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Side Effects Of Sitagliptin And Metformin

Sitagliptin For Diabetes Januvia

Sitagliptin For Diabetes Januvia

Take sitagliptin tablets once a day. Remember to follow any advice you have been given about your diet. The most common side-effects are feeling sick (nausea), headache, and nose or throat infections. About sitagliptin Type of medicine An antidiabetic medicine Used for Adults with type 2 diabetes mellitus Also called Januvia®; Janumet® (a combination tablet containing sitagliptin with metformin) Available as Tablets Insulin is a hormone which is made naturally in your body, in the pancreas. It helps to control the levels of sugar in your blood. If your body does not make enough insulin, or if it does not use the insulin it makes effectively, this results in the condition called sugar diabetes (diabetes mellitus). People with diabetes need treatment to control the amount of sugar (glucose) in their blood. This is because good control of blood glucose levels reduces the risk of complications later on. Some people can control the sugar in their blood by making changes to the food they eat but, for other people, medicines like sitagliptin are given alongside the changes in diet. Sitagliptin works in part by increasing the amount of insulin produced by your body. It also reduces the amount of a substance called glucagon being produced by your pancreas. Glucagon causes your liver to produce more sugar, so by reducing the amount of glucagon in your body, this also helps to reduce the levels of glucose in your blood. Before taking sitagliptin Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking sitagliptin it is important that your doctor knows: If you are pregnant, trying for a baby or breast-feeding. If you have any problems with the way your kidneys w Continue reading >>

Janumet - Uses, Side Effects, Interactions - Canoe.com

Janumet - Uses, Side Effects, Interactions - Canoe.com

How does this medication work? What will it do for me? This is a combination medication that contains 2 active ingredients: sitagliptin and metformin. They are used together, along with diet and exercise, to improve blood glucose (sugar) levels for adults with type 2 diabetes. Sitagliptin - metformin may be used in addition to other diabetes medications to reduce blood sugar levels, when other medications haven't provided adequate control. Sitagliptin belongs to the group of medications called DPP-4 inhibitors. It works by increasing the amount of incretin released by the intestine. Incretin is a hormone that raises insulin levels when blood glucose is high and decreases the amount of glucose made by the body. Metformin belongs to the group of medications called biguanides. It works by reducing the amount of glucose made by the liver and by making it easier for glucose to enter into the tissues of the body. This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here. Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor. Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it. What form(s) does this medication come in? Each light Continue reading >>

Janumet Side Effects Center

Janumet Side Effects Center

Janumet (sitagliptin/metformin HCl) is a combination of oral diabetes medicines for people with type 2 diabetes who do not use daily insulin injections. Janumet is not for treating type 1 diabetes. Common side effects of Janumet include: nausea, vomiting, stomach upset, diarrhea, constipation, headache, weakness, back pain, joint or muscle pain, a metallic taste in the mouth, or cold symptoms such as runny or stuffy nose, sneezing, and sore throat. Janumet does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if Janumet is prescribed with other anti-diabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Dosage of Janumet is individualized. Janumet is given twice daily with meals in 50 mg sitagliptin/500 mg metformin hydrochloride or 50 mg sitagliptin/1000 mg metformin hydrochloride doses. Hyperglycemia (high blood sugar) may result if you take Janumet with drugs that raise blood sugar, such as: isoniazid, diuretics (water pills), steroids, phenothiazines, thyroid medicine, birth control pills and other hormones, seizure medicines, and diet pills, or medicines to treat asthma, colds or allergies. Hypoglycemia (low blood sugar) may result if you take Janumet with drugs that lower blood sugar, such as: nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, or probenecid. It may also interact with amiloride, triamterene, cimetidine, ranitidine, digoxin, furosemide, morphine, nifedipine, procainamide, quinidine, trimethoprim, or vancomycin. Tell your doctor all medications you use. During pregnancy, Janumet should be used only when prescribed. Your doctor may Continue reading >>

Metformin And Sitagliptin (janumet)

Metformin And Sitagliptin (janumet)

are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>

What Are The Possible Side Effects Of Sitagliptin (januvia)?

What Are The Possible Side Effects Of Sitagliptin (januvia)?

