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Prediabetes Anti Diabetic Medication

Top 6 Breakthrough Diabetes Treatments You May Have Missed

Top 6 Breakthrough Diabetes Treatments You May Have Missed

Are you concerned you might be diagnosed with diabetes one day? You are not alone. Diabetes and prediabetes are two of the top pressing health issues in the nation. The number of Americans who are at risk for diabetes is astounding: it is reported that close to 86 million people in the U.S. have prediabetes, meaning their blood sugar levels are higher than normal but not yet high enough to be classified as type 2 diabetes. The American Diabetes Association (ADA) estimates a person diagnosed at age 50 dies six years earlier than a person without diabetes. One in three American adults will have diabetes in the year 2050 if current trends continue. Close to 29 million Americans, or 9% of the population, currently have diabetes. The vast majority of people, about 90 to 95 percent of those diagnosed with diabetes, have type 2 diabetes, according to the ADA. Insulin is a hormone the body needs to utilize the glucose (sugar) from food to provide energy for the body. In type 2 diabetes, the pancreas either doesn't make enough insulin, there is resistance to the effects of insulin, or both. Treatment typically begins with oral metformin, a veteran drug that is the backbone of many diabetes treatment regimens. From there, different drug classes may be added to metformin, and for some patients, the use of insulin may become necessary. However, the latest diabetes news is encouraging. New drugs, improved monitoring devices and an understanding of how diet and exercise can impact diabetes is adding up to positive outcomes for patients. As reported in August 2014 from research in The Lancet Diabetes & Endocrinology, the vast majority of people with type 2 diabetes are living longer lives due to better medications and treatments for both the disease and the numerous complications that Continue reading >>

Anti-diabetic Drugs

Anti-diabetic Drugs

Tweet Antidiabetic drugs are medicines developed to stabilise and control blood glucose levels amongst people with diabetes. Antidiabetic drugs are commonly used to manage diabetes. There are a number of different types of antidiabetic drug including: Insulin Pramlintide (Amylin) GLP-1 receptor agonists (such as Byetta and Victoza) Oral hypoglycemics (tablets) Antidiabetic drugs for type 1 diabetes For people with type 1 diabetes, daily insulin injections are essential to maintain health. Type 1 diabetics must also eat properly, keep blood glucose levels from going too low or too high, and monitor blood sugar levels. In America, pramlintide, marketed as Amylin, is used in addition to insulin by some people with type 1 diabetes to further help control their diabetes. Amylin is not currently prescribed in the UK. Antidiabetic drugs for type 2 diabetes For people with type 2 diabetes, diet and exercise may be enough to control blood glucose levels in some. However, when diet and exercise is no longer efficient, anti-diabetic drugs may be prescribed. Medication will either be taken orally in the form of tablets (oral hypoglycemics), or be injected (insulin and GLP-1 receptor agonists). Read more about oral hypoglycemics Antidiabetic treatment considerations for type 2 diabetes Biguanides, such as Metformin, are commonly prescribed as a first antidiabetic medication. If biguanides are not effective on their own you may be given alternative medication either instead of, or in addition to, biguanides. The type of medication you are offered could depend on a variety of factors as different medication have different advantages and disadvantages. Some common factors that your doctor will consider are as follows: How effective is the medication for reducing blood sugar levels? Wil Continue reading >>

Are There Any Medications For Prediabetes?

Are There Any Medications For Prediabetes?

