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Testosterone Cycle Diabetes

Steroid Induced Diabetes

Steroid Induced Diabetes

Share: The development and proper use of steroids has been a modern day miracle in many respects. It has aided innumerable people to rapidly recover from a wide variety of ailments, resistant to other treatments. For all their good, however, steroids are dangerous drugs that can cause serious harm if misused or abused. For many people, steroids conjure up the vision of muscle building and, in sports, illegal performance enhancement. While such reputations are quite well-deserved, in reality there are two classifications of steroids, the distinction of which is important. They are anabolic steroids and corticosteroids. Anabolic Steroids Anabolic steroids include the hormone testosterone and related compounds that have muscle-building (anabolic) and masculinizing (androgenic) effects. (1) They sometimes are used illegally and may be dangerous, but also may be needed for some people with blood levels of testosterone lower than normal. In diabetes, especially type 2, some men have decreased levels of testosterone. The normal values for total testosterone in men is 270-1070 ng/dL or 9-38 nmol/L. (2) In general, values below 220 to 250 ng/dL are marked as low in most laboratories; values between 250 and 350 ng/dL should be considered borderline low. (3) Studies have been done in patients with decreased levels of testosterone. A recent testosterone replacement study was conducted in Germany using the long acting testosterone undecanoate (not available in the United States). Patients were followed for up to four years. In this study, 56 percent of the patients had metabolic syndrome* at the start of the study, which dropped to 30 percent after they were treated with testosterone for 57 months. Lab values such as triglycerides and glucose dropped. Blood pressure dropped and wais Continue reading >>

Growth Hormone, Steroids And Diabetes

Growth Hormone, Steroids And Diabetes

If you check the medical literature for side effects of growth hormone use, you’ll note that diabetes often makes the list. A common effect of GH use is insulin resistance, which is considered a harbinger of full-blown diabetes. In fact, insulin resistance is often called “pre-diabetes.” Estimates are that as many as 50 million Americans fit the criteria for insulin resistance. GH enters the picture because it triggers the release of large amounts of free fatty acids into the blood. The free fatty acids, in turn, interfere with the uptake of glucose, or blood sugar, into cells, and the body attempts to compensate by producing more insulin. Insulin aides glucose uptake into cells, but as the body continues to release large amounts of insulin, the cells become resistant to it. Hence the insulin resistance. Bodybuilders and other athletes are aware of this GH side effect. They often counter it by adding insulin injections to their drug stacks, which serves two purposes: 1) It counters the hyperglycemia, or elevated blood glucose, brought on by GH-induced insulin resistance; 2) it has anticatabolic effects in muscle, and when used with GH and anabolic steroids, it appears to add a layer of anabolic efficiency. Insulin also favors amino acid uptake into muscle and triggers the enzyme that produces muscle glycogen, an effect that creates a fuller-appearing muscle. Of course, using insulin is not without its dangers. Injecting it without taking in carbohydrate can lead to a disastrous drop in blood glucose. That, in turn, can cause a person to pass out suddenly or, depending on the dose used, lapse into a coma. The coma effect has actually happened to several well-known professional bodybuilders. Luckily, they all survived. Then there are the aesthetic side effects of us Continue reading >>

Winstrol Side Effects Center

Winstrol Side Effects Center

Winstrol (anabolic steroids) is a synthetic steroid, similar to testosterone, used in the treatment of hereditary angioedema, which causes episodes of swelling of the face, extremities, genitals, bowel wall, and throat. Winstrol may decrease the frequency and severity of these attacks. The drug brand name Winstrol is no longer available in the U.S. Generic versions may still be available. Common side effects of Winstrol include: new or worsening acne, difficulty sleeping, headache, changes in sexual desire, nausea, vomiting, changes in skin color, or ankle swelling. In adolescent and adult males, side effects of Winstrol may include frequent or persistent erections of the penis, and the appearance or aggravation of acne. In women, side effects of Winstrol may include hoarseness, acne, changes in menstrual periods, or more facial hair. The use of anabolic steroids such as Winstrol may be associated with serious adverse reactions, many of which are dose related. Patients should be placed on the lowest possible effective dose. Medications that may interact with Winstrol include anticoagulants (blood thinners), insulin, or an oral diabetes medicine. Tell your doctor all medications you are taking. Winstrol is known to cause birth defects in a fetus. Do not take this medication if you are pregnant or could become pregnant during treatment. It is not known whether Winstrol is excreted in human milk. Many drugs are excreted in human milk and there is the potential for adverse reactions in nursing infants from anabolic steroids. Consult your doctor before breastfeeding. Our Winstrol (anabolic steroids) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of sid Continue reading >>

