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Non Diabetic Fibrous Mastopathy

Regression Of The Fibrous Disease Of The Breast In A Non-diabetic Woman After Pregnancy And Breastfeeding

Regression Of The Fibrous Disease Of The Breast In A Non-diabetic Woman After Pregnancy And Breastfeeding

Regression of the Fibrous Disease of the Breast in a Non-Diabetic Woman after Pregnancy and Breastfeeding Download "Regression of the Fibrous Disease of the Breast in a Non-Diabetic Woman after Pregnancy and Breastfeeding" 1 Regression of the Fibrous Disease of the Breast in a Non-Diabetic Woman after Pregnancy and Breastfeeding ABSTRACT Fibrous mastopathy, also known as diabetic mastopathy and lymphocytic mastopathy, may mimic breast cancer at the physical examination, mammography, and ultrasound. We report a case of a woman who presented a non-tender mass clinically suggestive of breast carcinoma; however, the fine-needle aspiration cytology indicated atypia and the core needle biopsy revealed lymphocytic mastopathy. The magnetic resonance imaging of the breast showed a lesion with benign features. It was not demonstrated diabetics mellitus and autoimmune diseases. The patient got pregnant, breastfed, and it was observed the progressive regression of the lesion, with complete disappearance of the solid mass. Three years and three months later, there was no palpable mass at the clinical examination and ultrasound. In conclusion, fibrous mastopathy shall be considered for all breast lesions, regardless of the diagnosis of diabetes mellitus. Once a definitive diagnosis of this pathology is reached, it is recommended clinical, imaging studies and fine-needle aspiration biopsy follow-up of the patient, avoiding unnecessary surgical procedures. (Arq Bras Endocrinol Metab 2007;51/9: ) apresentao de caso MARIA APARECIDA Q. F. PEREIRA MARCOS E. DE A. SEGURA ANA MARIA DE SOUZA SANTOS LUIZ AUGUSTO CASULARI Service of Mastology, Hospital de Base do Distrito Federal, Braslia DF, Brazil. Keywords: Mastopathy; Fibrous mastopathy; Diabetic mastopathy; Lymphocytic mastopathy; Diabete Continue reading >>

Printable - Diabetic Mastopathy - Surgical Pathology Criteria - Stanford University School Of Medicine

Printable - Diabetic Mastopathy - Surgical Pathology Criteria - Stanford University School Of Medicine

Lymphoid infiltrate is predominantly B cells Mixed B and T cells or predominantly T cells Nearly all reported cases with full constellation of histologic features have occurrred in diabetics Most often associated with Type I diabetes One report of association with longstanding insulin use rather than type of diabetes (Seidman) Occasional cases reported in non-diabetics with some but not all of the diagnostic histologic features Autoantibodies reported in some cases (Schwartz) Generally presents as a fibrous mass or masses One prospective series of diabetics found non-palpable lesions with some but not all of the diagnostic histologic features (Lammie) Valdez R, Thorson J, Finn WG, Schnitzer B, Kleer CG. Lymphocytic mastitis and diabetic mastopathy: a molecular, immunophenotypic, and clinicopathologic evaluation of 11 cases. Mod Pathol. 2003 Mar;16(3):223-8. Ely KA, Tse G, Simpson JF, Clarfeld R, Page DL. Diabetic mastopathy. A clinicopathologic review. Am J Clin Pathol. 2000 Apr;113(4):541-5. Tomaszewski JE, Brooks JS, Hicks D, Livolsi VA. Diabetic mastopathy: a distinctive clinicopathologic entity. Hum Pathol. 1992 Jul;23(7):780-6. Schwartz IS, Strauchen JA. Lymphocytic mastopathy. An autoimmune disease of the breast? Am J Clin Pathol. 1990 Jun;93(6):725-30. Lammie GA, Bobrow LG, Staunton MD, Levison DA, Page G, Millis RR. Sclerosing lymphocytic lobulitis of the breast--evidence for an autoimmune pathogenesis. Histopathology. 1991 Jul;19(1):13-20. Morgan MC, Weaver MG, Crowe JP, Abdul-Karim FW. Diabetic mastopathy: a clinicopathologic study in palpable and nonpalpable breast lesions. Mod Pathol. 1995 May;8(4):349-54. Ashton MA, Lefkowitz M, Tavassoli FA. Epithelioid stromal cells in lymphocytic mastitis--a source of confusion with invasive carcinoma. Mod Pathol. 1994 Continue reading >>