Yes. No. Kinda. OK, here’s the deal, the FDA hasn’t actually approved any medications for prediabetes, but doctors commonly prescribe two classes of medications “off label” to help treat the condition. The first class are thiazolidinediones, conveniently called TZDs, such as Actos. These are basically anti-insulin resistance medications. As prediabetes is a growing problem of insulin resistance, a medication to fight insulin resistance is a logical fit to try and prevent what we call conversion—that is moving from prediabetes to full-blown diabetes. The thought is that by reducing insulin resistance you can reduce overwork on the part of the pancreas (which is working overtime to try and overwhelm the insulin resistance) and thus delay the “burnout” of the pancreas that causes diabetes. The other class of drugs that seem to help are biguanides, such as Metformin. Met has a small effect on insulin resistance but for the most part attacks another part of the prediabetes equation which is the liver’s tendency to over produce hormones that raise the blood sugar level. There is also one other prescription for prediabetes that isn’t really a medication at all, but it works very well, and that is to lose some weight. Most people with prediabetes are overweight (you know who you are), and the more you weigh the more resistant your body is to the insulin you make, which means you need to make more, and so on. Hold on, hold on. Don’t stop reading yet! I can feel you tuning me out! I didn’t say you have to get skinny and svelte. Every little bit of weight you lose can lower your insulin resistance. Another way of thinking about that is that each pound you drop pushes diabetes further into the future. And that’s a prescription worth filling. Continue Learnin Continue reading >>

Medication Or Lifestyle Changes For Pre-diabetes

Medication Or Lifestyle Changes For Pre-diabetes

Most people at the pre-diabetes stage should focus first on lifestyle changes including diet, physical activity and maintaining a healthy weight. Medications may be prescribed to manage related conditions and prescriptions will likely be needed if pre-diabetes progresses into Type 2 diabetes. Should I be taking a medication? Once you have been tested to determine your blood sugar levels, your healthcare provider will be able to determine whether medication is appropriate. It is important to understand the possible side-effects of each medication, and what to do if you experience them. Depending on your unique health factors, your healthcare provider may also prescribe a blood sugar monitor that you can carry with you to check your blood sugar levels throughout the day. This information will help track what is happening in your body and will help you understand the effect of what you eat and drink on your blood sugar levels. This will help you learn which foods and drinks to avoid. Can I go from having pre-diabetes to having neither pre-diabetes NOR diabetes? Yes, it is possible. By committing to and maintaining a healthy lifestyle, some people are able to reverse their pre-diabetes or avoid or postpone its progression to diabetes. Even people who have diabetes can prevent it from progressing further and can avoid many diabetes complications by adopting a healthy lifestyle. How much can be avoided usually depends on the lifestyle changes that are made, and how early they are made. What treatments are most helpful? For most people, the “big three” lifestyle changes are diet, exercise, and weight loss. For smokers, a program to stop smoking is also extremely important. Some changes, like reducing stress, may seem small, but they can have a large impact on many differen Continue reading >>

Why All Diabetics Should Know About Turmeric

Why All Diabetics Should Know About Turmeric

By Sayer Ji • Originally published on GreenMedInfo.com Many diabetics already know about the benefits of a low-glycemic diet, but why haven’t they heard about turmeric, one of the world’s most extensively researched anti-diabetic plants? A recent literature review published in the International Journal of Endocrinology and Metabolism titled, “Anti-Hyperglycemic Effect and Insulin Sensitizing Effects of Turmeric and Its Principle Constituent Curcumin,” adds promising new support to the notion that the ancient Indian spice turmeric may provide an ideal drug alternative to treating and perhaps even preventing type 2 diabetes, which has become of the world’s most prevalent diagnoses. The study reviewed research published between 1998 to 2013 that indicates the active polyphenol in turmeric known as curcumin may provide an ideal intervention for type 2 diabetes, capable of mitigating characteristic pathophysiological hallmarks of the disease such as elevated blood sugar (hyperglycemia) and insulin resistance. Nineteen of the studies reviewed were cell (in vitro) and animal (in vivo), all which showed beneficial effects. Five of the studies were human clinical trials using turmeric or curcumin, three of which were performed in those with either diabetes or prediabetes. Amazingly, the animal and cell research literature review concluded that curcumin could improve the type 2 diabetic state through 10 distinctly different mechanisms, such as: Reduction in liver glucose production Reduction in liver glycogen production Stimulation of increased glucose uptake (by increasing GLUT4, GLUT2 and GLUT3 gene expressions) Increasing the activation of AMP kinase Promoting PPAR γ ligand- binding activity Suppressing hyperglycemia-induced inflammatory state Stimulating insulin Continue reading >>

