Novolog Peak

Fast-acting Insulin

Even when you think you’re doing everything right with your diabetes care regimen, it can sometimes seem like your blood glucose levels are hard to control. One potential source of difficulty that you may not have thought of is how you time your injections or boluses of rapid-acting insulin with respect to meals. Since the first rapid-acting insulin, insulin lispro (brand name Humalog), came on the market in 1996, most diabetes experts have recommended taking it within 15 minutes of starting a meal (any time between 15 minutes before starting to eat to 15 minutes after starting to eat). This advice is based on the belief that rapid-acting insulin is absorbed quickly and begins lowering blood glucose quickly. However, several years of experience and observation suggest that this advice may not be ideal for everyone who uses rapid-acting insulin. As a result, the advice on when to take it needs updating. Insulin basics The goal of insulin therapy is to match the way that insulin is normally secreted in people without diabetes. Basal insulin. Small amounts of insulin are released by the pancreas 24 hours a day. On average, adults secrete about one unit of insulin per hour regardless of food intake. Bolus insulin. In response to food, larger amounts of insulin are secreted and released in two-phase boluses. The first phase starts within minutes of the first bite of food and lasts about 15 minutes. The second phase of insulin release is more gradual and occurs over the next hour and a half to three hours. The amount of insulin that is released matches the rise in blood glucose from the food that is eaten. In people with normal insulin secretion, insulin production and release is a finely tuned feedback system that maintains blood glucose between about 70 mg/dl and 140 mg/d Continue reading >>

Novolog Vs Humalog: Which Is Better?

Ahhh yes, the million dollar question. In the land of type 1 diabetes and rapid acting insulin, everyone wants to know, which works better…Novolog vs Humalog? Thank You Insurance Companies (not!) You’re probably here because your insurance company has pulled the plug on your beloved insulin and is making you switch to the dark side. Whether they signed a deal with Lilly (Humalog) or Novo Nordisk (Novolog) you’re left in sheer panic because WTH insurance companies?! This is my life juice you’re messing with here. You’ve been reassured by your doctor…and their nurses…and the pharmacist that there is no difference between the two brands… It’s like pepsi vs coke – my doctors nurse. Well, if you know anything about pepsi or coke then you know… while it’s true that some can’t taste the difference, others most definitely can. Same is true with Novolog vs Humalog. Show me the differences! Novolog vs Humalog But first, the similarities. Both Novolog and Humalog are human insulin analogs. This means that they are a synthetically altered form of human insulin – the kind that you find naturally occurring in the human body (as opposed to being extracted from cows and pigs – like it was back in the 20’s). Both should begin working in about 15 minutes after injection, should peak in about 1 hour, and should continue to work for 2-4 hours. What’s with all the shoulds? Everyone reacts to medications differently; insulin is no exception. …which brings me to the differences In Humalog (insulin lispro) the amino acids for proline and lysine have been swapped. This means that the amino acid, proline, has been substituted for lysine in position 28 of the B-Chain, and lysine has be substituted for proline in position 29 of the B-Chain. In Novolog (insulin a Continue reading >>

Humalog Vs. Novolog: What’s The Difference?

The two leaders in the fast acting insulin market, Humalog and Novolog, are the most common types of fast acting insulin used by those with diabetes today. Fast Acting, mealtime insulin is a type of insulin that is injected before or right after eating. When you eat your blood glucose begins to rise. Fast acting insulin, Humalog and Novolog work to help manage these rises or spikes to keep your blood glucose levels more within range and balanced. When you use a fast acting insulin like Humalog or Novolog, you typically will continue to take a long acting insulin to help manage your levels between your meals and throughout the night. The question is though, is there really a difference between the two? Endocrinologists and other medical professionals don’t seem to really think there is, stating the two are virtually interchangeable. But that’s not really the full story. Humalog (Insulin Lispro) Insulin Lispro (Humalog) has been on the market since 1996, when it was first introduced by Eli Lily. Humalog is the first insulin analogue that was used clinically. Insulin Lispro received its name due to its structure. The difference between it and regular insulin was the switch between the lysine B28 (an amino acid) and proline B29. The formula consists of a hexametric solution available in vials and pen form. After a subcutaneous injection, the formula converts into a monomeric formula which allows it to have a fast absorption in the body. The one noted negative factor of Humalog is its short term control of glucose levels. Additionally, if it is injected and mealtime happens to be delayed, a hypoglycemic episode may occur. For Humalog to be most effective it is to be injected 15 minutes prior to the start of a meal. I recommend reading the following articles: Humalog is a Continue reading >>