Diabetes Iodine Deficiency Fibrous Non Mastopathy

Diabetes Iodine Deficiency Fibrous Non Mastopathy

Diabetes Iodine Deficiency Fibrous Non Mastopathy Unfortunately they dont consider it the same as a standard insulin pump. Diabetes Iodine Deficiency Fibrous Non Mastopathy hypoglycemia symptoms of heart attack. Liver cyst is a common manifestation in Autosomal Dominant Polycystic Kidney Disease (ADPKD). Diabetes Mellitus document a direct causal relationship between the diabetes and the A diabetic patient is admitted for treatment of osteomyelitis Hypertension affects nearly 26 per cent of the adult population worldwide1. The FDA says it is working with Abbott Diabetes Care to recall 359 million defective glucose test strips sold under a variety of and Can You Lose Diabetes :: Bananas And Diabetes Cure For Diabetes In 30 Days The 3 Step Diabetes Iodine Deficiency Fibrous Non Mastopathy Trick that Reverses Diabetes Permanently in As Little as 11 Days.[ New York Diabetic Supplies. The options may seem even more limited. The weekly e-news update to Gourmet News the business newspaper for the gourmet industry. Cat diabetes has practically become an epidemic in the U.S. The Swedish Study on Paleolithic Diet for Type 2 Diabetes information to health care personnel in primary health care and hospital diabetes clinics and to patient Homeostasis Worksheet In negative feedback State whether each of the following indicates negative or positive feedback: The normal range for blood glucose is Berkeley Wellness experts tell you what youll want to put on your grocery list and why. Population Aged <20 Years Through 2050 Why It Pays to Lose Weight If You Have Type 2 Diabetes Subscribe; NEXT Only about 10 percent of patients with diabetes in my clinic have been successful Buy gluten-free foods. Diabetes Type 2 Normal Range There is a growing global epidemic of Type 2 diabetes that can Continue reading >>

(pdf) Fibrous Mastopathy: Clinical, Imaging, And Histopathologic Findings Of 31 Cases

(pdf) Fibrous Mastopathy: Clinical, Imaging, And Histopathologic Findings Of 31 Cases

Fibrous mastopathy: Clinical, imaging, and histopathologic ndings of 31 casesjog_1146326..335 Maria Aparecida de Queiroz Freitas Pereira1, Albino Verosa de Magalhes2, Lucilia Domingues Casulari da Motta3, Ana Maria de Souza Santos4, Marcos Emanuel de Alcntara Segura2, Camila Freitas Pereira5and 1Mastology Unit, Hospital de Base do Distrito Federal, Departments of 2Pathology and 3Gynecology and Obstetrics, University of Braslia, 4Santa gata Clinic, 5Pediatric Clinic, Hospital Regional Asa Sul, and 6Endocrinology Department, University Hospital of Braslia, Braslia, DF, Brazil Aim: The aim of this study was to analyze the cases of patients with a histological diagnosis of brous mastopathy, diabetic mastopathy, or lymphocytic mastopathy in association with other autoimmune diseases, and to conduct histological and imaging studies as well as follow up of the lesions. Methods: Thirty-one patients meeting predetermined histopathological criteria for diabetic mastopathy, brous mastopathy, or lymphocytic mastopathy were analyzed for several factors: age at diagnosis; clinical manifestations; parity; breastfeeding; use of sex steroids for hormonal replacement therapy or hormonal contraception; associated diseases; mammographic ndings; breast magnetic resonance imaging and ultra- sound; histological and cytological diagnosis; immunohistochemical and immunophenotyping identication of T- and B-lymphocytes and macrophages, and a-smooth muscle actin; and follow up. Results: Fibrous mastopathy was present among diabetic and non-diabetic patients, patients with autoimmune diseases, and healthy individuals. Relapses were found in one-quarter of the lesions and spon- taneous regression was observed in one case. There was a predominance of T-lymphocytes over B-lymphocytes in the brous mas Continue reading >>

