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Sertraline And Type 2 Diabetes

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Sertraline-induced Hypoglycemia In Type 2 Diabetes Patients

1From the Section of Endocrinology, Temple University School of Medicine, Philadelphia, Pennsylvania 2Division of Endocrinology, Veterans Affairs Medical Center, Washington, DC, and George Washington University, Washington, DC. Objective: To report the clinical outcomes of 2 type 2 diabetes patients admitted for severe and precipitous hypoglycemia after initiation of sertraline and subsequent resolution after discontinuation of the medication. Methods: Case reports with literature review. Results: Case 1: A 58-year-old African American man with poorly controlled type 2 diabetes was admitted for unresponsiveness due to severe hypoglycemia. Twelve days prior to admission, he was started on sertraline and observed declining fasting blood sugar levels, with 2 episodes of symptomatic hypoglycemia. Despite discontinuation of insulin for 48 hours during admission, resolution of hypoglycemia only occurred after discontinuation of the sertraline. Despite titration of insulin to pre-admission dosage following discharge, he was re-admitted shortly for hyperosmolar hyperglycemic state. Case 2: An 85-year-old Caucasian man with well-controlled type 2 diabetes was admitted for 3 episodes of hypo Continue reading >>

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  1. JimBear

    Hi good folks!
    I have been prescribed Sertraline while various tests are made to find out what's causing a whole slew of other problems and I read in the leaflet that it can affect blood glucose levels in diabetic patients. It didn't say how it affected, though after being on for just three days my blood sugars soar after a meal. I have been adjusting my bolus to try and compensate and they are returning to somewhere near normal before the next meal, but I am being alarmed at seeing double figures, especially since this mini-heat wave we're having now where usually my numbers drop alarmingly. (past three days it's reached 27.8 in my non-air-conditioned office).
    I was just wondering if anyone else has had experience of this medication and how it affected them.
    Ta very much
    Jim

  2. mikeyB

    I have taken Sertraline, Jim, but I didn't find that it affected my blood sugar. I had to stop it after epileptic fits on two consecutive nights, waking up on the floor. I was hypo at the time, but not severely. That's in the side effect list as well, but that's not a new condition.
    Make sure you are drinking plenty of fluids this weather, fluid loss sticks your BG up.

  3. JimBear

    Wow you did have a rough time! (I deliberately didn't read the side effect list this time!)
    I am drinking loads, peeing loads and if I were to try and consume any more water I'd need to be plumbed in like the washing machine lol!

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