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Resveratrol Insulin Resistance

Resveratrol, Weight Loss, And Insulin Resistance

Resveratrol, Weight Loss, And Insulin Resistance

Resveratrol affects weight through several mechanisms - it improves blood glucose control, increases resting metabolic rate, leads to faster feelings of satiety, and more. Find out how resveratrol can help you lose fact and how to take it for best effect. The Link Between Obesity and Metabolic Disorders Statistics show that more than 2 in 3 adults in the US are considered overweight or obese. Obesity is defined by too much body fat. This is not just a cosmetic concern – it is a complex condition, which may lead to many health issues. So, how is obesity related to metabolic disorders? In the old days, body fat was considered to be merely storage of energy. Today, scientists know that body fat (especially fat around the belly) produces hormones, which play an important role in developing chronic, low level inflammation in the body. This inflammation contributes to the development of high blood pressure, increases the levels of triglycerides in the body, and the chances of developing insulin resistance and type 2 diabestes. How Does Resveratrol Help With Weight Loss and Metabolic Problems? Resveratrol is a substance (polyphenol), found in many plant sources. Resveratrol offers many health benefits; it is believed that it plays a role in cardiovascular protection, promotes longevity, and helps with weight loss and metabolic disorders. Most well known sources of resveratrol are red grapes and red wine. However, the amount of resveratrol in food sources is typically too low to get the desired health results. That is why many people decide to take resveratrol supplements. Results of clinical studies have shown that resveratrol: promotes weight loss by suppressing fat storage and accelerating fat metabolism leads to faster feelings of satiety, which in turn result in lower en Continue reading >>

Resveratrol Shows Activity Against Insulin Resistance And Retinal Disease

Resveratrol Shows Activity Against Insulin Resistance And Retinal Disease

A naturally occurring chemical found in grapes and other foods may help reverse some of the ills associated with aging and being overweight, new studies suggest. The chemical, resveratrol, has been shown to lengthen the life span of yeast and improve health in laboratory animals, but scientists do not yet know whether the substance might also benefit humans. Two new studies of older or overweight people suggest that it can, by helping boost the action of insulin. And a study in mice shows that the chemical works through a previously unknown mechanism to halt harmful blood vessel growth in the retina. As people age or gain weight, their ability to respond to insulin declines. Some people become mildly resistant to insulins action, so that their muscles and other tissues no longer take up and burn glucose efficiently. That condition, known as insulin resistance, is one of the first steps toward diabetes. Now, researchers have found that resveratrol imp This article is only available to Science News subscribers. Already a subscriber? Log in now . Or subscribe today for full access. Continue reading >>

Resveratrol Helps With Insulin Resistance And Pcos

Resveratrol Helps With Insulin Resistance And Pcos

Resveratrol Helps with Insulin Resistance and PCOS Polycystic Ovary Syndrome (PCOS) is a hormonal endocrine disorder that affects 1 in 10 women of childbearing age. PCOS occurs when abnormal levels of reproductive hormones, particularly an excess of androgen hormones such as testosterone, impact the proper functioning of the ovaries and metabolism. Women with PCOS tend to be insulin resistant, meaning their bodies do not respond to insulin properly, and produce excess insulin as a result. Insulin resistance is the precursor to type II diabetes, a common diagnosis alongside PCOS. Other symptoms of PCOS include: In many cases, PCOS can significantly impact a woman’s self-esteem and quality of life. Conventional treatments for PCOS typically include diet modification, surgery, and prescription medications such as birth control pills to help balance hormone levels. Many women are looking to alternative medicine to provide more natural methods of management. New research published in the Endocrine Society’s Journal of Clinical Endocrinology and Metabolism suggests that resveratrol, an antioxidant compound found in red wine, grapes, raspberries, and peanuts, may help manage the hormone imbalance that characterizes PCOS. Resveratrol is an anti-inflammatory compound that helps to protect plants from disease. When a plant is invaded by a fungus or infection, or under undue stress, injury, or ultraviolet irradiation, resveratrol comes to the rescue. These same protective mechanisms appear to engage in humans too. Studies have linked resveratrol to a reduced risk for life-threatening conditions such as cancer and coronary heart disease. The latest study is the first to assess resveratrol’s impact on the hormone and metabolic processes of women with PCOS. For this randomized Continue reading >>

Effect Of Resveratrol On Glucose Control And Insulin Sensitivity: A Meta-analysisof 11 Randomized Controlled Trials.

