diabetestalk.net

Substitute For Januvia

Januvia 50mg Tablet - Uses, Side Effects, Substitutes, Composition And More | Lybrate

Januvia 50mg Tablet - Uses, Side Effects, Substitutes, Composition And More | Lybrate

Prescription vs.OTC: Prescription by Doctor required Januvia 50Mg Tablet is a drug prescribed to patients with type 2 diabetes. It helps in reducing the blood sugar level in the body. It is classified under DDP-4 inhibitor class of medications. It is taken with diet and regular exercise and is sometimes prescribed along with other medications. It comes as a tablet and is consumed orally. However, note that it is used to lower blood sugar levels only and not to cure diabetes in itself. Possible side effects of Januvia 50Mg Tablet include nausea, chills, seizures , dizziness , Anxiety , headache fast heartbeat and slurred speech. It can also cause nightmares and cold sweats and severe skin reaction. Consult your doctor immediately if you notice any unusual effects. It can also cause some minor side effects like sore throat , sneezing , stuffy or runny nose or even cough . Januvia 50Mg Tablet is not used for treating type 1 diabetes and is not advised for people with high blood ketone levels. You should consult your doctor before you use Januvia 50Mg Tablet if you are pregnant , breast-feeding, have any kidney problems. It is also not advised for people that have a history of conditions like gallstones , Angioedema or swelling of pancreas. What are the side effects of Januvia 50Mg Tablet? In addition to its intended effect, Januvia 50Mg Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication. Taking Sitagliptin with alcohol may affect blood glucose levels in patients with diabetes . Taking metformin with alcohol can cause lactic acidosis and you may experience malaise, respiratory distress, slow Continue reading >>

(sitagliptin And Metformin Hcl) Tablets Or

(sitagliptin And Metformin Hcl) Tablets Or

JANUMET tablets contain 2 prescription medicines: sitagliptin (JANUVIA®) and metformin. Once-daily prescription JANUMET XR tablets contain sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. JANUMET or JANUMET XR should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUMET or JANUMET XR. Selected Risk Information About JANUMET and JANUMET XR Metformin, one of the medicines in JANUMET and JANUMET XR, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet; feel dizzy or lightheaded; have a slow or irregular heartbeat; feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; feel sleepy or drowsy; have stomach pains, nausea, or vomiting. Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Tell your doctor if you have any of the following, because you have a higher chance of getting lactic acidosis with JANUMET or JANUMET XR if you: have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye; have liver problems; drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinkin Continue reading >>

Sitagliptin Rivals Glimepiride For Glycemic Control With Less Hypoglycemia And No Weight Gain

Sitagliptin Rivals Glimepiride For Glycemic Control With Less Hypoglycemia And No Weight Gain

The addition of the highly selective, once-daily dipeptidyl peptidase (DPP)-4 inhibitor sitagliptin (Januvia), compared with glimepiride (Amaryl), to background metformin therapy provides similar glycemic control in type 2 diabetics but, importantly, produces significantly fewer hypoglycemic episodes and also results in weight loss, new data show. The findings were announced at the 46th European Association for the Study of Diabetes (EASD) meeting. Most therapeutic guidelines recommend the use of metformin as initial monotherapy for the treatment of type 2 diabetes, Barry Goldstein, MD, with Merck Laboratories in Rahway, New Jersey, explained in his presentation. However, metformin alone is often unsuccessful at achieving adequate glycemic control in type 2 patients, thus necessitating the addition of a second oral antihyperglycemic agent. Sulphonylureas are the most common oral antihyperglycemic agents used in combination with metformin among patients who do not achieve or maintain glycemic control on metformin alone, he added. A prior study had shown that the hemoglobin (Hb)A1C-lowering efficacy of adding sitagliptin to ongoing metformin therapy was non-inferior to the addition of the sulphonylurea glipizide. The present study included 1,035 type 2 diabetic patients who had inadequate glycemic control while on a stable dose of metformin following a two-week placebo-run-in phase. Patients were randomized to the addition of 30 weeks-treatment with sitagliptin 100 mg/day or glimepiride 1 mg/day (uptitrated to a potential maximum 6 mg/day) to ongoing metformin monotherapy. The primary efficacy analysis evaluated whether sitagliptin was non-inferior to glimepiride in reducing HbA1C from baseline at week 30 in the per-protocol study population. The study found overall mean Continue reading >>

