in a peer-reviewed journal. Funding for the study was provided by the U.S. National Institute on Aging. Previous research has shown a link between type 2 diabetes and dementia risk. Since people with type 1 diabetes are now routinely living into their senior years, Whitmer and her colleagues wondered if the same would be true for people with type 1 diabetes. Although both type 1 and type 2 diabetes cause problems with blood sugar regulation, the root cause of each disease is different. In type 1 diabetes , the immune system mistakenly attacks insulin -producing beta cells in the pancreas . This leaves people with type 1 diabetes with little to no insulin, acc Continue reading >>
Type 1 Diabetes Increases Dementia Risk
WASHINGTON Elderly people with type 1 diabetes were 83% more likely to develop dementia compared with those without the disease, findings from a study that involved more than 400,000 people older than aged 60 years indicate. Although it's known that type 2 diabetes increases dementia risk, little was known about the effect of type 1 diabetes on cognitive aging until now. Elderly people with type 1 diabetes are a population that is unique from elderly people with type 2 diabetes, said Rachel Whitmer, PhD, of Kaiser Permanente Division of Research in Oakland, California. They have a much younger age of diabetes onset, continuous insulin treatment, more frequent severe hypoglycemic episodes, but fewer vascular risk factors. To determine the prevalence of new dementia diagnoses, she and colleagues followed 490,344 people aged older than 60 years with no prior history of dementia, who were part of the Kaiser Permanente Northern California health system during a 12 year period. A total of 230 participants had type 1 diabetes. Whitmer and colleagues presented the results at the 2015 Alzheimer's Association International Conference . During the follow-up period, dementia was diagnosed in 16% of patients with type 1 diabetes and in 12% of patients without type 1 diabetes. After adjusting for stroke, peripheral artery disease, and hypertension, those with type 1 diabetes were 61% more likely to develop dementia than those without the disease, the researchers found. When people with type 2 diabetes were excluded from the comparison group, the relationship between type 1 diabetes and dementia was even stronger, with 73% more likely to develop dementia after adjustment. Since management of type 1 diabetes requires vigilance and constant self-care, cognitive impairment poses a parti Continue reading >>
The Alarming Diabetes-alzheimer’s Connection
The possible complications posed by diabetes—heart disease and damage to eyes, feet, nerves and so forth—are fairly familiar to the general public. But in recent years, scientists have been scrutinizing a risk that is both less well known and less understood—the heightened likelihood of dementia. Researchers have known for several years about diabetes and the higher risk of vascular dementia, the second most common kind. In ways, it seems only logical: Vascular dementia is caused by damaged blood vessels in the brain, just as diabetes hardens blood vessels elsewhere. The latest research is focused on Alzheimer’s disease, the most common neurodegenerative disorder and one for which it’s harder to figure out the precise relationship with diabetes. On this much, many scientists agree: The rate of Alzheimer’s disease could be cut by close to half if diabetes could be abolished. The connection between the two is so strong that Suzanne M. de la Monte, one of the top researchers in the field, has said that many cases of Alzheimer’s could be dubbed Type 3 diabetes. People who haven’t necessarily developed diabetes might still develop insulin resistance in the brain, said de la Monte, a professor of neurosurgery, pathology and laboratory medicine at Brown University. That’s why she uses the term Type 3 diabetes—one doesn’t necessarily cause the other. But in both cases, she said, people show certain markers at the cellular level. “Growing evidence supports the concept that Alzheimer’s disease is fundamentally a metabolic disease with molecular and biochemical features that correspond with diabetes mellitus and other peripheral insulin resistance disorders,” de la Monte wrote in 2014 in the journal Biochemical Pharmacology. But the picture is more comp Continue reading >>
Is There A Link Between Type 1 Diabetes And Dementia
A recent article by Serena Gordon on WebMD News HealthDay talks about the possible connection between diabetes and dementia. The article explains that with better treatment options available diabetes patients are living long enough to develop dementia. What a prize! Past research has shown a link between type 2 diabetes and dementia risk. Rachel Whitmer, a senior scientist in the division of research at Kaiser Permanente in Oakland, CA, and her colleagues wanted to know if people with Type 1 Diabetes would show the same amount of risk. The American Diabetes Association (ADA) states, Although both type 1 diabetes and type 2 diabetes cause problems with blood sugar regulation, the root cause of each disease is different. In type 1 diabetes, the immune system mistakenly attacks insulin-producing beta cells in the pancreas. This leaves people with type 1 diabetes with little to no insulin, and in type 2 diabetes, the body develops resistance to insulin and doesnt use carbohydrates effectively. As more studies are done to reveal how, if and why the two diseases are connected we will learn more about this debilitating aspects of Juvenile Diabetes. As if diabetic children and their families need one more thing to worry about Incidents of dementia are rising among people with type 1 diabetes. However, it is still unknown if these new findings are a result of better disease management and better treatment options or if the disease has a direct impact on brain cells. However, we do know that Type 1 diabetes takes a toll on the body in many ways, especially when the patient does not have the medication and supplies they need. Do you or someone you have a friend or loved one with type 1 diabetes? Have they experienced symptoms of dementia? Please share information and experiences Continue reading >>
Diabetes And Dementia - Is There A Connection?
