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Side Effects Of Actos Plus Metformin

Actoplus Met, Actoplus Met Xr (metformin And Pioglitazone) Drug Side Effects, Interactions, And Medication Information On Emedicinehealth.

Actoplus Met, Actoplus Met Xr (metformin And Pioglitazone) Drug Side Effects, Interactions, And Medication Information On Emedicinehealth.

oval, white, imprinted with 4833M, 15/850 What are the possible side effects of metformin and pioglitazone (Actoplus Met, Actoplus Met XR)? This medication may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or irregular heart rate, dizziness , or feeling very weak or tired. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any other serious side effects, such as: stomach pain, blood in your urine, painful urination; feeling short of breath, especially when lying down; pale skin, feeling light-headed, rapid heart rate, trouble concentrating; sudden unusual pain in your hand, arm, or foot; or nausea, stomach pain, low fever , loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). sneezing, runny nose, cough or other signs of a cold. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about metformin and pioglitazone (Actoplus Met, Actoplus Met XR)? You should not use this medication if you are allergic to metformin (Glucophage) or pioglitazone (Actos), or if you have kidney problems, severe heart failure, active bladder cancer , or metabolic acidosis. Do not use metformin and pioglitazone if you are in a state o Continue reading >>

Pioglitazone / Metformin

Pioglitazone / Metformin

Prices and Coupons for 60 tablets of pioglitazone / metformin 15mg/850mg Oral route (Tablet;Tablet, Extended Release) May cause or worsen congestive heart failure, is not recommended in patients with symptomatic heart failure, and is contraindicated in patients with established NYHA Class III or IV heart failure. Monitor patients for signs and symptoms of heart failure after initiation or dose increases and if heart failure occurs, consider dose reduction or discontinuing metformin/pioglitazone (immediate and extended-release formulations) and manage according to current standards of care. Lactic acidosis can occur due to metformin accumulation during treatment with metformin/pioglitazone (immediate and extended-release formulations) and may result in death, hypothermia, hypotension, and resistant bradyarrhythmias; risk factors include renal impairment, concomitant carbonic anhydrase inhibitor use (eg, topiramate), age 65 years or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (eg, acute congestive heart failure), excessive alcohol intake, and hepatic impairment. Onset is often subtle with nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain; laboratory abnormalities include elevated blood lactate (greater than 5 mmol/L), anion gap acidosis (without ketonuria or ketonemia), increased lactate:pyruvate ratio, and metformin levels generally greater than 5 mcg/mL. If acidosis is suspected, discontinue treatment, hospitalize the patient immediately, and promptly initiate hemodialysis . Buy Pioglitazone / Metformin for as low as Pioglitazone and metformin combination is used with proper diet and exercise to treat high blood sugar levels caused by type 2 diabetes . Pioglitazone w Continue reading >>

Actos Oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - Webmd

Actos Oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - Webmd

Sore throat , muscle pain , weight gain, or tooth problems may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: new/worsening vision problems (such as blurred vision ), bone fracture, reddish-colored urine, urgent need to urinate, pain while urinating. Pioglitazone may rarely cause liver disease. Tell your doctor right away if you develop symptoms of liver disease, including: dark urine, yellowing of eyes / skin , persistent nausea / vomiting , stomach / abdominal pain . Pioglitazone does not usually cause low blood sugar ( hypoglycemia ). Low blood sugar may occur if this drug is prescribed with other diabetes medications (such as insulin or a sulfonylurea). Low blood sugar is more likely if you drink large amounts of alcohol, do unusually heavy exercise , or do not consume enough calories from food. To help prevent low blood sugar , eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal. Symptoms of low blood sugar include sudden sweating , shaking, fast heartbeat, hunger , blurred vision , dizziness , or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar . If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the Continue reading >>

