Hyperglycaemia Enhances Nitric Oxide Production In Diabetes: A Study From South Indian Patients
Hyperglycaemia Enhances Nitric Oxide Production in Diabetes: A Study from South Indian Patients Affiliation Division of Medicinal Chemistry and Pharmacology, Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, 500007, India Affiliation Biomaterials Group, Lipid Science and Technology Division, Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, 500007, India Affiliation Division of Medicinal Chemistry and Pharmacology, Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, 500007, India Affiliation Biomaterials Group, Lipid Science and Technology Division, Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, 500007, India Affiliation Division of Medicinal Chemistry and Pharmacology, Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, 500007, India Affiliation Division of Medicinal Chemistry and Pharmacology, Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, 500007, India Affiliation Biomaterials Group, Lipid Science and Technology Division, Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, 500007, India Affiliation Cardiology Division, Mediciti Hospital, Hyderabad, 500063, India Current Address: Drug Discovery Research Center, Translational Health Science and Technology Institute (THSTI), Faridabad, 121001, India Affiliation Division of Medicinal Chemistry and Pharmacology, Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, 500007, India Continue reading >>
Nitrous Oxide Monitoring Certificate For Dental Hygienists And Dental Assistants
XV. Nitrous Oxide and the Medically Compromised Patient Nitrous Oxide and the Medically Compromised Patient An adequate medical history including all medications (even over-the-counterdrugs) that the patient may be taking is essential for the safe use of N2O-O2conscious sedation. For example, antihistamines takenfor an allergy may have a marked additive sedation effect when N2Ois administered. There are very few absolute contraindications regardingdrugs, but it should be remembered that N2O depresses the cerebral cortex, and any other drug that also depresses thecortex will probably have an additive effect. Conversely, any drug thatstimulates the cortex will probably have an antagonistic effect. This vital and rather complex system is subject to a large number ofdisorders, which may affect all of the other systems of the body, and inturn may be effected by them. The uncontrolled hypertensive patient is not a suitable candidate forany dental procedure except for emergency relief of pain. Elective workshould always be postponed until the blood pressure is controlled. On theother hand, pain may serve to increase the patient's blood pressure. Whenit necessary to treat these patients, sedation is desirable, and N2Omay be considered if the patient's fear is not extreme. A rather long list of drugs may be used in the treatment of hypertension.These are sympathetic depressant drugs, and include centrally acting agents,central and peripheral agents, ganglionic blocking agents, agents that blockneuroeffector transmission, Beta-adrenergic and alpha-adrenergic blockingdrugs. If N2O is used with these drugs that block the sympatheticoutflow from the central nervous system, then the myocardial depressioneffect of N2O will be the predominant effect. When combined withantihypertensive Continue reading >>
"no" News Is Good News: Nitric Oxide For Cvd & Diabetes
"NO" News is Good News: Nitric Oxide for CVD & Diabetes "From diabetes to hypertension, cancer to drug addiction, stroke to intestinal motility, memory and learning disorders to septic shock, sunburn to anorexia, male impotence to tuberculosis, there is probably no pathological condition where nitric oxide does not play an important role."homepage of the Nitric Oxide Society, www.nitricoxide.ws With over 82,000 recent studies to its credit, Nitric Oxide (NO), has become something of a biochemical superstar since the discovery of its vascular effects in the 1990s. The more researchers study it, the more clinical implications they find. We now recognize that many widespread diseases like cardiovascular disease, hypertension, dyslipidemia, diabetes, erectile dysfunction and sickle cell anemia involve, to varying degrees, abnormalities of NO production. Is there a common connectionand perhaps a common correctionfor these various conditions? Ever heard of Viagra? Nitroglycerine? Few people haven't. But most people, even many physicians, don't realize these are nitric oxide therapies. They increase NO production and release in the vasculature of specific tissues and blood vessels. In humans and other animals NO is internally produced from precursors like arginine, which are converted by enzymes called NO synthases into NO. The three synthases known at this time are Endothelial (think cardiovascular), Neuronal (think brainnervous system), and Inducible (think immune system). At this point, there are two basic therapeutic approaches to increasing NO: arginine-derived nitric oxide therapies (ADNO) in which arginine is delivered orally or intravenously and then converted internally into NO; and administration of NO gas via mask inhalation. The latter is standard for premature in Continue reading >>
Laughing Gas Nitrous Oxide A Never Again Experience | Diabetic Connect
