Safety And Efficacy Of Novolog Vs. Humalog In Insulin Pumps In Children And Adolescents
This trial is conducted in the United States of America (USA). It is demonstrated that intensive insulin therapy resulting in good glycaemic control can reduce or delay the incidence of complications secondary to Type 1 Diabetes. Insulin Aspart (NovoLog®) is an ideal insulin to use in an intensive insulin regimen using continuous subcutaneous insulin injection (CSII) therapy in the pediatric and adolescent age population. This trial compares the safety and efficacy of Insulin Aspart (NovoLog®) and Insulin Lispro (Humalog®) delivered by CSII in children and adolescents with type 1 diabetes. Study Type : Interventional (Clinical Trial) Actual Enrollment : 299 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Safety and Efficacy of Insulin Aspart Versus Insulin Lispro in Insulin Pumps in Children and Adolescents With Type 1 Diabetes Study Start Date : October 2004 Primary Completion Date : May 2006 Study Completion Date : May 2006 Resource links provided by the National Library of Medicine U.S. FDA Resources Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00097071 Show 52 Study L Continue reading >>
Asknadia: Allergic To Humalog And Medicare Will Not Pay For Novolog
AskNadia: Allergic to Humalog and Medicare Will Not Pay for NovoLog I got your email address from Insulin-Pumpers.org and hoped you can help me with an answer as to the current action of Medicare forcing people to use Humalog instead of NovoLog. Medicare has refused to pay for the NovoLog and I am allergic to Humalog. I was told you might have some useful tips to change their mind since being allergic to Humalog is not dire enough. You can most definitely appeal the Medicare policy on the insulin brand coverage. If using the insulin that is covered by Medicare has a contraindication, adversely affecting your health, they will need to reconsider their position with you. This is how I would move forward. Contact your prescribing doctor and request that they submit a reconsideration letter to Medicare by faxing it in with the proper coding; stating you are allergic to Humalog and NovoLog coverage is medically necessary for you. It usually takes Medicare 30 to 60 days to reconsider an appeal. In your case this can be expedited to 3 days because your daily insulin is medically necessary. If this is an option for you, pay out of pocket now for NovoLog and ask Medicare to reimburse you at a later date. But make sure the doctors pharmacy prescription states the same thing. You are allegoric to Humalog and must use NovoLog. There are 5 different stages to the appeals process as provided by the governments website : Level 5: Judicial review by a federal district court I also want you to be aware of another layer that sometimes can complicate the issue for patients. I recently read a press release from Tranquilmoney that states U.S. doctors leave $125 billion uncollected annually due to poor billing practices and up to 80% of all medical bills contain mistakes. Tranquilmoney CEO Continue reading >>
Humalog Vs Novolog
Introduction: Diabetic patients take various forms of insulin on a regular basis. One of these forms is called rapid acting insulin. This type of insulin takes its effect within minutes. Currently, the two of the forms available on the market are Lispro (Humalog) and Aspart (NovoLog). These can be used for both Type I and Type II diabetic patients. Patients must always be aware of their need for proper diet and exercise for increased function in treatment. Also, appropriate meal times and promotions are extremely important when receiving regular insulin. Unlike oral medications, these insulins provide rapid relief of high glucose levels. They are usually prescribed on a sliding scale meaning the dosage depends on the current insulin levels. These sliding scales differ from patient to patient depending on weight, activity level, and age. Regular insulin usually lasts for 2-4 hours and reaches their peak after one hour. It is important to check glucose levels before and after administering this type of insulin. These levels, as well as the dosage, applied, should be kept in a record by the patient. (5) It is very important that the patient realizes that regular insulins will need to be used in combination with various other treatments including and not limited to Oral medication, diet, exercise, and long lasting insulin. (1-10) Difference between Humalog and Novolog Humalog (Lispro) Below is the image of a vial of Humalog insulin. Patients should pay close attention to the markings and read the insulin vial before administering to help prevent administration errors. a. Humalog was introduced in 1996 and has been proven safe for use when used correctly. It allows for mealtime injection and close regularization of glucose levels. This image shows the structure of Lispro (Hu Continue reading >>
Humalog Vs. Novolog: What’s The Difference?