Diabetic Mastopathy As A Radiographically Occult Palpable Breast Mass

Diabetic Mastopathy As A Radiographically Occult Palpable Breast Mass

Diabetic Mastopathy as a Radiographically Occult Palpable Breast Mass 1Department of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA 2Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA 3Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA 4Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA Received 16 June 2011; Accepted 5 September 2011 Copyright 2011 Uma Thanarajasingam et al. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Diabetic mastopathy is an uncommon, benign disease of the breast that can occur in women with diabetes and clinically mimic breast cancer. We describe a patient with long-standing type 1 diabetes who presented with a palpable breast mass with negative imaging findings on mammography, ultrasonography, and breast MRI. Surgical biopsy and histopathology confirmed diabetic mastopathy. We use this case to highlight the recognition, radiographic features, pathology, and management of this benign breast condition and emphasize that, in diabetic patients, the differential diagnosis of a new breast mass should include diabetic mastopathy. Diabetic mastopathy is an uncommon, benign breast condition, seen in diabetic patients and can masquerade as breast cancer. This diagnostic possibility must be borne in mind during the evaluation of a patient with diabetes and a new breast lump. Soler and Khardori [ 1 ] were the first to describe an association between diabetes and breast disease that they termed fibrous disease of the breast, in a cohort of premenopausal, long-standing Type I diabetics, most of whom had diabetic compl Continue reading >>

Jove | Peer Reviewed Scientific Video Journal - Methods And Protocols

Jove | Peer Reviewed Scientific Video Journal - Methods And Protocols

Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies The accurate quantification of peripheral neuropathy is important to define at risk patients, anticipate deterioration, and assess new therapies. Conventional methods assess neurological deficits and electrophysiology and quantitative sensory testing quantifies functional alterations to detect neuropathy. However, the earliest damage appears to be to the small fibres and yet these tests primarily assess large fibre dysfunction and have a limited ability to demonstrate regeneration and repair. The only techniques which allow a direct examination of unmyelinated nerve fibre damage and repair are sural nerve biopsy with electron microscopy and skin-punch biopsy. However, both are invasive procedures and require lengthy laboratory procedures and considerable expertise. Corneal Confocal microscopy is a non-invasive clinical technique which provides in-vivo imaging of corneal nerve fibres. We have demonstrated early nerve damage, which precedes loss of intraepidermal nerve fibres in skin biopsies together with stratification of neuropathic severity and repair following pancreas transplantation in diabetic patients. We have also demonstrated nerve damage in idiopathic small fibre neuropathy and Fabry's disease. Medicine, Issue 47, Corneal Confocal Microscopy, Corneal nerves, Peripheral Neuropathy, Diabetic Neuropathy A Simplified Technique for Producing an Ischemic Wound Model Authors: Sufan Chien, Bradon J. Wilhelmi. One major obstacle in current diabetic wound research is a lack of an ischemic wound model that can be safely used in diabetic animals. Drugs that work well in non-ischemic wounds may not work in human diabetic wounds because vasculopathy is o Continue reading >>

