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Study Of Lipid Profile In Diabetics

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Comparison Of Lipid Profile Between Controlled And Uncontrolled Type - 2 Diabetic Subjects.

Comparison Of Lipid Profile Between Controlled And Uncontrolled Type - 2 Diabetic Subjects.

Department of Biochemistry, Shri Sathya Sai Medical College and Research Institute, Ammapettai, Nellikuppam, Kancheepuram (Dist), Tamil Nadu - 603108, India. Visit for more related articles at Research & Reviews: Journal of Medical and Health Sciences Abstract Diabetic patients with accompanied (but often unnoticed) dyslipidemia are soft targets of cardiovascular deaths. An early intervention to normalize circulating lipids shown to reduce cardiovascular complications and mortality. Glycated hemoglobin (HbA1c) is a routinely used marker for long term glycemic control. In the present study we have compared the lipid profiles between controlled diabetic subjects (HbA1c < 7%), moderately controlled (HbA1c > 7% and ≤ 9%) and Uncontrolled diabetic subjects (HbA1c >9%). We found that blood glucose levels and lipid profile parameters (except HDL) were increased significantly in uncontrolled diabetics and moderately controlled diabetics when compared to controlled diabetics. Keywords Diabetes, Glycated haemoglobin, blood glucose levels. Introduction Diabetes mellitus is a group of metabolic disease characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Diabetes causes about 5% of all deaths globally each year. The chronic hyperglycemia of diabetes is associated with long term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels. 50% of people with diabetes die of cardiovascular disease (CVD) (primarily heart disease and stroke) [1,2]. Low density Lipoprotein (LDL) is considered as an independent risk factor for the development of CVD [3]. The risk for CVD is higher in Diabetic subjects than non-diabetic subjects [4]. Glycated hemoglobin (HbA1c) is a routinely used marke Continue reading >>

Lipid Profile

Lipid Profile

A blood test, or the results of a blood test, that measures levels of lipids, or fats, including cholesterol and triglycerides. Factors such as your age, sex, and genetics influence your lipid profile. Certain aspects of your lifestyle, including your diet, level of physical activity, level of diabetes control, and smoking status, also affect your lipid profile. And some medical conditions can raise or lower cholesterol and triglyceride levels. A lipid profile is a direct measure of three blood components: cholesterol, triglycerides, and high-density lipoproteins (HDLs). Cholesterol is a vital substance that your body uses to produce such things as digestion-aiding material, hormones, and cell membranes. It is both produced by the body and absorbed from some of the foods you eat. Cholesterol and triglycerides are transported in the blood by combinations of lipids and proteins called lipoproteins. HDLs, the so-called “good” or “healthy” cholesterol, are lipoproteins made mostly of protein and little cholesterol. HDLs can help to clear cholesterol deposits in blood vessels left by another blood component called low-density lipoproteins, or LDLs. LDL levels may be calculated from the three directly measured lipids or may be more accurately measured by a direct test. LDLs and very-low-density lipoproteins (VLDLs) are the so-called “bad” cholesterols. Unlike HDLs, LDLs and VLDLs are high-cholesterol particles. While cholesterol is necessary for various bodily functions, too much cholesterol is harmful, since excess cholesterol can be deposited in blood vessel walls. These fat deposits can lead to atherosclerosis, or hardening of the arteries, and cardiovascular disease, the number one killer in the United States. High levels of triglycerides are also associated w Continue reading >>

