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Low Testosterone And Clinical Outcomes In Chinese Men With Type 2 Diabetes Mellitus Hong Kong Diabetes Registry

Low Testosterone And Clinical Outcomes In Chinese Men With Type 2 Diabetes Mellitus Hong Kong Diabetes Registry

Low testosterone and clinical outcomes in Chinese men with type 2 diabetes mellitus Hong Kong Diabetes Registry Author links open overlay panel Kitty Kit-TingCheungab To assess the implications of low testosterone on cardiovascular risk factors, metabolic syndrome (MES) and clinical outcomes in Chinese men with Type 2 Diabetes (T2D). A prospective cohort study carried out in a university hospital involving a consecutive cohort of 1239 Chinese men with T2D and a median disease duration of 9years followed up for 4.8years. Clinical characteristics, frequency of MES, serum total testosterone and clinical events were analyzed. Multivariate logistic regression was performed to examine the independent association of low testosterone with MES after adjustment for confounding covariates. Cox proportional hazards regression analysis was used to derive hazard ratio for clinical outcomes. More men with low testosterone had cardiovascular-renal disease and MES than those with normal testosterone. The adjusted odds ratio (OR) of low testosterone for MES was 2.63 (95% Confidence Interval [CI] 1.564.61). After a median follow-up of 4.8years, the hazard ratio (HR) of low testosterone was 2.22 (95% CI 1.234.01) for incident non-prostate cancer. In a multivariate Cox-regression model, the HRs were attenuated but remained significant with adjustment for MES and renal parameters. Chinese men with low testosterone had high prevalence of cardiovascular disease and MES with high incidence non-prostate cancer. Continue reading >>

Testosterone Levels And Type 2 Diabetes In Men: Current Knowledge And Clinical Implications

Testosterone Levels And Type 2 Diabetes In Men: Current Knowledge And Clinical Implications

Testosterone levels and type 2 diabetes in men: current knowledge and clinical implications Anne M Beatrice , Deep Dutta , Manoj Kumar , Shivaprasad Kumbenahalli Siddegowda , Ankur Sinha , Sayantan Ray , and Subhankar Chowdhury Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Find articles by Shivaprasad Kumbenahalli Siddegowda Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Correspondence: Manoj Kumar, Room 9A, 4th Floor, Ronald Ross Building, Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, 244 A Continue reading >>

Testosterone Enanthate Injection

Testosterone Enanthate Injection

Uses of Testosterone Enanthate Injection: It is used to treat breast cancer in women. It is used to treat low testosterone levels. It is used in certain children when puberty is delayed. It may be given to you for other reasons. Talk with the doctor. What do I need to tell my doctor BEFORE I take Testosterone Enanthate Injection? If you have an allergy to testosterone or any other part of testosterone enanthate injection. If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives ; itching; shortness of breath; wheezing ; cough; swelling of face, lips, tongue, or throat; or any other signs. If you are male and have breast or prostate cancer . If you have any of these health problems: Heart disease, kidney disease, or liver disease . If you are pregnant or may be pregnant. Do not take testosterone enanthate injection if you are pregnant. If you are breast-feeding. Do not breast-feed while you take testosterone enanthate injection. This is not a list of all drugs or health problems that interact with testosterone enanthate injection. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins ) and health problems. You must check to make sure that it is safe for you to take testosterone enanthate injection with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. What are some things I need to know or do while I take Testosterone Enanthate Injection? Tell all of your health care providers that you take testosterone enanthate injection. This includes your doctors, nurses, pharmacists, and dentists. If you have high blood sugar (diabetes), you will n Continue reading >>

How Does Puberty Affect Diabetes?

How Does Puberty Affect Diabetes?

