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Thiamine Blood Sugar

Using Vitamins (thiamine) For Improving Glucose Control

Using Vitamins (thiamine) For Improving Glucose Control

It was found that both supplementary CrProp and thiamine (given alone) have significant insulin-sensitizing and moderate blood-lipid-lowering properties, while the combined supplementation with these agents does not give synergistic effects in insulin-resistant rats . CrProp given separately increased kidney Cu and Cr levels, while thiamine alone increased hepatic Cu contents and decreased renal Zn and Cu contents." We previously found that thiamine mitigates metabolic disorders in spontaneously hypertensive rats, harboring defects in glucose and fatty acid metabolism. Mutation of thiamine transporter gene SLC19A2 is linked to type 2 diabetes mellitus . The current study extends our hypothesis that thiamine intervention may impact metabolic abnormalities in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, exhibiting obesity and metabolic disorders similar to human metabolic syndrome. Male OLETF rats (4 wk old) were given free access to water containing either 0.2% or 0% of thiamine for 21 and 51 wk. At the end of treatment, blood parameters and cardiac functions were analyzed. After sacrifice, organs weights, histological findings, and hepatic pyruvate dehydrogenase (PDH) activity in the liver were evaluated. Thiamine intervention averted obesity and prevented metabolic disorders in OLETF rats which accompanied mitigation of reduced lipid oxidation and increased hepatic PDH activity. Histological evaluation revealed that thiamine alleviated adipocyte hypertrophy, steatosis in the liver, heart, and skeletal muscle, sinusoidal fibrosis with formation of basement membranes (called pseudocapillarization) which accompanied significantly reduced expression of laminin 1 and nidogen-1 mRNA, interstitial fibrosis in the heart and kidney, fatty degeneration in the pancreas, thick Continue reading >>

Article: Thiamine, The Paradigm Shift In Diabetes | Opednews

Article: Thiamine, The Paradigm Shift In Diabetes | Opednews

Thiamine is the Spark Plug of Life . For original article, click here . The definition of diabetes is elevated blood sugar. Type One, juvenile diabetes, is caused by pancreatic failure, and insulin deficiency resulting in elevated blood sugar. The more common Type Two diabetes in adults is an "insulin resistance" problem associated with obesity and metabolic syndrome. In this second type of diabetes, insulin levels are adequate or even quite elevated, however, there is "insulin resistance", meaning the hormone message of the circulating insulin is ignored and blood sugar remains elevated in spite of large amounts of circulating insulin. Current research shows that diabetics have thiamine deficiency, and thiamine supplementation has been shown to prevent many of the complications of diabetes, namely, the nephropathy, neuropathy, retinopathy and vascular disease known to plague diabetics. This article will examine the role of vitamin B1, also called thiamine, in the patient with elevated blood sugar. For many years, Stuart Lindsey managed a neighborhood pharmacy observing his diabetic customers faithfully taking diabetic medications, yet showed little improvement in health. Here is a quote from Linsdey's article (1A): " After prolonged consumption of their diabetic medications, their health did not improve. This was disturbing to me (1A)" Finally, Stuart himself developed diabetes and painful neuropathy in his feet, so he began researching the disease. In a self-interested attempt to understand and cure his symptoms, Stuart discovered a 2005 paper by Dr. Thornalley detailing how many of his symptoms are actually due to thiamine deficiency (also called Vitamin B1).(7) Thiamine (Vitamin B1) levels are lower in diabetics, partly because the elevated blood sugar causes incre Continue reading >>

Influence Of Thiamine On Blood Sugar Levels In Diabetic Patients

Influence Of Thiamine On Blood Sugar Levels In Diabetic Patients

In the past few years there has been considerable interest in the relationship between carbohydrate metabolism and vitamin B1. As Williams and Spies1 pointed out in their recent monograph: "There is convincing evidence of frequent disturbances of glycogen storage and blood sugar in B1 avitaminosis. Further indications of this are found in clinical experience. A hyperglycemia and glycosuria in depancreatized dogs which does not respond to insulin but is cured by thiamin plus riboflavin has been reported. The whole matter of vitamin B1 deficiency in relation to sugar disturbances requires further study, as the evidence of some association of the two is strong but still obscure." Monauni2 claimed that thiamine is a two-sided regulator of blood sugar, raising the level when it is subnormal and lowering it when it is elevated. Several authors3 have shown that thiamine lowers the level of blood sugar and improves the sugar tolerance curve. Unfortunately, Continue reading >>

