Using Testosterone As Diabetes Treatment?
Home / Conditions / Type 2 Diabetes / Using Testosterone as Diabetes Treatment? Using Testosterone as Diabetes Treatment? Study shows effect low levels of the hormone have on blood glucose. Researchers at Tulane University have identified the role testosterone plays in blood glucose regulation, which they say could lead to new treatments for men with low testosterone due age or prostate cancer treatment. Men with low levels are more likely to develop diabetes suggesting hormone therapy could provide the answer to stop the disease. The study found testosterone helps men regulate blood glucose by triggering chemicals in cells within the pancreas that produce the hormone insulin. For the study, researchers used mice bred with pancreatic beta cells lacking a receptor for testosterone, feeding them a diet high in fat and sugar and tested their bodys response to it. Mice without receptors all secreted less insulin and developed glucose intolerance conditions similar to diabetes. The researchers then tested the effects of testosterone and glucose on human islet cells treated with a drug to inhibit the function of receptors, showing the same decreased insulin production exhibited in the mice. After observing the effect in human cells, researchers cultured mouse and human cells to observe the effects of testosterone on insulin production that could be blocked by glucagon-like peptide-1 suggesting testosterone amplifies the effects of GLP-1, often used to treat diabetes. Our study shows that testosterone is an anti-diabetic hormone in men, study author Dr. Franck Mauvais-Jarvis said. If we can modulate its action without side effects, it is a therapeutic avenue for type 2 diabetes. Male cell ARKO mice exhibit decreased glucose-stimulated insulin secretion (GSIS) Testosterone enh Continue reading >>
Low Testosterone Levels And Type 2 Diabetes
Low Testosterone Levels and Type 2 Diabetes A new study has found that a significant number of men who have Type 2 diabetes may have low testosterone levels, a condition that can trigger erectile dysfunction but can be treated with testosterone replacement therapy. The study, published in the April 2007 issue of the journal Diabetes Care, looked at 355 men over the age of 30 who had Type 2 diabetes. The researchers found that 17% of these men had low testosterone levels, and an additional 25% had borderline low levels of the male sex hormone. Obesity, as measured by body-mass index and waist circumference, was strongly associated with low testosterone levels in men. Of the men in the study who were found to have low testosterone levels, 70% reported erectile dysfunction and 63% reported low sex drive. The major symptoms of low testosterone levels tend to be low sex drive, reduced erection strength, reduced physical strength, fatigue, and changes in mood. As we revealed in the previous blog entry Diabetes and Erectile Dysfunction: Two New Studies, erectile dysfunction is reported by about half of men with diabetes, with increasing age being an important factor. Testosterone levels also decline in men with age. Other factors that may play a role in causing erectile dysfunction in men with diabetes are impaired circulation from blood vessel damage and neuropathy , or nerve damage. A combination of factors is often responsible for erectile dysfunction. Other studies have shown that men with erectile dysfunction who do not improve with use of sildenafil (brand name Viagra) are often found to have low testosterone levels. Whats more, 60% of these men do see improvement when testosterone replacement therapy is added to the sildenafil treatment. Testosterone replacement therap Continue reading >>
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Long-term Testosterone Treatment Reduced Hba1c In Men With Hypogonadism And Type 2 Diabetes
Long-Term Testosterone Treatment Reduced HbA1c in Men With Hypogonadism and Type 2 Diabetes Long-Term Testosterone Treatment Reduced HbA1c in Men With Hypogonadism and Type 2 Diabetes Fasting glucose, weight, waist circumference, and body mass index were also reduced with testosterone treatment. This article is part of Endocrinology Advisor's coverage of the American Diabetes Association's 77th Scientific Sessions (ADA 2017) , taking place in San Diego, CA. Our staff will report on medical research and technological advances in diabetes and diabetes education, conducted by experts in the field. Check back regularly for more news from ADA 2017 . Hypogonadal men with type 2 diabetes (T2D) who were treated with testosterone undecanoate (TU) injections demonstrated reductions in glycated hemoglobin A1c (HbA1c) and anthropometric measures, according to data presented at the 77th American Diabetes Association Scientific Sessions , June 9-13, in San Diego. As recommended by the [American Association of Clinical Endocrinologists]/[American College of Endocrinology] guidelines for the management of obesity, it is worthwhile measuring testosterone in men with T2D, especially if they are obese, study researcher Farid Saad, PhD, with Bayer AG, Berlin, said in an interview with Endocrinology Advisor. Correcting hypogonadism by testosterone therapy will result in major improvements of the diabetic state, provided that treatment is performed long enough (ie, for life) and is adequate (ie, testosterone levels achieved are high enough). According to Dr Saad, the registry study was initiated in 2004 to study effectiveness and safety of a new testosterone preparation that had become available in Germany that year. This preparation is a 3-monthly injection [of TU] requiring only 4 injecti Continue reading >>
Can Testosterone Replacement Therapy Help Men With Type 2 Diabetes?