Middle East Journal Of Family Medicine

Middle East Journal Of Family Medicine

Dr. Khalil Naemat. P.O. Box 1834 Amman 11910 Jordan. Objective: to know the incidence of hypertriglyceridaemia, its age and sex distribution and prevalence in NIDDM and IDDM and also to know the relationship between the glycaemic control and degree of hypertriglyceridaemia and incidence of complications of hypertriglyceridaemia in diabetes mellitus. Patients and Methods: one hundred and twenty patients of well-established diabetes mellitus were included in the study. All patients underwent the following investigations: 1. Base line investigations like blood CP with ESR, Blood urea, urine RE, ECG and x-ray chest. 2. Planned investigations: These included fasting and 2 hours post prandial blood glucose estimation, serum electrolytes, serum creatinine, serum amylase, uric acid, LFT's, TFT's, ETT and abdominal ultrasound to look for liver texture and for any evidence of fatty change; morphology, texture of kidney and pancreas and other abdominal viscera. 3. Total lipid profile which included: Total fasting lipids, Total fasting triglycerides, Total fasting cholesterol, HDL cholesterol and LDL cholesterol. Results: The commonest finding was hypertriglyceridaemia both in insulin- and non-insulin dependent diabetic patients. It was more so in non-insulin dependent diabetes mellitus (70%) as compared to insulin-dependent diabetics (30%). Conclusion: Hypertiglyceridaemia is the most common lipid abnormality in diabetes mellitus, which is more common in NIDDM than IDDM. Early diagnosis, good glycaemic control and dietary modification are usually enough for prevention and treating hypertriglyceridaemia in diabetes mellitus. Key words: lipid profile, diabetes mellitus, hypertriglyceridaemia Diabetes is a common endocrine disease and its complications are major stimuli for the enha Continue reading >>

Comparative Study Of Lipid Profile In Smokers, Tobacco Chewers And Diabetic Patients

Comparative Study Of Lipid Profile In Smokers, Tobacco Chewers And Diabetic Patients

Nepal Journals OnLine (NepJOL) is a service to provide access to Nepalese published research, and increase worldwide knowledge of indigenous scholarship. Read more . Department of Clinical Biochemistry, Maharajgunj Campus B. K.Yadav Department of Clinical Biochemistry, IOM, T U Teaching Hospital (TUTH) (e-mail: [email protected]/[email protected]) Comparative study of lipid profile in smokers, tobacco chewers and diabetic patients Background: Smoking, tobacco chewing and Diabetes mellitus have been well recognized risk factors for arteriosclerosis. This study was conducted to find out the effect of these factors on lipid profile in Nepal. Method: Serum lipid profile was Studied In 29 smokers, 13 tobacco chewers, 22 diabetic patients and 29 controls le. non smokers, non tobacco chewers and non diabetic individuals. Results: The mean serum total cholesterol (4.80.9 mmol/ltr) was significantly higher in smokers than in non smokers (p<0.01).Mean low density lipoprotein (LDL) cholesterol (3.20.8mmol/itr) and triglyceride (2.00.9mmol/itr) were significantly higher in smokers (p<0.005, p<0.05 respectively) whereas mean high density lipoprotein (HDL) cholesterol (0.770.18mmol/Itr)was significantly lower (p<0.05). Tobacco chewing was related to higher total cholesterol (p<0.005), higher LDL cholesterol (p<0.05) and higher triglyceride (p<0.05) levels. There was no significant difference in HDL cholesterol level, The diabetics had higher values of total cholesterol (5.00.9mmol/Itr) and triglyceride (2.10.8mmol/Itr) levels (p=0.000 and p<0.01 respectively) than controls. However, there were no significant differences in HDL cholesterol and LDL cholesterol levels. Conclusion: A moderate portion of the effect of cigarette smoking, tobacco chewing and Diabetes mellitus on risk Continue reading >>

Lipid Profile Of Type 2 Diabetic Patients At A Tertiaryhospital In Tanzania: Cross Sectional Study

Lipid Profile Of Type 2 Diabetic Patients At A Tertiaryhospital In Tanzania: Cross Sectional Study