Pioglitazone/metformin

Pioglitazone/metformin

Pioglitazone/metformin (also known by the brand names Actoplus Met, Piomet and Politor) is combination of two oral diabetes medications pioglitazone and metformin. The two oral antihyperglycemic agents with different mechanisms of action are used to improve glycemic control in patients with diabetes mellitus type 2. Mechanisms[edit] Pioglitazone is a member of the thiazolidinedione class, it decreases insulin resistance in the periphery and in the liver resulting in increased insulin dependent glucose disposal and decreased hepatic glucose output. Metformin is a member of the biguanide class, improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Indication[edit] Pioglitazone/metformin is indicated as an adjunct to diet and exercise: To improve glycemic control in patients with type 2 diabetes, or For patients who are already treated with a separate combination of pioglitazone and metformin, For patients whose diabetes is not adequately controlled with metformin alone, or For patients who have initially responded to pioglitazone alone and require additional glycemic control. Dosage and administration[edit] Recommended dose[edit] Use of antihyperglycemic agents in the management of type 2 diabetes should be individualized on the basis of effectiveness and tolerability. Pioglitazone/metformin should be given with meals; the initial starting dose is either the 15 mg/500 mg or 15 mg/850 mg tablet strength once or twice daily, and gradually titrated after assessing adequacy of therapeutic response, while not exceeding the maximum recommend Continue reading >>

Metformin And Pioglitazone Overview

Metformin And Pioglitazone Overview

Metformin/pioglitazone is a prescription medication used to treat type 2 diabetes. It is a single product containing 2 medications: pioglitazone and metformin. Pioglitazone belongs to a group of drugs called thiazolidinediones. These work by increasing the body’s sensitivity to insulin. Metformin belongs to a group of drugs called biguanides. These work by decreasing the amount of glucose absorbed from food and decreasing the amount of glucose that is produced by the liver. This medication comes in tablet form and is taken one or two times a day, with food. Common side effects of metformin/pioglitazone include upper respiratory tract infection, edema, diarrhea, headache, muscle pain, and weight gain. In combination with other medications to treat diabetes, metformin/pioglitazone can also cause hypoglycemia (low blood sugar), which can cause blurred vision and dizziness. Do not drive or operate heavy machinery until you know how metformin/pioglitazone affects you. Continue reading >>

Actos

Actos

Actos (pioglitazone) is an oral Type 2 diabetes drug that lowers blood sugar by decreasing insulin resistance and reducing the amount of glucose made in the liver. This allows the body to better dispose of excess blood sugar. Typically, the dose starts at 15 or 30 mg and is taken once a day, but some people may require a stronger dose. Doctors can increase the strength of the medicine by 15 mg increments to a maximum of 45 mg daily. However, numerous studies and a review by the U.S. Food and Drug Administration (FDA) link higher dosages and prolonged use to an increased risk of bladder cancer and other serious conditions. Actos is not intended to treat Type 1 diabetes or diabetic ketoacidosis. The drug can be used alone or with other Type 2 diabetes medicines such as metformin. There are two additional types of Actos that combine pioglitazone and metformin: Actoplus Met and Actoplus Met XR (extended release). What Does Actos Treat? Actos is approved to treat Type 2 diabetes in adults by improving glycemic (defined as causing glucose – sugar – in the blood) control. The drug comes in a tablet form to be taken by mouth daily and should be used in combination with diet and exercise. People with Type 2 diabetes do not make or use insulin well. Insulin is a hormone produced by the pancreas that regulates the amount of glucose in the blood. It moves blood sugar into cells where it is stored for later use as energy. Type 2 diabetes results in higher than normal levels of glucose because glucose does not enter cells. The body is then unable to use the glucose for energy. Type 2 diabetes is a lifelong (chronic) disease that can develop at any age, including during childhood. However, it mostly occurs in middle-aged and older people. The condition often develops slowly over t Continue reading >>

Actoplus Met, Actoplus Met Xr (metformin-pioglitazone) Dosing, Indications, Interactions, Adverse Effects, And More

Actoplus Met, Actoplus Met Xr (metformin-pioglitazone) Dosing, Indications, Interactions, Adverse Effects, And More

Severe renal disease: eGFR <30 ml/min/1.73 m Acute or chronic metabolic acidosis, including DKA with or without coma Temporarily discontinue in patients undergoing radiologic exams using iodinated contrast agents Do not initiate in patients aged 80 years CrCl demonstrates that renal function is not reduced because these patients are more susceptible to developing lactic acidosis Withhold metformin in presence of any condition associated with hypoxemia, dehydration, or sepsis Lactic acidosis should be suspected in any diabetic patient with metabolic acidosis lacking evidence of ketoacidosis (ketonuria and ketonemia); lactic acidosis is a medical emergency that must be treated in a hospital setting Pioglitazone may cause fluid retention and cause or exacerbate existing heart failure Edema; thiazolidinediones, which are peroxisome proliferator-activated receptor (PPAR) gamma agonists, can cause dose-related fluid retention, particularly when used in combination with insulin Pioglitazone exerts its antihyperglycemic effect only in presence of insulin; therefore, do not use in type 1 diabetes mellitus or for treatment of diabetic ketoacidosis May cause hypoglycemia; patients receiving therapy in combination with insulin or other antidiabetic medications (particularly insulin secretagogues such as sulfonylureas) may be at risk for hypoglycemia; a reduction in dose of the concomitant antidiabetic medication may be necessary to reduce the risk of hypoglycemia; hypoglycemia can also occur when caloric intake is deficient or when strenuous be necessary to reduce the risk of hypoglycemia exercise is not compensated by caloric supplement; hypoglycemia may be difficult to recognize in the elderly, and in people who are taking beta-adrenergic blocking drugs Rare reports of hepatitis Continue reading >>