Testosterone Levels And Type 2 Diabetes In Men: Current Knowledge And Clinical Implications

Testosterone Levels And Type 2 Diabetes In Men: Current Knowledge And Clinical Implications

Testosterone levels and type 2 diabetes in men: current knowledge and clinical implications Anne M Beatrice , Deep Dutta , Manoj Kumar , Shivaprasad Kumbenahalli Siddegowda , Ankur Sinha , Sayantan Ray , and Subhankar Chowdhury Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Find articles by Shivaprasad Kumbenahalli Siddegowda Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Correspondence: Manoj Kumar, Room 9A, 4th Floor, Ronald Ross Building, Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, 244 A Continue reading >>

Long Menstrual Cycle Is Associated With Type 2 Diabetes Mellitus In Korean Women

Long Menstrual Cycle Is Associated With Type 2 Diabetes Mellitus In Korean Women

Long Menstrual Cycle Is Associated with Type 2 Diabetes Mellitus in Korean Women Division of Endocrinology, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea. Corresponding author: Jee-Young Oh. Department of Internal Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, 911-1 Mok-dong, Yangcheon-gu, Seoul 158-710, Korea. [email protected] Received 2010 Oct 4; Accepted 2011 Jan 19. Copyright 2011 Korean Diabetes Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Long menstrual cycle is a risk factor for developing type 2 diabetes and cardiovascular disease in women. We aimed to evaluate the association between existing type 2 diabetes and oligomenorrhea before diagnosis of diabetes, and to observe the differences in this association among obese and non-obese Korean women. Patients with type 2 diabetes (n=118) and without any clinical evidence of abnormal glucose regulation (n=258) who attended the outpatient clinic of a university hospital and were over age 30. Patients self-reporting a menstrual cycle over 40 days during their 20s were defined as oligomenorrhea before diagnosis of diabetes. Obesity was defined as having a body mass index (BMI) over 25 kg/m2. The frequency of oligomenorrhea before diagnosis of diabetes was almost two-fold higher in women with type 2 diabetes than in the control group (16.1% vs. 8.5%, P=0.03). Oligomenorrhea was associated with type 2 diabetes after adjusting for age, BMI, systolic blood pressure, triglycerides, and high density lipoprotein ch Continue reading >>

Periods (menstruation) And Diabetes

Periods (menstruation) And Diabetes

Tweet Different stages of the menstrual cycle may have different effects on your blood glucose levels and the effect can also vary from person to person and from month to month. Recording your blood glucose results can be helpful in finding patterns in your levels and helping you to better control your diabetes. How will my period affect my sugar levels? There is not a definite answer to this as periods affect each one of us differently. However, many women report having higher blood sugar levels a few days prior to their period starting. During your period, you may experience high blood sugar levels but some women notice a sharp drop in sugar levels so it’s best to be prepared for unexpected changes to happen. Why does blood sugar rise before or during periods? Before and during your period, changes in the level of the hormones oestrogen and progesterone can induce temporary resistance to insulin which can last for up to a few days and then drop off. Some girls and women have consistent effects as to how their period affects blood sugar whereas other women may find that the effect on blood sugar varies from one month to another. Coping with periods The effect on blood sugar as a result of periods can change from one month to another so keeping a diary of your blood glucose numbers can help you to see if there are any patterns in your results across different months. If you are finding your blood glucose levels go very high before or during your period, you may need to either inject more insulin (if insulin dependent) or reduce your carbohydrate intake. If you increase your insulin, be careful to avoid hypoglycemia as your insulin sensitivity can sometimes return quickly. Speak to your health team if you need advice on how to manage your insulin doses or carbohydrate Continue reading >>

Low Testosterone And Clinical Outcomes In Chinese Men With Type 2 Diabetes Mellitus Hong Kong Diabetes Registry

Low Testosterone And Clinical Outcomes In Chinese Men With Type 2 Diabetes Mellitus Hong Kong Diabetes Registry