It’s possible. Research has shown that between 40% and 50% of diabetic men have low testosterone. Symptoms of low testosterone include decreased muscle mass, fatigue, changes in mood, depression, and anxiety. There are also sexual symptoms, most notably diminished sex drive and erectile dysfunction. A recent study published in The Journal of Sexual Medicine investigated the role of testosterone replacement therapy for diabetic men. The researchers used a type of testosterone called long-acting testosterone undecanoate. In the first part of the study, 199 diabetic men with low testosterone were divided into two groups. One group received testosterone replacement therapy. The other group received a placebo. After 30 weeks, the men who took testosterone saw some improvements in their erections, orgasms, and sexual desire. They were more satisfied with intercourse and with their sexual activities overall. Also at this time, 46% of the men who took testosterone felt that their health had improved with treatment. Seventeen percent of the men in the placebo group felt that way. At this point, the men were given the option of continuing their treatment for another 52 weeks. One hundred six men decided to move forward. At the end of that time, 70% of all the men felt that their health had improved. There were some exceptions, however. Men who were diagnosed with depression at the start of the study did not have as much improvement. Obese men did not benefit as much either. The authors of the study stressed the importance of screening for low testosterone and depression in men with type 2 diabetes. Testosterone replacement therapy could be a way to alleviate symptoms, including sexual ones, and improve quality of life. Diabetic men who are concerned about low testosterone shoul Continue reading >>
Testosterone Replacement Makes Type 2 Diabetic Men More Sensitive To Insulin
Follow all of ScienceDaily's latest research news and top science headlines ! Testosterone replacement makes Type 2 diabetic men more sensitive to insulin Testosterone is a metabolic hormone as well as a sex hormone, researchers say Men with Type 2 diabetes who have low testosterone levels can benefit significantly from testosterone treatment. That is the conclusion of researchers who conducted the first randomized, double-blind, placebo-controlled study of testosterone treatment in Type 2 diabetic men that comprehensively investigated the role of insulin resistance and inflammation, before and after treatment with testosterone. Men with Type 2 diabetes who have low testosterone levels can benefit significantly from testosterone treatment. That is the conclusion of University at Buffalo researchers who conducted the first randomized, double-blind, placebo-controlled study of testosterone treatment in Type 2 diabetic men that comprehensively investigated the role of insulin resistance and inflammation, before and after treatment with testosterone. The study, funded by the National Institutes of Health, was published online before print in Diabetes Care in November. "This is the first definitive evidence that testosterone is an insulin sensitizer and hence a metabolic hormone," said Paresh Dandona, MD, PhD, senior author on the paper and SUNY Distinguished Professor and chief of endocrinology, diabetes and metabolism in the Department of Medicine in the Jacobs School of Medicine and Biomedical Sciences at UB. He sees patients at UBMD Internal Medicine. The UB researchers found that low testosterone levels were associated with significantly decreased insulin sensitivity; this was demonstrated by a 36 percent decrease in the rate at which glucose is taken up by tissues whe Continue reading >>
Testosterone Levels And Type 2 Diabetes In Men: Current Knowledge And Clinical Implications
Testosterone levels and type 2 diabetes in men: current knowledge and clinical implications Anne M Beatrice , Deep Dutta , Manoj Kumar , Shivaprasad Kumbenahalli Siddegowda , Ankur Sinha , Sayantan Ray , and Subhankar Chowdhury Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Find articles by Shivaprasad Kumbenahalli Siddegowda Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Calcutta, India Correspondence: Manoj Kumar, Room 9A, 4th Floor, Ronald Ross Building, Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, 244 A Continue reading >>
Testosterone Deficiency, Diabetes And Metabolic Syndrome