Effect Of Resveratrol On Glucose Control And Insulin Sensitivity: A Meta-analysisof 11 Randomized Controlled Trials.

1. Am J Clin Nutr. 2014 Jun;99(6):1510-9. doi: 10.3945/ajcn.113.082024. Epub 2014Apr 2. Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysisof 11 randomized controlled trials. Liu K(1), Zhou R(1), Wang B(1), Mi MT(1). (1)From the Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing Key Laboratory of Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, Chongqing, PR China. BACKGROUND: The results of human clinical trials investigating the effects ofresveratrol on glucose control and insulin sensitivity are inconsistent.OBJECTIVE: We aimed to quantitatively evaluate the effects of resveratrol onglucose control and insulin sensitivity.DESIGN: We performed a strategic literature search of PubMed, Embase, MEDLINE,and the Cochrane Library (updated to March 2014) for randomized controlled trialsthat estimated the effects of resveratrol on glucose control and insulinsensitivity. Study quality was assessed by using the Jadad scale. Weighted meandifferences were calculated for net changes in glycemic measures by usingfixed-effects or random-effects models. We performed prespecified subgroup andsensitivity analyses to evaluate potential heterogeneity. Meta-regressionanalyses were conducted to investigate dose effects of resveratrol on fastingglucose and insulin concentrations in nondiabetic subjects.RESULTS: Eleven studies comprising a total of 388 subjects were included in this meta-analysis. Resveratrol consumption significantly reduced fasting glucose,insulin, glycated hemoglobin, and insulin resistance (measured by using thehomeostatic model assessment) levels in participants with diabetes. Nosignificant effect of resveratrol on glycemic measures o Continue reading >>

Resveratrol Reconsidered

Resveratrol Reconsidered

As we pointed out last week here at Diabetes Flashpoints, red wine has long been associated with a number of health benefits — including reduced insulin resistance and a lower risk of developing Type 2 diabetes — along with the risks inherent in drinking alcohol (which can include addiction and abuse, as well as higher blood triglyceride levels in some people). But the main study we discussed in last week’s post, published earlier this month by the journal JAMA Internal Medicine, found no reduction in overall mortality, or any other health benefits, from consuming higher levels of resveratrol — a compound in red wine that, in the context of the study, was a good marker for how much red wine the participants were drinking over the nine-year study period. This study cast doubt on the benefits of drinking red wine and, in particular, of consuming resveratrol, which is touted by some proponents as a wondrous health-enhancing, life-extending chemical. But another new study, also published earlier this month, takes a very different perspective on resveratrol. This research review, published in the journal European Endocrinology, notes that resveratrol may have several beneficial effects in people with Type 2 diabetes, including enhancing the effect of the oral drug metformin. According to an article on the review at NutraIngredients.com, a series of clinical trials at New York City’s Albert Einstein College of Medicine between 2005 and 2014 examined some of the diabetes-related effects of the chemical. In one study, a daily 500-milligram dose of resveratrol (in pill form) was found to slow the progression of prediabetes into full-blown Type 2 diabetes. Another study found that taking 1–2 grams of resveratrol daily improved glucose metabolism. In people with Type 2 Continue reading >>

19: Resveratrol Improves Insulin Resistance With Anti-inflammatory And Browning Effects In Adipose Tissue Of Overweight Humans | Journal Of Investigative Medicine

19: Resveratrol Improves Insulin Resistance With Anti-inflammatory And Browning Effects In Adipose Tissue Of Overweight Humans | Journal Of Investigative Medicine