A A A Medications and Drugs Brand Names: Januvia Generic Name: sitagliptin (Pronunciation: SI ta glip tin) What is sitagliptin (Januvia)? Sitagliptin is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating. Sitagliptin is for people with type 2 diabetes. Sitagliptin is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Sitagliptin may also be used for purposes not listed in this medication guide. What are the possible side effects of sitagliptin (Januvia)? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking sitagliptin and call your doctor at once if you have a serious side effect such as: pancreatitis - severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate; or urinating less than usual or not at all; swelling, weight gain, feeling short of breath; or severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Less serious side effects may include: runny or stuffy nose, sore throat; headache, back pain, joint or muscle pain; or This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about sitagliptin (Januvia)? Do not use this medication if you are allergic to sitagliptin or if you are in a state of diabetic ketoa Continue reading >>

Metformin And Sitagliptin

Metformin And Sitagliptin

Janumet 100 mg-50 mg oblong, red, imprinted with 577 What is the most important information I should know about metformin and sitagliptin? You should not use this medication if you are allergic to metformin (Glucophage) or sitagliptin (Januvia), if you have liver or kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking metformin and sitagliptin. Some people develop lactic acidosis while taking metformin. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or irregular heart rate, dizziness, or feeling very weak or tired. What is metformin and sitagliptin? Metformin and sitagliptin are oral diabetes medicines that help control blood sugar levels. Metformin works by decreasing glucose (sugar) production in the liver and decreasing absorption of glucose by the intestines. Sitagliptin works by regulating the levels of insulin your body produces after eating. The combination of metformin and sitagliptin is used to treat type 2 diabetes. This medication is not for treating type 1 diabetes. Metformin and sitagliptin may also be used for purposes not listed in this medication guide. What should I discuss with my health care provider before taking metformin and sitagliptin? Some people develop a life-threatening condition called lactic acidosis while taking metformin. You may be more likely to develop lactic acidosis if you have liver or kidney disease, congestive heart failure, a severe infection, if Continue reading >>

Sitagliptin

Sitagliptin

Sitagliptin is used along with diet and exercise and sometimes with other medications to lower blood sugar levels in patients with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Sitagliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing the amounts of certain natural substances that lower blood sugar when it is high. Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. Sitagliptin comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take sitagliptin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sitagliptin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Sitagliptin helps to control high blood sugar but does not cure diabetes. Continue to take sitagliptin even if you feel well. Do not stop taking sitagliptin withou Continue reading >>

Metformin And Sitagliptin

Metformin And Sitagliptin

Generic Name: metformin and sitagliptin (met FOR min and SI ta glip tin) Brand Name: Janumet, Janumet XR What is metformin and sitagliptin? Metformin and sitagliptin are oral diabetes medicines that help control blood sugar levels. Metformin works by decreasing glucose (sugar) production in the liver and decreasing absorption of glucose by the intestines. Sitagliptin works by regulating the levels of insulin your body produces after eating. Metformin and sitagliptin is a combination medicine that is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes. Metformin and sitagliptin may also be used for purposes not listed in this medication guide. Important Information You should not use this medicine if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment with insulin). This medicine may cause a serious condition called lactic acidosis. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. Before taking this medicine You should not use this medicine if you are allergic to metformin or sitagliptin (Januvia), or if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment with insulin). To make sure metformin and sitagliptin is safe for you, tell your doctor if you have ever had: kidney disease (your kidney function may need to be checked before you take this medicine); liver disease; heart disease; pancreatitis; high triglycerides (a type of fat in the blood); gallstones; or alcoholism. Some people takin Continue reading >>

What Is Janumet (metformin And Sitagliptin)?

What Is Janumet (metformin And Sitagliptin)?

Janumet is the brand name for a prescription drug that contains metformin and sitagliptin. It's used along with diet and exercise to lower blood sugar in people who have type 2 diabetes. If you have type 2 diabetes, your body doesn't make or use the hormone insulin normally, so it can't control the amount of sugar, or glucose, in the blood. Metformin belongs to a drug class known as biguanides. Biguanides lower blood-sugar levels in three ways: decreasing the glucose produced by your liver; slowing absorption of sugar in the digestive system; and increasing the amount of sugar that muscle cells absorb. Sitagliptin is known as a DPP-4 (dipeptidyl peptidase-4 ) inhibitor. Sitagliptin increases the amount of insulin your pancreas creates, reduces the glucose from your liver, and slows absorption of sugars in your gut. It also affects the brain, reducing the amount of food you eat by increasing your sense of fullness. Taking Janumet, along with adopting a healthy lifestyle, can decrease your risk of developing the serious or life-threatening complications of type 2 diabetes. These may include cardiovascular diseases, such as heart attack, stroke, and problems related to blood circulation; nerve damage; kidney disease; or eye conditions. Janumet is manufactured by Merck & Co. and was approved by the Food and Drug Administration (FDA) in 2007. Janumet Warnings The FDA requires a black-box warning for Janumet, because it may cause a rare but serious condition called lactic acidosis (a buildup of lactic acid in the blood). Stop taking the drug and call your doctor immediately or get emergency help if you experience any of the following side effects: Extreme weakness, fatigue, or discomfort Nausea, vomiting, or stomach pain Decreased appetite Deep and rapid breathing or shortnes Continue reading >>