Low testosterone and clinical outcomes in Chinese men with type 2 diabetes mellitus Hong Kong Diabetes Registry Author links open overlay panel Kitty Kit-TingCheungab To assess the implications of low testosterone on cardiovascular risk factors, metabolic syndrome (MES) and clinical outcomes in Chinese men with Type 2 Diabetes (T2D). A prospective cohort study carried out in a university hospital involving a consecutive cohort of 1239 Chinese men with T2D and a median disease duration of 9years followed up for 4.8years. Clinical characteristics, frequency of MES, serum total testosterone and clinical events were analyzed. Multivariate logistic regression was performed to examine the independent association of low testosterone with MES after adjustment for confounding covariates. Cox proportional hazards regression analysis was used to derive hazard ratio for clinical outcomes. More men with low testosterone had cardiovascular-renal disease and MES than those with normal testosterone. The adjusted odds ratio (OR) of low testosterone for MES was 2.63 (95% Confidence Interval [CI] 1.564.61). After a median follow-up of 4.8years, the hazard ratio (HR) of low testosterone was 2.22 (95% CI 1.234.01) for incident non-prostate cancer. In a multivariate Cox-regression model, the HRs were attenuated but remained significant with adjustment for MES and renal parameters. Chinese men with low testosterone had high prevalence of cardiovascular disease and MES with high incidence non-prostate cancer. Continue reading >>

Puberty And Type 1 Diabetes

Puberty And Type 1 Diabetes

Department of Endocrinology, IPGMER and SSKM Hospital, Kolkata, West Bengal, India Corresponding Author: Dr. Subhankar Chowdhury, Department of Endocrinology and Metabolism, IPGMER and SSKM Hospital, 244 AJC Bose Road, Kolkata - 700 020, West Bengal, India. E-mail: [email protected] Author information Copyright and License information Disclaimer Copyright : Indian Journal of Endocrinology and Metabolism This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Various data on type 1 diabetes mellitus (T1DM) have showed that the incidence of T1DM peaks at puberty. However, diabetes control and complications could be adversely affected by the physiological changes of puberty. In early years of insulin therapy, severe growth retardation with pubertal delay, like in Mauriac syndrome, have been reported. Insulin and leptin are metabolic factors, circulating in the periphery, which participate in the hypothalamic control of metabolism and reproduction. Insulin may be an important regulator of leptin in humans. Increased levels of advanced glycation end products suppress activation of the gonadotropin-releasing hormone (GnRH) pulse generator, resulting in pubertal delay. Glycemic control deteriorates during puberty as the lean body mass doubles mainly over a period of 25 years, which increases insulin requirement. There is also an increase in insulin resistance over the period of puberty. In normal individuals, fasting and postprandial insulin concentrations reach a peak in both sexes in mid to late puberty. Puberty, at all stages, has the worst insulin resistance. I Continue reading >>

Women And Diabetes | Diabetesnet.com

Women And Diabetes | Diabetesnet.com

Mon, 11/15/2010 - 11:33 -- Richard Morris Fluctuations in hormone levels occur through the menstrual cycle and these fluctuations can affect blood sugar control. When estrogen levels are naturally high, your body may be resistant to its own insulin or injected insulin. Many women find their blood sugar tends to be high 3-5 days before, during or after their periods. Since everyone is different, the only way to manage blood sugars in a setting where sensitivity to insulin changes is to test and record blood sugars four or more times a day the week before, during and after your period for at least 2 or 3 months to find your own pattern. This allows you to adjust your insulin doses and carb intake both before and during this time to better control your blood sugar. Premenstrual symptoms (PMS) can be worsened by poor blood sugar control. It helps to chart your feelings such as tenderness, bloating, grouchiness for a week before, during and after your period. Charting will help you know when your PMS reach their peak during your period so that before your PMS is most severe, you can check your blood sugar more often and take extra insulin or exercise to bring high blood sugars down. Food cravings during PMS are triggered by an increase in progesterone and can make it more difficult to control your blood sugar. Usually the craving is for chocolate or sweet foods. Give in to your cravings by trying sugar-free and fat-free versions, such as chocolate pudding. Take extra insulin or increase your exercise to compensate. You may feel less like exercising during your period. If so, extra insulin may be a good choice for keeping your blood sugar from rising. The extra insulin needed to overcome insulin resistance during this time will not cause weight gain. Treat yourself well duri Continue reading >>

How Does Puberty Affect Diabetes?

How Does Puberty Affect Diabetes?