Alternatives For Januvia

Alternatives For Januvia

Januvia is a brand name for an oral anti-hyperglycemic drug that lowers blood sugar or glucose levels. This prescription medication contains the active ingredient sitagliptin and belongs to a class of drugs called dipeptidyl peptidase-4 inhibitors. Januvia is taken once a day and works to regulate blood sugar levels in type 2 diabetics in two ways. Januvia.com notes that it helps increase the levels of insulin produced by the pancreas. Insulin is a hormone that is necessary to carry glucose from the blood into the cells of the body, where it can be used. Januvia also decreases blood glucose levels by decreasing the amount of glucose made by the liver. Like all medications, Januvia can cause side effects and may not be suitable for all patients. There are several alternative medications for treating type 2 diabetes. Video of the Day Metformin is commonly sold under the brand name Glucophage and is in the biguanide class of drugs. It is the most popularly prescribed medication and often the first line of treatment for patients with type 2 diabetes. Drugs.com notes that metformin works by reducing blood glucose levels as well as by heightening the sensitivity of body cells to the hormone insulin. Metformin is sometimes prescribed in combination with other diabetes medications or insulin. In individuals with pre-diabetes or a risk of becoming diabetic, metformin is often prescribed as a preventative measure, along with nutritional and exercise therapies. Glyburide is a medication in a class of diabetes drugs called sulfonylureas. These drugs bind to receptors on the beta cells of the pancreas to stimulate more production of insulin. DiabetesNet.com notes that sulfonylurea medications have been used for the treatment of diabetes for many years and are often prescribed with m Continue reading >>

Top Doc: Beware Of New Diabetes Medication

Top Doc: Beware Of New Diabetes Medication

An alarming link to pancreatic cancer should prompt users of the new diabetes drug Januvia to seek safer alternatives, says renowned physician Chauncey Crandall, M.D. Dr. Crandall’s advice for diabetes patients: First try to manage your health with improved diet and fitness, which can often be as effective as drugs. For those who require medication, choose an older drug — such as the longtime diabetes medicine metformin — as first-line defense. Only those who don’t benefit from older drugs with a long record of safety and effectiveness should consider a newer medicine like Merck's Januvia. "I think the bottom line is that all drugs carry risks," Dr. Crandall tells Newsmax Health. "Many have great benefits, but all have side effects and risks. The longer I’ve been in medicine the more I observe this, so we always need to weigh the risk-benefit ratio." ALERT: These 5 Things Activate Cancer In Your Body Dr. Crandall adds that he is particularly "suspicious"of new drugs, pushed by drug companies as better alternatives to tried-and-true treatments in heavy marketing campaigns aimed at doctors. "We are constantly bombarded by drug companies and reps who come to our offices proclaiming their new medicine is the best, and many physicians are pushed to use newer agents because of the persistence of drug company reps. But I’m always trying to wait for a track record — a historical foundation that shows a drug is OK." Renowned neurosurgeon Russell Blaylock, M.D., is also troubled by the new research findings and the implications for patients. "Based on what I have read I would very concerned as a patient, " said Dr. Blaylock, a Newsmax contributor and editor of the Blaylock Wellness Report. "The defenders [of the drugs] were either those directly on the payroll of Me Continue reading >>

Generic Januvia Availability

Generic Januvia Availability

Januvia is a brand name of sitagliptin, approved by the FDA in the following formulation(s): JANUVIA (sitagliptin phosphate - tablet;oral) Has a generic version of Januvia been approved? No. There is currently no therapeutically equivalent version of Januvia available in the United States. Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Januvia. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication. See also: Generic Drug FAQs. Patents are granted by the U.S. Patent and Trademark Office at any time during a drug's development and may include a wide range of claims. Use of dipeptidyl peptidase IV effectors for lowering the blood glucose level in mammals Patent 6,303,661 Issued: October 16, 2001 Inventor(s): Demuth; Hans-Ulrich & Rosche; Fred & Schmidt; Joem & Pauly; Robert P. & McIntosh; Christopher H. S. & Pederson; Ray A. Assignee(s): Probiodrug Novel therapeutic regimens are provided which comprise the administration of therapeutically effective amounts of an inhibitor to dipeptidyl peptidase (DP-IV) or enzymes of similar activity whereby their ability to degrade the incretins, GLP-1 and GIP, is reduced. As a result hyperglycemia, such as that accompanying food intake may be reduced due to improved insulin release. A preferred therapeutic regimen amongst a number of routes of administration and inhibitors that may be used comprises the oral administration of isoleucyl thiazolidine. April 24, 2017 ✓ Patent use: IMPROVEMENT OF GLYCEMIC CONTROL IN ADULTS WITH TYPE 2 DIABETES MELLITUS Beta-amino heterocyclic dipeptidyl pepti Continue reading >>