Lipid Profile of Type 2 Diabetic Patients at a TertiaryHospital in Tanzania: Cross Sectional Study Nyasatu G. Chamba1,2,Elichilia R Shao1,2,3,4,5*,Tolbert Sonda1,3and Isaack A. Lyarru1,2 1Department of Internal medicine Kilimanjaro Christian Medical University College, TumainiUniversity, Makumira PO BOX 2240, Moshi Tanzania 2Department of Internal Medicine Kilimanjaro Christian Medical Centre, PO BOX 3010Moshi Tanzania 3Kilimanjaro Clinical Research Institute, PO BOX 2236, Moshi Tanzania 4Better Human Health Foundation, PO BOX 1348, Moshi Tanzania 5Imagedoctors Organization, PO BOX 16341, Arusha Tanzania *Corresponding author: Elichilia R Shao, Department of Internal Medicine Kilimanjaro ChristianMedical University College, Tumaini University Makumira, Moshi, Tanzania. Tel: 255784491622; E-mail: Received:December 02, 2016; Accepted:December 08, 2016; Published:February 02, 2017 Citation: Nyasatu G. Chamba, Elichilia R Shao, Tolbert Sonda,Isaack A. Lyaruu(2017) Lipid Profile of Type 2 Diabetic Patients at a Tertiary Hospital inTanzania: Cross Sectional Study. J Endocrinol Diab 4(1): 1-6 DOI: Background:Patients with diabetes mellitus are at high risk of cardiovascularevents because of abnormal lipid status. Dyslipidemiais common in diabetes mellitus and is associatedwith cardiovascular complications. Early diagnosisand treatment is the main cornerstone in the preventionof its multiple complications. There is scarcity of dataon the magnitude and risk factors associated with dyslipidemiaamong diabetic patients in the Northern zoneof Tanzania. Objective:The aim of the study was to determine the prevalenceof abnormal lipid profile levels among patients attendingthe diabetes clinic at Kilimanjaro Christian MedicalCentre, Moshi Tanzania. Methodology:A cross-sectional study wa Continue reading >>

Studies On Lipid Profile In Patients With Non Insulin Dependent Diabetes Mellitus

Studies On Lipid Profile In Patients With Non Insulin Dependent Diabetes Mellitus

Studies on lipid profile in patients with non insulin dependent diabetes mellitus Md Manzurur Rahman Shah Choudhury, Towhidul Alam, AKM Shahidur Rahman Diabetes mellitus is a global health problem and is associated with abnormalities of lipids and lipoprotein metabolism in variable frequency. The aim of the present work was to study the lipid abnormalities in NIDDM patients. Dyslipidaemia is of special interest because to compare it between male and female NIDDM patients and as well as to see the impact between women of reproductive age group and post menopausal women. For this purpose total serum cholesterol, triglyceride, LDL-C, HDL-C and LDL/HDL ratio were determined of a total number of 160 subjects. Out of these 80 subjects were diabetic and 80 were non-diabetic control subjects of both sexes. In this study, the total serum cholesterol levels were higher in NIDDM than control subjects and showed significant statistical difference (P<0.05) between control and NIDDM subjects. The serum triglyceride levels were found higher amongst diabetics as compared to the normal healthy controls and showed statistically significant difference (P<0.05). Higher LDL-C levels were showed in NIDDM and revealed significant difference (P<0.05) in comparison to control non-diabetic subjects and NIDDM patients. HDL-C levels were found decreased in patients with NIDDM compared to controls. The findings in the patients with NIDDM between male and female revealed no significant difference (P>0.05) in mean TC, TG, HDL-C and LDL-C between male and female diabetic patient in unpaired t-test. With improvement of diabetic control some improvement of the lipid abnormalities can be achieved. Most studies have shown that improvement of lipid abnormalities occur with proper glycaemic control in pati Continue reading >>

A Study Of Lipid Profile Levels Of Type Ii Diabetes Mellitus | Sabahelkhier | Nova Journal Of Medical And Biological Sciences

A Study Of Lipid Profile Levels Of Type Ii Diabetes Mellitus | Sabahelkhier | Nova Journal Of Medical And Biological Sciences

