Diabetes Drug Could Be Dangerous: Study
Posted: May 15, 2002 3:35 PM ET | Last Updated: May 15, 2002 A number of patients with diabetes are being given a drug that could kill them, according to researchers in North Carolina. A study on metformin, also sold as Glucophage and Novo-Metformin, says nearly one in four patients could experience dangerous side effects. The study is published in the most current issue of the Journal of the American Medical Association. Metformin helps the body use insulin and is one of the most common drugs used to treat Type II diabetes, sometimes linked to obesity and called "adult-onset" or "non-insulin dependent" diabetes. There are at least 1.2 million Canadians with diabetes according to Health Canada. More than 90 per cent are Type II. Metformin can cause a side-effect called lactic acidosis, a buildup of lactic acid in the blood that is fatal in half of all cases. The label says it shouldn't be used by patients with kidney disease or by those taking heart medication. A study of metformin patients by the University of North Carolina in Chapel Hill found a quarter met that criteria. Fortunately, none of the patients developed lactic acidosis. "It is difficult to determine whether clinicians are aware they are prescribing metformin against a black-box warning," wrote the researchers. "Black-box" refers to the highlighted cautionary information on labels of drugs that have serious side effects. The Canadian Medical Association's guide to prescription drugs lists special precautions for metformin. Metformin is not recommended if you: Common reactions are loss of appetite, nausea and vomiting and a metallic taste in the mouth. Lead researcher Cheryl Horlen says several recent European studies have found similar rates of inappropriate use. Recent studies by Harvard Medical School a Continue reading >>
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I Took Metformin For A Week And Here's What Happened
Craig Cooper Men's Health Leave a comment 0 I admit it: I took metformin for a week, the leading prescribed drug for treatment of type 2 diabetes ( 59.2 million units prescribed ) in the United States alone and taken by 80 million people around the world. This medication has been around for more than half a century and is often touted as a wonder drug for individuals with type 2 diabetes as well as for those living with other health challenges. My reasons for taking metformin were highly personal: I have a genetic predisposition for both prostate cancer and type 2 diabetes (Im not diabetic but I swing in and out of pre-diabetes based on my daily blood sugar readings), and Im getting older (who isnt!). I did copious amounts of research and it seemed on all three counts ( prostate cancer prevention , managing type 2 diabetes (increasing insulin sensitivity), and anti-aging), it truly was a wonder drug. Oh, and I had also read that pretty much every billionaire in Silicon Valley was on it mainly for its purported life extension benefits (as it can mimic the effect of calorie restriction see more below). Before I went on it I wanted to get some key blood indicators taken, specifically: Testosterone (total, free, and bioavailable). The plan was to have these indicators measured before taking metformin and then again, one month later. I really wasnt looking at metformin as a drug I was looking at it more as a superfood. Could it really have all these purported benefits with no real side effects? Why wouldnt I take it? After all, I dont take any other drugs so I had no real risk of the cocktail effect whereby it could have possibly interacted with other medications. However I quickly changed my mind for the reasons set out below, but I wanted to first share with you some of t Continue reading >>
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Anything I Need To Know About Taking Metformin? : Diabetes
Can confirm. HOWEVER...I did an extended graduate research project into this (I have a Master of Science in Nutrition) and B12 absorption is reduced and deficiencies generally show up over time when Metformin has been taken over a period of several years. Simple solution is to take an OTC B-complex supplement once a day (it has B12, B6, folate, riboflavin, niacin, etc). If you are concerned have your doc/endo test B12 levels. Also, I am diabetic and on Metformin myself for over a decade now, and the supplementation has been sufficient to curb any low B12 for me, as well. Hope this helps! Continue reading >>
Stop The Metformin Madness