Anti-diabetes And Anti-obesity Medications: Effects On Weight In People With Diabetes

Anti-diabetes And Anti-obesity Medications: Effects On Weight In People With Diabetes

Choosing medications for people with diabetes involves consideration of a number of factors, including effects on weight. Improvements in glucose control are often linked to weight gain, but this does not have to be the inevitable result of diabetes treatment. Adding a drug that either promotes weight-loss or is weight neutral to one that promotes weight gain and providing medical nutrition therapy can be considered. The current approach to the treatment of both type 1 and type 2 diabetes is to achieve the best possible glucose control. Past clinical trials have shown that glycemia plays a key role in the prevention of both macro- and microvascular complications.1–5 The current American Diabetes Association (ADA) guidelines suggest a glycemic goal of having a hemoglobin A1c (A1C) < 7%, but also state that an A1C of ≤ 6% should be a goal if it can be achieved without risk of complications.6,7 During the past 20 years, a number of new medications to control blood glucose have been introduced, and new approaches to the use of older medications have been developed. In prescribing any medication, however, one must consider benefits versus risks. In terms of the treatment of hyperglycemia, certainly toxic side effects are of concern, as is hypoglycemia. One major area of concern, however, is the effect of such drugs on weight. Weight and diabetes, especially type 2 diabetes, are closely related. Obesity is a major risk factor for the development of type 2 diabetes, and the current increase in obesity in our society has fueled a major increase in the expression of this disease.8 Not only does weight, through the mechanism of insulin resistance, aggravate hyperglycemia, it also increases the risk for hypertension, hyperlipidemia, and other conditions that lead to cardiovasc Continue reading >>

Diagnosis

Diagnosis

Print The American Diabetes Association (ADA) recommends that blood glucose screening for adults begin at age 45, or sooner if you are overweight and have additional risk factors for prediabetes or type 2 diabetes. There are several blood tests for prediabetes. Glycated hemoglobin (A1C) test This test indicates your average blood sugar level for the past two to three months. Specifically, the test measures the percentage of blood sugar attached to the oxygen-carrying protein in red blood cells (hemoglobin). The higher your blood sugar levels, the more hemoglobin you'll have with sugar attached. In general: An A1C level below 5.7 percent is considered normal An A1C level between 5.7 and 6.4 percent is considered prediabetes An A1C level of 6.5 percent or higher on two separate tests indicates type 2 diabetes Certain conditions can make the A1C test inaccurate — such as if you are pregnant or have an uncommon form of hemoglobin (hemoglobin variant). Fasting blood sugar test A blood sample is taken after you fast for at least eight hours or overnight. In general: A fasting blood sugar level below 100 milligrams per deciliter (mg/dL) — 5.6 millimoles per liter (mmol/L) — is considered normal. A fasting blood sugar level from 100 to 125 mg/dL (5.6 to 7.0 mmol/L) is considered prediabetes. This result is sometimes called impaired fasting glucose. A fasting blood sugar level of 126 mg/dL (7.0 mmol/L) or higher indicates type 2 diabetes. Oral glucose tolerance test This test is usually used to diagnose diabetes only during pregnancy. A blood sample is taken after you fast for at least eight hours or overnight. Then you'll drink a sugary solution, and your blood sugar level will be measured again after two hours. In general: A blood sugar level less than 140 mg/dL (7.8 mmo Continue reading >>