Diabetes And Thiamine: A Novel Treatment Opportunity

Diabetes And Thiamine: A Novel Treatment Opportunity

Diabetes and Thiamine: A Novel Treatment Opportunity Author: Chandler Marrs, PhD 8 Comments Share: Underlying all diabetic conditions is poor sugar control or hyperglycemia. Hyperglycemia can be due to a lack of insulin as in Type 1 diabetes or insulin resistance as in Type 2 diabetes. In either case, the corresponding diabetic complications that evolve over time in many diabetics, the cardiovascular disease, retinopathy, peripheral nerve and vascular damage, represent the effects of sustained hyperglycemia. Until recently, the mechanisms by which diabetic vascular damage developed eluded researchers. Although multiple, seemingly discrete biomarkers had been identified, no single, unifying mechanism was understood. It turns out that diabetics, both Type 1 and Type 2, are severely deficient in thiamine or vitamin B1 and that thiamine is required for glucose control at the cell level. Why is thiamine deficient in diabetics and how does thiamine manage glucose control? The answers to those questions highlight the importance of micronutrients in basic cellular functioning, particularly mitochondrial functioning , and the role of excessive sugar in disease . Thiamine (thiamin) or vitamin B1 is an essential nutrient for all living organisms. The body cannot synthesize thiamine by itself and so it must be obtained from diet. Thiamine is present in yeast, pork, fish, various nuts, peas, asparagus, squash and grains (unprocessed) and because of the severity of the illnesses that thiamine deficiency evokes, many processed foods have been fortified with thiamine. Nevertheless, thiamine deficiencies thought resolved by modern nutritional technologies, are emerging once again. Modern thiamine deficits appear to be caused by diets of highly processed, carbohydrate and fat laden food Continue reading >>

Thiamine Essential For Diabetics | Diabetic Connect

Thiamine Essential For Diabetics | Diabetic Connect

Almost 30 million people in the United States suffer from diabetes, a chronic condition that affects the entire body and can lead to heart and nerve damage (neuropathy). One of the best ways to manage diabetes and prevent complications is to keep your blood sugar within a healthy range and eat a balanced diet full of vitamins and minerals. And research shows that getting enough of one vitamin in particular, B1, or thiamine, may help prevent diabetic neuropathy. The body uses thiamine to break down sugars that you consume, turn carbohydrates into energy, and aid in nervous system functions. In many populations, malnutrition is a primary reason for severe thiamine deficiency, which may cause serious neurological and muscular problems. For people with diabetes, the risk of thiamine deficiency increases because your body does not always absorb this vitamin properly, and it may be excreted in your urine. Without enough thiamine, you can experience pain, prickly sensations, nerve deadening, and other symptoms related to nerve damage. Studies have shown that thiamine, consumed through the diet or in supplement form, plays a role in vascular (relating to the nerves in your arms and legs) health, eye health, and kidney health. And some of the latest research has focused on using thiamine therapy as a means of preventing and treating early-stage diabetic neuropathy. In recent clinical trials, experts have found that thiamine supplements can prevent the development of early-stage nephropathy (kidney disease) in people with type 2 diabetes. As a treatment for general peripheral neuropathy, thiamine therapy helped reverse diuresis (increased urine flow) and glucosuria (excretion of glucose into the urine), and it also helped normalize cholesterol and triglyceride levels. Experts re Continue reading >>