Please find another dentist. There r to many out there today who focus on making sure your visit is painless and relaxing. Mine uses N. O. for relaxing patients for the novicane injections, not for pain as you found out does little to mask pain. Doesnt seem right peps going through that with todays advancement in denistry. My childhood dentist didnt give novicane before drilling out my cavities and would shove toliet paper down my throat if i cried. When he did give me needle for tooth extraction the needle went all the way through into my nose. When i became an adult i refused to go to any dentist i was so tramatized and scared. That is till i was forced. The place i choose babied me& gauranteed me other then the mild pinch feeling of injections i would feel nothing. They have a lady who does nothing but injections and she explained to me if ever more then a pinching feeling means the injector not doing it correctly and i should stop them and ask for someone else. I was amazed how painless the injections she did were, even in the top front where my childhood dentist went into my nose. my dentist says if i ever feel any pain even mild all i have to do is raise my hand and she'll stop. Feeling any pain means your not fully numb yet and gives alittle more novicane and waits at least another 15-20 minutes before beginning again. Were all different and some people like myself need more time for the novicane to fully take affect. If your dentist doesnt carter to your needs for a relaxing painless experience there r plenty out there who well. Its extremely important to my dentist that none of her patients r scared to come in for their visits. Look in the phone book and you should see ads advertising pain free dentistry.Sry so long but it bothers me so much dentists r still p Continue reading >>
Nitric Oxide - Diabetes Self-management
A clear, colorless gas that performs a number of important functions in the body. It seems to play a role in several medical conditions, including septic shock, dementia, and impotence, and it may partially account for the high rate of heart disease seen in people with diabetes. Nitric oxide is considered such an important chemical in the body that the journal Science named it the Molecule of the Year in 1992, and in 1998 three scientists won the Nobel Prize in Medicine for researching its role in the body. Scientists have long been familiar with nitric oxide as a component of car exhaust, cigarette smoke, and air pollution, but it wasnt until the late 1980s that researchers discovered that mammal cells also produce the gas and use it to communicate with other cells. Abnormalities in the bodys production of nitric oxide have been implicated in high blood pressure, atherosclerosis (narrowing of the arteries), diabetes, erectile dysfunction, and stroke. Scientists are furthest along in their understanding of nitric oxide in the area of heart disease. Normally, cells lining the inner wall of blood vessels secrete nitric oxide, which travels to the muscle cells around the blood vessels and causes them to widen, allowing easier blood flow. Impaired nitric oxide production may contribute to constricted blood vessels, high blood pressure (especially in the 90% of cases with no identifiable cause), and atherosclerosis. Scientists now know that nitroglycerin and similar drugs dilate blood vessels and help alleviate angina temporary chest pain resulting from insufficient oxygen to the heart because the drugs release nitric oxide. Nitric oxide also keeps blood platelets from clumping together and sticking to the inner walls of arteries, protecting the body from blood clots and at Continue reading >>
- American Diabetes Association® Releases 2018 Standards of Medical Care in Diabetes, with Notable New Recommendations for People with Cardiovascular Disease and Diabetes
- Leeds diabetes clinical champion raises awareness of gestational diabetes for World Diabetes Day
- Diabetes doctors: Which specialists treat diabetes?
Nitric Oxide, Oxidative Stress, And Interplay In Diabetic Endothelial Dysfunction
acts in the mitochondrial intermembrane space. In response to oxidative stress, is serine phosphorylated by protein kinase CII (PKCII) and isomerized by the peptidylprolyl cis/trans isomerase PIN-1 [ 70 , 71 ]; this isomerization allows the dephosphorylation of Ser-36 residue by the serine threonine phosphatase PP2A, inducing the translocation from the cytosol to the mitochondrial intermembrane space, through the TIM/TOM mitochondrial import machinery. In the mitochondrial intermembrane space, binds to cytochrome c, acting as an oxidoreductase and generating ROS. These ROS, in turn, activate the permeability transition pore, triggering organelle dysfunction, massive release of mitochondrial apoptotic factors, and ROS and eventually inducing cell apoptosis [ 71 ] (Figure 3 ). promotes RAC1 activation and triggers NADPH membrane oxidase-ROS production. acts in the mitochondrial intermembrane space (IMS). In response to oxidative stress, is serine phosphorylated by PKCII and isomerized by the peptidylprolyl cis/trans isomerase PIN1. This isomerization allows the dephosphorylation of Ser-36 residue by the serine threonine phosphatase PP2A, inducing the translocation from the cytosol to the IMS. In the IMS, binds to cytochrome c (Cyt c), generating ROS. These ROS activate the release of mitochondrial apoptotic factors, eventually inducing apoptosis. content in the mitochondria correlates with alteration of mitochondrial structure, decrease of mitochondrial calcium uptake, and enhanced mitochondrial ROS production, triggering the mitochondrial route of apoptosis [ 70 ]. It is worth noting that the mitochondrial H2O2 production induced by further increases intracellular H2O2 levels, maintaining or increasing PKCII activation in a positive control loop [ 72 , 73 ]. In keeping Continue reading >>
Nitric Oxide Levels In Patients With Diabetes Mellitus: A Systematic Review And Meta-analysis