Diabetes and dementia - is there a connection? Diabetes and dementia - is there a connection? What do diabetes and dementia have in common? Diabetes occurs when the body is unable to make enough insulin or use the insulin it makes properly. Insulin is a hormone used by the body to control glucose levels, or the amount of sugar, in your blood. Glucose is one of the main sources of fuel for the body, providing energy the body needs to perform all necessary functions. There are two main types of diabetes type 1 and type 2. A third type, gestational diabetes, occurs temporarily during pregnancy.Studies have shown that type 2 diabetes can be a risk factor for Alzheimers disease, vascular dementia and other types of dementia because cardiovascular problems associated with diabetes are also associated with dementia. These include: Heart disease or family history of heart disease Research has also proved that, similar to diabetes, glucose is not used properly in the brains of people with Alzheimers disease. This may be caused by nerve cell death, which reduces the brains ability to interpret messages.In the case of vascular dementia, brain cells die due to lack of oxygen, preventing brain cells from communicating with each other. Beta amyloid plaques, which build up in the brains of people with Alzheimers disease, have also been shown to prevent insulin receptors in the brain from doing their job. This can impact insulin production and cause brain cells to become insensitive to insulin. Is Alzheimers disease type 3 diabetes? Recent studies suggest that the brains of people with Alzheimers disease are in a diabetic state, partly due to the decrease in or insensitivity to insulin.There are many similarities in the brains of people with diabetes and the brains of people with Alzh Continue reading >>
What Is Type 3 Diabetes?
At first blush, it may be hard to imagine a connection between type 2 diabetes and Alzheimer’s disease or other forms of dementia. But it’s real—and it’s so strong that some experts are now referring to it as type 3 diabetes or brain diabetes. By any name, it’s the progression from type 2 diabetes to Alzheimer’s disease and other forms of dementia marked by memory deficits and a dramatic decline in cognitive function. While all people with diabetes have a 60 percent increased risk of developing any type of dementia, including Alzheimer’s, recent research suggests that women with type 2 diabetes have a 19 percent greater risk of a certain type, known as vascular dementia (which is caused by problems with blood supply to the brain) than men do. Overall, older adults with type 2 diabetes suffer from greater declines in working memory and executive functioning (a set of mental processes that involve planning, organization, controlling attention, and flexible thinking) than their peers do. Granted, not everyone who has type 2 diabetes will develop Alzheimer’s disease, vascular dementia, or any other form of dementia, and there are many people who have Alzheimer’s or another form of dementia who don’t have diabetes, notes Gary Small, M.D., a professor of psychiatry at the UCLA Semel Institute and author of The Alzheimer’s Prevention Program. But the reality is, “these risk factors tend to add up: If you have diabetes, that doubles the risk of developing Alzheimer’s. If you have a first-degree relative—a parent or sibling, for example—with Alzheimer’s, that doubles your risk.” And if you have poorly controlled blood pressure, abdominal (a.k.a., central) obesity, or sleep apnea, your risk of developing dementia is increased even more. Surprisin Continue reading >>
Study Links Type 1 Diabetes To Higher Risk Of Dementia
Study links type 1 diabetes to higher risk of dementia Study links type 1 diabetes to higher risk of dementia Best source of stem cells identified to stop diabetic blindness 26 June 2015 Type 1 diabetes could increase the risk of dementia and other cognitive problems, according to new research. The study, which will be presented at the Alzheimers Association International Conference in Washington D.C., suggested that people with type 1 diabetes could be as much as 83 per cent more likely to develop dementia as they age than people without the disease. The study was conducted by examining the records of 490,000 patients who were over the age of 60. Of these patients, 334 had type 1 diabetes. None of the 490,000 had dementia at the beginning of the study. During the 12-year study period, 16 per cent of the 334 type 1 patients developed dementia, compared to 12 per cent of the 490,000. Of the patients who had type 2 diabetes, 15 per cent developed dementia. "Our study found a modestly higher risk of all-cause dementia in people with type 1 diabetes. The next step is to figure out what that means, and how we can help people with type 1 diabetes age successfully," said study author Rachel Whitmer, senior scientist in the division of research at Kaiser Permanente in Oakland, California. Although there are strong links between type 2 diabetes and dementia , this is the first study to find similar links with type 1. Previous research has, however, found links between type 1 diabetes and cognitive decline. "The correlation with type 2 and dementia is so strong, but a correlation with type 1 diabetes hadn't yet been shown," said Helen Nickerson, the director of translational research for JDRF . However, this is a very preliminary study, and more research is needed to confirm the Continue reading >>