The two leaders in the fast acting insulin market, Humalog and Novolog, are the most common types of fast acting insulin used by those with diabetes today. Fast Acting, mealtime insulin is a type of insulin that is injected before or right after eating. When you eat your blood glucose begins to rise. Fast acting insulin, Humalog and Novolog work to help manage these rises or spikes to keep your blood glucose levels more within range and balanced. When you use a fast acting insulin like Humalog or Novolog, you typically will continue to take a long acting insulin to help manage your levels between your meals and throughout the night. The question is though, is there really a difference between the two? Endocrinologists and other medical professionals don’t seem to really think there is, stating the two are virtually interchangeable. But that’s not really the full story. Humalog (Insulin Lispro) Insulin Lispro (Humalog) has been on the market since 1996, when it was first introduced by Eli Lily. Humalog is the first insulin analogue that was used clinically. Insulin Lispro received its name due to its structure. The difference between it and regular insulin was the switch between the lysine B28 (an amino acid) and proline B29. The formula consists of a hexametric solution available in vials and pen form. After a subcutaneous injection, the formula converts into a monomeric formula which allows it to have a fast absorption in the body. The one noted negative factor of Humalog is its short term control of glucose levels. Additionally, if it is injected and mealtime happens to be delayed, a hypoglycemic episode may occur. For Humalog to be most effective it is to be injected 15 minutes prior to the start of a meal. I recommend reading the following articles: Humalog is a Continue reading >>
Humalog Vs. Novolog: Important Differences And More
Humalog and Novolog are two diabetes medications. Humalog is the brand-name version of insulin lispro, and Novolog is the brand-name version of insulin aspart. These drugs both help control blood glucose (sugar) in people with type 1 and type 2 diabetes. Humalog and Novolog are both rapid acting. That means they work more quickly than other types of insulin. There are important distinctions between Humalog and Novolog, however, and the drugs are not directly interchangeable. Check out this comparison so you can work with your doctor to choose a drug that’s right for you. Insulin is injected under your skin fat. It’s the most common type of treatment for type 1 diabetes because it works quickly. It’s also the only type of diabetes medication that’s absorbed into the bloodstream. Humalog and Novolog are both equivalent to the insulin made in your body. Unlike oral diabetes drugs, insulin provides fast relief for changes in your blood sugar. The type of insulin your doctor prescribes depends on how often and how much your blood sugar fluctuates each day. The table below provides quick facts at a glance. Brand name Humalog Novolog What is the generic drug? insulin lispro insulin aspart Is a generic version available? no no What does it treat? type 1 and type 2 diabetes type 1 and type 2 diabetes What form does it come in? solution for injection solution for injection What strengths does it come in? • 3-mL cartridges • 3-mL prefilled KwikPen • 3-mL vials • 10-mL vials • 3-mL FlexPen • 3-mL FlexTouch • 3-mL PenFill cartridges • 10-mL vials What is the typical length of treatment? long-term long-term How do I store it? Refrigerate at 36° to 46°F (2° to 8°C). Do not freeze the drug. Refrigerate at 36° to 46°F (2° to 8°C). Do not freeze the drug. Continue reading >>
Switching From Novolog To Humalog
Looks like Ill be switching insulins, due to new Rx coverage, effective in January 2018. My endo has said they are essentially the same, but I thought Id check in here. Also on Lantus, but that will stay the same. Doing MDI with a CGM right now. I think there are minor differences that can be noticeable for some people. I tried Humalog briefly and found that I needed much more of it for carbs and corrections, that I had to increase my basal rates (I was using it in a pump) and that it didnt last as long. My son has not used Humalog, but Ive heard the same as @Scott_Eric . Calebs endo discourages its use bc of experience hes seen with pumping - it being more susceptible to clogging. Any chance your insurance is Aetna? We got a similar notice. I made that switch and didnt notice much of a differenceI think humalog may be a tiny bit faster/have less of a tail, but hard to say. Im also on MDI (humalog and tresiba, formerly lantus), so the clogging/pumping concern wasnt an issue. I used NovoLog for years and Ive used Humalog for years. I dont see any functional difference between the two. I have noticed on the internet some people claim they find difference between the two. If thats true its now a your mileage may vary issue Ive used both. I need about 12% more insulin on Humalog than on Novolog on MDI. But in a previous thread on a different message board, I noted that there were others who had the opposite experience. Also Humalog gets started a little faster than Novolog for me and at least in previous years had a slightly shorter tail. However, this year Ive noticed that a typical mealtime dose (8 units) of Humalog takes between five and six hours to finish working, which is as long as Novolog took the last time I was on it about three years ago.It may be just that at m Continue reading >>
When Do Humalog And Novolog Insulins Really Work?