Medication For Type 2 Diabetes

Medication For Type 2 Diabetes

People with type 2 diabetes are often given medications including insulin to help control their blood glucose levels. Most of these medications are in the form of tablets, but some are given by injection. Tablets or injections are intended to be used in conjunction with healthy eating and regular physical activity, not as a substitute. Diabetes tablets are not an oral form of insulin.Speak with your doctor or pharmacist if you experience any problems. An alternative medication is usually available. All people with diabetes need to check their glucose levels on a regular basis. When taking medication, you may need to check your glucose levels more often to keep you safe and to ensure the medication is having the desired effect. In Australia there are seven classes of medicines used to treat type 2 diabetes: Biguanides Sulphonylureas Thiazolidinediones (Glitazones) Alpha-glucosidase Inhibitors. Dipeptidyl peptidase 4 (DPP4) inhibitors Incretin mimetics Sodium-glucose transporter (SGLT2) inhibitors Your doctor will talk to you about which tablets are right for you, when to take your tablets and how much to take. Your doctor can also tell you about any possible side effects. You should speak to your doctor or pharmacist if you experience any problems. Chemical name: METFORMIN , METFORMIN ER Points to remember about biguanides This group of insulin tablets helps to lower blood glucose levels by reducing the amount of stored glucose released by the liver, slowing the absorption of glucose from the intestine, and helping the body to become more sensitive to insulin so that your own insulin works better They need to be started at a low dose and increased slowly Metformin is often prescribed as the first diabetes tablet for people with type 2 diabetes who are overweight. It gene Continue reading >>

Compared With Januvia® Or Byetta® | Victoza® (liraglutide) Injection 1.2 Mg Or 1.8 Mg

Compared With Januvia® Or Byetta® | Victoza® (liraglutide) Injection 1.2 Mg Or 1.8 Mg

What is the most important information I should know about Victoza®? Victoza® may cause serious side effects, including: Possible thyroid tumors, including cancer. Tell your health care provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats and mice, Victoza® and medicines that work like Victoza® caused thyroid tumors, including thyroid cancer. It is not known if Victoza® will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Who should not use Victoza®? Do not use Victoza® if: you or any of your family have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). you are allergic to liraglutide or any of the ingredients in Victoza®. What should I tell my health care provider before using Victoza®? Before using Victoza®, tell your health care provider if you: have or have had problems with your pancreas, kidneys, or liver. have any other medical conditions or severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems with digesting food. are pregnant or breastfeeding or plan to become pregnant or breastfeed. Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, herbal supplements, and other medicines to treat diabetes, including insulin or sulfonylureas. How should I use Victoza®? You may give an injection of Victoza® and insulin in the same body area (such as your stomach area), but not right next to each other. Do not share your Victoza® pen with other people, even if the needle has been changed. You may give oth Continue reading >>

Onglyza: Just Like Januvia But With More Serious Side Effects?

Onglyza: Just Like Januvia But With More Serious Side Effects?

NOTE (April 2, 2013): Before you take Onglyza or Januvia please read about the new research that shows that they, and probably all incretin drugs, cause severely abnormal cell growth in the pancreas and precancerous tumors. You'll find that information HERE. When the FDA approves a new drug it requires no proof that the drug is more effective than similar, existing drugs, only that it is better than placebo. Which is something to keep in mind as Bristol-Myers Squibb unveils what is sure to be a saturation advertising campaign for its new DPP-4 inhibitor, Onlgyza. This mellifluous moniker is the brand name for Saxagliptin, which alert followers of drug news remember as the Januvia clone developed at the same times as Januvia whose release has been blocked due to its ability to cause "skin lesions" some of which necrotized (i.e. died and fell off) in monkeys. I have read through the Prescribing Information for Onglyza and cannot see any benefit it offers in comparison to Januvia, the other DPP-4 inhibitor currently on the market. Setting aside for the time being the advisability of controlling your blood sugar by turning off a tumor suppressor gene Onglyza offers nothing not offered by Januvia. Both inhibit the expression of the DPP-4 gene for a full 24 hours--which means that if your body was fighting a new, very small DPP-4 sensitive tumor, like ovarian cancer, melanoma, prostate cancer or lung cancer, the drug would keep DPP-4 from killing off the tumor cells. 1. Feeble impact on blood sugar: Onglyza lowered A1cs that averaged 8% by .5%, which does not bring them anywhere near a safe level even by the anemic standards of the ADA. When the highest dose of Onglyza was compared to a placebo, it allowed only 14% more of those taking it to achieve 7% A1cs. To better underst Continue reading >>