A Complete List Of Diabetes Medications

A Complete List Of Diabetes Medications

Diabetes is a condition that leads to high levels of blood glucose (or sugar) in the body. This happens when your body can’t make or use insulin like it’s supposed to. Insulin is a substance that helps your body use the sugar from the food you eat. There are two different types of diabetes: type 1 diabetes and type 2 diabetes. People with both types of diabetes need medications to help keep their blood sugar levels normal. The types of drugs that can treat you depend on the type of diabetes you have. This article gives you information about drugs that treat both types of diabetes to help give you an idea of the treatment options available to you. Insulin Insulin is the most common type of medication used in type 1 diabetes treatment. It’s also used in type 2 diabetes treatment. It’s given by injection and comes in different types. The type of insulin you need depends on how severe your insulin depletion is. Options include: Short-acting insulin regular insulin (Humulin and Novolin) Rapid-acting insulins Intermediate-acting insulin Long-acting insulins Combination insulins NovoLog Mix 70/30 (insulin aspart protamine-insulin aspart) Humalog Mix 75/25 (insulin lispro protamine-insulin lispro) Humalog Mix 50/50 (insulin lispro protamine-insulin lispro) Humulin 70/30 (human insulin NPH-human insulin regular) Novolin 70/30 (human insulin NPH-human insulin regular) Ryzodeg (insulin degludec-insulin aspart) Amylinomimetic drug Pramlintide (SymlinPen 120, SymlinPen 60) is an amylinomimetic drug. It’s an injectable drug used before meals. It works by delaying the time your stomach takes to empty itself. It reduces glucagon secretion after meals. This lowers your blood sugar. It also reduces appetite through a central mechanism. Most medications for type 2 diabetes are o Continue reading >>

Drugs Vs. Lifestyle For Preventing Diabetes

Drugs Vs. Lifestyle For Preventing Diabetes

In just one decade, the number of people with diabetes has more than doubled. According to the Center for Disease Control and Prevention, by 2050, one out of every three of us may have diabetes. What’s the big deal? Well, the “consequences of diabetes are legion.” Diabetes is the number one cause of adult-onset blindness, the number one cause of kidney failure, and the number one cause of surgical amputations. What can we do to prevent it? The onset of Type 2 diabetes is gradual, with most individuals progressing through a state of prediabetes, a condition now striking approximately one in three Americans, but only about one in ten even knows they have it. Since current methods of treating diabetes remain inadequate, prevention is preferable, but what works better: lifestyle changes or drugs? We didn’t know until a landmark study, highlighted in my video, How to Prevent Prediabetes from Turning into Diabetes, was published in the New England Journal of Medicine. Thousands were randomized to get a double dose of the leading anti-diabetes drug, or diet and exercise. The drug, metformin, is probably the safest diabetes drug there is. It causes diarrhea in about half, makes one in four nauseous, about one in ten suffer from asthenia (physical weakness and fatigue), but only about 1 in 67,000 are killed by the drug every year. And the drug worked. Compared to placebo, in terms of the percentage of people developing diabetes within the four-year study period, fewer people in the drug group developed diabetes. But diet and exercise alone worked better. The lifestyle intervention reduced diabetes incidence by 58 percent, compared to only 31 percent with the drug. The lifestyle intervention was significantly more effective than the drug, and had fewer side effects. More Continue reading >>

Pre-diabetes

Pre-diabetes

What Is It? In pre-diabetes, blood sugar levels are slightly higher than normal, but still not as high as in diabetes. If diabetes is "runaway blood sugar" think of pre-diabetes as blood sugar that is "halfway out the door." People almost always develop pre-diabetes before they get type 2 diabetes. The rise in blood sugar levels that is seen in pre-diabetes starts when the body begins to develop a problem called "insulin resistance." Insulin is an important hormone that helps you to process glucose (blood sugar). If usual amounts of insulin can't trigger the body to move glucose out of the bloodstream and into your cells, then you have insulin resistance. Once insulin resistance begins, it can worsen over time. When you have pre-diabetes, you make extra insulin to keep your sugar levels near to normal. Insulin resistance can worsen as you age, and it worsens with weight gain. If your insulin resistance progresses, eventually you can't compensate well enough by making extra insulin. When this occurs, your sugar levels will increase, and you will have diabetes. Depending on what a blood sugar test finds, pre-diabetes can be more specifically called "impaired glucose (sugar) tolerance" or "impaired fasting glucose." Impaired fasting glucose means that blood sugar increase after you haven't eaten for a while – for example, in the morning, before breakfast. Impaired glucose tolerance means that blood sugar levels reach a surprisingly high level after you eat sugar. To diagnose impaired glucose tolerance, doctors usually use what is called a "glucose tolerance test." For this test you drink a sugary solution, and then you have blood drawn after a short time. Having pre-diabetes does not automatically mean you will get diabetes, but it does put you at an increased risk. Pre- Continue reading >>

Oral Antidiabetic Drugs And Regression From Prediabetes To Normoglycemia: A Meta-analysis.