Common Side Effects Of Actoplus Met, Actoplus Met Xr (pioglitazone Hcl And Metformin Hcl) Drug Center - Rxlist

Common Side Effects Of Actoplus Met, Actoplus Met Xr (pioglitazone Hcl And Metformin Hcl) Drug Center - Rxlist

The dose of Actoplus MET is individualized on the basis of effectiveness and tolerability. The maximum recommended daily dose is pioglitazone 45 mg/metformin 2550 mg. Hyperglycemia ( high blood sugar ) may result if you take Actoplus MET with drugs that raise blood sugar, such as: isoniazid , diuretics (water pills), steroids, phenothiazines, thyroid medicine, birth control pills and other hormones, seizure medicines, and diet pills, or medicines to treat asthma , colds or allergies. Hypoglycemia (low blood sugar) may result if you take Actoplus MET with drugs that lower blood sugar, such as: alcohol, nonsteroidal anti-inflammatory drugs ( NSAIDs ), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, or probenecid. It may also interact with furosemide , nifedipine , cimetidine or ranitidine , amiloride or triamterene , digoxin , morphine , procainamide, quinidine, trimethoprim , or vancomycin . Tell your doctor all medications you are taking. During pregnancy, Actoplus MET should be used only when prescribed. Your doctor may direct you to use insulin instead during your pregnancy. This medication can promote ovulation and increase the risk of becoming pregnant. Metformin passes into breast milk in small amounts. It is unknown if pioglitazone passes into breast milk. Consult your doctor before breastfeeding. Our Actoplus MET (pioglitazone hydrochloride and metformin hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. This medication may cause lactic Continue reading >>

Side Effects Of Actos

Side Effects Of Actos

There are many possible side effects of Actos, including common problems such as headache, sinus infections, and upper respiratory infections. Most people actually tolerate the medicine well, and when side effects do occur, they usually don't require medical attention. However, certain Actos side effects are more serious and should be reported to your healthcare provider, including trouble breathing, low blood sugar, rapid weight gain, and vision changes. As with any medicine, there are possible side effects with Actos ( pioglitazone hydrochloride). However, not everyone who takes this drug will experience side effects. In fact, most people tolerate the medicine well. When Actos side effects do occur, they are generally minor and either require no treatment or can easily be treated by you or your healthcare provider. (This article covers many, but not all, of the possible side effects with Actos. Your healthcare provider can discuss a more complete list of Actos side effects with you.) Actos has been studied thoroughly in clinical trials where side effects seen with a group of people taking the drug are documented and compared to another group not taking the medicine. As a result, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine. Based on these studies, the most common side effects of Actos include: Continue reading >>

Actoplus Met Oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - Webmd

Actoplus Met Oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - Webmd

Nausea , vomiting , stomach upset, diarrhea , weakness , sore throat , muscle pain , weight gain, tooth problems or a metallic taste in the mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If stomach symptoms return later (after taking the same dose for several days or weeks), tell your doctor right away. Stomach symptoms that occur after the first days of your treatment may be signs of lactic acidosis . Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: new/worsening vision problems (such as blurred vision ), bone fracture, reddish-colored urine, urgent need to urinate, pain while urinating. Pioglitazone may rarely cause liver disease. Tell your doctor right away if you develop symptoms of liver disease, including: dark urine, yellowing of eyes / skin , persistent nausea / vomiting , stomach/ abdominal pain . This medication usually does not cause low blood sugar ( hypoglycemia ). Low blood sugar may occur if this drug is prescribed with other diabetes medications (such as insulin or a sulfonylurea). Low blood sugar is more likely if you drink large amounts of alcohol, do unusually heavy exercise , or do not consume enough calories from food. To help prevent low blood sugar , eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal. Symptoms of low blood sugar include sudden sweating , shaking, fast heartbeat, hunger , blurred vision , dizziness , or tingling hands/feet. It is a good habit t Continue reading >>