How Novolog® Works

Remember that although there is only one NovoLog® insulin, you might hear your health care providers refer to it by a few other names. As an insulin that you take at mealtime, NovoLog® is often called “mealtime” or "bolus" insulin. Because it goes to work quickly, it is also sometimes called “rapid-acting” or “fast-acting” insulin. And, because it is a slightly changed man-made version of insulin, it is also called analog insulin. NovoLog® helps control mealtime blood sugar spikes Mealtime insulin therapy with NovoLog® tries to mimic the normal pattern of how the body responds to rising blood sugar after meals. In a person who doesn't have diabetes, the pancreas releases a short burst, or "bolus," of insulin to handle the increase in blood sugar from each meal. As a bolus, or fast-acting, insulin, NovoLog® closely mimics these bursts, helping to control mealtime blood sugar spikes that happen in people with diabetes. Besides bolus insulin, there is also basal insulin. In fact, you may already be taking “long-acting” basal insulin. Maybe at night or in the morning—sometimes both. In people without diabetes, a steady amount of basal insulin is released into the blood day and night. This insulin helps control blood sugar between meals and during sleep. In some people with type 2 diabetes, especially those whose bodies are still naturally producing some insulin, replacing the natural basal insulin release with a man-made long-acting insulin is enough to control their blood sugar throughout the day. However, as the pancreas produces less insulin, stops producing insulin altogether, or the body has more trouble using it correctly, adding a bolus (mealtime) insulin may become necessary. Long-acting basal insulin plus a fast-acting bolus insulin, such as Continue reading >>

Information For Owners Of Canine's With Diabetes Mellitus

Diabetes in animals is very similar to that of humans. Therefore this page may contain links that are about humans or other animals. Background Information about Insulin When we eat, our bodies break food down into organic compounds, one of which is glucose. The cells of our bodies use glucose as a source of energy for movement, growth, repair, and other functions. But before the cells can use glucose, it must move from the bloodstream into the individual cells. This process requires insulin. Insulin is produced by the beta cells in the islets of Langerhans in the pancreas. When glucose enters our blood, the pancreas should automatically produce the right amount of insulin to move glucose into our cells. Canines with type 1 diabetes produce no insulin. Felines with type 2 diabetes do not always produce enough insulin. (Felines can be type 1 or 2 and Canines are always type 1) Insulin Tips: - NPH cannot be mixed with any Lente (L or U) insulin, they are chemically incompatible. - Insulin does not have to be refrigerated if kept at a moderate temp., although it is recommended. - Do not give cold injections, it could cause discomfort. - Popular opinion is to dispose of opened insulin after 30 days or 100 sticks. - To prevent abscesses, infections, and discomfort, only use syringes once. - Rotation of injection sites is recommended. - It is best to feed before the injection to make sure the animal eats. (generally 30 min. before) - Human insulins are shorter acting than animal insulins of the same type. - Never shake "cloudy" insulins. Roll the bottle between the palms of your hands. Duration and Peak Times for the Most Common Insulins There are more than 20 types of insulin products available in four basic forms, each with a different time of onset and duration of action. Continue reading >>