Oral Antidiabetic Drugs And Regression From Prediabetes To Normoglycemia: A Meta-analysis.

Abstract BACKGROUND: Impaired glucose tolerance, impaired fasting glucose, and elevated hemoglobin A(1c) are intermediate stages, considered prediabetes, a precursor to overt type 2 diabetes mellitus. Prediabetes is associated with increased risk for cardiovascular disease, independent of diabetes development. Data have shown that various oral antidiabetic drugs can help people regress from prediabetes to normoglycemia. OBJECTIVE: To evaluate the efficacy of oral antidiabetic drugs in promoting regression from prediabetes to normoglycemia. METHODS: MEDLINE (1950-November 2011), EMBASE (1990-November 2011), and Cochrane Central Register of Controlled Trials (indexed September 2011) were systematically searched. A manual search of references from reports of clinical trials and review articles was performed to identify additional relevant studies. Randomized controlled trials 12 weeks or more in duration evaluating any of the oral antidiabetic drugs and studying regression from prediabetes to normoglycemia were included. A random-effects model was used to calculate pooled odds ratios with 95% confidence intervals. RESULTS: Thirteen studies (N = 11,600 participants) were included in the meta-analysis. Use of oral antidiabetic drugs in prediabetic patients was shown to double the odds of achieving normoglycemia compared to controls (OR 2.03, 95% CI 1.54 to 2.67). When individual classes of oral antidiabetic drugs were evaluated, use of thiazolidinediones (OR 2.33, 95% CI 1.93 to 2.81) and α-glucosidase inhibitors (OR 2.02, 95% CI 1.26 to 3.24) was associated with significantly increased odds. However, biguanides (OR 2.04) and sulfonylureas (OR 1.84) failed to reach statistical significance (p = 0.06 and p = 0.39, respectively). CONCLUSIONS: In patients with prediabetes, ora Continue reading >>

Prediabetes - Medications

Prediabetes - Medications

XIAFLEX® is a prescription medicine used to treat adults with Dupuytren's contracture when a "cord" can be felt. It is not known if XIAFLEX® is safe and effective in children under the age of 18. Do not receive XIAFLEX® if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®. XIAFLEX® can cause serious side effects, including: Tendon rupture or ligament damage. Receiving an injection of XIAFLEX® may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, increased pain, or tears in the skin (laceration) in your treated finger or hand after your injection or after your follow-up visit Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX® because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®: hives swollen face breathing trouble chest pain low blood pressure dizziness or fainting Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not b Continue reading >>

Diabetes Medication - Guides And Information

Diabetes Medication - Guides And Information

Tweet Diabetes medications are a common form of treatment for people with diabetes. There are many different types of diabetes medicines, or anti-diabetic drugs, and this includes insulin, which has its own area within the site. Whilst each drug is unique in the way it works to help patients with diabetes keep their condition under control, some act similarly to one other and are grouped in the same class of drugs. The way in which they are administered can also differ, with some medicines taken orally and others injected directly into the blood. Are diabetes drugs suitable for all diabetics? Most diabetes drugs are designed for people with type 2 diabetes who are unable to control their blood sugar levels through strict diet and exercise alone. But some, such as metformin, are sometimes taken alongside insulin treatment for people with type 1 diabetes. Medication guides Explore the 18 most common medications for diabetes: Assists insulin in controlling post-meal glucose levels. Can more than one drug be taken at the same time? Depending on individual circumstances, a GP may prescribe more than one anti-diabetic drug to help treat a patient’s diabetes. Watch the video below for more information on the types of diabetes medication available. What are the side effects of anti-diabetic medicines? As with any type of medication, blood glucose-lowering drugs can have a number of side effects. These potentially harmful effects are listed in the patient information leaflet that accompanies the medication, so make sure you check this before starting your drug treatment. You may not experience any of the adverse effects listed, but if you do, consult your doctor and/or diabetes care team as they may be able to suggest another suitable medication for your condition. They will a Continue reading >>