When do Humalog and Novolog insulins really work? See also: Humalog & Heat and User's Reports A problem associated with the use of rapid insulins is that situations occur that cause people to perceive them as faster than they really are. For example, a person may feel perfectly normal at 70 mg/dl (3.9 mmol), take a bolus of rapid insulin for a meal, and a few minutes later begin to shake, sweat and have trouble thinking. Though the timing of the symptoms gives the impression that rapid insulin is responsible and acts very quickly, the symptoms are unlikely to be caused by the rapid insulin just given. More likely, another insulin given earlier is causing the blood sugar to drop. A drop of only a few mg/dl causes a person to go from feeling normal to feeling low. Because the meal bolus was just given, it often receives the blame for a low caused by an insulin that was given earlier. The kinetics of an insulin are when that insulin can be measured in the bloodstream, whereas an insulin's dynamics are when it actually affects the blood sugar. After an injection, peak levels of Humalog and Novolog insulins are seen in the bloodstream about 45 minutes later, as shown by the dashed kinetic line to the right. However, the effect on your blood sugar is not nearly this quick. The solid dynamic line to the right shows when these insulins are actually lowering the blood sugar. The maximum effect on lowering the glucose level is not seen until 2 hours after an injection and continues for over 4 hours. Another situation often seems to confirm for many the false impression that a rapid insulin is really rapid. This occurs when a carb or correction bolus is given and a low blood sugar begins only an hour or two later. Here, the rapid insulin is likely at fault, but again the low bloo Continue reading >>
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Novolog Vs Humalog: Which Is Better?
Ahhh yes, the million dollar question. In the land of type 1 diabetes and rapid acting insulin, everyone wants to know, which works better…Novolog vs Humalog? Thank You Insurance Companies (not!) You’re probably here because your insurance company has pulled the plug on your beloved insulin and is making you switch to the dark side. Whether they signed a deal with Lilly (Humalog) or Novo Nordisk (Novolog) you’re left in sheer panic because WTH insurance companies?! This is my life juice you’re messing with here. You’ve been reassured by your doctor…and their nurses…and the pharmacist that there is no difference between the two brands… It’s like pepsi vs coke – my doctors nurse. Well, if you know anything about pepsi or coke then you know… while it’s true that some can’t taste the difference, others most definitely can. Same is true with Novolog vs Humalog. Show me the differences! Novolog vs Humalog But first, the similarities. Both Novolog and Humalog are human insulin analogs. This means that they are a synthetically altered form of human insulin – the kind that you find naturally occurring in the human body (as opposed to being extracted from cows and pigs – like it was back in the 20’s). Both should begin working in about 15 minutes after injection, should peak in about 1 hour, and should continue to work for 2-4 hours. What’s with all the shoulds? Everyone reacts to medications differently; insulin is no exception. …which brings me to the differences In Humalog (insulin lispro) the amino acids for proline and lysine have been swapped. This means that the amino acid, proline, has been substituted for lysine in position 28 of the B-Chain, and lysine has be substituted for proline in position 29 of the B-Chain. In Novolog (insulin a Continue reading >>
Humalog Vs Novolog (novalog): What's The Difference?
Humalog and Novolog are both rapid acting forms of insulin that work for short periods of time. Humalog Vs Novolog: Both human insulin analogs Humalog is a brand name for insulin lispro. Humalog starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours. Novolog is a brand name for insulin aspart. NovoLog starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours. Novolog is commonly misspelled as Novalog. Both medicines may be prescribed along with long-acting or intermediate-acting insulins. Humalog Vs Novolog: What exactly is the difference? Insulin consists of two polypeptide chains (A and B) linked together by disulfide bonds. Insulin lispro is human insulin that has been modified so that the amino acid proline has been substituted for lysine in position 28 of the B-chain, and lysine has been substituted for proline at position 29 of the B-chain. Insulin Aspart is human insulin that has a single substitution of proline for aspartic acid in position 28 of the B-chain. These seemingly minor substitutions significantly increase the rate of absorption of these insulin analogs into blood after subcutaneous injection. Peak concentrations are reached quicker than with regular human insulin, postprandial glucose control (level of blood sugars after a meal) is also improved, and there is less risk of late hypoglycemia (low blood sugar). Humalog Vs Novolog: Are there any differences in effect in people with diabetes? One small study concluded that there were no differences between Insulin lispro (Humalog) and Insulin Aspart (Novolog) in people with type 1 diabetes. Insulin levels in blood were similar 30 minutes after subcutaneous injection of either Lispro or Aspart and both disa Continue reading >>
Humalog Vs. Novolog.