5 Types Of Insulin And How They Work

If you have to take insulin to treat diabetes, there’s good news: You have choices. There are five types of insulin. They vary by onset (how soon they start to work), peak (how long they take to kick into full effect) and duration (how long they stay in your body). You may have to take more than one type of insulin, and these needs may change over time (and can vary depending on your type of diabetes). Find out more about the insulin types best for you. What it’s called: Humalog (lispro), NovoLog (aspart), Apidra (glulisine) Rapid-acting insulin is taken just before or after meals, to control spikes in blood sugar. This type is typically used in addition to a longer-acting insulin. It often works in 15 minutes, peaks between 30 and 90 minutes, and lasts 3 to 5 hours. “You can take it a few minutes before eating or as you sit down to eat, and it starts to work very quickly,” says Manisha Chandalia, MD, director of the Stark Diabetes Center at the University of Texas Medical Branch, in Galveston. What it’s called: Humulin R, Novolin R Short-acting insulin covers your insulin needs during meals. It is taken about 30 minutes to an hour before a meal to help control blood sugar levels. This type of insulin takes effect in about 30 minutes to one hour, and peaks after two to four hours. Its effects tend to last about five to eight hours. “The biggest advantage of short-acting insulin is that you don't have to take it at each meal. You can take it at breakfast and supper and still have good control because it lasts a little longer,” Dr. Chandalia says. What it’s called: Humulin N (NPH), Novolin N (NPH) Intermediate-acting insulin can control blood sugar levels for about 12 hours or longer, so it can be used overnight. It begins to work within one to four hours, Continue reading >>

Insulin Aspart

(NovoLog, Novo Nordisk) Classification: Antidiabetic Agents; Insulins, Human Description: NovoLog is a rapid-acting human insulin analog. It is homologous with regular human insulin with the exception of a single substitution of praline at position B28 with aspartic acid. NovoLog is synthesized using Saccharomyces cerevisiae (bakerâ€™s yeast). Pharmacology: Insulins, including NovoLog regulate glucose metabolism by binding to cellular insulin receptors facilitating cellular uptake of glucose and simultaneously inhibiting the output of glucose from the liver. Pharmacokinetics: Type Onset Peak Duration Short-acting Â Â Insulin lispro (Humalog) Â Â Insulin aspart (NovoLog) Â Â Regular insulin (R) Â 15 min 15 min 0.5 to 1 hrs Â 30 to 90 min 40 to 50 min 2 to 4 hrs Â 3 to 6.5 hrs 3 to 5 hrs 8 to 12 hrs Indications: NovoLog is indication for the control of hyperglycemia associated with diabetes mellitus. Dosage: Variable depending on patient needs and response. Contraindications and Precautions: Â· Pregnancy category: C Â· Contraindicated during episodes of hypoglycemia Â· Contraindicated in patients with known hypersensitivity to NovoLog Â· Dosage requirements may be reduced in patients with hepatic or renal impairment Interactions: Interactions may occur with medications with hyperglycemic activity such as corticosteroids, Isoniazid, niacin, estrogens, oral contraceptives, phenothiazines and thyroid replacement therapy. Insulin requirements may be decreased in the presence of drugs with hypoglycemic activity, such as oral Antidiabetic agents, salicylates, sulfa antibiotics, monoamine oxidase inhibitors, beta-adrenergic blockers and alcohol. Mixing with other insulins: A single study in 24 healthy adult males showed that NovoLog is compatible with NPH h Continue reading >>

