What was your first week on Metformin like? Horrendous? Terrible? Filled with waves of nausea? The sickest you’ve felt in your life? Let’s reminisce for a minute: About a dozen years ago, on December 24, I went to the doctor for a routine physical. Are you envious of my holiday plans? This was in the years before Pinterest, so I was carrying on with regular life activities on Christmas Eve morn rather than bedazzling the cap of an Elf on the Shelf. Anyway, at the Christmas Eve check-up, my physician mentioned that he had read promising things about Metformin being used in women with PCOS. We chatted about Metformin for a bit, talked about other PCOS things, finished up the tests, and then I headed to the pharmacy to pick up the prescription. We had our traditional Christmas Eve dinner of ham, funeral potatoes, salad with asparagus and strawberries; rolls, and other delicious items. Breaking with tradition, this year’s Christmas Eve dinner was followed by Metformin for me. After dinner, we read the Christmas story from the Bible, watched a short film depicting the events in Luke 2, read a new Christmas book, and headed off to bed. That’s when the fun began. In sum: Worst Christmas Ever. Pros: Family, friends, gifts, good music, good food. Cons: Visiting the loo every 15 minutes, constant nausea, wanting to curl up in bed and not wake up for days. Public Service Announcement: Do not start Metformin for the first time on the day prior to a major holiday. My first year on Metformin was pretty rough. I felt like I had morning sickness every single day. I had diarrhea and nausea every morning. When I skipped a few doses hoping for relief, my symptoms would be twice as bad when I re-started. Looking back, I’m actually amazed that I kept taking the medication. If I st Continue reading >>
Taking Metformin At Night Genetic
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Metformin, The Liver, And Diabetes
Most people think diabetes comes from pancreas damage, due to autoimmune problems or insulin resistance. But for many people diagnosed “Type 2,” the big problems are in the liver. What are these problems, and what can we do about them? First, some basic physiology you may already know. The liver is one of the most complicated organs in the body, and possibly the least understood. It plays a huge role in handling sugars and starches, making sure our bodies have enough fuel to function. When there’s a lot of sugar in the system, it stores some of the excess in a storage form of carbohydrate called glycogen. When blood sugar levels get low, as in times of hunger or at night, it converts some of the glycogen to glucose and makes it available for the body to use. Easy to say, but how does the liver know what to do and when to do it? Scientists have found a “molecular switch” called CRTC2 that controls this process. When the CRTC2 switch is on, the liver pours sugar into the system. When there’s enough sugar circulating, CRTC2 should be turned off. The turnoff signal is thought to be insulin. This may be an oversimplification, though. According to Salk Institute researchers quoted on RxPG news, “In many patients with type II diabetes, CRTC2 no longer responds to rising insulin levels, and as a result, the liver acts like a sugar factory on overtime, churning out glucose [day and night], even when blood sugar levels are high.” Because of this, the “average” person with Type 2 diabetes has three times the normal rate of glucose production by the liver, according to a Diabetes Care article. Diabetes Self-Management reader Jim Snell brought the whole “leaky liver” phenomenon to my attention. He has frequently posted here about his own struggles with soarin Continue reading >>
When Do I Take Metformin For My Diet: Morning Or Night?
Metformin helps control blood sugar and increase your body's sensitivity to insulin. The drug is available only by prescription and sold under several different brand names, including Fortamet, Glumetza, Riomet, Glucophage and Glucophage XR. Your dosage will depend on your normal diet and exercise habits -- too much metformin can lead to low blood sugar and hypoglycemia. Always follow your doctor's directions for taking your medication. Video of the Day Metformin works by limiting your liver's production of glucose and stopping your body from absorbing some of the glucose in your bloodstream. Additionally, metformin increases your body's sensitivity to insulin, allowing your pancreas to produce less insulin. Keeping blood sugar levels stable can decrease hunger and food cravings, leading to weight loss. Metformin is not an appetite suppressant, nor does it boost metabolism; to lose weight, you'll still need to pay close attention to your diet and increase your physical activity. Standard vs. Extended Release Options The amount of metformin you'll take depends on why you are using the medication, how often you take the medicine, other medications you might be taking and the time between doses. The National Institutes of Health explains that metformin is available as a tablet or a liquid solution. Tablets come in an extended release dose -- Glucophage XR -- or in a standard release option. Extended release pills are designed to be taken once daily, with your evening meal. Standard tablet and liquid solutions may be taken once or multiple times daily -- with meals. Metformin should be taken with food. Always follow your doctor's orders. It's typical to start with a 500 milligram dose once daily, then increase both the amount of medication and the frequency. If you're using Continue reading >>
Timing Your Metformin Dose