One of the hardest things about being an adolescent is going through puberty and facing the challenges that it brings. The emotional roller coasters and the physical changes seem endless and impossible. But how does a teen go through puberty with diabetes? How are things different for them? The following article explores the relationship between puberty and diabetes. How does puberty affect Type 1 diabetes? During puberty, many physical changes occur that can affect one’s diabetes. Most importantly, the growth hormone causes lean body mass to double over in the 2 to 5 years during puberty. This increase in the growth hormone makes it harder for insulin to work in the body. That struggle is called insulin resistance. A normal child would just make more insulin, but a child with diabetes that does not make insulin or that has limited insulin must increase the amount of insulin that they give themselves to keep their blood sugar under control. This increase can be up to 30-50% more insulin than normal. Also, an earlier onset of puberty can lead to a diagnosis of Type 1 diabetes in some girls because of the increase in estrogen that occurs during puberty. I recommend reading the following articles: Signs and symptoms of diabetes as an adolescent Due to hormones, puberty is the most common time for the onset of Type 1 diabetes. Adolescents have the same signs and symptoms as other ages for diabetes: Weight loss Excessive thirst Increased appetite Elevated levels of ketones in the blood or urine Elevated levels of glucose in the blood or urine To be diagnosed with diabetes, these symptoms will need to have been experienced for several weeks. If the individual is underweight or of a normal weight, then Type 1 diabetes is suspected. If they are overweight, it could then be ei Continue reading >>

Diabetic Using Steroids

Diabetic Using Steroids

I'm a type 1 diabetic and this is my first time taking steroids . I'm 20 years old, healthy, and am in complete control of my diabetes. I'm about to start a cycle of test and tren . Does anyone know if this is really really dangerous? Or is anyone on here diabetic and has taken steroids? I've looked everywhere but i cant seem to find anything on diabetics and steroids. Disappointment* Known SCAMMER - Do Not Trust * I had a friend that had a hell of a time stabilizing blood sugar levels on cycle. Id just monitor them very carefully. i wonder what kind of effect it has on insulin .. seeing that certain diabetics need the insulin does it effect them different than people without who stack with insulin. Disappointment* Known SCAMMER - Do Not Trust * some steroids increase insulin sensitivity ...some decrease it .... I'm a type 1 diabetic and this is my first time taking steroids. I'm 20 years old, healthy, and am in complete control of my diabetes. I'm about to start a cycle of test and tren. Does anyone know if this is really really dangerous? Or is anyone on here diabetic and has taken steroids? I've looked everywhere but i cant seem to find anything on diabetics and steroids. Don't do tren as a first cycle i am on it now should be used for advance users, stuff is very strong and can cause alot of more sides, you will get as good of gains just takeing test than stacking it with tren as it is your first cycle. As for you being a diabetic should consult to a doctor first and see what he sais about it. Thanks for the replies. Regarding the tren , I've been reading alot about it and I see that it is very powerful, but are you saying that it would be pointless for me to do it right now and I wouldnt get the usual results just because it's my first time cycling? No, he's sayin Continue reading >>

Sex Hormones, Insulin Sensitivity, And Diabetes Mellitus

Sex Hormones, Insulin Sensitivity, And Diabetes Mellitus

Sex Hormones, Insulin Sensitivity, and Diabetes Mellitus Cristin M. Bruns, M.D., is a Clinical Instructor in the Department of Medicine, Section of Endocrinology, Diabetes and Metabolism at the University of Wisconsin-Madison. Joseph W. Kemnitz, Ph.D., is Director of the Wisconsin National Primate Research Center and Professor of Physiology, University of Wisconsin-Madison. Search for other works by this author on: Cristin M. Bruns, M.D., is a Clinical Instructor in the Department of Medicine, Section of Endocrinology, Diabetes and Metabolism at the University of Wisconsin-Madison. Joseph W. Kemnitz, Ph.D., is Director of the Wisconsin National Primate Research Center and Professor of Physiology, University of Wisconsin-Madison. Search for other works by this author on: ILAR Journal, Volume 45, Issue 2, 1 January 2004, Pages 160169, Cristin M. Bruns, Joseph W. Kemnitz; Sex Hormones, Insulin Sensitivity, and Diabetes Mellitus, ILAR Journal, Volume 45, Issue 2, 1 January 2004, Pages 160169, Sex differences and the role of gonadal hormones in modulating insulin sensitivity and glucose tolerance are of increasing interest and importance because of the increasing prevalence of type 2 diabetes mellitus and the metabolic abnormalities associated with aging. Body composition is closely associated with insulin sensitivity, and increased body fat, particularly in the visceral compartment, is a risk factor for developing type 2 diabetes mellitus. Sex differences in body composition and/or insulin sensitivity are evident in humans throughout the lifespan. Ovarian hormones influence insulin sensitivity across the menstrual cycle, during pregnancy, and in the menopausal transition. Similarly, estrogens and progestins used for contraception and hormone replacement therapy affect gluc Continue reading >>