One of the hardest things about being an adolescent is going through puberty and facing the challenges that it brings. The emotional roller coasters and the physical changes seem endless and impossible. But how does a teen go through puberty with diabetes? How are things different for them? The following article explores the relationship between puberty and diabetes. How does puberty affect Type 1 diabetes? During puberty, many physical changes occur that can affect one’s diabetes. Most importantly, the growth hormone causes lean body mass to double over in the 2 to 5 years during puberty. This increase in the growth hormone makes it harder for insulin to work in the body. That struggle is called insulin resistance. A normal child would just make more insulin, but a child with diabetes that does not make insulin or that has limited insulin must increase the amount of insulin that they give themselves to keep their blood sugar under control. This increase can be up to 30-50% more insulin than normal. Also, an earlier onset of puberty can lead to a diagnosis of Type 1 diabetes in some girls because of the increase in estrogen that occurs during puberty. I recommend reading the following articles: Signs and symptoms of diabetes as an adolescent Due to hormones, puberty is the most common time for the onset of Type 1 diabetes. Adolescents have the same signs and symptoms as other ages for diabetes: Weight loss Excessive thirst Increased appetite Elevated levels of ketones in the blood or urine Elevated levels of glucose in the blood or urine To be diagnosed with diabetes, these symptoms will need to have been experienced for several weeks. If the individual is underweight or of a normal weight, then Type 1 diabetes is suspected. If they are overweight, it could then be ei Continue reading >>

Men And Low Testosterone

Men And Low Testosterone

As the years go by, mens bodies go through certain changes some of them visible, and some of which can only be felt. When a man passes 40 years of age, one of these changes is likely to be a gradual reduction in testosterone production. Most men are loath to talk about it, and they may not even know whats happening to them. But they may complain of having lower strength, gaining weight, and not feeling like myself. While the interaction between diabetes and testosterone is a topic that could use more studying, existing research makes clear that men with diabetes are more likely to have low testosterone and men with low testosterone are more likely to have diabetes. This article examines the factors that may lead to low testosterone, and outlines some steps you might be able to take to help reverse this process. Testosterone is the hormone that turns boys into men. It gives you facial hair, puts muscle on your frame, and changes the pitch of your voice. It speeds up the muscle recovery process and creates a sense of strength its probably part of the reason why some men in their 20s feel like they can get away with anything. Its critical to male sexual behavior and reproduction, with additional beneficial effects on bone density and emotional well-being. Unlike women, men do not experience a sudden drop in hormones as part of the aging process. Testosterone declines gradually, generally starting after age 40. According to a study published in the European Journal of Endocrinology, once this process starts, the typical rate of decline is between 0.5% and 2% per year. This gradual decrease in testosterone can leave men with less energy and a lower libido. Certain lifestyle habits and physical conditions can speed up the decline in testosterone and one condition that is lin Continue reading >>

Old School Cycles For Badass Results!!! - John Doe Bodybuilding

Old School Cycles For Badass Results!!! - John Doe Bodybuilding

Old School Steroid Cycles for Badass Results!!! I'm old school, through and through!!My ideal look is that of 1970's Mike Mentzer (pictured). I care nothing about looking like the next Mr. Olympia, nor am I going to put my body through all of the drugs and bullshit it takes to even try. Of course anabolics arepart of the game. I believe there is a happy medium with them that can allow for both good looks as well as good health . Guys now use way too many steroids , they just have it all wrong. 90% of them could achieve what they're going for with less than half of the doses they're using. The biggest issue people have is dieting.They have never dieted hard enough to see what they're using is doing for them. Once diet is keyed in, then you will see the changes. The next issue is their choice of what anabolics to use. Guys seem to think that 500mg/week of testosterone is a beginner dose.They pop so many oral steroids that they could never shed the layer of fat/water to see the muscles if their life depended on it. They become their own worst enemies.In their quest for a good physique they essentially destroy it. I figured it out about 5-6 years ago, and since switching to this way of cycling gear I haven't looked back. For starters, you only get one set of organs, so taking care of them is top priority. Did you know that a healthy liver burns fat at a much faster rate? Have you ever seen a competitor who looked great for a few years and then all of a sudden looked like shit? They are punishing their bodies to the point they actually regress, and nobody wants that. If you're going to use orals then my advice is to keep it brief and limit using them to once a year. I'm not a fan of dbol or anadrol, they make me feel awful and take away my appetite, and the water retention Continue reading >>

Effect Of Combined Hormonal And Insulin Therapy On The Steroid Hormone Receptors And Growth Factors Signalling In Diabetic Mice Prostate

Effect Of Combined Hormonal And Insulin Therapy On The Steroid Hormone Receptors And Growth Factors Signalling In Diabetic Mice Prostate