Diabetes And Alzheimer's Linked
Diabetes may increase your risk of Alzheimer's. Reduce this risk by controlling your blood sugar. Diet and exercise can help. Diabetes and Alzheimer's disease are connected in ways that aren't yet fully understood. While not all research confirms the connection, many studies suggest people with diabetes, especially type 2 diabetes, are at higher risk of eventually developing Alzheimer's dementia or other dementias. Taking steps to prevent or control diabetes may help reduce your risk of cognitive decline. Understanding the connection Diabetes can cause several complications, such as damage to your blood vessels. Diabetes is considered a risk factor for vascular dementia. This type of dementia occurs due to brain damage that is often caused by reduced or blocked blood flow to your brain. Many people with diabetes have brain changes that are hallmarks of both Alzheimer's disease and vascular dementia. Some researchers think that each condition fuels the damage caused by the other. Ongoing research is looking at trying to better understand the link between Alzheimer's and diabetes. That link may occur as a result of the complex ways that type 2 diabetes affects the ability of the brain and other body tissues to use sugar (glucose) and respond to insulin. Diabetes also may increase the risk of developing mild cognitive impairment, a condition in which people experience more thinking (cognitive) and memory problems than are usually present in normal aging. Mild cognitive impairment may precede or accompany Alzheimer's disease and other types of dementia. As researchers examine the connections between diabetes and Alzheimer's, they're also studying potential ways to prevent or treat both diseases. Reducing your risk Working with your health care team to prevent diabetes or ma Continue reading >>
Type 1 Diabetes Identified As Risk Factor For Alzheimers
Type 1 diabetes identified as risk factor for Alzheimers The first study of dementia risk, including Alzheimers disease, in older adults with Type 1 diabetes was reported July 20 at the Alzheimers Association International Conference 2015 in Washington, D.C. People in the study with Type 1 diabetes were 93% more likely to get dementia, and 73% more after adjustment for heart health risk factors, compared with people without diabetes, according to a news release. Two other studies presented at the conference suggest an association between school performance in 9- and 10-year-old children and late life dementia, according to the release. Other research reports identified loneliness, low physical activity and high TV viewing as risk factors for cognitive decline and dementia. Evidence is growing that there are lifestyle habits that you can adopt to maintain or potentially improve your health including your brain health as you age, Maria Carrillo, PhD, Alzheimers Association chief information officer, said in the release. Many of the habits are familiar. Often, the same healthful practices that are good for your overall health are also good for your brain. Controlling heart health numbers, getting formal education, being physically and socially active can help keep the brain and body healthy and potentially reduce the risk of cognitive decline, Carrillo said. The complete list of lifestyle habits that can reduce cognitive decline can be found at alz.org. First study of Type 1 diabetes and risk of dementia in late life Studies have shown Type 2 diabetes is associated with a greater risk of dementia, including Alzheimers disease; however, little is known about how Type 1 diabetes affects cognitive aging and dementia risk, according to the release. At the conference, Rachel W Continue reading >>
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Diabetes And Dementia Risk | Ask D'mine