Women And Diabetes | Diabetesnet.com

Women And Diabetes | Diabetesnet.com

Mon, 11/15/2010 - 11:33 -- Richard Morris Fluctuations in hormone levels occur through the menstrual cycle and these fluctuations can affect blood sugar control. When estrogen levels are naturally high, your body may be resistant to its own insulin or injected insulin. Many women find their blood sugar tends to be high 3-5 days before, during or after their periods. Since everyone is different, the only way to manage blood sugars in a setting where sensitivity to insulin changes is to test and record blood sugars four or more times a day the week before, during and after your period for at least 2 or 3 months to find your own pattern. This allows you to adjust your insulin doses and carb intake both before and during this time to better control your blood sugar. Premenstrual symptoms (PMS) can be worsened by poor blood sugar control. It helps to chart your feelings such as tenderness, bloating, grouchiness for a week before, during and after your period. Charting will help you know when your PMS reach their peak during your period so that before your PMS is most severe, you can check your blood sugar more often and take extra insulin or exercise to bring high blood sugars down. Food cravings during PMS are triggered by an increase in progesterone and can make it more difficult to control your blood sugar. Usually the craving is for chocolate or sweet foods. Give in to your cravings by trying sugar-free and fat-free versions, such as chocolate pudding. Take extra insulin or increase your exercise to compensate. You may feel less like exercising during your period. If so, extra insulin may be a good choice for keeping your blood sugar from rising. The extra insulin needed to overcome insulin resistance during this time will not cause weight gain. Treat yourself well duri Continue reading >>

Steroid Use For Type 1 Diabetics??? Help

Steroid Use For Type 1 Diabetics??? Help

Just wondering if someone can relate to steroid usage? Is this a bad way to go or can it be okay as long as you monitor your blood sugar levels frequently? I hav only been type 1 now for 2 years and I cannot gain anymore weight. I wok out hard and am constantly active thorughout each and everyday. I was considering using a steroid called SUSTENNON, but I really need more advise and understanding beofre i do anything of the sort. Please help .... D.D. Family T1 since 1977 - using Novolog in an Animas pump. Steroids will increase your blood sugar and make control more difficult. So using them is especially not good for diabetics. If you want to build muscle, a better approach is to use more insulin during workouts. Insulin is after all the anabolic hormone. Be sure to consume enough carbs so that you don't go low, though. This is important. I have also had difficulty building muscle. I found that increasing insulin levels during and after workouts (that 60 minute window) sorted it out. Mark is right, I was given steroids for an allergic reaction and my BG was 350 constant until the drug was out of my system. I agree also. I think that roids will make your BGs much more difficult to control. If you look at the bodybuilding and diabetes forum on the exercise section, you will find that a number of us here are using insulin instead to build muscle. The bottom line is that insulin is one of the most powerful anabolic hormones out there. So, what many of us do is to take some insulin (with food of course) right after a workout. So, for example, after a workout, I'll take enough insulin to cover 30 g of carbs but will eat 45 g of carbs (since the insulin will work harder right after a workout). I can understand the appeal of roids, but I'd avoid them, especially because of you Continue reading >>