19: RESVERATROL IMPROVES INSULIN RESISTANCE WITH ANTI-INFLAMMATORY AND BROWNING EFFECTS IN ADIPOSE TISSUE OF OVERWEIGHT HUMANS AFMR Presidential Plenary Session (Scientific Session II), 1:05 PM 3:05 PM, Wednesday, April 13, 2016 19: RESVERATROL IMPROVES INSULIN RESISTANCE WITH ANTI-INFLAMMATORY AND BROWNING EFFECTS IN ADIPOSE TISSUE OF OVERWEIGHT HUMANS 1Endocrinology, Albert Einstein College of Medicine, Bronx, NY, United States 2Harvard Medical School, Boston, MA, United States Purpose of Study Resveratrol is a plant-derived polyphenol whose beneficial metabolic effects in rodents include improved insulin sensitivity, reduced inflammation, and increased muscle mitochondrial biogenesis. We set out to confirm these findings in insulin resistant human subjects, by examining the effects of resveratrol on insulin sensitivity, muscle mitochondria, and adipose inflammation. Methods Used Specifically, resveratrol 2 gm/day (RV) or placebo (PL) were administered for 28 days in a randomized, double-blinded fashion to n=21 non-diabetic subjects (17 M; Age=522; BMI=31.90.9 kg/m2; HOMA-IR=3.90.2). All subjects participated in 6-hour, stepped euglycemic hyperinsulinemic (30 and 80 mU/m2.min) pancreatic clamp studies to assess hepatic and peripheral insulin sensitivity, with biopsies of vastus lateralis muscle and subcutaneous abdominal adipose tissue, before and after RV and PL. Muscle mitochondria were analyzed for quantity, size, area in a field, and the % area covered, using electron microscopy with Volocity image analysis. Summary of Results RV induced a 22% (p=0.035) increase in glucose uptake, but did not affect glucose production. There were no changes in quantity (p=0.829) or percent area (p=0.897) of muscle mitochondria. There were no changes in basal or resting energy exp Continue reading >>

Effects Of Resveratrol On Glucose And Insulin Dynamics And Blood Lipid Concentrations In Insulin-resistant Horses - Tufts University

Effects Of Resveratrol On Glucose And Insulin Dynamics And Blood Lipid Concentrations In Insulin-resistant Horses - Tufts University

Source: TUFTS UNIVERSITY submitted to EFFECTS OF RESVERATROL ON GLUCOSE AND INSULIN DYNAMICS AND BLOOD LIPID CONCENTRATIONS IN INSULIN-RESISTANT HORSES Cooperating Schools of Veterinary Medicine Horses do not suffer from coronary artery disease, but a metabolic syndrome has been described in this species that is similar to Metabolic Syndrome (MetS) in humans. Equine metabolic syndrome (EMS) is a clinical syndrome of obesity or regional adiposity, hyperinsulinemia, insulin resistance (IR), and an increased predisposition to laminitis. Resveratrol, a plant phenol lowering blood cholesterol concentration in humans, has also been shown to improve insulin sensitivity in rodents and might therefore be effective for managing IR in horses. This study will evaluate the clinical efficacy of resveratrol in insulin-resistant horses. We hypothesize that resveratrol lowers plasma insulin concentrations, improves insulin sensitivity, and alters blood lipid concentrations in insulin-resistant horses. We hypothesize that resveratrol lowers insulin concentrations, increases insulin sensitivity, alters blood lipid concentrations in horses with naturally-occurring hyperinsulinemia and insulin resistance (IR). These horses suffer from equine metabolic syndrome (EMS), which is a clinical syndrome of obesity or regional adiposity, hyperinsulinemia, IR, and an increased predisposition to laminitis. Our specific aims are: 1. To determine whether resveratrol lowers plasma insulin concentrations at rest and during dynamic tests. 2. To investigate the effects of resveratrol on insulin sensitivity in insulin-resistant horses. 3. To examine the effects of resveratrol on blood concentrations of adrenocorticotropin hormone (ACTH), leptin, triglyceride, non-esterified fatty acids, and cholesterol. Res Continue reading >>

Effects Of Resveratrol On Glucose Control And Insulin Sensitivity In Subjects With Type 2 Diabetes: Systematic Review And Meta-analysis

Effects Of Resveratrol On Glucose Control And Insulin Sensitivity In Subjects With Type 2 Diabetes: Systematic Review And Meta-analysis

Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis Department of Endocrinology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009 China Xiangyun Zhu, Email: [email protected]_yxuhz . Received 2017 Jun 28; Accepted 2017 Sep 18. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated. This article has been cited by other articles in PMC. Although the regular consumption of resveratrol has been known to improve glucose homeostasis and reverse insulin resistance in type 2 diabetes mellitus (T2DM), the reported results are inconsistent. Thus, we aimed to assess the effects of resveratrol on glycemic control and insulin sensitivity among patients with T2DM. We searched for relevant articles published until June 2017 on PubMed-Medline, Embase, Cochrane Library, and Web of Science. Randomized controlled trials in T2DM patients administered with resveratrol as intervention were included. After study selection, quality assessment and data extraction were performed independently by two authors, and STATA and RevMan software were used for statistical analysis. Nine randomized controlled trials involving 283 participants were included. Meta-analysis showed that resveratrol significantly improved the fasting plasma glucose ( 0.29 mmol Continue reading >>

Resveratrol And Insulin Sensitivity

Resveratrol And Insulin Sensitivity

Resveratrol is a polyphenol with powerful antioxidant and anti-inflammatory properties. It has been widely publicized for its cardiovascular, anti-carcinogenic, and anti-aging benefits . Resveratrol activates sirtuins , which can increase insulin sensitivity and protect against oxidative damage. Previous research with resveratrol has demonstrated improvements in dysglycemia and insulin sensitivity; however, there has been some inconsistency in study results. According to a new review published three weeks ago inNutrition & Metabolism, researchers demonstrated that resveratrol does improve glycemic control and insulin sensitivity in individuals with type II diabetes. This review consisted of 9 randomized controlled trials, with doses ranging from 8 mg/d to as high as 3 g/d with a duration of 4 weeks to 12 months. The overall results demonstrated that resveratrol significantly reduced fasting glucose levels but only at a dosage of 100 mg/d or more. In addition, HOMA-IR, fasting insulin levels, and blood pressure were also reduced by resveratrol. In a previous study published earlier this year in theInternational Heart Journal, researchers demonstrated resveratrols benefits in improving arterial stiffness and reducing oxidative damage in patients with type II diabetes. This study used the same dosage of 100 mg, which has been shown to reduce fasting glucose levels. Resveratrol can act through several mechanisms, including binding and activating estrogen receptors to increase nitric oxide bioavailability and facilitate the vasodilatation. In addition, it decreases reactive oxygen species production in vascular endothelial cells. Oxidative stress is elevated in chronic disease such as obesity and diabetes. These results support resveratrol supplementation as a potential str Continue reading >>

Resveratrol Improves Insulin Resistance, Glucose And Lipid Metabolism In Patients With Non-alcoholic Fatty Liver Disease: A Randomized Controlled Trial - Sciencedirect

Resveratrol Improves Insulin Resistance, Glucose And Lipid Metabolism In Patients With Non-alcoholic Fatty Liver Disease: A Randomized Controlled Trial - Sciencedirect

Volume 47, Issue 3 , March 2015, Pages 226-232 Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: A randomized controlled trial Non-alcoholic fatty liver disease is a major health problem worldwide. Resveratrol is a natural polyphenol found in edible plants that has a variety of biochemical and physiological effects. To evaluate the effect of resveratrol on insulin resistance, glucose and lipid metabolism in non-alcoholic fatty liver disease. Double-blind, randomized, placebo-controlled trial: 60 subjects with non-alcoholic fatty liver disease were given 2 placebo capsules (placebo group) or 2 150mg resveratrol capsules (resveratrol group) twice daily for three months. Liver ultrasound imaging, anthropometric profile, serum liver enzymes, insulin, glucose, C-peptide, lipid profile, and inflammation-related cytokines were compared pre and post-treatment. Compared with the placebo group, resveratrol significantly decreased aspartate aminotransferase, glucose and low-density lipoprotein cholesterol [6.00 (9.00, 3.00) IU/L, 0.640.31mmol/L, and 0.410.35mmol/L, respectively, P0.001] alanine aminotransferase, total cholesterol [7.00 (11.0, 2.50) IU/L and 0.670.50mmol/L, respectively, P=0.002], and homeostasis model assessment insulin resistance index (0.601.15, P=0.016). In the resveratrol group significant reductions of the levels of tumour necrosis factor-alpha, cytokeratin 18 fragment, and fibroblast growth factor 21 [0.531.30pg/mL, 26.9 (70.3, 5.12) IU/L and 23.3 (43.0, 0.31) pg/mL, respectively, P<0.05] and elevation of adiponectin level [1.22 (0.37, 1.60) ng/mL, P=0.025] were observed. Resveratrol supplementation may benefit patients with non-alcoholic fatty liver disease. Continue reading >>