Testosterone Deficiency, Diabetes and Metabolic Syndrome Testosterone is the key male hormone . It regulates a mans libido (sex drive) and the development of secondary male sex characteristics, such as facial and body hair, the testes and thepenis. Testosterone also protects the health of bone and muscle tissues. Testosterone deficiency is associated with many chronic health conditions, including type 2 diabetes mellitus and other metabolic disorders. Testosterone deficiency has been estimated to affect about 1 in 200 Australian men, although this may under-represent the true number due to not all cases being diagnosed. In men from Boston, USA, testosterone deficiency was found to affect about 1 in 18 men aged 3079 years, but in men aged 6079 this increased to about 1 in 8. Significantly, there is also a strong association between testosterone deficiency and diabetes . A study in the United Kingdom found that 42% of men with type 2 diabetes also had low or borderline levels of testosterone. For more information about testosterone deficiency, see Male Hypogonadism (Primary Hypogonadism and Secondary/Hypogonadotrophic Hypogonadism) . Testosterone deficiency, diabetes and the metabolic syndrome The association between low levels of testosterone (a condition known as hypogonadism) and type 2 diabetes mellitus are well recognised, but it also appears that testosterone deficiency is common in men with diabetes regardless of type. Metabolic syndrome is a condition characterised by several co-occurring metabolic imbalances (e.g. impaired insulin metabolism, obesity , high blood pressure );it often precedes type 2 diabetes mellitus, and is also associated with testosterone deficiency. There is considerable evidence that men with metabolic syndrome are more likely to develop hyp Continue reading >>
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The Link Between Low Testosterone And Diabetes
The connection might not seem obvious at first, but low testosterone and diabetes often go hand in hand. In fact, men with type 2 diabetes are twice as likely to have low testosterone as men who don't have diabetes. However, the link between these two conditions does not mean that low testosterone actually causes diabetes. It is possible that some of the lifestyle factors that increase the risk of diabetes also increase the risk of low testosterone. The good news? In addition to sticking to a heart-healthy diet and exercise, certain treatments may help both low testosterone and diabetes. Low Testosterone and Diabetes: What’s the Link? Low testosterone levels in men are associated with insulin resistance or reduced insulin sensitivity, says Ahmer Farooq, DO, assistant professor of urology at Loyola University Medical Center in Maywood, Ill. When you have insulin resistance, your body produces insulin but doesn't use it properly. As a result, glucose builds up in your blood rather than being absorbed by cells. Insulin resistance can lead to type 2 diabetes and increase your risk for a number of health problems, including heart disease. A study published in 2013 in the journal BioMed Research International found that low testosterone levels may help predict if a man will develop insulin resistance or type 2 diabetes in the future. According to the researchers, in a group of more than 300 obese and non-obese men, 44 percent had both type 2 diabetes and low testosterone, compared with 33 percent who had low testosterone but did not have diabetes. The researchers also noted that 25 percent of those with type 2 diabetes and low testosterone were not obese, concluding that low testosterone is linked to insulin resistance regardless of body weight. Yet, body weight can be a fa Continue reading >>
The Role Of Testosterone In Type 2 Diabetes And Metabolic Syndrome In Men.
1. Arq Bras Endocrinol Metabol. 2009 Nov;53(8):901-7. The role of testosterone in type 2 diabetes and metabolic syndrome in men. (1)Bayer Schering Pharma AG, Berlin. [email protected] Over the last three decades, it has become apparent that testosterone plays asignificant role in glucose homeostasis and lipid metabolism. The metabolicsyndrome is a clustering of risk factors predisposing to diabetes mellitus type2, atherosclerosis and cardiovascular morbidity and mortality. The maincomponents of the syndrome are visceral obesity, insulin resistance, glucoseintolerance, raised blood pressure and dyslipidemia (elevated triglycerides, low levels of high-density lipoprotein cholesterol), and a pro-inflammatory andthrombogenic state. Cross-sectional epidemiological studies have reported adirect correlation between plasma testosterone and insulin sensitivity, and lowtestosterone levels are associated with an increased risk of type 2 diabetesmellitus, dramatically illustrated by androgen deprivation in men with prostatecarcinoma. Lower total testosterone and sex hormone-binding globulin (SHBG)predict a higher incidence of the metabolic syndrome. There is evidence thathypotestosteronemia should be an element in the definition of the metabolicsyndrome since low levels of testosterone are associated with or predict thedevelopment of the metabolic syndrome and of diabetes mellitus. Administration oftestosterone to hypogonadal men reverses part of the unfavorable risk profile forthe development of diabetes and atherosclerosis. So far, studies on the effectsof normalization of testosterone in hypogonadal men on glucose homeostasis arelimited, but convincing, and if diabetes mellitus is viewed in the context of themetabolic syndrome, the present results of testosterone t Continue reading >>
Could Testosterone Therapy Benefit Men With Type 2 Diabetes?