We're sorry, an error occurred. We are unable to collect your feedback at this time. However, your feedback is important to us. Please try again later. Need help navigating life with diabetes? Ask D'Mine!That would be our weekly advice column, hosted by veteran type1 and diabetes author W il Dubois . This week he's offering some wisdom on the connection between mental capacity and diabetes. Yes, they can be related. Read on for more... {Got your own questions? Email us at [email protected] } Dan, type 3 from New Jersey, writes: Ihave a question that relates to older folks with Type 1. Specifically, howlikely or common is it that Type 1 would cause or contribute to dementia? Ihave noticed changes in an older parent and wonder whether or how much diabetesis contributing. Thanks as always for your informative columns! Wil@Ask DMine answers: Lets see I used to know the answer tothat question But now I cant seem to remember it :) Sorry. Icouldnt resist. But before any of you itchy-fingered flamers cut loose, restassured that I do know that dementia is no laughing matter. Ive experienced itfirst hand. Under my own roof. But to answeryour question, Dan, yes, diabetesas always it seemshas a role to play. First andforemost, its been known for a long, long time that theres a link between T2 diabetes and dementia, especially dementia of theAlzheimers variety. Quoting the Alzheimers Association, numerous studies have foundT2s suffer a lower level of cognitive function and are at higher risk fordementia than individuals without diabetes as they age. Most research suggestsa two-fold risk of developing dementia for type 2s oversugar-normals. But what aboutus T1s? The sad truth is that until recently, we simply didnt live long enoughfor anyone to worry about it. Then, enter Ra Continue reading >>
Population-based Cohort Study On Dementia Risk In Patients With Type 1 Diabetes Mellitus
Population-Based Cohort Study on Dementia Risk in Patients with Type 1 Diabetes Mellitus Kuo C.-L.a,b Lu C.-L.b Chang Y.-H.b Li C.-Y. b,c aDepartment of Psychiatry, Tsaotun Psychiatric Center, Ministry of Health and Welfare, Nantou, Taiwan bDepartment of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan cDepartment of Public Health, College of Public Health, China Medical University, Taichung, Taiwan I have read the Karger Terms and Conditions and agree. I have read the Karger Terms and Conditions and agree. Buy a Karger Article Bundle (KAB) and profit from a discount! If you would like to redeem your KAB credit, please log in . Save over 20% compared to the individual article price. Buy Cloud Access for unlimited viewing via different devices Access to all articles of the subscribed year(s) guaranteed for 5 years Unlimited re-access via Subscriber Login or MyKarger Unrestricted printing, no saving restrictions for personal use * The final prices may differ from the prices shown due to specifics of VAT rules. For additional information: Background: The risk of dementia increases by 1528% in patients with type 2 diabetes mellitus (DM). However, studies on dementia risk in type 1 DM have been neither comprehensive nor conclusive. Methods: We carried out a cohort study involving 1,077 patients registered to have type 1 DM from 1998 to 2009 and 32,310 matched non-DM controls who were selected from Taiwan National Health Insurance Claims. These participants were followed up from their first clinical appearance for type 1 DM treatment in 19982009 to the date of dementia diagnosis or the last day of 2011. The Cox proportional hazard model was employed to estimate the hazard ratio (HR) of dementia incidence. Results: The incidence rates of deme Continue reading >>
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Managing Diabetes In People With Dementia
The number of patients with both type 2 diabetes and dementia is rising, which poses new challenges in blood glucose monitoring and medicines administration. Continue reading >>
T1d Patients Face Nearly Double Risk For Dementia
T1D Patients Face Nearly Double Risk for Dementia Findings still significant after controlling for vascular risk factors. by Kristina Fiore Kristina Fiore, Staff Writer, MedPage Today This article is a collaboration between MedPage Today and: Note that this study was published as an abstract and presented at a conference. These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal. WASHINGTON -- Patients with type 1 diabetes are at higher risk of developing dementia later in life than the general population, researchers reported here. In an analysis of more than 490,000 patient records from Kaiser Permanente Northern California, those with type 1 diabetes had a significantly higher risk of cognitive impairment in older age compared with controls (HR 1.83, 95% CI 1.3-2.5), Rachel Whitmer, PhD , of Kaiser Permanente Northern California, reported here at the Alzheimer's Association International Conference . The findings remained significant after controlling for vascular risk factors such as stroke, peripheral arterial disease (PAD), and hypertension, as well as when compared with healthy patients who didn't have type 2 disease. "We know a lot about type 2 diabetes and how vascular risk factors and poor glycemic control can elevate risk for dementia, but we also need to look at this risk in type 1," Whitmer said. "Type 2 diabetes is the larger public health issue, but we should be thinking about type 1 as well." Studies have indeed shown that type 2 diabetes is associated with dementia risk, but there's been less work on a potential link between type 1 disease and cognitive impairment. "There's certainly been a lot on type 2 diabetes and development of dementia, but I'm not aware of similar findings in older type 1 [patien Continue reading >>