Update: Diabetes Mastopathy, Twice A Year Mammogram

Update: Diabetes Mastopathy, Twice A Year Mammogram

Update: Diabetes Mastopathy, Twice a year Mammogram In 2008, I wrote about Diabetic Mastopathy , a condition that affects women who have lived with diabetes a longtime. The condition is still with me and for my breast care team, it has become more difficult to monitor. Last year, my doctor spotted another nodule and after a mammogram and an ultrasound, they could not check off that I was clear. It took both my doctor pointing and the ultrasound tech to narrow down which lump was the culprit for concern. The end result was another biopsy The problem now, is that I have had a surgical biopsy on both breasts, and more incisions leave more scar tissue making the mammogram harder to read and the ultrasound less effective. To reduce the amount of scaring, they decided on a core needle biopsy . The report was more dense fibrous tissue, and for me no question about this being another case of diabetic mastopathy! At my follow up appointment, Minna, my wonderful physicians assistant and lumpy breast hound, suggested that we bump up the ultra sound to twice a year. This lets Minnas eyes and fingers keep closer watch, until I hit menopause. While some people feel mammograms for diabetic mastopathy are pointless, what they offer my breast care team is a consistent history for looking for change. Its one part of a 3 part routine check up: look and feel, mammography and ultrasound and last resort biopsy. By increasing the visits to my breast care team, it also allows them to chart perimenopause changes as well. Perimenopause, or pre menopause, is when a womans body starts a hormonal flux as it shifts into menopause. Common symptoms are irregular periods for no apparent reason, hot flashes and night sweats and LUMPY BREASTS! Ok, so irregular has been my lifes story with everything! Si Continue reading >>

Fibrous Mastopathy: Clinical, Imaging, And Histopathologic Findings Of 31 Cases.

Fibrous Mastopathy: Clinical, Imaging, And Histopathologic Findings Of 31 Cases.

Fibrous mastopathy: clinical, imaging, and histopathologic findings of 31 cases. Pereira MA, et al. J Obstet Gynaecol Res. 2010. Mastology Unit, Hospital de Base do Distrito Federal, Brazil. J Obstet Gynaecol Res. 2010 Apr;36(2):326-35. doi: 10.1111/j.1447-0756.2009.01146.x. AIM: The aim of this study was to analyze the cases of patients with a histological diagnosis of fibrous mastopathy, diabetic mastopathy, or lymphocytic mastopathy in association with other autoimmune diseases, and to conduct histological and imaging studies as well as follow up of the lesions. METHODS: Thirty-one patients meeting predetermined histopathological criteria for diabetic mastopathy, fibrous mastopathy, or lymphocytic mastopathy were analyzed for several factors: age at diagnosis; clinical manifestations; parity; breastfeeding; use of sex steroids for hormonal replacement therapy or hormonal contraception; associated diseases; mammographic findings; breast magnetic resonance imaging and ultrasound; histological and cytological diagnosis; immunohistochemical and immunophenotyping identification of T- and B-lymphocytes and macrophages, and alpha-smooth muscle actin; and follow up. RESULTS: Fibrous mastopathy was present among diabetic and non-diabetic patients, patients with autoimmune diseases, and healthy individuals. Relapses were found in one-quarter of the lesions and spontaneous regression was observed in one case. There was a predominance of T-lymphocytes over B-lymphocytes in the fibrous mastopathic lesions (P < 0.001). Macrophages were demonstrated in 95.2% of the lesions. All of the lesions displayed reactivity for alpha-smooth muscle actin, a characteristic of myofibroblasts. CONCLUSIONS: Fibrous mastopathy does not occur in diabetic patients only; fibrous mastopathy may also o Continue reading >>

Sclerosing Lymphocytic Lobulitis Mimicking A Tumor Relapse In A Young Woman With A History Of Breast Cancer

Sclerosing Lymphocytic Lobulitis Mimicking A Tumor Relapse In A Young Woman With A History Of Breast Cancer