I have never been a fan of Metformin. It seemed too good to be true. Many years ago I had a conversation with a researcher about all of its possible therapeutic indications. His lab was actively pursuing the anti-cancer angle. That should have been a clue that Metformin might be causing more damage than we recognized, but it wasn’t. At that point, I was still enamored with the wonders of pharmacology and hadn’t yet begun my path toward understanding medication adverse reactions. Indeed, it wasn’t until very recently, when a family member began suffering from one of these reactions, that I began my investigation in full. This is what I learned. Type 2 Diabetes is Big Business The global profits from Type 2 diabetes medications rested at a paltry $23 billion dollars in 2011 but are expected to grow to over $45 billion annually by 2020. The market growth is bolstered in large part by the ever-expanding demand for therapeutics like Metformin or Glucophage. Metformin is the first line of treatment and standard of care for insulin resistance across all populations of Type 2 diabetics with over 49 million Americans on Metformin in 2011-2012. It is particularly popular in women’s health with an increasing reliance on Metformin for the metabolic dysfunction observed in women with PCOS, PCOS-related infertility and even gestational diabetes. Metformin is prescribed so frequently and considered so innocuous that it is sometimes euphemistically referred to as vitamin M. If we quickly scan the safety research for metformin, there is little immediate evidence suggesting any side effects whatsoever. In fact, in addition to controlling blood sugar by blocking the hepatic glucose dump, this drug is suggested to promote weight loss, increase ovulation in women, (thereby helping a Continue reading >>
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Anti-aging drug could let you live to 120 in good reddit reddit: the front page of Metformin is a standard anti-diabetic drug, An anti-aging drug would require longer discussions with the FDA as its a new class but Metformin now being trialed as an anti-aging reddit.com Could drugs delay the diseases of ageing? () gt; For more than 60 years metformin has been used as a very Anti-Aging Pill Metformin to Be Tested Next Year A diabetes medication will buy real viagra online be tested as the world x27;s first anti-aging drug in clinical trials next year. If successful, the trials could result in people taking the Is Metformin an Anti-aging Drug? Josh Mitteldorf Is Metformin an Anti-aging Drug Vladimir Anisimov from University of Glasgow has proposed that it x27;s time to test metformin for its anti-cancer and life Metformin The Anti-Aging Miracle Drug Jeffrey Dach MD Metformin, The Anti-Aging Miracle Drug. Click to share on Reddit (Opens buying cialis online in new window) Metformin Anti Aging Dosage Metformin May Promote Anti-Aging WorldHealth Metformin, a drug that has been widely used to treat diabetes, is being tested on humans for it x27;s anti-aging properties. Metformin Wins FDA Approval Life Extension Anti-Aging Human Study on Metformin Wins FDA Approval quot;New Anti-Aging Drug quot;Scientists think the best candidate for an anti-aging drug is metformin, The Diabetes Drug That Could Be an Anti-Aging Miracle A pile of empty pill blister packs. Metformin, a generic diabetes pill, is the subject of a new study on its anti-aging properties. But pharmaceutical companies are Common Drug Has The Potential To Slow Aging, Boost Cancer An anti-aging powerhouse right under our noses? Metformin, a drug commonly prescribed for diabetes, may slow aging and cancer tumor growth, Continue reading >>
Comparison Of Two Insulin Sensitizers, Metformin And Myo-inositol, In Women With Polycystic Ovary Syndrome (pcos).
Abstract Insulin resistance (IR) plays a pivotal role in PCOS. Insulin-sensitizer agents such as metformin and inositols have been shown to improve the endocrine and metabolic aspects of PCOS. The purpose of this study is to compare their effects on the clinical and metabolic features of the women with PCOS. Fifty PCOS women with IR and/or hyperinsulinemia were randomized to treatment with metformin (1500 mg/day) or myo-inositol (4 g/day). IR was defined as HOMA-IR >2.5, while hyperinsulinemia was defined as a value of AUC for insulin after a glucose load over the cutoff of our laboratory obtained in normal women. The Matsusa Index has been calculated. The women have been evaluated for insulin secretion, BMI, menstrual cycle length, acne and hirsutism, at baseline and after 6 months of therapy. The results obtained in both groups were similar. The insulin sensitivity improved in both treatment groups. The BMI significantly decreased and the menstrual cycle was normalized in about 50% of the women. No significant changes in acne and hirsutism were observed. The two insulin-sensitizers, metformin and myo-inositol, show to be useful in PCOS women in lowering BMI and ameliorating insulin sensitivity, and improving menstrual cycle without significant differences between the two treatments. KEYWORDS: Androgens; amenorrhea; insulin resistance; insulin sensitizer; polycystic ovary syndrome Continue reading >>
Dr. Keith Roach: Is Metformin A Lifetime Medication?