Effect Of Resveratrol On Glucose Control And Insulin Sensitivity: A Meta-analysis Of 11 Randomized Controlled Trials

Effect Of Resveratrol On Glucose Control And Insulin Sensitivity: A Meta-analysis Of 11 Randomized Controlled Trials

Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials From the Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing Key Laboratory of Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, Chongqing, PR China, Search for other works by this author on: From the Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing Key Laboratory of Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, Chongqing, PR China, Search for other works by this author on: From the Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing Key Laboratory of Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, Chongqing, PR China, Address correspondence to M-T Mi or B Wang, Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing Key Laboratory of Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, Chongqing 400038, PR China. E-mail: [email protected] or [email protected] . Search for other works by this author on: From the Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing Key Laboratory of Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, Chongqing, PR China, Search for other works by this author on: The American Journal of Clinical Nutrition, Volume 99, Issue 6, 1 June 2014, Pages 15101519, Kai Liu, Rui Zhou, Bin Wang, Man-Tian Mi; Ef Continue reading >>

Resveratrol Activates Duodenal Sirt1 To Reverse Insulin Resistance In Rats Through A Neuronal Network

Resveratrol Activates Duodenal Sirt1 To Reverse Insulin Resistance In Rats Through A Neuronal Network

Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network Nature Medicine volume 21, pages 498505 (2015) | Download Citation Resveratrol improves insulin sensitivity and lowers hepatic glucose production (HGP) in rat models of obesity and diabetes 1 , 2 , 3 , 4 , 5 , but the underlying mechanisms for these antidiabetic effects remain elusive. One process that is considered a key feature of resveratrol action is the activation of the nicotinamide adenine dinucleotide (NAD+)dependent deacetylase sirtuin 1 (SIRT1) in various tissues 1 , 3 , 6 , 7 , 8 . However, the low bioavailability of resveratrol raises questions about whether the antidiabetic effects of oral resveratrol can act directly on these tissues 9 , 10 . We show here that acute intraduodenal infusion of resveratrol reversed a 3 d high fat diet (HFD)induced reduction in duodenalmucosal Sirt1 protein levels while also enhancing insulin sensitivity and lowering HGP. Further, we found that duodenum-specific knockdown of Sirt1 expression for 14 d was sufficient to induce hepatic insulin resistance in rats fed normal chow. We also found that the glucoregulatory role of duodenally acting resveratrol required activation of Sirt1 and AMP-activated protein kinase (Ampk) in this tissue to initiate a gutbrainliver neuronal axis that improved hypothalamic insulin sensitivity and in turn, reduced HGP. In addition to the effects of duodenally acting resveratrol in an acute 3 d HFDfed model of insulin resistance, we also found that short-term infusion of resveratrol into the duodenum lowered HGP in two other rat models of insulin resistancea 28 d HFDinduced model of obesity and a nicotinamide (NA)streptozotocin (STZ)HFD-induced model of mild type 2 diabetes. Together, these studies Continue reading >>

Effect Of Resveratrol On Visceral White Adipose Tissue Inflammation And Insulin Sensitivity In A Mouse Model Of Sleep Apnea

Effect Of Resveratrol On Visceral White Adipose Tissue Inflammation And Insulin Sensitivity In A Mouse Model Of Sleep Apnea

Effect of resveratrol on visceral white adipose tissue inflammation and insulin sensitivity in a mouse model of sleep apnea International Journal of Obesity volume 39, pages 418423 (2015) | Download Citation Sleep fragmentation (SF) increases food intake and the risk of obesity, and recruits macrophages to visceral white adipose tissue (VWAT) promoting tissue inflammation and insulin resistance. Administration of resveratrol (Resv) has been associated with significant improvements in high-fat diet-induced obesity, inflammation and insulin resistance. Male mice were subjected to SF or sleep control conditions for 8 weeks, and treated with either Resv or vehicle (Veh). Fasting plasma levels of glucose, insulin and leptin were obtained and VWAT insulin sensitivity tests were performed (phosphorylated AKT/total AKT), along with flow-cytometric assessments for VWAT macrophages (M1 and M2) and T-cell lymphocytes (CD4+, CD8+ and T regulatory cell (Treg)). SF-Veh and SF-Resv mice showed increased food consumption and weight gain. However, although SF-Veh mice exhibited increased fasting insulin and leptin levels, and reduced VWAT p-AKT/AKT responses to insulin, such alterations were abrogated in SF-Resv-treated mice. Increases in M1, reduced M2 counts and increased tumor necrosis factor- release emerged in SF-Veh macrophages compared with all other three groups. Similarly, increased CD8+ and reduced Treg lymphocyte counts were apparent in SF-Veh. Resveratrol does not reverse the SF-induced increases in food intake and weight gain, but markedly attenuates VWAT inflammation and insulin resistance, thereby providing a potentially useful adjunctive therapy in the context of sleep disorders manifesting metabolic morbidity. Subscribe to International Journal of Obesity for full acce Continue reading >>