Thiamine Diabetes Complications

Thiamine Diabetes Complications

A few years ago my gfr was only 57, I started taking 250 mg of thiamine daily and in 6 months it was 76. If you look up thiamine diabetes complications in search you will find many good pages that say it can prevent not only CKD but also diabetic retinopathy, diabetes related heart attacks and diabetes related amputations. I think all diabetics should either take high dose thiamine or benfotiamine which is a more or less fat soluble verion of thiamine. I would strongly recommend benfotiamine over thiamine, it's much more effective and can be tolerated in higher doses. I would strongly recommend benfotiamine over thiamine, it's much more effective and can be tolerated in higher doses. Dr. Rosedale recommends benfotiamine to all of his diabetic patients. He says it acts like Metformin, but is better. I've been taking 300mg/day for over a year but haven't noticed any difference. My gfr has always been fine. My dr is diabetic and she takes thiamine. She said a gfr of 74 is fine for someone my age, I'm 59, but some places online talk like it should be 100 or so for someone my age. She said most of her patients my age have a gfr in the mid 60's. I do think all diabetic patients should take that dosage of benfotiamine or more. It is widely regarded as the best thing you can take for glycation. I don't believe it will do anything for your blood glucose readings themselves though, so I wouldn't compare it to metformin or a lot of other supplements in that regard, but does help prevent the damage that higher blood sugar can cause, and even has shown to heal it. You could try upping this to 600 mg a day, you can get it from Vitacost pretty cheaply, I take 600 mg a day and like it. It's not one of those things that you can really notice anything acute going on, it's more like you Continue reading >>

Are Diabetic Complications Due To Vitamin B1 (thiamine) Deficiency?

Are Diabetic Complications Due To Vitamin B1 (thiamine) Deficiency?

Are Diabetic Complications Due To Vitamin B1 (Thiamine) Deficiency? One of the worst things about having diabetes is the worry of the complications that it brings, including nerve damage, kidney and eye problems, and heart failure. We are told that these are the inevitable result of not keeping blood sugar levels within strict limits. But is this really true? Pharmacist Dr Stuart Lindsey is a type 2 diabetes sufferer who believes that many of the complications of diabetes are down to vitamin deficiencies caused by the disease and that their symptoms can be better helped by simple vitamin supplements than by drugs. His findings have just been published in the Journal of Orthomolecular Medicine. Dr Lindsey was a high street pharmacist for fifteen years, during which time he saw many people with diabetes getting onto what he calls the sugar-med treadmill. After prolonged treatment with their diabetic medications, the health of these patients did not improve. This disturbed him. Then, pain in his feet led to his being given a diagnosis of type 2 diabetes himself, which prompted him to take a hard look at conventional assumptions and treatment. High levels of sugar in the blood are damaging and diabetes drugs aim to correct them by driving more sugar into the cells. But exactly what damage does high blood sugar do? It appears that one of its effects is to stimulate the kidneys to excrete vitamin B1 (thiamine) at a much higher rate than normal, leading to an acute deficiency of this vitamin. The breakthrough research that never made the news In 2005, researcher Paul Thornalley, at the University of Essex, wrote a paper showing that many diabetic symptoms and complications may be due to a deficiency of thiamine. Interestingly, one of the symptoms of beriberi, the classic thia Continue reading >>

Protecting Against Glycation And High Blood Sugar With Benfotiamine

Protecting Against Glycation And High Blood Sugar With Benfotiamine

For decades, European doctors have prescribed diabetic patients a fat-soluble form of vitamin B1 called benfotiamine to treat neuropathies and help prevent complications such as blindness, kidney failure, heart attack, and limb amputation. Benfotiamine blocks destructive biochemical pathways that enable high blood sugar levels to damage nerves and small blood vessels. Benfotiamine also inhibits the formation of advanced glycation end products in both diabetic and normal aging organisms. Glycation not only causes kidney, nerve, and retinal damage in diabetics, but is also a significant contributory factor in cardiovascular disease and other aging disorders in adults without diabetes.1-6 Here, we’ll explore how to use benfotiamine to help protect against the dangers of elevated blood sugar and toxic glycation reactions. AGE, RAGE, and Tissue Damage Sugar molecules, in excess quantity or over long periods of time, wreak havoc on human tissues. As the number of people with type 2 diabetes has skyrocketed over the past 20 years, we’ve learned to recognize strong relationships between blood sugar levels and many chronic conditions previously thought to be purely age-related. The link seems to be the total lifetime exposure to blood sugar that’s the culprit. In other words, diabetics develop problems sooner because of their chronic higher sugar levels, but even non-diabetic people eventually suffer tissue injury related to the interaction between blood sugar and tissue proteins. Studies of diabetic patients have shown that prolonged tissue exposure to elevated glucose levels results in the production of a class of molecules called “advanced glycation end products” (AGEs).1-4 These molecules are proteins and lipids that have become bonded to some of the sugar molecule Continue reading >>