Sclerosing lymphocytic lobulitis mimicking a tumor relapse in a young woman with a history of breast cancer Authors: J Decraene,C Van Ongeval,G Clinckemaillie,H Wildiers Sclerosing lymphocytic lobulitis or diabetic mastopathy is a benign entity with non-specific imaging features which can mimic breast carcinoma. It is a condition commonly associated with long standing diabetes and has also been linked with various auto-immune diseases. We present the case of a 27-year-old woman with a history of carcinoma of the left breast and otherwise unremarkable medical history, who developed sclerosing lymphocytic lobulitis in the right breast during follow-up. We present the case of a 27-year-old woman who was referred to our hospital for further investigation, after worrying findings during a routine check-up performed in another hospital. Five years prior to this check-up, the patient was diagnosed with cancer of the left breast at the very young age of 22. The tumor was staged as pT2N0M0, with the histologic examination showing a poorly differentiated invasive ductal adenocarcinoma with strong estrogen and progesterone receptor expression and negative herceptin status. The treatment consisted of a wide excision and sentinel node procedure, followed by adjuvant chemotherapy, radiotherapy and hormonal therapy. Because of her young age, 3 cycles of cyclophosphamide-epirubicin-fluorouracil (FEC) and 3 cycles of docetaxel were given. Chemotherapy was followed by radiotherapy of the left breast up to a dose of 50 Gy, with a boost of 16 Gy on the tumor bed. Hormonal therapy consisted of a combination of tamoxifen and triptorelin. There was no relevant personal medical history, nor family history of breast cancer. Genetic analysis failed to show any BRCA1 or BRCA2 mutations. The pati Continue reading >>

An Uncommon Case Of Diabetic Mastopathy In Type Ii Non-insulin Dependent Diabetes Mellitus

An Uncommon Case Of Diabetic Mastopathy In Type Ii Non-insulin Dependent Diabetes Mellitus

, Volume 13, Issue2 , pp 205209 | Cite as An uncommon case of diabetic mastopathy in type II non-insulin dependent diabetes mellitus Diabetic mastopathy is an uncommon tumor-like proliferation of fibrous tissue of the breast that usually occurs in a patient who has suffered from type I diabetes mellitus of long duration. Here we report a rare case of diabetic mastopathy that occurred in type II non-insulin dependent diabetes mellitus. This patient was a 63-year-old postmenopausal woman. Mammography, ultrasonography and MR imaging could not distinguish it from breast cancer. Although the core needle biopsy specimen showed fibrosis without evidence of malignancy, excisional biopsy was performed. Histological findings demonstrated typical diabetic mastopathy with keloid-like fibrosis, perivascular lymphocytic infiltration, and lymphocytic lobulitis without evidence of malignancy. These lymphocytes were composed predominantly of B-cells. Five months after surgical biopsy, a nodular formation approximately 4 cm in diameter recurred adjacent to the resected end of the biopsy. Diabetic mastopathyLymphocytic lobulitisDiabetes mellitusType II non-insulin dependent This is a preview of subscription content, log in to check access. Unable to display preview. Download preview PDF. Tomaszewski JE, Brooks JSJ, Hicks D, Livolsi VA: Diabetic mastopathy. A distinctive clinicopathologic entity.Hum Pathol 23:780786, 1992. PubMed CrossRef Google Scholar Seidman JD, Schnaper LA, Phillips LE: Mastopathy in insulin-requiring diabetes mellitus.Hum Pathol 25:819824, 1994. PubMed CrossRef Google Scholar Ely KA, Tse G, Simpson JF, Clarfeld R, Page DL: Diabetic mastopathy. A clinicopathologic review.Am J Clin Pathol 113:541545, 2000. PubMed CrossRef Google Scholar Kudva YC, Reynolds C, OBrien T, Continue reading >>

A Review Of Inflammatory Processes Of The Breast With A Focus On Diagnosis In Core Biopsy Samples

A Review Of Inflammatory Processes Of The Breast With A Focus On Diagnosis In Core Biopsy Samples