Actos - Lawsuit Information & The Common Side Effects

Actos - Lawsuit Information & The Common Side Effects

Actos is the brand name of pioglitazone, an oral anti-diabetic used to treat Type II or Non-Insulin Dependent Diaetes Mellitus (NIDDM). Though it is effective in treating Type II diabetes, especially when used along with dietary and lifestyle medications it has been linked to serious side effects, some of which may be dangerous or life threatening. Concerns about the medication have arisen over adverse events such as kidney disease, bladder cancer and congestive heart failure. Another member of the same thiazolidinedione (TZD) class of anti-diabetic medications, Avandia (rosiglitazone) has also been the subject of intensive investigation in both the United States and Europe. Because this class of medications has proven to be so dangerous, the FDA placed temporary restrictions on the use of Avandia and has required that a black-box warning be placed on Actos. The black-box warning on Actos warns that people with a history of heart failure should not use the medication. The FDA also required that the Warnings and Precautions section of the prescription information for Actos be updated to include notice about the possibility of bladder cancer in those who have used it for over one year. Takeda is one of the top 20 largest pharmaceutical companies in the world. They partnered with Eli Lilly to market Actos and in 2011, sales reached $3.85 billion in the U.S. alone. Before the drug lost patent protection and became available for generic use, it made up 27 percent of the manufacturers yearly revenue and was the best-selling anti-diabetic medication in the U.S. Takeda has received thousands of lawsuits by patients who have been diagnosed with bladder cancer. These lawsuits state that the manufacturer, Takeda, had knowledge of the dangers of Actos and failed to adequately warn Continue reading >>

Actoplus Met New Fda Drug Approval | Centerwatch

Actoplus Met New Fda Drug Approval | Centerwatch

ACTOplus met is a single dose combination of two approved drugs for the treatment of type 2 diabetes: Actos (pioglitazone) and metformin. Actos reduces insulin resistance and metformin lowers the amount of blood sugar made by the liver. ACTOplus met is specifically indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus who are already treated with a thiazolidinedione and metformin or who have inadequate glycemic control on a thiazolidinedione alone or metformin alone. ACTOplus met is supplied as a tablet for oral administration. The recommended initial dose is as follows: Starting dose for patients inadequately controlled on metformin monotherapy Based on the usual starting dose of pioglitazone (15-30 mg daily), ACTOplus met may be initiated at either the 15 mg/500 mg or 15 mg/850 mg tablet strength once or twice daily, and gradually titrated after assessing adequacy of therapeutic response. Starting dose for patients who initially responded to pioglitazone monotherapy and require additional glycemic control Based on the usual starting doses of metformin (500 mg twice daily or 850 mg daily), ACTOplus met may be initiated at either the 15 mg/500 mg twice daily or 15 mg/850 mg tablet strength once daily, and gradually titrated after assessing adequacy of therapeutic response. Starting dose for patients switching from combination therapy of pioglitazone plus metformin as separate tablets ACTOplus met may be initiated with either the 15 mg/500 mg or 15 mg/850 mg tablet strengths based on the dose of pioglitazone and metformin already being taken. At the time of FDA approval, no efficacy studies had been conducted with ActoPlus Met single tablets. However, efficacy and safety of the separate components had been previ Continue reading >>

Actoplus Met - Fda Prescribing Information, Side Effects And Uses

Actoplus Met - Fda Prescribing Information, Side Effects And Uses

WARNING: CONGESTIVE HEART FAILURE AND LACTIC ACIDOSIS Thiazolidinediones, including pioglitazone, which is a component of Actoplus Met, cause or exacerbate congestive heart failure in some patients [see Warnings and Precautions (5.1) ]. After initiation of Actoplus Met, and after dose increases, monitor patients carefully for signs and symptoms of heart failure (e.g., excessive, rapid weight gain, dyspnea, and/or edema). If heart failure develops, it should be managed according to current standards of care and discontinuation or dose reduction of Actoplus Met must be considered [see Warnings and Precautions (5.1) ]. Actoplus Met is not recommended in patients with symptomatic heart failure [see Warnings and Precautions (5.1) ]. Initiation of Actoplus Met in patients with established New York Heart Association (NYHA) Class III or IV heart failure is contraindicated [see Contraindications (4) and Warnings and Precautions (5.1) ]. Post-marketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. The onset of metformin-associated lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Metformin-associated lactic acidosis was characterized by elevated blood lactate levels (greater than 5 mmol/L), anion gap acidosis (without evidence of ketonuria or ketonemia), an increased lactate:pyruvate ratio; and metformin plasma levels generally greater than 5 mcg/mL [see Warnings and Precautions (5.2) ]. Risk factors for metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs (e.g., carbonic anhydrase inhibitors such as topiramate), age 65 years old or greater, having a ra Continue reading >>