Low Testosterone In Men With Type 2 Diabetes: Significance And Treatment

Low Testosterone In Men With Type 2 Diabetes: Significance And Treatment

Low Testosterone in Men with Type 2 Diabetes: Significance and Treatment Department of Medicine, Austin Health/Northern Health, University of Melbourne, Heidelberg, VIC 3084, Australia Address all correspondence and requests for reprints to: Dr. Mathis Grossmann; Department of Medicine Austin Health/Northern Health, University of Melbourne, Studley Road, Heidelberg, VIC 3084, Australia. Search for other works by this author on: The Journal of Clinical Endocrinology & Metabolism, Volume 96, Issue 8, 1 August 2011, Pages 23412353, Mathis Grossmann; Low Testosterone in Men with Type 2 Diabetes: Significance and Treatment, The Journal of Clinical Endocrinology & Metabolism, Volume 96, Issue 8, 1 August 2011, Pages 23412353, The relationship between testosterone and diabetes in men is an important issue, given that one third of U.S. men aged 65 yr or older have diabetes, with a similar percentage having low testosterone levels. The medical literature from 1970 to March 2011 was reviewed for key articles. In population-based studies, low testosterone is commonly associated with type 2 diabetes and the metabolic syndrome, and it identifies men with an adverse metabolic profile. The difference in testosterone levels between men with diabetes compared to men without diabetes is moderate and comparable in magnitude to the effects of other chronic diseases, suggesting that low testosterone may be a marker of poor health. Although the inverse association of testosterone with diabetes is partially mediated by SHBG, low testosterone is linked to diabetes via a bidirectional relationship with visceral fat, muscle, and possibly bone. There is consistent evidence from randomized trials that testosterone therapy alters body composition in a metabolically favorable manner, but changes ar Continue reading >>

Old School Cycles For Badass Results!!! - John Doe Bodybuilding

Old School Cycles For Badass Results!!! - John Doe Bodybuilding

Old School Steroid Cycles for Badass Results!!! I'm old school, through and through!!My ideal look is that of 1970's Mike Mentzer (pictured). I care nothing about looking like the next Mr. Olympia, nor am I going to put my body through all of the drugs and bullshit it takes to even try. Of course anabolics arepart of the game. I believe there is a happy medium with them that can allow for both good looks as well as good health . Guys now use way too many steroids , they just have it all wrong. 90% of them could achieve what they're going for with less than half of the doses they're using. The biggest issue people have is dieting.They have never dieted hard enough to see what they're using is doing for them. Once diet is keyed in, then you will see the changes. The next issue is their choice of what anabolics to use. Guys seem to think that 500mg/week of testosterone is a beginner dose.They pop so many oral steroids that they could never shed the layer of fat/water to see the muscles if their life depended on it. They become their own worst enemies.In their quest for a good physique they essentially destroy it. I figured it out about 5-6 years ago, and since switching to this way of cycling gear I haven't looked back. For starters, you only get one set of organs, so taking care of them is top priority. Did you know that a healthy liver burns fat at a much faster rate? Have you ever seen a competitor who looked great for a few years and then all of a sudden looked like shit? They are punishing their bodies to the point they actually regress, and nobody wants that. If you're going to use orals then my advice is to keep it brief and limit using them to once a year. I'm not a fan of dbol or anadrol, they make me feel awful and take away my appetite, and the water retention Continue reading >>

Effect Of Combined Hormonal And Insulin Therapy On The Steroid Hormone Receptors And Growth Factors Signalling In Diabetic Mice Prostate

Effect Of Combined Hormonal And Insulin Therapy On The Steroid Hormone Receptors And Growth Factors Signalling In Diabetic Mice Prostate