Novolog Insulin Peak - Medhelp

Common Questions and Answers about Novolog insulin peak ), I have to wait until about a half hour AFTER I eat to take my Novalog so the insulin doesn't peak before the carbs digest. I then sometimes need to take a few units of insulin several hours later to cover the very slowly-digesting food that elevates my glucose after that first injection of insulin has peaked and petered out. You may want to experiment with fat-free meals for a few meals to see if the insulin works better when the food is digesting quicker. It sounds like you need a specialist that can help you with both carb counting and your insulin intake. Any changes in your insulin intake can take time to adjust. The fact that you are testing so much shows that you are trying to take care of your diabetes. Have you talked to your doctor about the highs and lows? Has your doctor talked to you about going to the pump? There are so many varibles that come into play here. I would suggest speaking to your doctor. I have been taking novolog for several years now but have lost my insurance and can't afford the novolog so while have to buy regular insulin to replace the rapid acting insulin . My doseage of novolog is 4 units before meals so is that how much regular insulin I should take? MY DOCTOR PRESCRIBED LANTUS INSULIN TO REPLACE THE HUMULIN L INSULIN THAT I HAD TAKEN FOR SEVERAL YEARS. I HAVE NOTICED THAT WHEN I TAKE THE LANTUS INSULIN PRESCRIBED DOSAGE(S) THAT APPROXIMATELY 15-30 MINUTES LATER I START TO SWEAT PROFUSELY. IS THIS A NORMAL REACTION TO THE LANTUS INSULIN? I VOICED MY CONCERNS TO MY DOCTOR AND HE HAD NO COMMENT. I AM ALSO TAKING SEVERAL DOSES OF HUMULIN R AND HAVE GAINED WEIGHT SINCE I STARTED TAKING THE LANTUS. PLEASE ADVISE. THANK YOU. Ionutz,My son uses synthetic human insulin -- novolog . Ani Continue reading >>

Insulin

Insulin, Regular Insulin, NPH Insulin, Lispro, Insulin Lente, Ultralente Insulin, Novolin, Humulin, Novolog, Fiasp, Humalog, Short-Acting Insulin, Bolus Insulin, Aspart, Apidra, Glulisine, Insulin-Related Errors, Insulin Pen Injection sites: Abdomen , outer thigh, back of arm, flank and buttocks Insert needle at 90 degree angle into skin Insulin injection is subcutaneous (not intramuscular) Intramuscular Injection results in rapid absorption and risk of Hypoglycemia Prevent too deep of injection (esp. longer needles) by pinching an inch of skin at the injection site Hold needle in place for 5-10 seconds after injection to prevent leakage of Insulin Rotate injection sites to prevent lipohypertrophy (see adverse effects below) More consistent absorption than traditional Insulin Basal agents release at more constant rate New anologues are however 10 fold more expensive than Regular Insulin and NPH Vials of NPH and Regular are each $26 per vial OTC at Walmart as of 2017 Contrast with $250 per vial for analogues Outcomes are similar with newer analogues versus older NPH and Regular Combination agents are discouraged unless noncompliant Insulin 70/30 is also $26 OTC at Walmart as of 2017 (Reli-On) Reduces flexibility in meal and activity timing Longer needles risk deeper, intramuscular penetration, with more rapid absorption and Hypoglycemia risk Insulin Pen needles 4 mm are sufficiently long Insulin syringe needles should be at least 6 mm long to clear the syringe stopper Smaller needles (higher gauge) 30 or 31 are preferred for the least discomfort on insertion Select smallest Insulin syringe that will hold each of the Insulin doses, allowing for added coverage Prescribe syringes in number of boxes (100 syringes per box) Syringes are sized at 100 units Insulin/ml Insulin P Continue reading >>

Label: Novolog- Insulin Aspart Injection, Solution

DEA Schedule: None Marketing Status: New Drug Application Find additional resources (also available in the left menu) More Info on this Drug Continue reading >>

