Tagi Pharma, Inc.: Pharmaceutical Manufacturers, Suppliers, And Distributors
For more informationtry a trial or see the plans and pricing Serving hundreds of leading biopharmaceutical companies globally: Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors.Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data.The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free.thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user.Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. Continue reading >>
Medicine Information - Kaiser Permanente
Brand name(s): Fortamet, Glucophage XR, Glumetza Rarely, too much metformin can build up in the body and cause a serious (sometimes fatal) condition called lactic acidosis. Lactic acidosis is more likely if you are an older adult, if you have kidney or liver disease, dehydration, heart failure, heavy alcohol use, if you have surgery, if you have X-ray or scanning procedures that use iodinated contrast, or if you are using certain drugs. For some conditions, your doctor may tell you to stop taking this medication for a short time. Ask your doctor or pharmacist for more details.Stop taking this medication and get medical help right away if you have any symptoms of lactic acidosis, such as unusual tiredness, dizziness, severe drowsiness, chills, blue/cold skin, muscle pain, fast/difficult breathing, slow/irregular heartbeat, or stomach pain with nausea/vomiting/diarrhea. Metformin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in patients with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Metformin works by helping to restore your body's proper response to the insulin you naturally produce. It also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb. This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.Metformin may be used with lifest Continue reading >>
Metformin Hydrochloride - Tagi Pharma, Inc.
Prescription Drug Information: Metformin Hydrochloride By TAGI Pharma, Inc. | Last revised: 5 June 2017 METFORMIN HYDROCHLORIDE- metformin hydrochloride tablet, extended release Metformin hydrochloride extended-release tablets, USP is an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N,N -dimethylimidodicarbonimidic diamide hydrochloride) is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. The structural formula is as shown: Metformin hydrochloride is a white to off-white crystalline compound with a molecular formula of C4 H11 N5 HCl and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. Metformin hydrochloride extended-release tablets, USP contain 500 mg or 750 mg of metformin hydrochloride as the active ingredient. In addition, each tablet contains the following inactive ingredients: copovidone, carboxymethylcellulose sodium, hypromellose, microcrystalline cellulose and magnesium stearate. Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Its pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Unlike sulfonylureas, metformin does not produce hypoglycemia in either patients with type 2 diabetes or normal subjects (except in special circumstances, Continue reading >>
Metformin Hydrochloride - Heritage Pharmaceuticals Inc.
Prescription Drug Information: Metformin Hydrochloride METFORMIN HYDROCHLORIDE- metformin hydrochloride tablet Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. The onset of metformin associated lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Metformin associated lactic acidosis was characterized by elevated blood lactate levels (>5 mmol/Liter), anion gap acidosis (without evidence of ketonuria or ketonemia), an increased lactate/pyruvate ratio; and metformin plasma levels generally >5 mcg/mL [see Warnings and Precautions ( 5.1 ) ]. Risk factors for metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs (e.g. carbonic anhydrase inhibitors such as topiramate), age 65 years old or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (e.g., acute congestive heart failure), excessive alcohol intake, and hepatic impairment. Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high risk groups are provided [see Dosage and Administration ( 2.3 ), (2.7), Contraindications ( 4 ), Warnings and Precautions ( 5.1 )]. If metformin-associated lactic acidosis is suspected, immediately discontinue metformin hydrochloride tablets and institute general supportive measures in a hospital setting. Prompt hemodialysis is recommended [see Warnings and Precautions ( 5.1 ) ]. Metformin hydrochloride tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus. The recommen Continue reading >>
Metformin Manufacturer Information
Given that most people take a generic form of Glucophage because of costs, combined with Paiges bad experience with one type, I decided to add to her excellent research (thank you, Paige, with my apology for not having credited you properly!) and create a free-standing Metformin Thread. Heres what Paige came up with after searching the net for anecdotal information on several of the Metformin generics. Please remember that your experience may differ. Heritage: Not a lot of data (there is now; see below) Sandoz: Works (not for me, much; see below for why) The actual medication and the amount of it, metformin hydrochloride, is the same for brand name and generics. Thats required by law. The difference between performance then, are the fillers used to bind the medication into a pill, as well as any coatings. People can be so affected by the particular fillers used, that they may not be able to absorb much of the medication. This is apparently what happened when Armour reformulated two years ago. That reformulation contained new fillers, and non-absorption complaints followed in massive numbers a month or so later. Fillers matter. In fact, some of them, as youll see below, might kill you. Extended Release Metformin is the worst form you can use. There isnt a single manufacturer who doesnt use fillers that make proper absorption difficult, and reports of digestive issues with it is legion. Furthermore, there is never a good reason to use it. Take regular Metformin and simply divide it up during the day or evening. Caveat Emptor has never been so important as it is here. I went hunting for filler information from every company I could find. Walmart Mail Order (as opposed to Walmart stores, whose warehouses different than the mail order warehouses currently use Sandoz) now us Continue reading >>