Thiamin (vitamin B1) Deficiency In Diabetics

Thiamin (vitamin B1) Deficiency In Diabetics

What is thiamin? Thiamin (or thiamine) is one of the water-soluble B vitamins. It is also known as vitamin B1. What does thiamin do? The body needs thiamin to convert carbohydrates into glucose, the main source of energy in the body. As thiamin is an essential co-factor in carbohydrate metabolism, low levels are thought to have an impact on glucose control in the body. What foods contain thiamin? Vegetables containing thiamin include broccoli, onions, green beans, carrots, kale, and tomatoes. More nutrient-rich and ranking as very good sources of vitamin B1 are green peas, Brussels sprouts, spinach, cabbage, aubergine and romaine lettuce. Thiamin deficiency in diabetics - the research Thiamin levels are lower in diabetics in part because the elevated blood sugar causes increased thiamin excretion by the kidney at a rate twenty-five times higher than normal. This leads to an acute deficiency of thiamin - a conditional also known as beri-beri. In diabetes the small blood vessels in the body can become damaged. When the blood vessels that supply blood to the kidneys are involved, the kidneys stop working correctly and important proteins, such as albumin, are lost from the blood into the urine. In 2007 researchers from the Department of Biological Sciences at the University of Essex, UK, lead by P. J. Thornalley recruited 26 Type 1 diabetics and 48 Type 2 diabetics and 20 healthy volunteers to compare against. The study found that compared to the controls, Type 1 and Type 2 diabetics had, respectively, 76% and 75% lower blood-plasma thiamin levels. Diabetics excrete thiamin much faster Furthermore, Thornalley examined how the body processes thiamin and found that compared to the controls, Type 1 and Type 2 diabetics excreted thiamin through the urine 24 times faster and 16 Continue reading >>

The Impact Of Thiamine Treatment In The Diabetes Mellitus

The Impact Of Thiamine Treatment In The Diabetes Mellitus

The Impact of Thiamine Treatment in the Diabetes Mellitus We are experimenting with display styles that make it easier to read articles in PMC. The ePub format uses eBook readers, which have several "ease of reading" features already built in. The ePub format is best viewed in the iBooks reader. You may notice problems with the display of certain parts of an article in other eReaders. Generating an ePub file may take a long time, please be patient. The Impact of Thiamine Treatment in the Diabetes Mellitus Khanh vinh quoc Luong and Lan Thi Hoang Nguyen Thiamine acts as a coenzyme for transketolase (Tk) and for the pyruvate dehydrogenase and -ketoglutarate dehydrogenase complexes, enzymes which play a fundamental role for intracellular glucose metabolism. The relationship between thiamine and diabetes mellitus (DM) has been reported in the literature. Thiamine levels and thiamine-dependent enzyme activities have been reduced in DM. Genetic studies provide opportunity to link the relationship between thiamine and DM (such as Tk, SLC19A2 gene, transcription factor Sp1, -1-antitrypsin, and p53). Thiamine and its derivatives have been demonstrated to prevent the activation of the biochemical pathways (increased flux through the polyol pathway, formation of advanced glycation end-products, activation of protein kinase C, and increased flux through the hexosamine biosynthesis pathway) induced by hyperglycemia in DM.Thiamine definitively has a role in the diabetic endothelial vascular diseases (micro and macroangiopathy), lipid profile, retinopathy, nephropathy, cardiopathy, and neuropathy. Keywords: Thiamine, Diabetes Mellitus, Vitamin B1 Diabetes mellitus (DM) has emerged as a major health problem throughout the world. The prevalence of DM is increasing rapidly in all age gro Continue reading >>

The Potential Role Of Thiamine (vitamin B1) In Diabetic Complications.