It wasn't until recently that I started thinking about building up a tolerance to insulin. Do you build up a chemical familiarity, a resistance of sorts, to a drug after taking it for ... oh, say a few decades? Do PWD eventually become the Dread Pirate Roberts, building up a tolerance to iocane powder? "I realize this is probably ridiculous, and I'm sure there aren't any studies on this," I said to my doctor the other week. "But it has prompted me to want to try a different kind of fast acting insulin, to see if I have better results. Is that something I'm able to do, to have a script written for a one-off in order to assess how the insulin might work for me?" "We can do that." And I left the appointment, expecting my pharmacy to auto-dial me when my order was complete. Instead, a three-month supply of Novolog ended up on my doorstep, having been accidentally shuttled through my mail order pharmacy and eating up my insurance order that was intended for my normal course of Humalog. Which is why I'm experimenting with Novolog for the next few months, as a result of a shipping error. I've been taking Humalog for over ten years, after switching from Regular insulin before starting on my insulin pump, so I feel like I'm familiar with how Humalog acts in my pump and on my blood sugars. Switching to a different, but similar, rapid-acting analog should hopefully be a seamless transition. Last night was my first pump-load of Novolog, despite the last unopened bottle of Humalog in my stash. (I didn't want to use up the Humalog entirely, then switch to Novolog, because if I absolutely hated the new insulin, I'd be stuck with it.) So far, last night was entirely uneventful, and the biggest change I've noticed (in less than 24 hours of use) is that the bottle of Novolog plays host t Continue reading >>
Humalog Vs. Novolog
font size A A A 1 2 Next Are Humalog and Novolog the Same Thing? Humalog (insulin lispro [rDNA origin]) and NovoLog (insulin aspart [rDNA origin] injection) are forms of insulin, a hormone produced in the body, used to treat type 1 (insulin-dependent) diabetes in adults. Both Humalog and NovoLog are usually given together with another long-acting insulin. A difference is that Humalog is sometimes also used together with oral medications to treat type 2 (non insulin-dependent) diabetes in adults. Another difference is that NovoLog is also used to treat type 1 diabetes in children who are at least 2 years old. What Are Possible Side Effects of Humalog? Humalog (atorvastatin) is a statin used for the treatment of elevated total cholesterol, LDL, triglycerides, and to elevate HDL cholesterol. Side effects of Humalog include: injection site reactions (e.g., pain, redness, irritation). Low blood sugar (hypoglycemia), is the most common side effect of insulin lispro such as Humalog. Symptoms of low blood sugar may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, trouble concentrating, confusions, or seizure (convulsions). Low blood potassium levels (hypokalemia). Symptoms include dry mouth, increased thirst, increased urination, uneven heartbeats, muscle pain or weakness, leg pain or discomfort, or confusion What Are Possible Side Effects of Novolog? Novolog is available in generic form. Common side effects of Novolog include: injection site reactions (e.g., pain, redness, irritation). What is Humalog? Humalog is a man-made fast-acting insulin used to control high blood sugar in adults and children with diabetes mellitus. It is not known if Humalog is safe and effective in children younger than 3 ye Continue reading >>
Compare Humalog Vs. Novolog
Humalog (insulin lispro) is the most effective medication for lowering your blood sugar. Works quickly to control your sugar levels after meals. Dose can be easily adjusted to create a regimen that's tailored to your body's needs. Humalog (insulin lispro) can be used even if you have liver or kidney problems, unlike other anti-diabetic medications. When used correctly, this medication will l lower blood sugar every time you use it and prevent the harmful, long-term effects of high sugar levels on your organs and blood vessels. You can easily change the dose of Novolog (insulin aspart) to fit your individual needs. Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression. Can use Novolog (insulin aspart) even if you have liver or kidney problems, unlike many other blood sugar-lowering medicines. 280 reviews so far Have you used Humalog (insulin lispro)? Leave a review 177 reviews so far Have you used Novolog (insulin aspart)? Leave a review Continue reading >>
Comparison Of Insulin Aspart And Lispro: Pharmacokinetic And Metabolic Effects.