Full List Of Metformin Recalls, Fda 2012-2017
Metformin is a popular generic, widely used and generally well tolerated for the treatment of type 2 diabetes. If you use sharps check out this helpful article on Sharps Container Disposal. Despite being made by dozens of manufacturers around the world, to date there have been only 15 recalls of the popular drug, with most being minor. The exceptions are a 27,000 kilo recall from Smruthi Organics in early 2014, and a recall of 117,049 sample cartons from Bristol-Myers Squibb in 2012. The next biggest Metformin recall after that came from Actavis Laboratories and affected 13,284 bottles in 2015. Metformin Recalls There have been 15 total recalls of Metformin from 2012 through 2017. The Metformin recalls involved a grand total of over 150,000 bottles of the popular diabetes medication. The most recent was a Class II event in late 2016 from Ascend Laboratories. Several other companies have been the focus of Metformin recalls. Most of the incidents were relatively small, in the sub-7,000 bottles range. The biggest by pill count was a 2012 recall from Bristol-Myers Squibb that affected over 117,000 sample packs. Metformin Facts Metformin is a diabetes medication in oral form that helps manage blood sugar levels. It’s used in cases of type 2 diabetes. It’s sometimes given along with insulin and other medications. It’s not meant for type 1 diabetes. Serious side effects can include allergic reaction with difficulty breathing or facial swelling, and dangerous or even fatal lactic acidosis marked by numbness, fatigue, slow heart rate, and vomiting. More common side effects are nausea, upset stomach, vomiting, and diarrhea. Major Metformin Recalls There have been three major Metformin recalls and several minor ones. The biggest in terms of bottles/cartons was a 2012 recall Continue reading >>
Ndc Code 51224-007-50 Metformin Hydrochloride
All contents of this website are provided on an "as is" and "as available" basis without warranty of any kind. The contents of the National Drug Codes List website are provided for educational purposes only and are not intended in any way as medical advice, medical diagnosis or treatment. Reliance on any information provided by the National Drug Codes List website or other visitors to this website is solely at your own risk. Many of Over the Counter drugs are not reviewed by the FDA but they might be marketed to the public if the product complies with the applicable rules and regulations. The information in this website is intended for healthcare providers and consumers in the United States. The absence of a warning or notice for a given drug or drug combination is not indication that the drug or drug combination are safe, appropriate or effective for any given patient. If you have questions or concerns about the substances you are taking, check with your healthcare provider. If you think you may have a medical emergency, please call your doctor or 911 immediately. Continue reading >>
Dailymed - Metformin Hydrochloride- Metformin Hydrochloride Tablet, Extended Release
Compared with placebo, improvement in glycemic control was seen at all dose levels of metformin hydrochloride extended-release tablets and treatment was not associated with any significant change in weight (see DOSAGE AND ADMINISTRATION for dosing recommendations for metformin hydrochloride extended-release tablets). A 24-week, double-blind, randomized study of metformin hydrochloride extended-release tablets, taken once daily with the evening meal, and metformin hydrochloride tablets, taken twice daily (with breakfast and evening meal), was conducted in patients with type 2 diabetes who had been treated with metformin hydrochloride tablets 500 mg twice daily for at least 8 weeks prior to study entry. The metformin hydrochloride tablets dose had not necessarily been titrated to achieve a specific level of glycemic control prior to study entry. Patients qualified for the study if HbA1C was 8.5% and FPG was 200 mg/dL. Changes in glycemic control and body weight are shown in Table 3. Table 3: Summary of Mean Changes from Baseline * in HbA1C, Fasting Plasma Glucose, and Body Weight at Week 12 and at Final Visit (24-week study) There have been postmarketing cases of metformin-associated lactic acidosis, including fatal cases. These cases had a subtle onset and were accompanied by nonspecific symptoms such as malaise, myalgias, abdominal pain, respiratory distress, or increased somnolence; however, hypotension and resistant bradyarrhythmias have occurred with severe acidosis. Metformin-associated lactic acidosis was characterized by elevated blood lactate concentrations (> 5 mmol/L), anion gap acidosis (without evidence of ketonuria or ketonemia), and an increased lactate: pyruvate ratio; metformin plasma levels were generally > 5 mcg/mL. Metformin decreases liver uptake of Continue reading >>
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News, Why Does Metformin Stink? Here's Why.