The Potential Role Of Thiamine (vitamin B1) In Diabetic Complications.

1. Curr Diabetes Rev. 2005 Aug;1(3):287-98. The potential role of thiamine (vitamin B1) in diabetic complications. (1)Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex CO4 3SQ, United Kingdom. [email protected] Accumulation of triosephosphates arising from high cytosolic glucoseconcentrations in hyperglycemia is one likely or potential trigger forbiochemical dysfunction leading to the development of diabetic complications.This may be prevented by disposal of excess triosephosphates via the reductivepentosephosphate pathway. This pathway is impaired in experimental and clinicaldiabetes by mild thiamine deficiency. The expression and activity of thethiamine-dependent enzyme, transketolase--the pacemaking enzyme of the reductive pentosephosphate pathway, is consequently decreased. Correction of thiaminedeficiency in experimental diabetes by high dose therapy with thiamine and thethiamine monophosphate prodrug, Benfotiamine, restores disposal oftriosephosphates by the reductive pentosephosphate pathway in hyperglycemia. Thisprevented multiple mechanisms of biochemical dysfunction: activation of proteinkinase C, activation of the hexosamine pathway, increased glycation and oxidativestress. Consequently, the development of incipient diabetic nephropathy,neuropathy and retinopathy were prevented. Both thiamine and Benfotiamineproduced other remarkable effects in experimental diabetes: marked reversals ofincreased diuresis and glucosuria without change in glycemic status. High dosethiamine also corrected dyslipidemia in experimental diabetes--normalizingcholesterol and triglycerides. Dysfunction of beta-cells and impaired glucosetolerance in thiamine deficiency and suggestion of a link of impaired glucosetolerance with die Continue reading >>

Effect Of High Dose Thiamine Therapy On Risk Factors In Type 2 Diabetics

Effect Of High Dose Thiamine Therapy On Risk Factors In Type 2 Diabetics

Received date: October 13, 2012; Accepted date: November 24, 2012; Published date: November 30, 2012 Citation: Alam SS, Riaz S, Waheed Akhtar M (2012) Effect of High Dose Thiamine Therapy on Risk Factors in Type 2 Diabetics. J Diabetes Metab 3:233. doi: 10.4172/2155-6156.1000233 Copyright: 2012 Alam SS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: Traditional and more recently, a host of nontraditional risk factors of type 2 diabetes mellitus have adopted significance as promoters of the pathologies associated with this disease. High dose Vitamin B1 (thiamine) has been found at preclinical level to play an ameliorative role through a number of intracellular metabolic pathways. In order to demonstrate this clinically, pioneering research on the effect of high dose thiamine on associated markers of biochemical dysfunction, incipient diabetic nephropathy, hemostasis (plasminogen activation inhibitor/PAI-1), oxidative stress (plasma thiols) and second messenger signaling (protein kinase C/ PKC ) was conducted. Subjects and methods: Type 2 diabetics were enrolled in randomized, double blind placebo controlled clinical trial for 6 months. Patients were divided into two groups and administered 300 mg/day thiamine or placebo for 3 months, followed by a 2 month washout period. Normal healthy controls participated for baseline estimations only. Plasma and urinary thiamine levels, microalbuminuria, PAI-1, oxidative stress marker plasma thiols were estimated. The messenger signaling PKC profile was determined in normal controls and in type 2 diabetics. Results: Lower plasma Continue reading >>