Abstract OBJECTIVE: To compare insulin levels and actions in patients with type 1 diabetes after subcutaneous injection of the rapid-acting insulin analogs aspart and lispro. RESEARCH DESIGN AND METHODS: Seven C-peptide-negative patients with type 1 diabetes (two men and five women) were studied at the General Clinical Research Center at Temple University Hospital two times, 1 month apart. Their plasma glucose was normalized overnight by intravenous infusion of insulin. The next morning, they received subcutaneous injections of either aspart or lispro (9.4 +/- 1.9 U) in random order. For the next 4-5 h, their plasma glucose was clamped at approximately 5.5 mmol/l with a variable infusion of 20% glucose. The study was terminated after 8 h. RESULTS: Both insulin analogs produced similar serum insulin levels (250-300 pmol/l) at approximately 30 min and disappeared from serum after approximately 4 h. Insulin aspart and lispro had similar effects on glucose and fat metabolism. Effects on carbohydrate metabolism (glucose uptake, glucose oxidation, and endogenous glucose production) peaked after approximately 2-3 h and disappeared after approximately 5-6 h. Effects on lipid metabolism (plasma free fatty acid, ketone body levels, and free fatty acid oxidation) appeared to peak earlier (at approximately 2 h) and disappeared earlier (after approximately 4 h) than the effects on carbohydrate metabolism. CONCLUSIONS: We conclude that both insulin aspart and lispro are indistinguishable from each other with respect to blood levels and that they are equally effective in correcting abnormalities in carbohydrate and fat metabolism in patients with type 1 diabetes. Continue reading >>
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What Is The Difference Between Humalog Vs Novolog Insulin?
Novolog and Humalog, are both diabetic drugs used to control blood sugar levels in diabetic patients. They are both fast acting drugs, meaning that they work faster compared to other insulin medicines. According to American Diabetes Association, both medications start to work after 15 minutes. However, they reach their peak after 1 hour, while their effects can be felt up to 2 to 4 hours. Both insulin drugs provide mealtime glucose control. After taking these drugs, you should eat a few minutes later to avoid the risk of having hypoglycemia. You may need to use these drugs with intermediate acting insulin or long acting insulin drugs to manage blood glucose levels between meals. Humalog (Insulin Lispro) Humalog or insulin lispro is a fast acting insulin which is commonly used to treat type 2 diabetes in adults, but can also be used by patients with type 1 diabetes. For insulin lispro to be most effective, you are supposed to take this drug 15 minutes before a meal or immediately after you eat. To remember your dosage, make sure you use this insulin at the same time every day. The drug is usually a part treatment program that includes exercise and diet. Therefore, you will need to carefully follow your medication, exercise and diet program to avoid adverse changes in blood sugar. Insulin lispro is administered by subcutaneously injecting the insulin in the upper arm, thigh or a buttock. Your doctor may adjust your dosage based on physical activity, acute illness or changes in eating pattern. Insulin lispro comes in 10 ml vials, 3 ml vials, 3 ml KwikPens and 3ml cartridges. Humalog KwikPen is a pen that is lightweight and comes prefilled with insulin lispro that you can use on the go. You should not take it if you are allergic to insulin lispro or another drug ingredient. Continue reading >>
Rapid-Acting Analogues Short-Acting Insulins Intermediate-Acting Insulins Long-Acting Insulins Combination Insulins Onset: 12 - 18 min Peak: 1-3 hours Duration: 3-5 hours Solution: Clear Comments: NovoLog should generally be given immediately before a meal (start of meal within 5-10 minutes after injection) because of its fast onset of action. NovoLog is homologous with regular human insulin with the exception of a single substitution of the amino acid proline by aspartic acid in position B28 (beta chain). Insulin lispro (Humalog) and insulin aspart (Novolog), when administered intravenously, show pharmacodynamic parameters similar to regular insulin. Mixing NPH: If NovoLog is mixed with NPH human insulin, NovoLog should be drawn into the syringe first. The injection should be made immediately after mixing. Regular insulin: Compatible - but NO support clinically for such a mixture. Draw up Novolog first before drawing up Regular Insulin. Mixtures should not be administered intravenously. When used in external subcutaneous infusion pumps for insulin, NovoLog should not be mixed with any other insulins or diluent. When rapid-acting insulin is mixed with either an intermediate- or long-acting insulin, the mixture should be injected within 15 min before a meal. INDICATIONS AND USAGE Treatment of Diabetes Mellitus NovoLog is an insulin analog indicated to improve glycemic control in adults and children with diabetes mellitus. DOSAGE AND ADMINISTRATION Dosing NovoLog is an insulin analog with an earlier onset of action than regular human insulin. The dosage of NovoLog must be individualized. NovoLog given by subcutaneous injection should generally be used in regimens with an intermediate or long-acting insulin [see package insert for Warnings and Precautions (5), How Supplied Continue reading >>