Safety And Efficacy Of Sitagliptin-metformin In Fixed Combination For The Treatment Of Type 2 Diabetes Mellitus

Safety And Efficacy Of Sitagliptin-metformin In Fixed Combination For The Treatment Of Type 2 Diabetes Mellitus

Safety and Efficacy of Sitagliptin-Metformin in Fixed Combination for the Treatment of Type 2 Diabetes Mellitus Oxford Centre for Diabetes Endocrinology and Metabolism and the NIHR Oxford Biomedical Research Centre, Oxford, UK. Corresponding author email: [email protected] Copyright 2013 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article published under the Creative Commons CC-BY-NC 3.0 license. This article has been cited by other articles in PMC. The biguanide, metformin, is considered first-line treatment for type 2 diabetes. Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor acts through the incretin pathway and has a glucose dependent mode of action. The complementary hypoglycemic properties of these drugs make fixed dose combination treatment an attractive prospect. Evidence from recent clinical trials suggests a beneficial effect of the combination on efficacy, demonstrated by significant improvement of hemoglobin A1c (HbA1c), fasting and postprandial glucose levels. The fixed dose combination is likely to have greater patient tolerability compared with monotherapy with either agent because of low rates of hypoglycemia, weight neutrality, and lower rates of side effects. High acquisition cost and paucity of long-term safety data are, however, potential barriers to their wider use. An overview of the pharmacology and clinical outcomes from recent trials of the metformin-sitagliptin combination and how the combination could fit into the type 2 diabetes treatment algorithm is presented in this review. Keywords: metformin, sitagliptin, DPP-4 inhibitors, incretin-based therapies, type 2 diabetes Diabetes mellitus is a global epidemic, and type 2 diabetes accounts for almost 90% of patients with the disease. Continue reading >>

Metformin & Sitagliptin Overview

Metformin & Sitagliptin Overview

Sitagliptin/metformin is a prescription medication used to treat type 2 diabetes in adults. Sitagliptin/metformin is a single tablet containing 2 prescription drugs. Sitagliptin belongs to a group of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors, which help lower blood sugar levels. Metformin belongs to a group of drugs called biguanides, which decrease the amount of sugar made by the liver and help cells to respond to insulin. This medication comes in tablet form and is taken twice a day, with meals. Sitagliptin/metformin is also available as an extended release tablet and is taken once a day with a meal preferably in the evening. Take sitagliptin/metformin extended release tablets whole. Do not break, cut, crush, dissolve, or chew sitagliptin/metformin extended release tablets before swallowing. If you cannot swallow Janumet XR tablets whole, tell your doctor. Common side effects include stuffy nose, headache, sore throat, nausea, vomiting, and diarrhea. Continue reading >>