The biggest problem many people have with Metformin is that it causes such misery when it hits their stomachs that they can't keep taking it even though they know it is the safest and most effective of all the oral diabetes drugs. In many cases all that is needed is some patience. After a rocky first few days many people's bodies calm down and metformin becomes quite tolerable. If you are taking the regular form of Metformin with meals and still having serious stomach issues after a week of taking metformin, ask your doctor to prescribe the extended release form--metformin ER or Glucophage XR. The extended release form is much gentler in its action. If that still doesn't solve your problem, there is one last strategy that quite a few of us have found helpful. It is to take your metformin later in the day, after you have eaten a meal or two. My experience with metformin--and this has been confirmed by other people--is that it can irritate an empty stomach, but if you take it when the stomach contains food it will behave. There are some drugs where it matters greatly what time of day you take the drug. Metformin in its extended release form is not one of them. As the name suggests, the ER version of the pill slowly releases the drug into your body over a period that, from my observations, appears to last 8 to 12 hours. Though it is supposed to release over a full 24 hours, this does not appear to be the case, at least not with the generic forms my insurer will pay for. Because there seems to be a span of hours when these extended release forms of metformin release the most drug into your blood stream, when you take your dose may affect how much impact the drug has on your blood sugars after meals or when you wake up. For example, the version I take, made by Teva, releases Continue reading >>
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Drug information provided by: Micromedex This medicine usually comes with a patient information insert. Read the information carefully and make sure you understand it before taking this medicine. If you have any questions, ask your doctor. Carefully follow the special meal plan your doctor gave you. This is a very important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed. Metformin should be taken with meals to help reduce stomach or bowel side effects that may occur during the first few weeks of treatment. Swallow the extended-release tablet whole with a full glass of water. Do not crush, break, or chew it. While taking the extended-release tablet, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about. Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way. You may notice improvement in your blood glucose control in 1 to 2 weeks, but the full effect of blood glucose control may take up to 2 to 3 months. Ask your doctor if you have any questions about this. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the Continue reading >>
[bedtime Administration Of Metformin May Reduce Insulin Requirements].
Abstract The administration of metformin, as glucophage retard, at bedtime instead of supper time may improve diabetes control by reducing morning hyperglycemia. This modification of glucophage treatment was tried in 3 groups of diabetic patients: I. those with secondary failure of routine treatment with sulfonylurea (SU) and glucophage; II. those with combined SU and bedtime insulin; III. Type 1 patients with early morning hypoglycemia. The first 3 months of observation in 258 patients showed that 136 (52.7%) reacted very well to the change. In Group I the addition of insulin to SU could be postponed. In Group II, night insulin could be reduced or eliminated. In Group III, evening or night insulin could be reduced by up to 70%. There was no early morning hypoglycemia nor morning hyperglycemia. The success rate in the 2 Type 2 groups was better (72% and 60%) than in the Type 1 group (34%). 30 patients (11.6%) had to stop the treatment because of side effects of the glucophage (mainly diarrhea or nausea). So far, we have found no clinical signs that might indicate which patients might benefit from this modification of treatment. A fasting blood sugar done within 2-3 days after the change in treatment may immediately indicate whether the new treatment is effective. Continue reading >>
What Time Of Day Do You Take Metformin?
Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. I am on two 500 mg. Metformin twice a day. I'm unsure of when to take them, as I've read so many different things. Some people take them before eating, some after. The thing that most concerns me is what time of day should I be taking them? My bottle just says two twice day. Is it best to take them with breakfast early in the a.m. (I eat at 7:00 a.m.) and then wait until dinner (which varies for me--I don't eat "dinner" at a set time, but it is usually around 4 p.m. or so). When do YOU take Metforming (if that is the drug you are using). Thanks for any advice you can give. I've been taking Metformin earlier in the day (around 3 p.m.) and I eat snacks before bed (low carb), and also oftentimes take p.m. pain meds. I have found that my morning glucose reading is often too high (137-140). I can't sleep if my stomach is growling, so I have to eat something before I can sleep! It actually becomes a fairly personal thing as to when it suits you best to take your Metformin and depends on a few things. Some people experience gastric side effects for the first few weeks of taking Metformin, this can range from cramps, wind to diarrhea - for people who experience this, often the advice is to eat something before take the Metformin - the instruction from the Doctor can be "Take with food", which can be translated as don't take it on an empty stomach. I personally was very lucky and had no issues and so that didn't apply to me (I'm on the same dose as you). I generally don't eat breakfast, but take my Metformin just before leaving the house for work in the morning, or at weekends when I get up. The eveni Continue reading >>
Metformin Weight Loss – Does It Work?