Nova Journal of Medical and Biological Sciences A study of lipid profile Levels of Type II Diabetes Mellitus Murwan Khalid Sabahelkhier, Mohammed Ali Awadllah, Atif Saeed Mohammed Idrees, Ali Abdel-Ghaffar Abel Rahheem Mohammed, Mohammed Abdel Rahman Idris This study consists of two parts; the Part one is to evaluate the level of Blood glucose and lipid profile among diabetic patients(121 patients) which are compared with non-diabetic subjects (60 persons) and part two is to correlate lipid profile with cardiovascular abnormalities among type II diabetic patients. The diabetic patients were collected from Jabir Aboeleiz Center for Diabetes (51.911.22 years). Sixty healthy non-diabetic subjects were chosen as controls (52.4410.76years). Blood glucose, total cholesterol (TC), triglycerides (TG) and high density lipoprotein (HDL) were measured by enzymatic colorimetric methods in both groups, and low density lipoprotein cholesterol (LDL) was calculated for each sample. Among diabetic patients, there is high glucose level, serum total cholesterol, triglycerides and LDL cholesterol (p<0.5), while low level of HDL cholesterol was observed when compared to non-diabetic subjects. No statistically variation was found in the level of glucose and lipid profile between male and female diabetic patients. In our study, we have found that serum lipid - cholesterol, triglycerides and low-density lipoprotein - levels were significantly (p < 0.05) correlated to cardiovascular abnormalities, while HDL had shown a statistically non-significant correlation (p>0.05). The study concluded that higher level of cholesterol, triglyceride and LDL-cholesterol in diabetic patients compared to non-diabetic subjects with lower level of serum HDL-cholesterol in diabetic patient compared to non- diabet Continue reading >>

Lipids And Lipoproteins In Patients With Type 2 Diabetes

Lipids And Lipoproteins In Patients With Type 2 Diabetes

Insulin resistance and type 2 diabetes are associated with a clustering of interrelated plasma lipid and lipoprotein abnormalities, which include reduced HDL cholesterol, a predominance of small dense LDL particles, and elevated triglyceride levels. Each of these dyslipidemic features is associated with an increased risk of cardiovascular disease. Increased hepatic secretion of large triglyceride-rich VLDL and impaired clearance of VLDL appears to be of central importance in the pathophysiology of this dyslipidemia. Small dense LDL particles arise from the intravascular processing of specific larger VLDL precursors. Typically, reduced plasma HDL levels in type 2 diabetes are manifest as reductions in the HDL2b subspecies and relative or absolute increases in smaller denser HDL3b and HDL3c. Although behavioral interventions such as diet and exercise can improve diabetic dyslipidemia, for most patients, pharmacological therapy is needed to reach treatment goals. There are several classes of medications that can be used to treat lipid and lipoprotein abnormalities associated with insulin resistance and type 2 diabetes, including statins, fibrates, niacin, and thiazolidinediones. Clinical trials have shown significant improvement in coronary artery disease after diabetic dyslipidemia treatment. Type 2 diabetes is associated with a cluster of interrelated plasma lipid and lipoprotein abnormalities, including reduced HDL cholesterol, a predominance of small dense LDL particles, and elevated triglycerides (1). These abnormalities occur in many patients despite normal LDL cholesterol levels. These changes are also a feature of the insulin resistance syndrome (also known as the metabolic syndrome), which underlies many cases of type 2 diabetes. In fact, pre-diabetic individuals Continue reading >>

Association Of Lipid Profile With Diabetic Retinopathy- A Comparative Study. - Scopemed.org - Deposit For Medical Articles

Association Of Lipid Profile With Diabetic Retinopathy- A Comparative Study. - Scopemed.org - Deposit For Medical Articles