Metformin/sitagliptin Side Effects In Detail - Drugs.com

Metformin/sitagliptin Side Effects In Detail - Drugs.com

Applies to metformin / sitagliptin: oral tablet, oral tablet extended release Very common (10% or more): Hypoglycemia (13.8% when combined with sulfonylurea; 10.9% when combined with insulin ) Common (1% to 10%): Hypoglycemia, decrease levels of vitamin B12 without clinical manifestations and rarely associated with anemia Rare (less than 0.1%): Lactic acidosis due to metformin Common (1% to 10%): Hypoglycemia (5% or more when combined with glyburide ) Very rare (less than 0.01%): Lactic acidosis, vitamin B12 deficiency [ Ref ] In metformin-treated patients, the incidence of lactic acidosis has been about 1.5 cases per 10,000 patient years. The risk of lactic acidosis has been particularly high in patients with underlying renal insufficiency and rarely in patients with normal renal function. Concomitant cardiovascular or liver disease, sepsis , and hypoxia have also increased the risk of lactic acidosis. Signs and symptoms of severe acidosis may include vomiting, abdominal pain , nausea, dyspnea , hypothermia, hypotension , and bradycardia . Long-term treatment with metformin has been associated with a decrease in vitamin B12 absorption. Malabsorption of vitamin B12, due to intrinsic factor deficiency and possibly other mechanisms, in as many as 30% of treated patients, were reported. Megaloblastic anemia has occurred. Decreased levels of vitamin B12 appear to be reversible with discontinuation of metformin or vitamin B12 supplementation.[ Ref ] Common (1% to 10%): Diarrhea, nausea, flatulence , vomiting Uncommon (0.1% to 1%): Constipation , upper abdominal pain, dry mouth Postmarketing reports: Indigestion, abdominal discomfort, dyspepsia , abdominal pain, acute pancreatitis (including fatal and non-fatal hemorrhagic and necrotizing pancreatitis), mouth ulceration, sto Continue reading >>

What Patients Say About Janumet 50 1000

What Patients Say About Janumet 50 1000

Janumet 50 1000 is the brand name (and dosage level) of sitagliptin-metformin, a combination prescription drug used in the management of type 2 diabetes. (50 refers to 50 mg of sitagliptin while 1000 refers to 1000 mg of metformin.) In addition to diet and exercise, Janumet 50 1000 is prescribed when the use of metformin or sitagliptin alone does not adequately control the condition. At PatientsLikeMe, where more than 130,000 patients are sharing their experiences with conditions, symptoms, treatments and more, 21 patients report using Janumet 50 1000 or a lower daily dosage (50 mg sitagliptin / 500 mg metformin). What can we learn from these patients’ experiences? Quite a bit, actually, thanks to PatientsLikeMe’s unique data-sharing platform. Looking at the three treatment evaluations submitted for Janumet, all three patients rate the effectiveness as “Moderate,” while side effects were marked as “Mild,” “Moderate” and “Severe,” respectively. The chief complaint from the patient who reported “Severe” side effects was diarrhea. However, she writes, “Blood sugars are going down.” JOIN PATIENTSLIKEME TODAY What about you? Have you taken Janumet 50 1000 or a different dosage of this combination diabetes medication? Join PatientsLikeMe and add your experiences to our growing body of knowledge. Then, stay to exchange advice and support, research common treatments and learn from other patients like you. Continue reading >>

Compare Januvia Vs. Metformin

Compare Januvia Vs. Metformin

Oral blood sugar-lowering medicine. Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class. It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines. One of the few diabetes medicines that lowers the risk of death from diabetes-related complications. Rarely causes low blood sugar. 143 reviews so far Have you used Januvia (sitagliptin)? Leave a review 938 reviews so far Have you used Glucophage (metformin)? Leave a review Continue reading >>

What Is Janumet (sitagliptin & Metformin) Side Effects, Dosage, And Uses. | Omudhome Ogbru, Pharmd | Rxeconsult

What Is Janumet (sitagliptin & Metformin) Side Effects, Dosage, And Uses. | Omudhome Ogbru, Pharmd | Rxeconsult

Janumet is a combination of Januvia (sitagliptin) and metformin. Januvia reduces blood glucose by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4) while metformin reduces blood glucose by increasing the sensitivity of muscle, liver, fat and other tissues to insulin. Janumet is used for treating type 2 diabetes in combination with diet and exercise. It is not used for treating type 1 diabetes. Janumet 50/1000 mg reduced hemoglobin A1C by 1.9% after 24 weeks while A1C increased by 0.2% in the placebo group. 66% of individuals treated with Janumet 50/1000 mg achieved A1C less than 7%. Only 20% and 23% of individuals treated with sitagliptin or metformin alone achieved A1C less than 7%. Sitagliptin and metformin are excreted by the kidneys Janumet is administered orally twice a day with meals. The maximum daily dose is 100/2000 mg. Common: Abdominal pain, nausea, diarrhea, vomiting, weakness, headache, runny nose, sore throat, upper respiratory infection. Serious: Lactic acidosis, pancreatitis, hypoglycemia (when combined with insulin or sulfonylurea). Drugs that increaseglucoselevels (e.g., steroids, estrogens, quinolone class of antibiotics) How to obtain prescription assistance for Janumet Continue reading >>

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