Could testosterone therapy benefit men with type 2 diabetes? Men with type 2 diabetes and low testosterone levels can benefit significantly from testosterone treatment, according to a study published in Diabetes Care. With testosterone treatment, fat turned to muscle in men with diabetes. Senior author Dr. Paresh Dandona, of the Department of Medicine in the Jacobs School of Medicine and Biomedical Sciences at the University of Buffalo (UB), NY, and his coauthors already knew that low testosterone levels coincide with significantly decreased insulin sensitivity. In 2004, they demonstrated a link between low testosterone levels and type 2 diabetes . Six years later, they extended this to obesity . In a study of more than 2,000 men, they observed that 33% of participants with type 2 diabetes, whether obese or not, had low testosterone levels, as did 25% of non-diabetic, obese males. In 2012, the team found that teenage boys with obesity have 50% less testosterone than their lean peers. The researchers had also associated obesity with oxidative and inflammation . Inflammatory mediators are known to interfere with insulin signaling. Testosterone: anti-inflammatory and insulin-sensitizing? In the present study, the team hypothesized that testosterone may be an anti-inflammatory and insulin-sensitizing agent, since it has been known for some time that testosterone reduces adiposity and increases skeletal muscle. The participants were 94 men with type 2 diabetes, of whom 44 had low testosterone levels. Before treatment, those with low testosterone levels expressed significantly lower levels of insulin-signaling genes and diminished insulin sensitivity. The men with low testosterone were randomized to receive a testosterone injection or a placebo every week for 24 weeks. Testo Continue reading >>
Low Testosterone And Your Health
Testosterone Replacement Treatment Options Researchers are unlocking the mysteries of how low testosterone is related to men's overall health. Along the way, they're uncovering connections between low testosterone and other health conditions. Diabetes , metabolic syndrome , obesity , and high blood pressure have all been linked to testosterone deficiency. Low testosterone isn't known to cause these health problems, and replacing testosterone isn't the cure. Still, the associations between low testosterone and other medical conditions are interesting and worth a look. Does Low Testosterone Indicate Poor Health? In recent years, researchers have noticed general links between low testosterone and other medical conditions. One showed that in 2,100 men over age 45, the odds of having low testosterone were: 1.8 times higher for men with high blood pressure Experts don't suggest that low testosterone causes these conditions. In fact, it might be the other way around. That is, men with medical problems or who are in poor general health might then develop low testosterone. Research into the relationship between low testosterone and several other health conditions is ongoing. A link between diabetes and low testosterone is well established. Men with diabetes are more likely to have low testosterone. And men with low testosterone are more likely to later develop diabetes. Testosterone helps the body's tissues take up more blood sugar in response to insulin . Men with low testosterone more often have insulin resistance : they need to produce more insulin to keep blood sugar normal. As many as half of men with diabetes have low testosterone, when randomly tested. Scientists aren't sure whether diabetes causes low testosterone, or the other way around. More research is needed, but s Continue reading >>
Low Testosterone In Men With Type 2 Diabetes: Significance And Treatment
Low Testosterone in Men with Type 2 Diabetes: Significance and Treatment Department of Medicine, Austin Health/Northern Health, University of Melbourne, Heidelberg, VIC 3084, Australia Address all correspondence and requests for reprints to: Dr. Mathis Grossmann; Department of Medicine Austin Health/Northern Health, University of Melbourne, Studley Road, Heidelberg, VIC 3084, Australia. Search for other works by this author on: The Journal of Clinical Endocrinology & Metabolism, Volume 96, Issue 8, 1 August 2011, Pages 23412353, Mathis Grossmann; Low Testosterone in Men with Type 2 Diabetes: Significance and Treatment, The Journal of Clinical Endocrinology & Metabolism, Volume 96, Issue 8, 1 August 2011, Pages 23412353, The relationship between testosterone and diabetes in men is an important issue, given that one third of U.S. men aged 65 yr or older have diabetes, with a similar percentage having low testosterone levels. The medical literature from 1970 to March 2011 was reviewed for key articles. In population-based studies, low testosterone is commonly associated with type 2 diabetes and the metabolic syndrome, and it identifies men with an adverse metabolic profile. The difference in testosterone levels between men with diabetes compared to men without diabetes is moderate and comparable in magnitude to the effects of other chronic diseases, suggesting that low testosterone may be a marker of poor health. Although the inverse association of testosterone with diabetes is partially mediated by SHBG, low testosterone is linked to diabetes via a bidirectional relationship with visceral fat, muscle, and possibly bone. There is consistent evidence from randomized trials that testosterone therapy alters body composition in a metabolically favorable manner, but changes ar Continue reading >>