Metformin weight loss claims are something that are often talked about by health professionals to be one of the benefits of commencing metformin therapy, but are they true? At myheart.net we’ve helped millions of people through our articles and answers. Now our authors are keeping readers up to date with cutting edge heart disease information through twitter. Follow Dr Ahmed on Twitter @MustafaAhmedMD Metformin is possibly one of the most important treatments in Type II Diabetes, so the question of metformin weight loss is of the utmost importance, as if true it could provide a means to lose weight as well as control high sugar levels found in diabetes. What is Metformin? Metformin is an oral hypoglycemic medication – meaning it reduces levels of sugar, or more specifically glucose in the blood. It is so effective that the American Diabetes Association says that unless there is a strong reason not to, metformin should be commenced at the onset of Type II Diabetes. Metformin comes in tablet form and the dose is gradually increased until the maximum dose required is achieved. How Does Metformin Work & Why Would it Cause Weight Loss? Metformin works by three major mechanisms – each of which could explain the “metformin weight loss” claims. These are: Decrease sugar production by the liver – the liver can actually make sugars from other substances, but metformin inhibits an enzyme in the pathway resulting in less sugar being released into the blood. Increase in the amount of sugar utilization in the muscles and the liver – Given that the muscles are a major “sink” for excess sugar, by driving sugar into them metformin is able to reduce the amount of sugar in the blood. Preventing the breakdown of fats (lipolysis) – this in turn reduces the amount of fatt Continue reading >>
Metformin Can Cause Night Sweats
Dear Dr. Roach • As a preventive measure for prediabetes, my doctor recommended I take 500 mg of metformin twice a day (morning and evening). I have been following this regimen for two months. I am a female, 58, and other than needing to lose about 20 pounds, am in good health, exercise every day and eat a healthy diet. The same day I started the medication, my night sweats started up again, with a vengeance. On the metformin, my quality of sleep was negatively affected by four to five episodes of bad hot flashes every night. Because hot flashes/night sweats were not mentioned as a side effect either by my doctor or on the information pamphlet, I notified my doctor. He suggested stopping the metformin for two to four weeks to see if the night sweats subsided. I had immediate relief with the night sweats the first day I stopped the medication. Some research indicates that metformin causes hypoglycemia, which then causes the night sweats. A sometimes-mentioned desirable side effect is weight loss. What is your take on metformin and whether it is a help or a hindrance to good health? — R.M.T. Answer • Metformin was tested in a large trial to see whether it could help prevent people at high risk for diabetes from developing overt diabetes, and it was successful at doing so. It wasn’t quite as successful as a good diet and regular exercise, but many experts do use metformin, especially in overweight people, to help them lose weight and reduce their diabetes risk. In my opinion, it works best when combined with a healthy diet and regular exercise. However, it does have side effects. Gastrointestinal side effects, especially diarrhea but also nausea, are the most common. Hot flashes are listed as occurring in 1 to 10 percent of people taking the medication, and I found Continue reading >>
Can Metformin Help With Weight Loss?
Metformin is a drug prescribed to manage blood sugar levels in people with type 2 diabetes. You may have heard that metformin can also help you lose weight. But is it true? The answer is a resounding maybe. Here’s what you should know about what metformin can do for weight loss, as well as why your doctor may prescribe it for you. According to research, metformin can help some people lose weight. However, it’s not clear why metformin may cause weight loss. One theory is that it may prompt you to eat less by reducing your appetite. It may also change the way your body uses and stores fat. Although studies have shown that metformin may help with weight loss, the drug is not a quick-fix solution. According to one long-term study, the weight loss from metformin tends to occur gradually over one to two years. The amount of weight lost also varies from person to person. In the study, the average amount of weight lost after two or more years was four to seven pounds. Taking the drug without following other healthy habits may not lead to weight loss. Individuals who follow a healthy diet and exercise while taking metformin tend to lose the most weight. This may be because metformin is thought to boost how many calories you burn during exercise. If you don’t exercise, you likely won’t have this benefit. In addition, any weight loss you have may only last as long as you take the medication. That means if you stop taking metformin, there’s a good chance you will return to your original weight. And even while you’re still taking the drug, you may slowly gain back any weight you’ve lost. In other words, metformin may not be the magic diet pill some people have been waiting for. It has been shown to reduce weight in some, but not others. One of the benefits of metformin Continue reading >>
Metformin Weight Loss – How It Works, Benefits, And Side Effects