Association of Lipid Profile with Diabetic Retinopathy- A Comparative Study. Diabetic retinopathy (DR) remains a leading cause of visual disability and blindness. It is a major microvascular complication of diabetes and is frequently accompanied by lipid exudation. Dyslipidemia leads to development of hard exudates and Clinically Significant Macular Edema (CSME). These, in turn, interfere with vision. The elevated lipid levels are associated with endothelial dysfunction which appears to play an important role in the pathogenesis of Diabetic Retinopathy, particularly in relation to breakdown of blood-retinal barrier. The current study was undertaken to determine the association of serum lipid profile with diabetic retinopathy and its severity. In the present study, 200 patients having type II diabetes mellitus of age group ranging from 45 to 80 years were studied. 100 age and sex matched controls were also studied. The patients were categorized with respect to the presence or absence of diabetic retinopathy. In the group having retinopathy, patients were subcategorized depending on the severity / grade of retinopathy and presence or absence of CSME. All the three groups had a near equal sex distribution with only a slight male predominance. A significant correlation was found between the patient age and diabetic retinopathy. In the present study, the duration since diagnosis of diabetes (diabetic age) ranged from 5 - 25 years. It is found that patients with retinopathy significantly had a longer mean duration of diabetes as compared to those diabetics without retinopathy. Most of the diabetics included in the study had poor glycemic control suggested raised FBS and PPBS levels. The mean values of FBS and PPBS were higher in group 1 (diabetics with diabetic retinopathy) Continue reading >>

[ps 01-30] Evaluation Of Serum Lipid Profile Among Hypertensive And Type 2 Diabetes Mellitus Patients In Sudan

[ps 01-30] Evaluation Of Serum Lipid Profile Among Hypertensive And Type 2 Diabetes Mellitus Patients In Sudan

The aim of the current study is to assess the impact of hyperglycemia and elevated blood pressure on serum lipid profile in Sudanese patients. The results will influence the monitoring and management policies so as to avoid complications related to hypertension and diabetes mellitus. This is a cross sectional case control study conducted in Khartoum state, Sudan at 2015. A total of 228 participants we enrolled in this study. Out of them 68 were known hypertensive, 42 were known diabetics, 24 were both hypertensive and diabetic and 94 were sex and age matched controls. Fasting blood glucose was measured by calibrated glucometer. Parameters of lipid profile were determined by using clinical chemistry analyser (Echo, Italy) and commercial kits (Biosystem, Spain). Mean triacylglycerol level among hypertensive and hypertensive patients combined with diabetes was significantly higher than that of controls (p < 0.023, p < 0.007) respectively. Hypertensive patients combined with diabetes also showed significantly higher triacylglycerols level than the diabetic group (p < 0.019). Apart from fasting blood glucose, No significant difference was observed between diabetics and controls in all study parameters. In contrast to the reported data, our results clearly demonstrate that lipid profile is not influenced by type 2 diabetes mellitus. However, hypertension increases the level of triacylglycerols significantly. This increase is even worse when hypertension is combined with diabetes. Interestingly, neither diabetes nor hypertension alters the levels of cholesterol, LDL-C and HDL-C. Further studies are therefore recommended, probably at DNA level, to reveal the causes of low cholesterol level among Sudanese hypertensive and diabetic patients compared to other populations. Copyrig Continue reading >>

Correlation Of Lipid Profile And Risk Of Developing Type 2 Diabetes Mellitus In 10-14 Year Old Children

Correlation Of Lipid Profile And Risk Of Developing Type 2 Diabetes Mellitus In 10-14 Year Old Children

Correlation of Lipid Profile and Risk of Developing Type 2 Diabetes Mellitus in 10-14 Year Old Children Habiba N.M.a Fulda K.G.b Basha R.a Shah D.a Fernando S.a Nguyen B.c Xiong Y.c Franks S.F.b Matches S.J.a Magie R.D.a Bowman W.P.a Nusrath M. Habiba, MD, FAAP Associate Professor and Assistant Clerkship Director Department of Pediatrics, University of North Texas Health Science Center Fort Worth, Texas (USA) Tel. +1-817-735-2363, Fax +1-817-735-2653, E Mail [email protected] Background/Aims: The role of lipid profile in predicting the risk of Type 2 diabetes mellitus (T2DM) in children is not clearly established. Our aim is to screen non-diabetic children aged 10-14 years for risk of developing T2DM and evaluate the association of abnormal lipids and socioeconomic status (SES). Methods: Data on race/ethnicity, family history, body mass index percentile, blood pressure and presence of neck pigmentation (acanthosis nigricans) were collected from 149 non-diabetic children. Using these factors, children were classified into low risk (<3 risk factors) and high risk (>3 risk factors) groups. Logistic regression model and chi-square tests were used to evaluate the association of blood lipid profile and demographic variables. Independent t-test was used to compare the ratio of Total Cholesterol (TC) and High Density Lipids (HDL) with T2DM risk. Results: 60% of children were at high risk for developing T2DM. HDL (p<0.001), triglycerides (p=0.02) and TC/HDL ratio (p<.001) were significantly abnormal in high risk group. Low SES showed a marginal association with high risk group. There were no gender or age differences between high and low risk groups. Conclusions: The significant determinants associated with high risk group were modifiable factors providing an opportunit Continue reading >>