Pre-diabetes Prescription Drugs

Pre-diabetes Prescription Drugs

Click here for the Health Tip link. Q: My doctor told me I need to take drugs for something he calls pre-diabetes. After reading your tips on the pharmaceutical industry, can you give me any advice on whether or not I need to take them? A That’s a great question because it exemplifies how doctors let themselves off the hook by reaching for a prescription pad. Generally, most pre-diabetics are overweight and maybe diabetes runs in the family. You carry your weight in your midsection. Your primary exercise is lifting a fork and you do like your refined “white” carbohydrates. Here’s what happens: Whenever we eat, our blood sugar (glucose) rises and in order to move the glucose molecule into our cells, where it’s used for energy, the pancreas, a gland safely tucked behind your intestines, produces the hormone insulin. In pre-diabetes, this entire response system becomes fatigued. The cells receiving glucose become resistant to the insulin (insulin resistance) and the pancreas responds by going into overdrive and producing more insulin (hyperinsulinemia). In time, the system finally breaks down, blood sugar starts to rise, and the “pre-diabetes” of hyperinsulinism and insulin resistance changes to diabetes, which is high blood sugar. The prescription drug for pre-diabetes is metformin, which works by reducing insulin resistance. Later, when you develop diabetes, a second drug is added that literally flogs your pancreas to make more insulin. When the action of these two meds starts to fail (you can only flog so much before the system collapses altogether), your doctor gives up and you start taking injections of synthetic insulin. Pre-diabetes is considered a risk not only because it can lead to diabetes but also because it increases your risk of developing heart Continue reading >>

Therapeutic Use Of Metformin In Prediabetes And Diabetes Prevention

Therapeutic Use Of Metformin In Prediabetes And Diabetes Prevention

Go to: Pathophysiology and Diagnosis of Prediabetes The defects in glucose metabolism that underlie type 2 diabetes begin many years before the diagnosis of diabetes is made [6, 7]. The development of insulin resistance, in which the action of insulin on glucose metabolism is blunted, occurs early in the pathogenesis of dysglycaemia. Increased secretion of insulin initially compensates for the presence of insulin resistance; however, a simultaneous and progressive loss of β-cell mass and β-cell function limits the ability of the pancreas to maintain euglycaemia by increasing insulin secretion [8]. The early manifestations of prediabetic dysglycaemia represent one or both of [9]: impaired glucose tolerance (IGT), in which postprandial glucose control is impaired but fasting plasma glucose (FPG) is normal; impaired fasting glucose (IFG), in which a chronic elevation of FPG occurs in the absence of a deterioration in postprandial glucose control. Table 1 shows the usually accepted diagnostic criteria for the diagnosis of prediabetes based on measurements of glycaemia [4, 8–10]. A simple blood test is sufficient to diagnose IFG, while a 75 g oral glucose tolerance test (OGTT) is required for the diagnosis of IGT. The originally used cutoff level for IFG (110 mg/dL [6.1 mmol/L]) was reduced to that shown in Table 1 (100 mg/dL [5.6 mmol/L]) by an Expert Committee of the American Diabetes Association in 2003, in order to equalise the prognostic impact of diagnosis of IFG or IGT, in terms of the future risk of diabetes in a subject with either condition [11]. It should be noted that the World Health Organization (WHO) diagnostic criteria for IFG retains the 110 mg/dL (6.1 mmol/L) cutoff value for diagnosing IFG [12]. Diagnostic criteria from the American Diabetes Associatio Continue reading >>

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