News, Why does metformin stink? Here's why. Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. News, Why does metformin stink? Here's why. Diabetes Drug Stinks 'Like Dirty Socks', Doctors Find WASHINGTON The commonly used diabetes drug metformin stinks, literally, and this may explain why many patients stop taking it, U.S. doctors reported on Monday.The drug smells like fish or dirty socks to some people and this could account for the well-known side effects of the drug, which can make people nauseated, they said. But the problem could be solved by coating the pills so they do not smell or release the odor into the stomach, where it can be burped up, they wrote in a letter to the Annals of Internal Medicine. "We wonder why this reaction to metformin has not been previously reported," Dr. Allen Pelletier of the Medical College of Georgia and colleagues wrote in a letter to the journal. "Patients may report that metformin nauseates them but do not further elaborate or distinguish this as a visceral reaction to the smell of the medication." The first had taken brand-name metformin (Glucophage, made by Bristol-Myers Squibb) for several years before being switched to an immediate release, generic version of metformin, which he refused to take. "He reported that it smelled like 'dead fish' and nauseated him," they wrote. An extended release generic version, coated to make it dissolve more slowly, solved the problem. A second man refused to ever take metformin again, even coated formulations, they said. "Our cases show that the distinctive odor of metformin (independent of other, well-known gastrointestinal adverse effects of the medication) causes Continue reading >>
Which Generic Brand Metformin
Would like to make a decision regarding which generic brand of Metformin ER to buy. You have years of experience and knowledge. Have been pre-diabetic since my 20's. Started watching carb count in my early 50's and have kept myself from going full on diabetic. My age is now tracked on the geologic time scale. My GP and naturopath both want to see my fasting blood sugar lower, currently 115-120 upon waking, and both doctors keep pestering me about it. Keep my carbs around 40-50 gm./day. Front load my carbs and meat/veggies dinner. Tried eating protein snack before bed. Can't bring the fasting blood sugar any lower and both doctors have given me prescriptions for Metformin ER. Still sitting on them. Wish to avoid as much stomach upset as possible. Glucophage XL highly recommended but not covered by my insurance and way to spendy out of pocket. Any other way to purchase? Been doing research on generic brands and the Amneal from Walmart looks like a no-go. Teva no-go. Sun no-go. What brands work well and spare one from cramping and so forth. My online research predominates with the Extended Release as it makes Metformin easier on the stomach. That true? Was thinking of starting with 500 mg. ER 1/day with night meal to affect fasting blood sugar. Increase 500 mg. when I can tolerate the meds. Sound reasonable? Looking forward to your vast reservoir of knowledge. I had a very bad time with metformin. When I switched to metformin ER things got better. But it has to be metformin ER made by Teva. Metformin ER from other manufacturers gives me terrible gas and cramping. I think that there was a blog post here where the author also found the Teva was the best (and also most expensive) generic version. "My fitness trajectory in my senior years does not have to be a continuous down Continue reading >>
Oser Communications Group
cover previous page 11 next page back cover C h a i n D r u g s t o r e D a i l y S u n d a y, A u g u s t 7 , 2 0 1 61 2CARE-DRIVEN VALUE-ADDEDPHARMACY ACCREDITATIONThe Compliance Team's (TCT) pharma-cyaccreditation is the first accreditationmodel that is operations-based and care-driven, built upon existing day-to-daypharmacy routines while incorporatingsimplified measures to account fortoday's star-ratings payment and regula-tory realities.There's also a hands-on aspect toThe Compliance Team's accreditationprocess that isn't found in other national-ly recognized accreditation programs.Each new participating pharmacy isassigned a TCT Advisor who acts as amentorthroughout the implementationprocess, conducting a series of webinarsand teleconferences dealing with everyaspect of a pharmacy's daily business andpatient care practices.Process simplification is the key.The Compliance Team's industry-leadingSafety-Honesty-Caringquality stan-dards serve as plain language templatesfor setting in place an operations-basedmeasured improvement program thathelps pharmacies streamline their patientcare practices andimprove overall opera-tional efficiencies with-out disrupting their exist-ingeveryday work envi-ronments to do so.In addition, its Medicare-approvedDMEPOS accreditation is included inevery TCT Community Pharmacy pro-gram. Also featured are tracks for Infusion,Sterile and Non-sterile Compounding,Specialty Drugs, Long Term Care and anIn-store Clinic accreditation based on itsPart A Medicare-approved program forRural Health Clinics.Adding to all that, the companygives participating pharmacies access toits national Patient QualityMeasurement satis-faction reporting andbenchmarking data-base service, theindustry'soldest andlargest, and more than200 accreditation-related docume Continue reading >>
Metformin Smelling Fishy? What You Can Do.