Diabetes mellitus causes changes in various organs, including those of the urogenital system (Ciardullo et al. 2004). Experimental studies have shown that type 1 diabetes mellitus causes atrophy of secretory cells, hypertrophied stroma, inflammatory cells, prostatic intraepithelial neoplasia and dilation of organelles involved in glandular secretion in the ventral prostate (Ribeiro et al. 2006; Fávaro et al. 2009). Several studies have also reported a reduction in serum testosterone levels and its receptor expression in the prostate of diabetic mice as a consequence of disturbances in hormone metabolism (Tesone et al. 1976, 1980). In diabetic patients, insulin therapy has a fundamental role in attenuating the systemic effects of the disease and improving the quality of life. However, Wang et al. (2000) showed that controlling the glucose level of diabetic mice by administering insulin did not restore the prostate weight. In contrast, the concomitant administration of testosterone and insulin in diabetic rats resulted in partial morphophysiological recovery of the prostate (Tesone et al. 1980). The ventral lobe of the prostate has a simple epithelium with high columnar cells and stroma characterized by stromal cells, extracellular matrix, growth factors, regulatory molecules and enzymes involved in tissue remodelling (Marker et al. 2003). Proteins, such as insulin-like growth factor (IGF) and vascular endothelial growth factor (VEGF), are important mitogenic factors for maintaining prostatic function (Djavan et al. 2001; Zhu et al. 2009). IGF is produced by prostatic stromal cells and acts as paracrine growth factor in the glandular epithelium. IGF acts using two types of transmembrane receptors (IGFR). IGF-1 is expressed in prostatic stromal and epithelial cells; howev Continue reading >>

Puberty And Type 1 Diabetes

Puberty And Type 1 Diabetes

Department of Endocrinology, IPGMER and SSKM Hospital, Kolkata, West Bengal, India Corresponding Author: Dr. Subhankar Chowdhury, Department of Endocrinology and Metabolism, IPGMER and SSKM Hospital, 244 AJC Bose Road, Kolkata - 700 020, West Bengal, India. E-mail: [email protected] Author information Copyright and License information Disclaimer Copyright : Indian Journal of Endocrinology and Metabolism This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Various data on type 1 diabetes mellitus (T1DM) have showed that the incidence of T1DM peaks at puberty. However, diabetes control and complications could be adversely affected by the physiological changes of puberty. In early years of insulin therapy, severe growth retardation with pubertal delay, like in Mauriac syndrome, have been reported. Insulin and leptin are metabolic factors, circulating in the periphery, which participate in the hypothalamic control of metabolism and reproduction. Insulin may be an important regulator of leptin in humans. Increased levels of advanced glycation end products suppress activation of the gonadotropin-releasing hormone (GnRH) pulse generator, resulting in pubertal delay. Glycemic control deteriorates during puberty as the lean body mass doubles mainly over a period of 25 years, which increases insulin requirement. There is also an increase in insulin resistance over the period of puberty. In normal individuals, fasting and postprandial insulin concentrations reach a peak in both sexes in mid to late puberty. Puberty, at all stages, has the worst insulin resistance. I Continue reading >>

Growth Hormone, Steroids And Diabetes

Growth Hormone, Steroids And Diabetes

If you check the medical literature for side effects of growth hormone use, you’ll note that diabetes often makes the list. A common effect of GH use is insulin resistance, which is considered a harbinger of full-blown diabetes. In fact, insulin resistance is often called “pre-diabetes.” Estimates are that as many as 50 million Americans fit the criteria for insulin resistance. GH enters the picture because it triggers the release of large amounts of free fatty acids into the blood. The free fatty acids, in turn, interfere with the uptake of glucose, or blood sugar, into cells, and the body attempts to compensate by producing more insulin. Insulin aides glucose uptake into cells, but as the body continues to release large amounts of insulin, the cells become resistant to it. Hence the insulin resistance. Bodybuilders and other athletes are aware of this GH side effect. They often counter it by adding insulin injections to their drug stacks, which serves two purposes: 1) It counters the hyperglycemia, or elevated blood glucose, brought on by GH-induced insulin resistance; 2) it has anticatabolic effects in muscle, and when used with GH and anabolic steroids, it appears to add a layer of anabolic efficiency. Insulin also favors amino acid uptake into muscle and triggers the enzyme that produces muscle glycogen, an effect that creates a fuller-appearing muscle. Of course, using insulin is not without its dangers. Injecting it without taking in carbohydrate can lead to a disastrous drop in blood glucose. That, in turn, can cause a person to pass out suddenly or, depending on the dose used, lapse into a coma. The coma effect has actually happened to several well-known professional bodybuilders. Luckily, they all survived. Then there are the aesthetic side effects of us Continue reading >>