Diabetes W/out Insurance

Diabetes W/out Insurance

Phoenix Diabetes and Endocrinology has compiled this information to help our patients manage their diabetes in the event they have lost their health insurance or have a very limited budget and cannot afford preferred therapies. Many type II diabetics can maintain good blood sugar control if they focus on diet, weight management and exercise as the primary therapy and use these cheaper medications discussed below when additional therapies are needed. Type I or insulin deficient diabetes patients will have a much harder time controlling their blood sugars with cheaper medications. Several insulin manufacturers have programs for diabetics without any health insurance to provide insulin at no charge. The forms for these programs are found at our needymeds link. For the type II diabetics: Some types of diabetes medications do not have generic alternatives. These include Byetta and Januvia as well as many of the modern insulin. These medications may need to be discontinued. Older insulins such as Novolin N and Regular human insulin work differently and will require more blood sugar monitoring to be used safely. Therefore, understand that these recommendations are based on cost considerations rather than obtaining optimal diabetes control while your financial resources are limited. Additionally, realize ignoring diabetes is not wise either. One ER visit for dehydration or infection due to poorly controlled blood sugars will be very expensive. Therefore, these recommendations are intended to help control costs, not replace needed medical care. Lab work There are many places where discounted lab work is available at less than half the cost of traditional labs. One such place is Lab Express 602-273-9000. A comprehensive metabolic panel cost $45 and hemoglobin A1c costs $65. I bel Continue reading >>

What Patients Say About Janumet 50 1000

What Patients Say About Janumet 50 1000

Janumet 50 1000 is the brand name (and dosage level) of sitagliptin-metformin, a combination prescription drug used in the management of type 2 diabetes. (50 refers to 50 mg of sitagliptin while 1000 refers to 1000 mg of metformin.) In addition to diet and exercise, Janumet 50 1000 is prescribed when the use of metformin or sitagliptin alone does not adequately control the condition. At PatientsLikeMe, where more than 130,000 patients are sharing their experiences with conditions, symptoms, treatments and more, 21 patients report using Janumet 50 1000 or a lower daily dosage (50 mg sitagliptin / 500 mg metformin). What can we learn from these patients’ experiences? Quite a bit, actually, thanks to PatientsLikeMe’s unique data-sharing platform. Looking at the three treatment evaluations submitted for Janumet, all three patients rate the effectiveness as “Moderate,” while side effects were marked as “Mild,” “Moderate” and “Severe,” respectively. The chief complaint from the patient who reported “Severe” side effects was diarrhea. However, she writes, “Blood sugars are going down.” JOIN PATIENTSLIKEME TODAY What about you? Have you taken Janumet 50 1000 or a different dosage of this combination diabetes medication? Join PatientsLikeMe and add your experiences to our growing body of knowledge. Then, stay to exchange advice and support, research common treatments and learn from other patients like you. Continue reading >>

What Is Good Substitute For Januvia? I Seem To Always Have Side Effects,

What Is Good Substitute For Januvia? I Seem To Always Have Side Effects,

Question Originally asked by Community Member Gary Lipnick What Is Good Substitute For Januvia? I Seem To Always Have Side Effects, Answer Gary- Hello! There are a few different medications that can treat Type 2 diabetes. Click here, it will take you to alternate medications. You should also consult with your physician. He or she knows your medical history and can lead you in the right direction. I hope this helps. Cherise Community Moderator You should know Answers to your question are meant to provide general health information but should not replace medical advice you receive from a doctor. No answers should be viewed as a diagnosis or recommended treatment for a condition. Answered By: Cherise Nicole Continue reading >>

Januvia (sitagliptin) Drug Side Effects, Interactions, And Medication Information On Emedicinehealth.