Dr. Keith Roach: Is metformin a lifetime medication? DEAR DR. ROACH: I have been taking metformin 500 mg once daily for several months, with little results. I am in my 70s, and overweight by 25 pounds. My average sugar level is still around 160. I read that metformin will drop your glucose level by only 20 percent. Will that percentage increase if I take more? If so, by how much? Do I have to take metformin for the rest of my life? Will my body ever correct itself? - R.I. ANSWER: Average sugar level, also called estimated average glucose, is a way to describe blood sugar control in people with diabetes or prediabetes. A level of 160 is equivalent to an A1c level (a more commonly used measure of blood sugar control) of about 7.2 percent This is a reasonable level for most people in their 70s, where lower levels ("tighter" control) increase the risk for dangerously low blood sugars. Most medicines are more effective at higher doses. For metformin, 500 mg twice daily is the most common dose I see. Although it can be dosed up to 1,000 mg twice daily, it's not much more effective in most people, and is more likely to cause side effects, especially nausea. Not everybody with Type 2 diabetes needs to be on medicine forever. Losing weight, exercising regularly and having a prudent diet with small amounts of simple sugars all may help treat diabetes, and I have had many patients stop all their diabetes medications when adhering to these recommendations. Readers may email Dr. Roach questions to [email protected] or request an order form of available health newsletters at 628 Virginia Dr., Orlando, FL 32803. Digital access or digital and print delivery. Continue reading >>
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It is a bit weird that doctors are only supposed to prescribe these drugs for medical conditions and not enhancement. If the effects are beneficial and the drug is safe, why not allow healthy people to take it? Of course, it's not hard to get a prescription if you want one. I just wish everyone didn't have to play this game of off-label prescriptions and lying to doctors. Edit: Disclaimer: I take modafinil and I find it very useful. Because our society has not debated the consequences of cognitive enhancement, and we are worse off for it. There are moral arguments for and against enhancement, but the way it currently is prohibited, yet tolerated (nearly everyone who really wants to can game the prescription requirement), is the worst way to handle it. So why not allow healthy people to take it? Because it distorts the competition - not who studied the most wins, but he who enhanced himself best. If you allow some enhancement, why not others forms? What about artificial limbs for athletes? Where does enhancement stop? What about everyone then feeling pressured to enhance themselves to still be able to compete, if they want to or not? I'd say the status quo is bad but not the worst. It would be better if cognitive-enhancing drugs were available for anyone who wanted them. It would be worse if using drugs for cognitive enhancement was illegal. I don't think the sports analogy maps. Sports are artificial competitions and usually zero-sum. Commerce is cooperative. Intelligent individuals often benefit the less lucky. They invent new technologies that end up helping everyone. If you allow some enhancement, why not others forms? What about artificial limbs for athletes? I guess that would be the Paralympics, but I don't have a problem with it. Cyborg kickboxing sounds more in Continue reading >>
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Today I Was Diagnosed Type 2 And Put On Metformin 500mg : Diabetes
It is wise to discuss any side effects from any new med with your doctor ASAP. The dose will probably be reduced to one 500mg daily in the short term, although your side effects are not unusual and should pass (no pun intended) soon. If they do not improve discuss ceasing the med with your doc. It's more than just cutting carbs, it's discovering when you may need to cut drastically and when you can consume some safely. For example I am zero carb at breakfast but can handle quite a significant load at dinner - but you may be different. That testing technique works. I was diagnosed with T2 1 month ago. My sugar level has been getting lower and lower and today it was at 53! (way too low) If you find yourself dropping low consistently, reach out to your doctor. They may decide to cut the dosage or stop it temporarily. My doctor said we caught it early and in a months time I've also dropped 10 lbs. and eat much better. Being a college kid, I can't rely on ramen noodles to get me by anymore. Even if you don't want to, make sure you have a good meal before taking Metformin. I became really sick when I first started taking the medicine. My dosage was cut from 2 pills a day to 1. Talk to your doctor and see if that is an option. When my doc cut the 2nd pill, the afternoon/evening nauseousness went away. Continue reading >>
'can I Take Metformin If I Want To Lose Weight?'