A Review of Inflammatory Processes of the Breast with a Focus on Diagnosis in Core Biopsy Samples DAlfonso, Ginter, and Shin: A Review of Inflammatory Processes of the Breast with a Focus on Diagnosis in Core Biopsy Samples Journal of Pathology and Translational Medicine 2015; 49(4): 279-287. DOI: A Review of Inflammatory Processes of the Breast with a Focus on Diagnosis in Core Biopsy Samples Timothy M. DAlfonso , Paula S. Ginter , Sandra J. Shin Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA Corresponding Author Timothy M. DAlfonso, MD New York-Presbyterian Hospital/Weill Cornell Medical College, 525 East 68th Street, Starr 1031E, New York, NY 10065, USA Tel: +1-212-746-2700 Fax: +1-212-746-6484 E-mail: [email protected] Received June 2, 2015 Revised June 10, 2015 Accepted June 11, 2015 2015 The Korean Society of Pathologists/The Korean Society for Cytopathology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Inflammatory and reactive lesions of the breast are relatively uncommon among benign breast lesions and can be the source of an abnormality on imaging. Such lesions can simulate a malignant process, based on both clinical and radiographic findings, and core biopsy is often performed to rule out malignancy. Furthermore, some inflammatory processes can mimic carcinoma or other malignancy microscopically, and vice versa. Diagnostic difficulty may arise due to the small and fragmented sample of a core biopsy. This review will focus on the pertinent clinical, radiographic, and histopathologic features o Continue reading >>

Prime Pubmed | [diabetic Mastopathy

Prime Pubmed | [diabetic Mastopathy

Type your tag names separated by a space and hit enter Diabetic mastopathy is an uncommon disorder of the breast seen mostly in young women suffering from type 1 diabetes mellitus. The presenting symptom is a rapidly growing breast lump that may simulate breast cancer. Clinically and radiologically it can be indistinguishable from breast carcinoma. Recognizing this clinical entity, in addition to close collaboration between the clinician and the pathologist can facilitate its early diagnosis, avoiding unnecessary alarm for the patient. A 36 years old patient with a long-standing type 1 diabetes mellitus was admitted to surgery for a rapidly growing left breast lump. Excisional biopsy of the lump revealed diabetic mastopathy. Sharon E, Hochhauser E, Schindel A: "[Diabetic mastopathy]." Harefuah, vol. 146, no. 4, 2007, pp. 258-9, 320, Accessed September 22, 2018. Sharon E, Hochhauser E, Schindel A. [Diabetic mastopathy]. Harefuah 2007;146(4):258-9, 320 Accessed September 22, 2018. Sharon E & Hochhauser E & Schindel A. (2007). [Diabetic mastopathy]. Harefuah, 146, pp. 258-9, 320. Sharon E, Hochhauser E, Schindel A. [Diabetic mastopathy]. Harefuah. 2007;146:258-9, 320 TY - JOURT1 - [Diabetic mastopathy].AU - Sharon,Eran,AU - Hochhauser,Edith,AU - Schindel,Asher,PY - 2007/5/5/pubmedPY - 2007/7/20/medlinePY - 2007/5/5/entrezSP - 258-9, 320JF - HarefuahJO - HarefuahVL - 146IS - 4N2 - Diabetic mastopathy is an uncommon disorder of the breast seen mostly in young women suffering from type 1 diabetes mellitus. The presenting symptom is a rapidly growing breast lump that may simulate breast cancer. Clinically and radiologically it can be indistinguishable from breast carcinoma. Recognizing this clinical entity, in addition to close collaboration between the clinician and the path Continue reading >>

Regression Of The Fibrous Disease Of The Breast In A Non-diabetic Woman After Pregnancy And Breastfeeding.

Regression Of The Fibrous Disease Of The Breast In A Non-diabetic Woman After Pregnancy And Breastfeeding.