Insulin Aspart (rdna Origin) Injection

Pharmacologic classification: human insulin analogue Therapeutic classification: antidiabetic Pregnancy risk category C Available forms Available by prescription only 10-ml vial for injection: 100 units of insulin aspart per ml (U-100) 3-ml PenFill cartridges: Indications and dosages Control of hyperglycemia in patients with diabetes mellitus. Adults: Individualize dosage based on the patient’s needs. Typical daily insulin requirements are 0.5 to 1 unit/kg daily divided in a meal-related treatment regimen. About 50% to 70% of this dose may be provided with NovoLog and the remainder by an intermediate-acting or long-acting insulin. Give within 5 to 10 minutes of start of meal by S.C. injection in the abdominal wall, thigh, or upper arm. Pharmacodynamics Antidiabetic action: Thought to bind to insulin receptors on muscle and fat cells to lower blood glucose and by facilitating the cellular uptake of glucose and inhibiting the output of glucose from the liver. Pharmacokinetics Absorption: NovoLog is as bioavailable as regular human insulin. It has a faster absorption and onset and shorter duration of action compared to regular human insulin. Distribution: Low plasma protein-binding (0% to 9%), similar to regular insulin. Metabolism: No information available. Excretion: Half-life is shorter than that of regular human insulin (81 minutes compared with 141 minutes, respectively). Contraindications and precautions Contraindicated during hypoglycemia and in patients hypersensitive to NovoLog or one of its excipients. Use cautiously in patients prone to hypoglycemia and hypokalemia, such as those who are fasting, have autonomic neuropathy, or who are using potassium-lowering drugs or drugs sensitive to serum potassium levels. Interactions Drug-drug. ACE inhibitors, disopyramid Continue reading >>

Just How Quick Is Fiasp, Novo Nordisk’s Faster-acting Insulin?

Fiasp, a new, faster-acting insulin from Novo Nordisk, is generating a lot of interest and carries with it much potential for improved diabetes care. A sort of acronym for faster acting insulin asparte, Fiasp starts working within two minutes of injection and can even be effective in lowering blood sugar when taken up to 20 minutes after a meal. Existing fast-acting insulin formulations such as Humalog, Apidra and Novo Nordisk’s own NovoLog (called NovoRapid in Europe and Canada), take 10 to 20 minutes to begin lowering blood sugar after injection. According to Novo Nordisk, Fiasp, “has its maximum effect between 1 and 3 hours after the injection and the effect lasts for 3 to 5 hours.” “Our goal in developing Fisap was to try and get closer to mimicking the body’s own insulin response to food,” says Michael Bachner, Associate Director for Product Communications for Novo Nordisk. “Doing that creates a lot of opportunities for how this might be applied to improve care.” Fiasp was approved for use in Europe in January and approved in Canada in late March. Approval in the United States is pending with Novo Nordisk expecting to hear back form the FDA in the fourth quarter of this year, Bachner says. (The FDA application is the Danish pharmacy giant’s second attempt at U.S. approval.) Interest in the new insulin is keen, according to chat boards and as reported by Mike Hoskins for the DiabetesMine team in late April. Tim Street, a diabetes writer, reports an uptick in views to his site since he started reporting on Fiasp. His website diabettech.com—“Where diabetes and technology meet”—says when he started writing about Fiasp visits to his site went from between 200 and 500 per day to between 500 and 1,000 per day. To date, Street has penned six artic Continue reading >>

Novolog® (insulin Aspart Injection) 100 U/ml Indications And Usage

NovoLog® is contraindicated during episodes of hypoglycemia and in patients hypersensitive to NovoLog® or one of its excipients. Never Share a NovoLog® FlexPen, NovoLog® FlexTouch®, PenFill® Cartridge, or PenFill® Cartridge Device Between Patients, even if the needle is changed. Patients using NovoLog® vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens. Changes in insulin strength, manufacturer, type, or method of administration may affect glycemic control and predispose to hypoglycemia or hyperglycemia. These changes should be made cautiously under close medical supervision and the frequency of blood glucose monitoring should be increased. NovoLog® (insulin aspart injection) 100 U/mL is an insulin analog indicated to improve glycemic control in adults and children with diabetes mellitus. NovoLog® is contraindicated during episodes of hypoglycemia and in patients hypersensitive to NovoLog® or one of its excipients. Never Share a NovoLog® FlexPen, NovoLog® FlexTouch®, PenFill® Cartridge, or PenFill® Cartridge Device Between Patients, even if the needle is changed. Patients using NovoLog® vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens. Changes in insulin strength, manufacturer, type, or method of administration may affect glycemic control and predispose to hypoglycemia or hyperglycemia. These changes should be made cautiously under close medical supervision and the frequency of blood glucose monitoring should be increased. Hypoglycemia is the most common adverse effect of insulin therapy. The timing of hypoglycemia may reflect the time-action profile of the insulin formulation. Glucose monitoring is re Continue reading >>