Benfotiamine | Diabetes Forum The Global Diabetes Community

Benfotiamine | Diabetes Forum The Global Diabetes Community

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community I have recently been diagonised as having type 2 Diabetes and since diagnosis have been taking Benfotiamine ( Vitamin B1 in fat soluble type ) , it seems to be very effective at reducing blood sugar levels ! After consuming high GI index meals my blood sugar can be as low as 4.8 ! with Benfotamine , without Benfotiamine for one day it's been up to 10.1 , It has also started reducing my pins and needles I am continuing to "experiment" with Benfotiamine and have started a blog detailing my sugar levels , you can read this if you want at Look forward to comments , I am aslo exploring B12 as Methy cobalamine to get the pins and needles even better Welcome onboard, I've never really checked Benfotamine out, but after a quick google it looks to have a beneficial effects, no doubt someone on the forum will have more info. We do have more information about Benfotiamine for those who are interested. Here is a link which has other links embedded. Take a look. I noticed the same thing with benfotiamine. It gave me hypos (I'm type 1) even at a relatively low dose (20mg per day). You might also what to check out lycopene for some similar results; although, I'd be careful if you're using it with meds/insulin. I retested my blood sugar level after starting benfotiamine again and it was lower than without at 7.2 . It's very interesting that vitamin B 1 is intrinsically involved in stopping Diabetic complications mild thiamine deficiency inhibits a metabolic pathway which reduces the activity of transketolase the above link is only an abstract , taking ordinary Vitamin B1 doesn't seem to help benfotiamine is readily taken up through the gut and thus allows this activi Continue reading >>

7 Vitamins That Help Control Blood Sugar

7 Vitamins That Help Control Blood Sugar

Vitamin deficiencies are quite common among diabetics. Given the importance of vitamins to cellular processes especially glucose metabolism and energy production in cells, low levels of certain vitamins may impair glucose utilization and lead to poor blood sugar control. This article identifies and discusses the vitamins that are most important to glycemic control and diabetes complications. The B vitamins are especially important to glucose metabolism. They usually serve as cofactors in cellular reactions utilizing glucose. Therefore, they have been extensively studied to determine their benefits for controlling blood sugar levels. Because the B vitamins are water soluble, they are easily excreted from the body along with urine. This is especially important for diabetics as they easily develop deficiencies of the B vitamins. Vitamin B1 or thiamine is a coenzyme in the metabolism of keto sugars. It is also important for the breakdown of pyruvic acid, a product released during glucose metabolism. Therefore, vitamin B1 can help improve how cells utilize glucose. This can lead to better control of blood sugar levels. However, available studies do not always agree on the importance of vitamin B1 supplementation for diabetics. Clinical data show that patients with Type 1 diabetes usually have low vitamin B1 levels and can, therefore, benefit from vitamin B1 supplements. On the other hand, Type 2 diabetes patients usually have normal blood levels of vitamin B1. However, one study demonstrated that although diabetics have normal levels of this vitamin, its transportation across tissues is impaired. Therefore, even normal levels of the vitamin may not be sufficient to effectively control blood glucose levels in diabetics. Vitamin B1 supplementation has been proven to prevent an Continue reading >>

Best Vitamins For Diabetics

Best Vitamins For Diabetics

Eating a varied diet rich in natural sources of vitamins is a good idea for diabetics. Nutritional support is critical for diabetics because diabetes tends to drain nutrients. When levels of glucose are high in the blood, the body tries to ‘wash’ the excess sugar out. This is why diabetics need to use the washroom frequently. Unfortunately, diabetics also lose nutrients via their urine. Research studies show that diabetics are repeatedly found to be deficient in important water-soluble vitamins and minerals. What’s more, the loss of these vitamins worsens the body’s ability to manage blood sugar, creating a vicious cycle. Combining a healthy diabetes diet plan and a daily exercise routine with the best vitamin supplements for diabetics goes a long way in achieving stable blood sugar levels. What Vitamins Are Diabetics Deficient In? The term vitamin is short for “Vital Amino Acid”. This means that these are vital for the proper functioning of hundreds of chemical processes in the body which the body cannot manage by itself. Proper blood sugar control is one such function for which vitamins are critical. There are 13 essential vitamins that the human body requires and they must be obtained from an external source — through food and/or supplements. Diabetics need two kinds of vitamins: Water Soluble – Vitamins B1, B2, B3, B6, B12, C, Biotin, and Folate are water-soluble and cannot be stored in the body for longer periods of time. Diabetics are often deficient in these vitamins since they pass greater amounts of urine daily. As their body tries to get rid of extra sugar, diabetics lose more water-soluble vitamins than most others. That’s why diabetics need to to get these vitamins daily in doses larger than what normal people need. Luckily, you can get all Continue reading >>

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