Actoplus Met (pioglitazone,metformin) Dosage, Indication, Interactions, Side Effects | Empr

Actoplus Met (pioglitazone,metformin) Dosage, Indication, Interactions, Side Effects | Empr

Select the drug indication to add to your list Pioglitazone (as HCl), metformin HCl; 15mg/500mg, 15mg/850mg; tabs. Adjunct to diet and exercise to improve glycemic control in type 2 diabetes in patients already on pioglitazone and metformin, or when response to pioglitazone or metformin alone is inadequate. Give in divided doses with meals. Individualize. Previously on pioglitazone and/or metformin: switch on a mg/mg basis. Initially 15mg/500mg twice daily or 15mg/850mg once daily; may titrate gradually as needed; max 45mg pioglitazone/2550mg metformin per day. With CHF (NYHA Class I or II): initially 15mg/500mg or 15mg/850mg once daily. Concomitant strong CYP2C8 inhibitors: max 15mg/850mg daily. Renal impairment (eGFR 3045mL/min/1.73m2): not recommended. If eGFR <45mL/min/1.73m2, assess risk/benefit; discontinue if eGFR <30mL/min/1.73m2. NYHA Class III or IV heart failure. Severe renal impairment (eGFR <30mL/min/1.73m2). Metabolic acidosis. Diabetic ketoacidosis. Symptomatic HF: not recommended. Monitor for signs/symptoms of CHF; discontinue or reduce dose if occurs. Increased risk of metformin-associated lactic acidosis in renal or hepatic impairment, concomitant use of certain drugs (eg, cationic drugs), 65yrs of age, undergoing radiological contrast study, surgery and other procedures, hypoxic states, and excessive alcohol intake; discontinue if lactic acidosis occurs. Discontinue at time of, or prior to intravascular iodinated contrast imaging in patients with eGFR 3060mL/min/1.73m2, history of hepatic impairment, alcoholism, heart failure, or will be given intra-arterial contrast; reevaluate eGFR 48hrs after procedure and restart therapy if renally stable. Suspend therapy if dehydration occurs or before surgery. Avoid if clinical or lab evidence of hepatic diseas Continue reading >>

Actoplus Met Side Effects

Actoplus Met Side Effects

Applies to metformin / pioglitazone: oral tablet, oral tablet extended release Common (1% to 10%): Cardiac failure, chest pain[ Ref ] Thiazolidinediones , including pioglitazone can cause dose-related fluid retention which can cause or exacerbate congestive heart failure in some patients. Combination with insulin and use in patients with NYHA Class I and II congestive heart failure may increase risk.[ Ref ] Very common (10% or more): Abdominal pain , diarrhea, loss of appetite, nausea, vomiting Very common (10% or more): Abdominal pain, diarrhea, loss of appetite, nausea, vomiting[ Ref ] Gastrointestinal events occur most frequently during initiation of therapy and resolve spontaneously in most cases.[ Ref ] Very rare (less than 0.01%): Vitamin B12 absorption decreased, lactic acidosis Very rare (less than 0.01%): Vitamin B12 absorption decreased, lactic acidosis[ Ref ] Very common (10% or more): Hypoglycemia (27.3%) Mean weight increase in patients receiving pioglitazone monotherapy for 1 year was 2 to 3 kg. In combination with metformin, mean weight increase over 1 year was 1.5 kg. The mechanism of weight gain is unclear, but probably involves a combination of fluid retention and fat accumulation.[ Ref ] Common (1% to 10%): Upper respiratory infection Common (1% to 10%): Upper respiratory infection, pharyngitis Common (1% to 10%): Hypoesthesia, headache, taste disturbance Common (1% to 10%): Hypoesthesia, headache[ Ref ] Visual disturbances have been reported early in treatment and may be related to changes in blood glucose due to temporary alteration in the turgidity and refractive index of the lens. Macular edema has been reported postmarketing in patients taking pioglitazone or another thiazolidinedione. Some patients presented with blurred vision or decreased vis Continue reading >>

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