Januvia (sitagliptin) Drug Side Effects, Interactions, And Medication Information On Emedicinehealth.

What are the possible side effects of sitagliptin (Januvia)? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking sitagliptin and call your doctor at once if you have a serious side effect such as: pancreatitis - severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate; or swelling, weight gain, feeling short of breath; or severe skin reaction -- fever , sore throat , swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. nausea, stomach pain, diarrhea , constipation . This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about sitagliptin (Januvia)? Do not use this medication if you are allergic to sitagliptin or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). Before taking sitagliptin, tell your doctor if you have kidney disease , if you are on dialysis, or if you have a history of pancreatitis. You may take this medicine with or without food. Follow your doctor's instructions. Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are taking sitagliptin. Stop taking sitagliptin and call your doctor at once if you have severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, or fast heart rate. Take care not to let your blood sugar get too low. Low blood sugar (h Continue reading >>

Herbal Therapies For Type 2 Diabetes Mellitus: Chemistry, Biology, And Potential Application Of Selected Plants And Compounds

Herbal Therapies For Type 2 Diabetes Mellitus: Chemistry, Biology, And Potential Application Of Selected Plants And Compounds

Evidence-Based Complementary and Alternative Medicine Volume 2013 (2013), Article ID 378657, 33 pages 1Department of Veterinary Medicine, National Chung Hsing University, Taichung 402, Taiwan 2Department of Life Science, National Taiwan Normal University, Taipei 116, Taiwan 3Institute of Chemistry, University of the Philippines, Diliman, Quezon City 1100, Philippines 4Agricultural Biotechnology Research Center, Academia Sinica, No. 128, Academia Sinica Road, Section 2, Nankang, Taipei 115, Taiwan 5Graduate Institute of Immunology, China Medical University, Taichung 404, Taiwan 6Center for Neuropsychiatry, China Medical University Hospital, Taichung 404, Taiwan 7Institute of Pharmacology, Yang-Ming University, Taipei 112, Taiwan 8Institute of Zoology, National Taiwan University, Taipei 106, Taiwan 9Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan Received 6 February 2013; Accepted 11 March 2013 Academic Editor: William C. Cho Copyright © 2013 Cicero L. T. Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Diabetes mellitus has been recognized since antiquity. It currently affects as many as 285 million people worldwide and results in heavy personal and national economic burdens. Considerable progress has been made in orthodox antidiabetic drugs. However, new remedies are still in great demand because of the limited efficacy and undesirable side effects of current orthodox drugs. Nature is an extraordinary source of antidiabetic medicines. To date, more than 1200 flowering plants have been claimed to have antidiabetic properties. Among them, one-third have been Continue reading >>

About Januvia

About Januvia

Sitagliptin, marketed under the brand name "Januvia," is an anti-diabetic medication that can be used alone or in combination with other oral anti-diabetic drugs to control diabetes blood sugar levels. The advantage of Januvia over other available medications is that it is less likely side effects, especially weight gain and hypoglycemia (low blood sugar levels), making it an attractive alternative. It is considered a second line treatment to be used after primary therapy fails. Januvia Is A Dipeptidyl Peptidase-4 Inhibitor Januvia is in a class of medications called Dipeptidyl peptidase-4 (DPP) Inhibitors. To understand how Januvia works, it is first important to understand what happens when food enters the body. When food hits the stomach a class of chemical messengers called Incretins are released. The two main Incretins are glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP). When released, these hormones have three actions: they stimulate release of insulin from the pancreas, they reduce gastric emptying and cause a decrease in food intake, and finally they inhibit the release of glucagon, a hormone that works exactly opposite as insulin. Januvia Lowers HbA1c Levels But very quickly after Incretins are released, they are enzymatically broken down by DDP, halting their action. Januvia works by inhibiting the DDP enzyme. This allows Incretins to exist longer in the body and therefore to exert their physiologic actions on the pancreas and liver, leading to better diabetes management. In fact, use of Januvia has been associated with a 0.7% decrease in HbA1c (glycated hemoglobin) levels. HbA1c is one marker used to monitor how well diabetes is controlled. Januvia Only Appropriate In Type 2 Diabetics Because Januvia works by increasing insulin production Continue reading >>

More in diabetes