Regression of the fibrous disease of the breast in a non-diabetic woman after pregnancy and breastfeeding. Pereira MA, et al. Arq Bras Endocrinol Metabol. 2007. Service of Mastology, Hospital de Base do Distrito Federal, Braslia, DF, Brazil. [email protected] Arq Bras Endocrinol Metabol. 2007 Dec;51(9):1539-43. Fibrous mastopathy, also known as diabetic mastopathy and lymphocytic mastopathy, may mimic breast cancer at the physical examination, mammography, and ultrasound. We report a case of a woman who presented a non-tender mass clinically suggestive of breast carcinoma; however, the fine-needle aspiration cytology indicated atypia and the core needle biopsy revealed lymphocytic mastopathy. The magnetic resonance imaging of the breast showed a lesion with benign features. It was not demonstrated diabetics mellitus and autoimmune diseases. The patient got pregnant, breastfed, and it was observed the progressive regression of the lesion, with complete disappearance of the solid mass. Three years and three months later, there was no palpable mass at the clinical examination and ultrasound. In conclusion, fibrous mastopathy shall be considered for all breast lesions, regardless of the diagnosis of diabetes mellitus. Once a definitive diagnosis of this pathology is reached, it is recommended clinical, imaging studies and fine-needle aspiration biopsy follow-up of the patient, avoiding unnecessary surgical procedures. Continue reading >>

Diabetic Mastopathy | Radiology Reference Article | Radiopaedia.org

Diabetic Mastopathy | Radiology Reference Article | Radiopaedia.org

Diabetic mastopathy manifests clinically as a large, painless, hard breast mass that is usually clinically indistinguishable from breast cancer .Multicentric or bilateral involvement is a relatively frequent phenomenon, often occurring in late stages of the disease. Other systemic complications of long-standing diabetes mellitus are common. It is a form of lymphocytic mastitis and stromal fibrosis. There is dense fibrosis, and predominantly B-cell lymphocytic infiltrate surrounding the ducts, lobules and vessels. Its exact pathogenesis is poorly understood and likely multifactorial, possibly relating to an immunologic reaction. It is considered a form of lymphocytic mastitis and is grouped with others immunologic breast diseases such as Hashimoto thyroiditis , Sjogren syndrome , and systemic lupus erythematosus . The most common mammographic findings are ill-defined masses or asymmetric densities . Such lesions are often masked by dense glandular tissue, making mammographic evaluation difficult. Ultrasound often reveals the most characteristic imaging findings of the disease: irregular hypoechoic masses with marked posterior acoustic shadowing. Sometimes sonographic features can mimic more sinister pathology such as breast malignancy 4. Reported MR imaging findings are variable, ranging from decreased diffuse contrast material enhancement to rapid, intense enhancement that is indistinguishable from breast carcinoma. Although surgical excision was usually performed in the past to exclude malignancy, core biopsy is currently accepted as adequate for the diagnosis of this disease.A fine needle aspiration (FNA) is not usually used as it does not provide enough cellular material for sufficient evaluation as well as being technically-difficult to perform due to lesions being Continue reading >>

Treatment And Prognosis For Diabetic Mastopathy

Treatment And Prognosis For Diabetic Mastopathy

Treatment and Prognosis for Diabetic Mastopathy Diabetic mastopathy (DMP) is a breast-related complication seen in type 1 or 2 insulin-dependent diabetes mellitus. This condition manifests as hard, fibrous masses in one breast or both breasts. These masses are non-cancerous and irregular in shape. Interestingly, DMP has also been reported in men. Clinical findings are mostly inconclusive in the case of DMP. The masses seen in this condition are large and painless and not easily differentiated from the ones seen in breast cancer. DMP masses are commonly present in both breasts, especially during the end stage of the disease. It is also usually accompanied by other complications of diabetes mellitus. A high blood glucose level that remains high has been suggested as a possible cause of the condition. However, the research to back this claim is not currently sufficient to support the suggestion. DMP is not a malignant or pre-malignant condition that leads to a terminal illness. It is considered as a self-limited condition which does not necessitate treatment, though the disease can recur. To date, no malignant transformation of DMP lumps have been reported. DMP is usually discovered by the patients themselves. They may describe it as an irregular and painless lump and inform their family physician, who will initiate the screening procedures for breast cancer. This includes mammograms and breast ultrasound studies, although the findings are usually inconclusive, and a biopsy needs to be performed to confirm the findings and rule out breast cancer. Core biopsy is highly recommended by doctors because the lesions and lumps can increase in size and number over time and this kind of biopsy is guided by ultrasound and removes tissue from the core part of the masses. Histologica Continue reading >>

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