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Sitagliptin Metformin Side Effects

Janumet (metformin Hydrochloride/sitagliptin) Dose, Indications, Adverse Effects, Interactions... From Pdr.net

Janumet (metformin Hydrochloride/sitagliptin) Dose, Indications, Adverse Effects, Interactions... From Pdr.net

Janumet XR Oral Tab ER: 100-1000mg, 50-1000mg, 50-500mg For the treatment of type 2 diabetes mellitus uncontrolled by diet and exercise and when treatment with one antidiabetic agent alone does not result in adequate control. NOTE: During concurrent use of metformin; sitagliptin and insulin or sulfonylureas, it may be necessary to lower the dose of insulin or the sulfonylurea to minimize the risk of hypoglycemia. For use when switching from metformin plus sitagliptin as separate tablets to the single, combination tablet. Oral dosage (immediate-release tablets, Janumet) The usual starting dose is the dose of metformin and sitagliptin already being taken. Administer the total daily dose in 2 divided doses as Janumet tablets (500 mg metformin; 50 mg sitagliptin or 1,000 mg metformin; 50 mg sitagliptin), with meals. Gradually titrate after assessing adequacy of therapeutic response. The maximum recommended dose of sitagliptin 100 mg and metformin 2,000 mg. Oral dosage (extended-release tablets, Janumet XR) The usual starting dose is the total daily dose of sitagliptin and metformin already being taken. Administer the dose required PO once daily with a meal, preferably in the evening. In patients with inadequate glycemic control on this dose of metformin, titrate gradually in order to reduce gastrointestinal side effects associated with metformin. Do not exceed the maximum daily recommended dose of sitagliptin 100 mg and metformin 2,000 mg. For use when initial treatment with metformin alone does not result in adequate glycemic control. Oral dosage (immediate-release tablets, Janumet) For patients taking metformin 500 mg twice daily, the usual starting dose is sitagliptin 50 mg; metformin 500 mg PO twice daily with meals. For patients taking metformin 850 mg twice daily, th Continue reading >>

Metformin/sitagliptin Side Effects In Detail - Drugs.com

Metformin/sitagliptin Side Effects In Detail - Drugs.com

Applies to metformin / sitagliptin: oral tablet, oral tablet extended release Very common (10% or more): Hypoglycemia (13.8% when combined with sulfonylurea; 10.9% when combined with insulin ) Common (1% to 10%): Hypoglycemia, decrease levels of vitamin B12 without clinical manifestations and rarely associated with anemia Rare (less than 0.1%): Lactic acidosis due to metformin Common (1% to 10%): Hypoglycemia (5% or more when combined with glyburide ) Very rare (less than 0.01%): Lactic acidosis, vitamin B12 deficiency [ Ref ] In metformin-treated patients, the incidence of lactic acidosis has been about 1.5 cases per 10,000 patient years. The risk of lactic acidosis has been particularly high in patients with underlying renal insufficiency and rarely in patients with normal renal function. Concomitant cardiovascular or liver disease, sepsis , and hypoxia have also increased the risk of lactic acidosis. Signs and symptoms of severe acidosis may include vomiting, abdominal pain , nausea, dyspnea , hypothermia, hypotension , and bradycardia . Long-term treatment with metformin has been associated with a decrease in vitamin B12 absorption. Malabsorption of vitamin B12, due to intrinsic factor deficiency and possibly other mechanisms, in as many as 30% of treated patients, were reported. Megaloblastic anemia has occurred. Decreased levels of vitamin B12 appear to be reversible with discontinuation of metformin or vitamin B12 supplementation.[ Ref ] Common (1% to 10%): Diarrhea, nausea, flatulence , vomiting Uncommon (0.1% to 1%): Constipation , upper abdominal pain, dry mouth Postmarketing reports: Indigestion, abdominal discomfort, dyspepsia , abdominal pain, acute pancreatitis (including fatal and non-fatal hemorrhagic and necrotizing pancreatitis), mouth ulceration, sto Continue reading >>

Janumet (metformin,sitagliptin) Dosage, Indication, Interactions, Side Effects | Empr

Janumet (metformin,sitagliptin) Dosage, Indication, Interactions, Side Effects | Empr

Adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes when treatment with both sitagliptin and metformin is appropriate. Not for treatment of type 1 diabetes or diabetic ketoacidosis. Not studied in patients with history of pancreatitis. Individualize. Swallow whole. Take with food. Not currently treated with metformin: initially 50mg/500mg twice daily. Previously on metformin alone: initially 50mg twice daily of sitagliptin plus metformin dose. Previously on metformin 850mg twice daily: start with 50mg/1000mg twice daily. Previously on sitagliptin and metformin: switch on a mg/mg basis. May titrate gradually up to max 100mg sitagliptin/2000mg metformin per day. Renal impairment (eGFR 30<45mL/min/1.73m2): not recommended. Severe renal impairment (eGFR <30mL/min/1.73m2). Metabolic acidosis, diabetic ketoacidosis. Increased risk of metformin-associated lactic acidosis in renal or hepatic impairment, concomitant use of certain drugs (eg, cationic drugs), 65yrs of age, undergoing radiological contrast study, surgery and other procedures, hypoxic states, and excessive alcohol intake; discontinue if lactic acidosis occurs. Discontinue at time of, or prior to intravascular iodinated contrast imaging in patients with eGFR 3060mL/min/1.73m2, history of hepatic impairment, alcoholism, hypoxemia, or will be given intra-arterial contrast; reevaluate eGFR 48hrs after procedure and restart therapy if renally stable. Suspend therapy if dehydration occurs or before surgery. Avoid if clinical or lab evidence of hepatic disease. Consider risks/benefits in patients with known risk factors for heart failure; monitor for signs/symptoms; evaluate and consider discontinuing if develops. Assess renal function prior to starting and periodically thereafter; m Continue reading >>

Metformin And Sitagliptin

Metformin And Sitagliptin

Generic Name: metformin and sitagliptin (met FOR min and SI ta glip tin) Brand Name: Janumet, Janumet XR What is metformin and sitagliptin? Metformin and sitagliptin are oral diabetes medicines that help control blood sugar levels. Metformin works by decreasing glucose (sugar) production in the liver and decreasing absorption of glucose by the intestines. Sitagliptin works by regulating the levels of insulin your body produces after eating. Metformin and sitagliptin is a combination medicine that is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes. Metformin and sitagliptin may also be used for purposes not listed in this medication guide. Important Information You should not use this medicine if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment with insulin). This medicine may cause a serious condition called lactic acidosis. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. Before taking this medicine You should not use this medicine if you are allergic to metformin or sitagliptin (Januvia), or if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment with insulin). To make sure metformin and sitagliptin is safe for you, tell your doctor if you have ever had: kidney disease (your kidney function may need to be checked before you take this medicine); liver disease; heart disease; pancreatitis; high triglycerides (a type of fat in the blood); gallstones; or alcoholism. Some people takin Continue reading >>

Sitagliptin-metformin Tablet, Extended Release Multiphase 24 Hr (tablet, Er Hr)

Sitagliptin-metformin Tablet, Extended Release Multiphase 24 Hr (tablet, Er Hr)

Nausea , vomiting , stomach upset, diarrhea , headache , or a metallic taste in the mouth may occur. A tablet may also appear in your stool. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If stomach symptoms return later (after taking the same dose for several days or weeks), tell your doctor right away. Stomach symptoms that occur after the first days of your treatment may be signs of lactic acidosis . Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: joint pain , signs of kidney problems (such as change in the amount of urine), unusual skin blisters , signs of heart failure (such as shortness of breath, swelling ankles /feet, unusual tiredness, unusual/ sudden weight gain ). Get medical help right away if you have any very serious side effects, including: signs of disease of the pancreas (such as severe stomach/ abdominal pain which may spread to the back, persistent nausea / vomiting ). This medication does not usually cause low blood sugar ( hypoglycemia ). Low blood sugar may occur if this drug is prescribed with other diabetes medications , or if you do not consume enough calories from food, or if you do unusually heavy exercise . Talk with your doctor or pharmacist about whether the dose of your other diabetes medication(s) needs to be lowered. Symptoms of low blood sugar include sudden sweating , shaking, fast heartbeat, hunger , blurred vision , dizziness , or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar . If you don't have these Continue reading >>