'Can I Take Metformin If I Want To Lose Weight?' Some doctors are now prescribing this diabetes drug for weight loss. But is it safe? Metformin is a drug designed to treat patients with Type 2 diabetes, but it comes with an interesting side effect: weight loss . And Reddit is filled with stories from people who have lost weight on the drug. Was trying to lose weight for a long time with no success, one person wrote of being prescribed metformin. Im on 1000 mg a day and am down 10 pounds. I saw weight loss at first with 500 mg twice per day, another wrote. The difference was almost immediate. While some people say the drug didnt do much for them, others swear by iteven those that dont have Type 2 diabetes, saysFatima Cody Stanford, M.D., an instructor of medicine and pediatrics at Harvard Medical School and obesity medicine physician at Massachusetts General Hospital. In fact, Cody Stanford says that she often prescribes the medication to overweight or obese people who don't have Type 2 diabetes. Heres what you need to know about the drug. (Hit the reset buttonand burn fat like crazy with The Body Clock Diet !) Metformin causes a decrease in the release of glucose from a persons liver. This helps to lower a persons blood sugar when its too high and restore the way someone uses food to make energy, according to the Mayo Clinic . " Weight loss can occur because it decreases appetite in some people who take it," says women's health expert Jennifer Wider , M.D. In order for the prescription to work effectively, the amount of metformin you take must be balanced against your diet and exercise because it helps level out your blood sugar, the clinic says. For that reason, if you change your diet or exercise, you doctor may need to change the amount of metformin you take. Check Continue reading >>
Avoid The Metformin Bandwagon
From diabetes to cancer, berberine matches - or beats - this patent medicine every time! As many know, metformin is the number one prescription medication for type-2 diabetes. The patent for the name-brand of this patent medicine, Glucophage®, expired years ago and as a result generic-brand competition (metformin) brought this patent medicine’s price down so that it’s relatively inexpensive, especially when compared with nearly any other medication still covered by a patent. Mainstream medical research has found other uses for this un-natural molecule, including (but not limited to) lipid, blood pressure, and insulin resistance lowering effects, anti-cancer effects, improvement of polycystic ovarian syndrome, combatting Alzheimer’s disease, and extending life span in mice. Surprising guests on the metformin bandwagon Some proponents of natural therapies – including, surprisingly, two nationally and internationally circulated health magazines – have climbed on the metformin bandwagon, writing articles about the “health benefits” of metformin, and even advocating that otherwise healthy people take this patent medicine every day as a preventive. They admit that there are known side effects, but write that these are few, and that the benefits outweigh the risks. If there aren’t any natural treatment alternatives that are as effective, or more effective, than a patent medicine or other un-natural molecule – especially in serious or life-threatening situations – then the use of a patent medication of course makes sense. But when there are natural alternatives that work just as well or better, the rule is – and always should be – to “Copy Nature.” Human bodies are formed from the molecules of planet Earth, and powered by the energies of this planet Continue reading >>
Should I Already Take Metformin As Prediabetic?
Should I already take metformin as prediabetic? I had gestational diabetes and gave birth to my son in October last year. Last week I took the follow up OGTT. The fasting numbers were ok (97), but after two hours i had 197. My GP wanted to look at my A1C so I had that test done yesterday. Fasting numbers were good again (92) and I had an A1C of 5% even after not really paying extra attention to my food the last couple of months. I didn't follow any kind of diet, but I don't eat outrageous meals either. I was slightly overweight at the start of my pregnancy, but because I was very strict about my diet with GD, I only gained 4kgs. I now weigh about 5kg less than before I got pregnant and am back to a normal BMI. Anyway. I'm puzzled. My GP said I'm prediabetic, but shouldn't the A1C be elevated as well? Especially after three months of eating basically everything that I wanted including many desserts during the holiday season. I was put on metformin, but I was wondering if that is really necessary. It seems a bit much. Shouldn't I try getting things under control with diet and exercise before starting medication? Continue reading >>
Doc Wants Me To Start Metformin, But You All Scared Me About It! : Pcos
I have been diagnosed with PCOS for about 3 years. When i graduated college (2011) i was 130lbs and in great shape and had no symptoms. I since then had gained 35 pounds and CANT shed it. I have literally tried anything and i am getting increasingly more frustrated. GYN said i should take metformin, but after reading everyone's horror stories about it i am really afraid to try it.(although the instructions say if you have vomiting or diarrhea to stop taking it immediately and consult your doctor, which i wonder if people actually did?) I have a schedule that isn't really conducive to having stomach issues (work full time, 2 days a week internship and grad school classes at night). I also know that people only say something about metformin if they have had a bad experience. Does anyone have any good stories? Did anyone have NO side effects at all? Im too afraid to take the risk! Continue reading >>