Men And Low Testosterone
As the years go by, mens bodies go through certain changes some of them visible, and some of which can only be felt. When a man passes 40 years of age, one of these changes is likely to be a gradual reduction in testosterone production. Most men are loath to talk about it, and they may not even know whats happening to them. But they may complain of having lower strength, gaining weight, and not feeling like myself. While the interaction between diabetes and testosterone is a topic that could use more studying, existing research makes clear that men with diabetes are more likely to have low testosterone and men with low testosterone are more likely to have diabetes. This article examines the factors that may lead to low testosterone, and outlines some steps you might be able to take to help reverse this process. Testosterone is the hormone that turns boys into men. It gives you facial hair, puts muscle on your frame, and changes the pitch of your voice. It speeds up the muscle recovery process and creates a sense of strength its probably part of the reason why some men in their 20s feel like they can get away with anything. Its critical to male sexual behavior and reproduction, with additional beneficial effects on bone density and emotional well-being. Unlike women, men do not experience a sudden drop in hormones as part of the aging process. Testosterone declines gradually, generally starting after age 40. According to a study published in the European Journal of Endocrinology, once this process starts, the typical rate of decline is between 0.5% and 2% per year. This gradual decrease in testosterone can leave men with less energy and a lower libido. Certain lifestyle habits and physical conditions can speed up the decline in testosterone and one condition that is lin Continue reading >>
Testosterone Increasing Insulin Sensitivity
A known link between low testosterone levels and decreased insulin sensitivity could lead to a treatment for men with type 2. New study shows that increasing testosterone levels can help male patients with type 2 diabetes increase their response to insulin. In individuals with insulin resistance, their body produces insulin, but does not effectively utilize their insulin. Insulin resistance leads to a build up of glucose in the blood rather than being absorbed by the cells. Ultimately, insulin resistance can lead to diabetes as well as other health issues such as heart disease. Testosterone is a hormone that regulates many functions of the body. During puberty, testosterone is responsible for muscle growth, deepening a man’s voice, and increasing the size of the genitalia. In adulthood, testosterone not only maintains a man’s muscles and bones but also his interest in sex. Testosterone levels begin to decrease after 30 years old, which is followed by a decrease in sex drive. Many men mistake the decrease in sex drive as them simply getting older. Researchers at the University of Buffalo conducted a double blind, placebo-controlled study of testosterone treatment in type two diabetic men. The study evaluated the effect of testosterone replacement therapy on insulin resistant men with type two diabetes and hypogonadism. The study recruited 94 men with type two diabetes with 50 being eugonadal, normal testosterone levels, while 44 had hypogonadism, low testosterone levels. Baseline lean body mass and body fat were taken prior to study. Subcutaneous fat samples were taken to assess insulin signaling genes. The men with hypogonadism were randomized to receive either intramuscular testosterone (250mg) injections or placebo (1mL saline) every two weeks for 24 weeks. The re Continue reading >>
Testosterone Level And Risk Of Type 2 Diabetes In Men: A Systematic Review And Meta-analysis
Testosterone level and risk of type 2 diabetes in men: a systematic review and meta-analysis 1Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China 2Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China 3Department of Clinical Laboratory, Jinshan Hospital of Fudan University, Shanghai, China Correspondence should be addressed to J Zhang or L Ding: zhangjinan{at}hotmail.com or dlm196969{at}163.com Background Type 2 diabetes is a risk factor for testosterone deficiency and impaired sex steroid status. Some studies also investigated the association of testosterone level with diabetes risk in men, but reported controversial findings. To clarify this issue, we conducted a systematic review and meta-analysis. Methods PubMed, EMBASE and Web of Science were searched for eligible cohort or nested casecontrol studies published up to August 15, 2017. Meta-analysis was used to calculate the pooled relative risk (RR) of type 2 diabetes associated with higher testosterone level. Results Thirteen cohort or nested casecontrol studies with 16,709 participants were included. Meta-analysis showed that higher total testosterone level could significantly decrease the risk of type 2 diabetes in men (RR = 0.65; 95% CI 0.500.84; P = 0.001), and higher free testosterone level could also decrease the risk of type 2 diabetes in men (RR = 0.94; 95% CI 0.900.99; P = 0.014). After excluding two studies that did not calculate RRs by quartiles of testosterone levels, both higher total testosterone and free testosterone levels could decrease the risk of type 2 diabetes in men, and the pooled RRs were 0.62 (95% CI 0.510.76; P < 0.001) and 0.77 (95% CI 0.610.98; P = 0.03), respectively. Conclusion This meta Continue reading >>
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