Janumet 50 Mg/1000 Mg Tablets

Janumet 50 Mg/1000 Mg Tablets

Brand Information Consumer medicine information (CMI) leaflet Please read this leaflet carefully before you start using Janumet 50 mg/1000 mg tablets. Download CMI (PDF) Download large text CMI (PDF) What is in this leaflet This leaflet answers some common questions about JANUMET. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking JANUMET against the benefits they expect it will have for you. If you have any concerns about taking this medicine, ask your doctor or pharmacist. Keep this leaflet with the medicine. You may need to read it again. What JANUMET is used for JANUMET helps to lower blood sugar levels in patients with type 2 diabetes mellitus along with diet and exercise. JANUMET can be used alone, or in combination with insulin, or sulfonylurea medicines such as glimepiride, gliclazide and glibenclamide. Type 2 diabetes mellitus Type 2 diabetes mellitus is a condition in which your body does not make enough insulin and the insulin that your body produces does not work as well as it should. Your body can also make too much sugar. When this happens, sugar (glucose) builds up in the blood resulting in high blood sugar (hyperglycaemia). This can lead to serious medical problems. The main goal of treating diabetes is to lower your blood sugar to a normal level. Lowering and controlling blood sugar may help prevent or delay complications of diabetes, such as heart disease, kidney disease, blindness and foot amputation. High blood sugar can be lowered by diet and exercise and by certain medicines. How JANUMET works JANUMET contains two active ingredients, sitagliptin (as phosphate monohydrate) and metformin hydrochlor Continue reading >>

Sitagliptin For Diabetes Januvia

Sitagliptin For Diabetes Januvia

Take sitagliptin tablets once a day. Remember to follow any advice you have been given about your diet. The most common side-effects are feeling sick (nausea), headache, and nose or throat infections. About sitagliptin Type of medicine An antidiabetic medicine Used for Adults with type 2 diabetes mellitus Also called Januvia®; Janumet® (a combination tablet containing sitagliptin with metformin) Available as Tablets Insulin is a hormone which is made naturally in your body, in the pancreas. It helps to control the levels of sugar in your blood. If your body does not make enough insulin, or if it does not use the insulin it makes effectively, this results in the condition called sugar diabetes (diabetes mellitus). People with diabetes need treatment to control the amount of sugar (glucose) in their blood. This is because good control of blood glucose levels reduces the risk of complications later on. Some people can control the sugar in their blood by making changes to the food they eat but, for other people, medicines like sitagliptin are given alongside the changes in diet. Sitagliptin works in part by increasing the amount of insulin produced by your body. It also reduces the amount of a substance called glucagon being produced by your pancreas. Glucagon causes your liver to produce more sugar, so by reducing the amount of glucagon in your body, this also helps to reduce the levels of glucose in your blood. Before taking sitagliptin Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking sitagliptin it is important that your doctor knows: If you are pregnant, trying for a baby or breast-feeding. If you have any problems with the way your kidneys w Continue reading >>

Metformin And Sitagliptin (janumet)

Metformin And Sitagliptin (janumet)

are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>

Type 2 Side Effects Of Sitagliptin, Metformin And Rampipril?

Type 2 Side Effects Of Sitagliptin, Metformin And Rampipril?

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community Type 2 side effects of Sitagliptin, Metformin and Rampipril? I have had Type 2 for 17 years. Been through diet, metformin, gliclazide and now on Januvia (sitagliptin) 100mg. Januvia working very well - last two annual checks were 6.1. I also (at my diabetic consultants recommendation) still take Metformin and Gliclazide to "help" the Stitagliptin. Finally, I take 10mg Ramipril. Sometimes I think I rattle when I walk! Since I retired (now 60), I have been trying to lose weight and get fitter. Part of the driver for this is that every time I go to my GP with anything it's always put down to my diabetes. Sometimes I think if I went in with a broken arm, it would be my diabetes..... Over the last couple of years I have increasingly felt listless, with a lack of energy, sleepy during the day and my muscles ache constantly making any walking a chore. Additionally, I have had occasional dizzy spells for 10 to 30 seconds when I stand up of (strangely) when I go into bright light. Never when I am sat down or driving. I have a blood pressure tester and have tested myself and my BP is OK during these dizzy spells (currently 120/70). I have also tested my blood sugars and they are neither high or low. Having been to the gym every day for six weeks (weight circuits + 30 mins walking up 6% incline) with no improvement in these symptoms. If anything the dizzy spells are getting worse, So, I am starting to look a bit wider and wonder if I have the side effects of Stitagliptin (body aches, muscle aches, lack or loss of strength) and Metformin (muscle pain, sleepiness) and of Ramipril (tiredness/weakness, dizziness, faintness and lightheadedness) - all taken from their Continue reading >>

What Is Janumet (metformin And Sitagliptin)?