Do you find it extremely difficult to refrain from eating all the time? Have you gained too much weight? Or did your doctor just tell you that you have polycystic ovaries? If you answered “yes” to any one of these questions, chances are your body is resistant to insulin. According to the National Institute of Diabetes and Digestive and Kidney Diseases, insulin resistance can lead to diabetes type 2, prediabetes, and infertility. This can take a toll on your physical and emotional health (1). To counteract these health problems, doctors often prescribe the drug Metformin. This drug has helped many to lose weight and improve insulin sensitivity, and it can definitely help you too. So, read on to find out how Metformin can help you lose weight, the dosage, side effects, and much more. What Is Metformin? Metformin is a drug that helps to control the blood glucose levels. It is a derivative of biguanide (a group of drugs that prevent the production of glucose by the liver) that helps to improve insulin sensitivity, thereby reducing the sugar levels in the blood and the risk of diabetes type 2. It also helps regulate the amount of sugar absorbed in the intestine. Metformin was first synthesized in the 1920s. But only in 1957, it was made available in the market as an effective antidiabetic drug. It is generally sold under the brand name Glucophage and is taken orally. It is taken by people who are obese and at the risk of developing diabetes type 2 and by women who have irregular periods and are at a risk of PCOs and infertility (2). So, how does Metformin aid weight loss? Find out next. Metformin And Weight Loss – How It Works ? In obese individuals, metformin acts by suppressing the production of sugar by the liver. It reduces the rate of gluconeogenesis and glycogeno Continue reading >>
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3 Things You Need To Know About Metformin
September 30, 2015 by Dr. Brooke in Be Better , Eat Better , pcos 3 Things You Need To Know About Metformin Metformin is recommended by doctors for women with PCOS that want to loose weight or otherwise manage their PCOS and insulin resistance. But there are 3 very important things that you need to know about it including the fact that it's not the only option! Let me first say, I dont hate Metformin for women with PCOS . For some women it really does help spur ovulation, control blood sugar and help with some weight management but.its not without its share of issues. And its definitely not the magic bullet for weight loss although its usually presented that way. How Metformin (or its generic form: Glucophage) Works Metformin is typically given with meals throughout the day, or more commonly now the extended release version is given once with dinner or at bedtime. While only having to pop a pill one time per day is always appealing, this once a day dosing (especially at bedtime) is where I see the most problems with my patients. It lowers both fasting and post meal glucose levels by decreasing the glucose absorption in your intestines after a meal; as well as decreasing the amount of glucose your liver makes for later use. It also does help improve insulin sensitivity by increasing glucose movement into a cell. All sounds good so far right? Not so fast, here are the most common issues I see in women using Metformin: Metformin is notorious for causing sometimes severe digestive issues including stomach pain or upset, nausea, vomiting, diarrhea and even a sense of body weakness or metallic taste in the mouth in some. And it is touted as not causing low blood sugar as many older blood sugar lowering drugs did, however I see it every day in my practice that Metformin can m Continue reading >>
Diabetes-prevention Drug Metformin Can Cause Night Sweats
DEAR DR. ROACH: As a preventive measure for prediabetes, my doctor recommended I take 500 mg of metformin twice a day (morning and evening). I have been following this regimen for two months. The same day I started the medication, my night sweats started up again, with a vengeance. On the metformin, my quality of sleep was negatively affected by four to five episodes of bad hot flashes every night. Since hot flashes/night sweats were not mentioned as a side effect either by my doctor or on the information pamphlet, I notified my doctor. He suggested stopping the metformin for two to four weeks to see if the night sweats subsided. I had IMMEDIATE relief with the night sweats being eliminated the first day I stopped the medication. I am a 58-year-old female, and other than needing to lose about 20 pounds, am in good health, exercise every day and eat a healthy diet. Some research indicates that metformin causes hypoglycemia, which then causes the night sweats. A sometimes-mentioned desirable side effect is weight loss. What is your take on metformin and whether it is a help or a hindrance to good health? -- R.M.T. ANSWER: Metformin was tested in a large trial to see whether it could help prevent people at high risk for diabetes from developing overt diabetes, and it was successful at doing so. It wasn't quite as successful as a good diet and regular exercise, but many experts do use metformin, especially in overweight people, to help them lose weight and reduce their diabetes risk. In my opinion, it works best when combined with a healthy diet and regular exercise. However, it does have side effects. Gastrointestinal side effects, especially diarrhea but also nausea, are the most common. Hot flashes are listed as occurring in up to 10 percent of people taking the medicati Continue reading >>
Can You Take Metformin At Night
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