Lipid Profile In Adolescent Girls With Type 1 Diabetes Mellitus And Hyperandrogenemia

Lipid Profile In Adolescent Girls With Type 1 Diabetes Mellitus And Hyperandrogenemia

Lipid Profile in Adolescent Girls with Type 1 Diabetes Mellitus and Hyperandrogenemia Agnieszka Zachurzok ,1 Grazyna Deja ,2 Aneta Gawlik ,1 Agnieszka Drosdzol-Cop ,3 Katarzyna Klimek ,4and Ewa Malecka-Tendera 1 1Department of Pediatrics and Pediatric Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Medykow Street 16, 40-752 Katowice, Poland 2Department of Pediatric Diabetes, School of Medicine in Katowice, Medical University of Silesia, Medykow Street 16, 40-752 Katowice, Poland 3Department of Womans Health, School of Medicine in Katowice, Medical University of Silesia, Medykow Street 12, 40-752 Katowice, Poland 4Department of Instrumental Analysis, School of Pharmacy in Sosnowiec, Medical University of Silesia, Jednosci Street 8, 41-200 Sosnowiec, Poland Received 17 January 2016; Revised 30 March 2016; Accepted 6 April 2016 Copyright 2016 Agnieszka Zachurzok et al. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Study Objectives. The study aim was to evaluate whether hyperandrogenemia in adolescent girls with type 1 diabetes mellitus (T1DM) may adversely influence lipid profile. Design and Participants. Lipid levels in 16 diabetic girls with biochemical hyperandrogenemia (T1DM-H) aged 16.3 1.2 years were compared to 38 diabetic girls with normal androgen levels (T1DM-N) aged 15.8 1.2 years. 15 healthy girls served as controls (CG). In all patients, anthropometric measurements were done, and androgens and SHBG were assessed. Results. In T1DM-H, total cholesterol (TC) and low density cholesterol (LDL-ch) were significantly higher than in CG (196.1 41.2 versus 162.7 31.7 mg/dL Continue reading >>

Study Of Glycosylated Haemoglobin And Lipid Profile In Type 2 Diabetes Mellitus With And Without Retinopathy

Study Of Glycosylated Haemoglobin And Lipid Profile In Type 2 Diabetes Mellitus With And Without Retinopathy

Study of Glycosylated Haemoglobin and Lipid Profile in Type 2 Diabetes Mellitus with and without Retinopathy Title:Study of Glycosylated Haemoglobin and Lipid Profile in Type 2 Diabetes Mellitus with and without Retinopathy Authors: Dr Varsha.P.S, Dr Zubaida.P.A, Dr K.G. Sajeeth Kumar, Dr Rajalekshmi.G Introduction: Type 2 diabetes accounts for approximately 90 to 95% of all diagnosed cases of diabetes. Diabetes mellitus is associated with microvascular complications, such as diabetic retinopathy (DR).A case control study was conducted to find out the relation of Glycosylated haemoglobin and serum lipids in diabetics and in diabetic retinopathy. Materials and Methods: The study was done in 3 groups: diabetics, diabetics with retinopathy and normal control groups. Results: The mean HbA1c level , Mean values of total cholesterol, triglycerides, VLDL, LDL, were found to be significantly higher in diabetics with retinopathy and Mean values of HDL was significantly lower in diabetics with retinopathy, when compared to diabetics without complications and with normal controls. Conclusion: Higher levels of HbA1c and serum cholesterol, triglycerides, and LDL levels are responsible for microvascular changes in diabetes and leading to retinopathy Keywords: Glycosylated haemoglobin, lipid profile, type 2 diabetes mellitus with and without retinopathy. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence ofdiabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27: p 1047-53. Rizza R, Gerich J, Haymond M, et al. Control of blood sugar in insulin-dependent diabetes: comparison of an artificial endocrine pancreas, subcutaneous insulin infusion and intensified conventional insulin therapy. N Engl J Med. 1980;303:13131318. American Diabetes Associa Continue reading >>