What Is Janumet (metformin And Sitagliptin)?

Janumet is the brand name for a prescription drug that contains metformin and sitagliptin. It's used along with diet and exercise to lower blood sugar in people who have type 2 diabetes. If you have type 2 diabetes, your body doesn't make or use the hormone insulin normally, so it can't control the amount of sugar, or glucose, in the blood. Metformin belongs to a drug class known as biguanides. Biguanides lower blood-sugar levels in three ways: decreasing the glucose produced by your liver; slowing absorption of sugar in the digestive system; and increasing the amount of sugar that muscle cells absorb. Sitagliptin is known as a DPP-4 (dipeptidyl peptidase-4 ) inhibitor. Sitagliptin increases the amount of insulin your pancreas creates, reduces the glucose from your liver, and slows absorption of sugars in your gut. It also affects the brain, reducing the amount of food you eat by increasing your sense of fullness. Taking Janumet, along with adopting a healthy lifestyle, can decrease your risk of developing the serious or life-threatening complications of type 2 diabetes. These may include cardiovascular diseases, such as heart attack, stroke, and problems related to blood circulation; nerve damage; kidney disease; or eye conditions. Janumet is manufactured by Merck & Co. and was approved by the Food and Drug Administration (FDA) in 2007. Janumet Warnings The FDA requires a black-box warning for Janumet, because it may cause a rare but serious condition called lactic acidosis (a buildup of lactic acid in the blood). Stop taking the drug and call your doctor immediately or get emergency help if you experience any of the following side effects: Extreme weakness, fatigue, or discomfort Nausea, vomiting, or stomach pain Decreased appetite Deep and rapid breathing or shortnes Continue reading >>

Important Information About The Side Effects Of

Important Information About The Side Effects Of

JANUMET tablets contain 2 prescription medicines: sitagliptin (JANUVIA®) and metformin. Once-daily prescription JANUMET XR tablets contain sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. JANUMET or JANUMET XR should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUMET or JANUMET XR. Metformin, one of the medicines in JANUMET and JANUMET XR, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet; feel dizzy or lightheaded; have a slow or irregular heartbeat; feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; feel sleepy or drowsy; have stomach pains, nausea, or vomiting. Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Tell your doctor if you have any of the following, because you have a higher chance of getting lactic acidosis with JANUMET or JANUMET XR if you: have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye; have liver problems; drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinking; get dehydrated (lose large amounts of body fluids, w Continue reading >>

Janumet - Uses, Side Effects, Interactions - Canoe.com

Janumet - Uses, Side Effects, Interactions - Canoe.com

How does this medication work? What will it do for me? This is a combination medication that contains 2 active ingredients: sitagliptin and metformin. They are used together, along with diet and exercise, to improve blood glucose (sugar) levels for adults with type 2 diabetes. Sitagliptin - metformin may be used in addition to other diabetes medications to reduce blood sugar levels, when other medications haven't provided adequate control. Sitagliptin belongs to the group of medications called DPP-4 inhibitors. It works by increasing the amount of incretin released by the intestine. Incretin is a hormone that raises insulin levels when blood glucose is high and decreases the amount of glucose made by the body. Metformin belongs to the group of medications called biguanides. It works by reducing the amount of glucose made by the liver and by making it easier for glucose to enter into the tissues of the body. This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here. Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor. Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it. What form(s) does this medication come in? Each light Continue reading >>