Type 2 Diabetes Risk Linked To Low Testosterone Levels

Type 2 Diabetes Risk Linked To Low Testosterone Levels

Type 2 diabetes risk linked to low testosterone levels Type 2 diabetes risk linked to low testosterone levels Low levels of testosterone in men could increase their risk of developing Type 2 diabetes, a study funded by Diabetes UK suggests. Researchers from the University of Edinburgh have found that low testosterone levels are linked to a resistance to insulin a hormone that controls blood glucose levels. This study is the first to directly show how low testosterone levels in fat tissue could be involved in the onset of Type 2 diabetes. Testosterone, which is present throughout the body, acts on fat cells through molecules known as androgen receptors. These receptors enable testosterone to activate genes known to be linked to obesity and diabetes. Obesity is a known risk factor for Type 2 diabetes. However, the researchers stated that the study showed that low testosterone is a risk factor irrespective of body weight. The research showed that mice with impaired testosterone function were more likely to be insulin resistant than mice in which testosterone functioned normally. These findings could help explain why older men are more at risk of developing Type 2 diabetes, because testosterone levels fall in men as they age. Impaired testosterone function linked to weight gain in mice The study also showed that mice with no androgen receptors in their fat tissue were more likely to show signs of insulin resistance compared to mice with androgen receptors. The mice that lacked androgen receptors also became fatter, compared to other mice and developed full insulin resistance, when both types of mice were fed a high-fat diet. Scientists believe that a protein called RBP4 plays a crucial role in regulating insulin resistance when testosterone is impaired. They found that lev Continue reading >>

Type 1 Diabetic Attempting To Cycle (first Time)

Type 1 Diabetic Attempting To Cycle (first Time)

Type 1 Diabetic Attempting to Cycle (first time) Type 1 Diabetic Attempting to Cycle (first time) Welcome to the EliteFitness.com Bodybuilding Site! Please join this discussion about Type 1 Diabetic Attempting to Cycle (first time) within the Anabolic Steroids category. Excerpt: Hello, I'm a Type 1 Diabetic, and I'm going to be attempting my first "cycle" here in about a month, month and a half. With that, I'll cover some of the basics (about me), so that they're out of the way: Goals: Decrease body fat, increase muscle STRENGTH, and I wouldn't mind a bit of a nicer look :) Age: 26 years Height: 6'1" Weight: 228 lbs BF %: Using Calipers ~19-20% Training: M/F Heavy lifting doing Legs, Chest with 30 mins cardio (Always do a little abs with lifting, so I won't Read more or register here to join the discussion below... Type 1 Diabetic Attempting to Cycle (first time) Hello, I'm a Type 1 Diabetic, and I'm going to be attempting my first "cycle" here in about a month, month and a half. With that, I'll cover some of the basics (about me), so that they're out of the way: Goals: Decrease body fat, increase muscle STRENGTH, and I wouldn't mind a bit of a nicer look M/F Heavy lifting doing Legs, Chest with 30 mins cardio (Always do a little abs with lifting, so I won't keep specifying) W/Sun Heavy lifting doing Back, Shoulders Thursday Ice Hockey (1.5 hour game as a goaltender = exhausting) Saturday/Sunday Ice Hockey Practice 1-2 hours a day (again = exhausting) Diet: Around 200-220 grams of protein/day, 150 grams of carbs, 100-120 grams of fat. Reasoning behind this is I'm SENSITIVE AS HELL to carbs. I eat a banana and seem to gain 5 lbs of flab right off the bat! Proteins and fats I can eat all day (and enjoy doing so!) but a damned cup of oatmeal every morning will HALT fat bu Continue reading >>

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