Lipid Profile Abnormalities Seen In T2dm Patients In Primary Healthcare In Turkey: A Cross-sectional Study

Lipid Profile Abnormalities Seen In T2dm Patients In Primary Healthcare In Turkey: A Cross-sectional Study

Lipid profile abnormalities seen in T2DM patients in primary healthcare in Turkey: a cross-sectional study Medical Faculty, Department of Family Medicine, Bezmialem Vakif University, Adnan Menderes Boulevard, 34093 Fatih, Istanbul, Turkey Aclan Ozder, Email: [email protected] . Received 2014 Aug 28; Accepted 2014 Nov 29. Copyright Ozder; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated. This article has been cited by other articles in PMC. Diabetes is characterized by chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. We aimed to research association between serum lipid profile and blood glucose, hypothesizing that early detection and treatment of lipid abnormalities can minimize the risk for atherogenic cardiovascular disorder and cerebrovascular accident in patients with type 2 diabetes mellitus. Fasting blood glucose (FBG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG) and glycated haemoglobin (HbA1c) levels were evaluated. A hepatic ultrasound was performed for every diabetic to evaluate hepatosteatosis. The study was done from January 2014 to June 2014 among 132 patients with T2DM who were admitted to outpatient clinic of Family Medicine department in a university hospital. The patients whose taking multi-vitamin supplementation or having hepatic, renal or metab Continue reading >>

Lipid Profile And Persistent Lipid Abnormalities In Diabetic Patients – A Retrospective Study

Lipid Profile And Persistent Lipid Abnormalities In Diabetic Patients – A Retrospective Study

Abstract The purposes of this study are the characterization the lipid profile and the suitability of the statins treatment according to the cardiovascular profile. Also, in statin-treated patients, we aim to determine the prevalence of persistent lipid abnormalities. Observational and retrospective study of outpatient diabetic patients of a hospital consultation, between Jun/2014 and Jun/2015. Of the 199 diabetic patients included, 58.6% were treated with statins and only 13.9% were treated with statin dose adequate for its cardiovascular profile. The patients without overt cardiovascular disease had higher total cholesterol (178.0 vs 157.5 mg/dl; p = 0.003), HDL-C (51.0 vs 43.0 mg/dl; p = 0.005), LDL-C (97.0 vs 79.0 mg/dl; p = 0.004) and non-HDL-C (127.0 vs 112.5 mg/dl; p = 0.04) and higher prevalence of patients who achieved HDL-C goals (64.3 vs 33.3%; p < 0.0001). Almost half of statin-treated patients (46.8%) failed to achieve the LDL-C goals, 35.8% and 51.6% failed the triglycerides and HDL-C goals, respectively. Only 11.7% achieved all three goals. In statin-treated patients, we found a statistically significant difference between patients with and without cardiovascular disease on the prevalence of patients reaching the target HDL-C (68.1 vs 35.4%; p = 0.001). There were no differences in the prevalence of patients who achieved LDL-C and triglyceride goals. There is a suboptimal utilization of statins and a substantial percentage of diabetic patients that do not achieve the therapeutic goals. We emphasize the need for an effort to optimize the lipid profile of diabetics in order to contribute to reducing the prevalence of cardiovascular diseases in this population. Resumo Os objetivos são a caracterização do perfil lipídico e a avaliação do tratamento com Continue reading >>

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