Increases Insulin Sensitivity

Increases Insulin Sensitivity

Better Glycemic Control with Resveratrol Resveratrol It may become “a valuable new strategy for treating insulin resistance and type 2 diabetes” By Will Block hallmark of many thrill seekers is the incessant need to up the ante—to find something that’s newer, faster, more dangerous, etc., in order to get that adrenaline rush they crave. But is the need for more of whatever they’re getting a psychological or a physiological phenomenon? In one sense, the question answers itself, because all of psychology is rooted in physiology: every thought, feeling, emotion, etc., consists of neurochemical events in the brain, and those events can be influenced by the biochemical effects of hormones—adrenaline, for example—originating elsewhere in the body. Could it be that a certain neurological resistance to the effects of adrenaline sets in when the thrills keep on coming, causing the daredevil to keep pushing the envelope? We don’t know. But we do know that resistance to another hormone, insulin, is very common. Insulin may seem boring by comparison with the glamorous adrenaline, but we ignore its great importance at our peril. If our cells become resistant to it and we therefore need ever more of it, we could be in for big trouble, spelled d-i-a-b-e-t-e-s, for which insulin resistance is the precursor condition. How to Prevent Insulin Resistance But what’s the precursor to insulin resistance? The development of this condition is a multistep process with strong genetic and environmental influences, and much is known about medical conditions—most notably obesity—that tend to produce it. How they produce it is another matter, about which little is known. From a practical perspective, though, all we need to know is how to prevent insulin resistance and how best t Continue reading >>

Resveratrol Improves Insulin Sensitivity

Resveratrol Improves Insulin Sensitivity

Resveratrol, a polyphenolic compound found in red wine and widely touted for its antioxidant and cell signaling effects, also improves insulin sensitivity, according to a recent study by researchers at the Albert Einstein College of Medicine, Bronx, NY. Found in large concentrations in red wine, resveratrol is among the most well-studied dietary supplement ingredients. Though results of human clinical studies have been highly variable, there is evidence to suggest that resveratrol: Inhibits neuronal cell dysfunction and death, thus reducing risk of Alzheimer's, Huntington's and other neurodegenerative disorders (Marambaud P, et al J. Biol. Chem. 2005: 280 (45): 37377–82; Parker JA, et al. Nat. Genet. 2005: 37 (4): 349–50). Stimulates endothelial nitric oxide synthase activity (Duffy SJ, Vita JA. Current Opinion in Lipidology. 2003 14 (1): 21–7) while simultaneously inhibiting platelet aggregation (Olas B, Wachowicz B. Platelets 2005:16 (5): 251–60) potentially lowering cardiovascular risk. Inhibits progression of cardiac fibrosis (Olson ER, et al. Am. J. Physiol. Heart Circ. Physiol. 2005: 288 (3): H1131–8). Increases natural production of testosterone while beneficially modulating estrogen receptors (Bhat KP, et al. Cancer Res. 2001: 61 (20): 7456–63). Increases intracellular glutathione levels in the lungs, reducing oxidative stress (Kode A, et al. Am. J. Physiol. Lung Cell Mol Physiol. 2008: 294 (3): L478–88). Mimics the longevity benefits of calorie restriction by modulating SIRT 1 and mTOR gene expression (Morselli E, et al. Aging (Albany NY). 2009:1 (12): 961–70). Some holistic and functional medicine practitioners advocate resveratrol supplementation for general health promotion, longevity, and reduction of cardiovascular risk, believing that the Continue reading >>

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