Researchers have discovered what many people with diabetes have known for years: The popular Type 2 diabetes drug metformin (brand names Glumetza, Riomet, Glucophage, Fortamet, and others) has a distinctive scent that, for some people, is enough to cause them to stop taking it. But as the most widely prescribed diabetes drug in the United States, metformin plays an important role in helping people with Type 2 diabetes control their blood glucose levels, and experts have suggested several solutions for dealing with the medicine’s unique scent. In a letter published in the Annals of Internal Medicine, physicians from the Medical College of Georgia described two adult men with Type 2 diabetes who complained of a “dead fish” odor of metformin that had led both men to stop taking the medicine. Searching the medical literature for more information, author J. Russell May, PharmD, and colleagues found no reports of this issue. Upon searching the Internet, however, the researchers came across hundreds of message board posts referencing metformin’s odor, and an informal survey of pharmacists found that many could identify the medicine by its distinct smell. May and his colleagues wrote to the journal to raise awareness of this issue and questioned whether nausea, one of the most commonly reported side effects of metformin, could in some cases in fact be a reaction the fishy odor. May noted that “Metformin is an excellent drug, but the immediate-release formulation may have an odor to it. The smell is fishy or like the inside of an inner tube, and in a patient’s mind…they may think the drug isn’t good.” (A manufacturer of metformin notes that there has been no association between the odor of metformin and its effectiveness.) The authors indicated that switching t Continue reading >>
Fda Warns Sun Pharmaceutical Of Quality Problems
FDA Warns Sun Pharmaceutical of Quality Problems The US FDA has sent Indian drug maker Sun Pharmaceutical Industries a letter warning that its quality control problems persist. Sun Pharmaceutical Industries is Indias largest drug manufacturer. It supplies many generic medications to the U.S. market. But the giant is once again in trouble with US regulators. The Food and Drug Administration has issued another warning letter to the company because one of its major manufacturing plants has fallen short on quality control. The problems the FDA noted in its most recent communication are very similar to those named in a letter sent earlier this year. Sun Pharmaceutical purchased another large Indian generic drug maker, Ranbaxy, which also ran afoul of FDA on quality control problems. Ranbaxy agreed to pay $500 million in fines in May 2013 after pleading guilty to making false statements and violating drug safety laws. Another Indian generic drug manufacturer, Dr. Reddys Laboratories, has also been the target of FDA scrutiny. The company received a warning letter last month because of quality control problems, especially data integrity. Indian drug makers provide at least 40 percent of the generic drugs Americans take each year. This is not the first time we have written about trouble with poor quality control in certain Indian manufacturing plants. You can read more here and here . The message we hear repeatedly from the FDA about generic drugs is thatthe agency has everythingunder control and there is nothing to worry about. Nevertheless, we keep reading about violations in India and other countries. Unfortunately, the FDA rarely reveals which medications have been affected. There is no country of origin label on your prescription bottle so you have no way of knowing whethe Continue reading >>
Ndc 51224-007 Metformin Hydrochloride
Certain drugs tend to produce hyperglycemia and may lead to loss of glycemic control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving metformin, the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from a patient receiving metformin, the patient should be observed closely for hypoglycemia.In healthy volunteers, the pharmacokinetics of metformin and propranolol, and metformin and ibuprofen were not affected when coadministered in single-dose interaction studies.Metformin is negligibly bound to plasma proteins and is, therefore, less likely to interact with highly protein-bound drugs such as salicylates, sulfonamides, chloramphenicol, and probenecid, as compared to the sulfonylureas, which are extensively bound to serum proteins. Manufactured by: CSPC Ouyi Pharmaceutical Co., Ltd.Shijiazhuang, Hebei, ChinaManufactured for: TAGI Pharma, Inc.South Beloit, IL 61080Rev. 05/2016 Metformin hydrochloride extended-release tablets, USP is an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. The structural formula is as shown:Metformin hydrochloride is a white to off-white crystalline compound with a molecular formula of C4H11N5 HCl and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformi Continue reading >>
Metformin 500mg (51224-007) - Medication Videos - Myrx.tv
Metformin is the name of the medication. It comes in the form of a tablet, and should be taken by mouth. It belongs to a class of medications called Biguanide. This medication is used to treat type-2 diabetes and pre-diabetes conditions. Normally, when you eat food, the body breaks down all of the sugars and starches into a sugar called glucose. This is the basic fuel for the cells in the body. The body needs Insulin to be able to use this sugar for energy. Insulin takes the sugar from the blood into the cells. In type 2 diabetes, either the body does not produce enough insulin or the cells ignore the insulin. This causes glucose to build up in the blood instead of going into cells. It can lead to serious diabetes complications. Metformin belongs to a group of medications called Biguanides. They work by decreasing the amount of sugar produced by the liver and increasing the amount of sugar absorbed by muscle cells. As a result you get more sugar in the cells and less is in the blood. This medication comes as a tablet. You should put it in your mouth and swallow it with a glass of water. Do not chew, break or crush it. Swallow it whole. Tell your physician if you become pregnant. There are not enough studies about this medication in pregnant women. Use the medication during pregnancy only if clearly needed. Continue reading >>