Janumet (sitagliptin / Metformin Hydrochloride) - Summary

Janumet (sitagliptin / Metformin Hydrochloride) - Summary

Published Studies Related to Janumet (Sitagliptin / Metformin) A treatment strategy implementing combination therapy with sitagliptin and metformin results in superior glycaemic control versus metformin monotherapy due to a low rate of addition of antihyperglycaemic agents. [2011.09] AIMS: Combination therapy with sitagliptin and metformin has shown superior efficacy compared with metformin monotherapy. In this study, we compare two strategies: initial combination therapy with sitagliptin/metformin as a fixed-dose combination (FDC) and initial metformin monotherapy, with the option to add additional antihyperglycaemic agents (AHAs) in either treatment arm during the second phase of the study in order to reach adequate glycaemic control... CONCLUSIONS: A strategy initially implementing combination therapy with sitagliptin/metformin FDC was superior to a strategy initially implementing metformin monotherapy, even when accounting for the later addition of supplemental AHAs. Sitagliptin/metformin FDC was generally well tolerated. (c) 2011 Blackwell Publishing Ltd. The effect of initial therapy with the fixed-dose combination of sitagliptin and metformin compared with metformin monotherapy in patients with type 2 diabetes mellitus. [2011.07] AIMS: This study was conducted to compare the glycaemic efficacy and safety of initial combination therapy with the fixed-dose combination of sitagliptin and metformin versus metformin monotherapy in drug-naive patients with type 2 diabetes... CONCLUSION: Compared with metformin monotherapy, initial treatment with sitagliptin/metformin FDC provided superior glycaemic improvement with a similar degree of weight loss and lower incidences of abdominal pain and diarrhoea. (c) 2011 Blackwell Publishing Ltd. A treatment strategy implementing Continue reading >>

What Are The Possible Side Effects Of Metformin And Sitagliptin (janumet, Janumet Xr)?

What Are The Possible Side Effects Of Metformin And Sitagliptin (janumet, Janumet Xr)?

JANUMET® XR (sitagliptin and metformin HCl) Extended-Release Tablets JANUMET XR tablets contain two oral antidiabetic medications used in the management of type 2 diabetes: sitagliptin and metformin hydrochloride extended-release. Sitagliptin Sitagliptin is an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin phosphate monohydrate drug substance is used to manufacture JANUMET XR. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine phosphate (1:1) monohydrate with an empirical formula of C16H15F6N5O•H3PO4•H2O and a molecular weight of 523.32. The structural formula is: Sitagliptin phosphate monohydrate is a white to off-white, crystalline, non-hygroscopic powder. It is soluble in water and N,N-dimethyl formamide; slightly soluble in methanol; very slightly soluble in ethanol, acetone, and acetonitrile; and insoluble in isopropanol and isopropyl acetate. Metformin Hydrochloride Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is a white to off-white crystalline compound with a molecular formula of C4H11N5•HCl and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. The structural formula is as shown: JANUMET XR consists of an extended-release metformin core tablet coated with an immediate-release layer of sitagliptin. The sitagliptin layer is coated with a soluble polymeric film. JANUMET XR is available for oral administration as tablets containing 64.25 mg sitagliptin phosphate monohyd Continue reading >>

Janumet Side Effects Center

Janumet Side Effects Center

Janumet (sitagliptin/metformin HCl) is a combination of oral diabetes medicines for people with type 2 diabetes who do not use daily insulin injections. Janumet is not for treating type 1 diabetes. Common side effects of Janumet include: nausea, vomiting, stomach upset, diarrhea, constipation, headache, weakness, back pain, joint or muscle pain, a metallic taste in the mouth, or cold symptoms such as runny or stuffy nose, sneezing, and sore throat. Janumet does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if Janumet is prescribed with other anti-diabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Dosage of Janumet is individualized. Janumet is given twice daily with meals in 50 mg sitagliptin/500 mg metformin hydrochloride or 50 mg sitagliptin/1000 mg metformin hydrochloride doses. Hyperglycemia (high blood sugar) may result if you take Janumet with drugs that raise blood sugar, such as: isoniazid, diuretics (water pills), steroids, phenothiazines, thyroid medicine, birth control pills and other hormones, seizure medicines, and diet pills, or medicines to treat asthma, colds or allergies. Hypoglycemia (low blood sugar) may result if you take Janumet with drugs that lower blood sugar, such as: nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, or probenecid. It may also interact with amiloride, triamterene, cimetidine, ranitidine, digoxin, furosemide, morphine, nifedipine, procainamide, quinidine, trimethoprim, or vancomycin. Tell your doctor all medications you use. During pregnancy, Janumet should be used only when prescribed. Your doctor may Continue reading >>

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