Information For Owners Of Canine's With Diabetes Mellitus

NPH INSULIN IS NOT BEING DISCONTINUED IT IS STILL MANUFACTURED BY ELI LILLY & NOVO NORDISK Diabetes in animals is very similar to that of humans. Therefore this page may contain links that are about humans or other animals. Background Information about Insulin When we eat, our bodies break food down into organic compounds, one of which is glucose. The cells of our bodies use glucose as a source of energy for movement, growth, repair, and other functions. But before the cells can use glucose, it must move from the bloodstream into the individual cells. This process requires insulin. Insulin is produced by the beta cells in the islets of Langerhans in the pancreas. When glucose enters our blood, the pancreas should automatically produce the right amount of insulin to move glucose into our cells. Canines with type 1 diabetes produce no insulin. Felines with type 2 diabetes do not always produce enough insulin. (Felines can be type 1 or 2 and Canines are always type 1) Insulin Tips: - NPH cannot be mixed with any Lente (L or U) insulin, they are chemically incompatible. - Insulin does not have to be refrigerated if kept at a moderate temp., although it is recommended. - Do not give cold injections, it could cause discomfort. - Popular opinion is to dispose of opened insulin after 30 days or 100 sticks. - To prevent abscesses, infections, and discomfort, only use syringes once. - Rotation of injection sites is recommended. - It is best to feed before the injection to make sure the animal eats. (generally 30 min. before) - Human insulins are shorter acting than animal insulins of the same type. - Never shake "cloudy" insulins. Roll the bottle between the palms of your hands. Duration and Peak Times for the Most Common Insulins There are more than 20 types of insulin products Continue reading >>

Types Of Insulin For Diabetes Treatment

Many forms of insulin treat diabetes. They're grouped by how fast they start to work and how long their effects last. The types of insulin include: Rapid-acting Short-acting Intermediate-acting Long-acting Pre-mixed What Type of Insulin Is Best for My Diabetes? Your doctor will work with you to prescribe the type of insulin that's best for you and your diabetes. Making that choice will depend on many things, including: How you respond to insulin. (How long it takes the body to absorb it and how long it remains active varies from person to person.) Lifestyle choices. The type of food you eat, how much alcohol you drink, or how much exercise you get will all affect how your body uses insulin. Your willingness to give yourself multiple injections per day Your age Your goals for managing your blood sugar Afrezza, a rapid-acting inhaled insulin, is FDA-approved for use before meals for both type 1 and type 2 diabetes. The drug peaks in your blood in about 15-20 minutes and it clears your body in 2-3 hours. It must be used along with long-acting insulin in people with type 1 diabetes. The chart below lists the types of injectable insulin with details about onset (the length of time before insulin reaches the bloodstream and begins to lower blood sugar), peak (the time period when it best lowers blood sugar) and duration (how long insulin continues to work). These three things may vary. The final column offers some insight into the "coverage" provided by the different insulin types in relation to mealtime. Type of Insulin & Brand Names Onset Peak Duration Role in Blood Sugar Management Rapid-Acting Lispro (Humalog) 15-30 min. 30-90 min 3-5 hours Rapid-acting insulin covers insulin needs for meals eaten at the same time as the injection. This type of insulin is often used with Continue reading >>