Diabetes mellitus causes changes in various organs, including those of the urogenital system (Ciardullo et al. 2004). Experimental studies have shown that type 1 diabetes mellitus causes atrophy of secretory cells, hypertrophied stroma, inflammatory cells, prostatic intraepithelial neoplasia and dilation of organelles involved in glandular secretion in the ventral prostate (Ribeiro et al. 2006; Fávaro et al. 2009). Several studies have also reported a reduction in serum testosterone levels and its receptor expression in the prostate of diabetic mice as a consequence of disturbances in hormone metabolism (Tesone et al. 1976, 1980). In diabetic patients, insulin therapy has a fundamental role in attenuating the systemic effects of the disease and improving the quality of life. However, Wang et al. (2000) showed that controlling the glucose level of diabetic mice by administering insulin did not restore the prostate weight. In contrast, the concomitant administration of testosterone and insulin in diabetic rats resulted in partial morphophysiological recovery of the prostate (Tesone et al. 1980). The ventral lobe of the prostate has a simple epithelium with high columnar cells and stroma characterized by stromal cells, extracellular matrix, growth factors, regulatory molecules and enzymes involved in tissue remodelling (Marker et al. 2003). Proteins, such as insulin-like growth factor (IGF) and vascular endothelial growth factor (VEGF), are important mitogenic factors for maintaining prostatic function (Djavan et al. 2001; Zhu et al. 2009). IGF is produced by prostatic stromal cells and acts as paracrine growth factor in the glandular epithelium. IGF acts using two types of transmembrane receptors (IGFR). IGF-1 is expressed in prostatic stromal and epithelial cells; howev Continue reading >>

Testosterone Enanthate Injection

Testosterone Enanthate Injection

Uses of Testosterone Enanthate Injection: It is used to treat breast cancer in women. It is used to treat low testosterone levels. It is used in certain children when puberty is delayed. It may be given to you for other reasons. Talk with the doctor. What do I need to tell my doctor BEFORE I take Testosterone Enanthate Injection? If you have an allergy to testosterone or any other part of testosterone enanthate injection. If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives ; itching; shortness of breath; wheezing ; cough; swelling of face, lips, tongue, or throat; or any other signs. If you are male and have breast or prostate cancer . If you have any of these health problems: Heart disease, kidney disease, or liver disease . If you are pregnant or may be pregnant. Do not take testosterone enanthate injection if you are pregnant. If you are breast-feeding. Do not breast-feed while you take testosterone enanthate injection. This is not a list of all drugs or health problems that interact with testosterone enanthate injection. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins ) and health problems. You must check to make sure that it is safe for you to take testosterone enanthate injection with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. What are some things I need to know or do while I take Testosterone Enanthate Injection? Tell all of your health care providers that you take testosterone enanthate injection. This includes your doctors, nurses, pharmacists, and dentists. If you have high blood sugar (diabetes), you will n Continue reading >>

Low Testosterone In Men With Type 2 Diabetes: Significance And Treatment

Low Testosterone In Men With Type 2 Diabetes: Significance And Treatment

Low Testosterone in Men with Type 2 Diabetes: Significance and Treatment Department of Medicine, Austin Health/Northern Health, University of Melbourne, Heidelberg, VIC 3084, Australia Address all correspondence and requests for reprints to: Dr. Mathis Grossmann; Department of Medicine Austin Health/Northern Health, University of Melbourne, Studley Road, Heidelberg, VIC 3084, Australia. Search for other works by this author on: The Journal of Clinical Endocrinology & Metabolism, Volume 96, Issue 8, 1 August 2011, Pages 23412353, Mathis Grossmann; Low Testosterone in Men with Type 2 Diabetes: Significance and Treatment, The Journal of Clinical Endocrinology & Metabolism, Volume 96, Issue 8, 1 August 2011, Pages 23412353, The relationship between testosterone and diabetes in men is an important issue, given that one third of U.S. men aged 65 yr or older have diabetes, with a similar percentage having low testosterone levels. The medical literature from 1970 to March 2011 was reviewed for key articles. In population-based studies, low testosterone is commonly associated with type 2 diabetes and the metabolic syndrome, and it identifies men with an adverse metabolic profile. The difference in testosterone levels between men with diabetes compared to men without diabetes is moderate and comparable in magnitude to the effects of other chronic diseases, suggesting that low testosterone may be a marker of poor health. Although the inverse association of testosterone with diabetes is partially mediated by SHBG, low testosterone is linked to diabetes via a bidirectional relationship with visceral fat, muscle, and possibly bone. There is consistent evidence from randomized trials that testosterone therapy alters body composition in a metabolically favorable manner, but changes ar Continue reading >>

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