Nitric oxide levels in patients with diabetes mellitus: A systematic review and meta-analysis Open Access funded by Brazilian Government This meta-analysis evaluated NO levels in diabetes patients. Thirty studies were eligible for inclusion in the meta-analysis. There is an increase in NOx levels in European T1DM and T2DM patients, and Asian T2DM patients. Meta-analysis is considered a powerful tool for pooling data from different studies. Altered serum nitric oxide (NO) levels in patients with diabetes mellitus (DM) have been reported by different studies; however, results are still controversial. Until this date, no meta-analysis evaluated the association of NO levels with DM. Thus, this paper describes a meta-analysis conducted to evaluate if there is a relationship between NO levels and type 1 DM (T1DM) or type 2 DM (T2DM). A literature search was done to identify all studies that investigated NO levels between T1DM or T2DM patients (cases) and non-diabetic subjects (controls). Measurement of nitrate and nitrite (NOx the stable NO products) were used to estimate NO concentrations because they closely reflect NO bioavailability. Weighted mean differences (WMD) of NOx levels between case and control samples were calculated for T1DM and T2DM groups. Thirty studies were eligible for inclusion in the meta-analysis (8 in T1DM samples and 22 in T2DM samples). NOx levels were increased in European T1DM patients compared with controls [random effect model (REM) WMD=8.55, 95% CI 2.88 14.21]. No other ethnicity was evaluated in T1DM studies. NOx levels were also increased in both European (REM WMD=18.76, 95% CI 1.67 35.85) and Asian (REM WMD=18.41, 95% CI 8.01 28.81) T2DM patients, but not in Latin American patients compared with controls. This meta-analysis detected a signif Continue reading >>
- Olive oil in the prevention and management of type 2 diabetes mellitus: a systematic review and meta-analysis of cohort studies and intervention trials
- Glycaemic control in people with type 2 diabetes mellitus during and after cancer treatment: A systematic review and meta-analysis
- Effects of Insulin Plus Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) in Treating Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Nitric Oxide And Diabetes
Scientists around the world are working feverishly to increase our understanding of the nitric oxide in the human body. The results so far have been nothing short of astounding. Having already identified numerous incredible benefits related to increased blood, oxygen and nutrient flow, scientists are now doing research into the effect of nitric oxide on some of society’s most vexing health issues like diabetes. Diabetics have a lower level of nitric oxide than normal and that low NO may contribute to the complications that plague diabetics. Nitric oxide may ameliorate the symptoms of of the associated conditions inherent to diabetes like reduced blood flow, kidney disease, retinopathy and ulcers. The effect of nitric oxide on diabetes is a very important topic for personal reasons. My oldest son was diagnosed with Type 1 diabetes at age 7. As opposed to Type 2 diabetes which is characterized by insulin resistance, in Type 1 Diabetes, the body produces too little or no insulin at all. Insulin is a critical hormone for causing the cells to take up glucose, their primary fuel. Without insulin, there is no way for the glucose to get into the cells. Without glucose, the cells die. Perhaps out of desperation, when the body notices a lack of insulin, it starts to burn fats. That may sound great to some people, but it can be devastating. Your internal organs and brain are mostly made of fats and become a food source in this desperate situation. Without insulin, no matter what the body breaks apart to use for fuel, it cannot get glucose into the cells. However, the glucose, or sugar doesn’t just go away, it stays in the blood. The body does try to excrete the excess glucose through the urine, however, it ends up becoming dehydrated because of the reverse osmosis that pulls w Continue reading >>
- American Diabetes Association® Releases 2018 Standards of Medical Care in Diabetes, with Notable New Recommendations for People with Cardiovascular Disease and Diabetes
- Diabetes and Sleep Apnea: How Sleep Affects Blood Glucose and Diabetes
- Diabetes and eye disease: How diabetes affects vision and eye health
Nitric Oxide And Diabetes!
Diabetes has become a national health problem. Fortunately, there are clinical studies to show that nitric oxide can positively affect the complications of diabetes. This blog will help you understand the hard facts, complications, and the potential of a proper nitric oxide / l-arginine protocol to help with this devastating disease. Now before we start you might be wondering why an endocrine disease is showing up on a web site focused on cardiovascular health. The answer is that diabetes directly affects the vascular system giving rise to most of the complications. One noted clinical expert in this area, Dr. J. Joseph Prendergast says, “Many people still think diabetes is a disease about sugar. It’s not the sugar! It’s the complications!” Dr. Prendergast is not discounting the need to control your blood sugar. That’s extremely important. What he’s trying to get people to understand is that unregulated glucose (blood sugar) causes high levels of oxidative stress which damages the endothelial cells and their ability to properly produce nitric oxide – the master signaling molecule for your cardiovascular system. To prevent the complications you also need to repair the damage to the endothelium. The Hard Facts! Diabetes is a disease in which the body does not produce insulin (Type 1) or does not properly respond to insulin (Type 2). According to the most recent statistics from the Diabetes Association of Greater Cleveland (updated in February of 2009)17.9 million American have been diagnosed with diabetes. What makes this “America’s largest healthcare epidemic” is that 57 million Americans are in a pre-diabetic condition where their blood glucose levels are higher than normal but not high enough to be diagnosed with type 2 diabetes. Almost 25% of the Am Continue reading >>
- American Diabetes Association® Releases 2018 Standards of Medical Care in Diabetes, with Notable New Recommendations for People with Cardiovascular Disease and Diabetes
- Diabetes and Sleep Apnea: How Sleep Affects Blood Glucose and Diabetes
- Diabetes and eye disease: How diabetes affects vision and eye health
Nitric Oxide Supplements
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community I'd like some advice on Nitric Oxide Suppliments. I'm looking for one that focuses just on Nitric Oxide and doesnt contain any thing else eg cafine, creatine, no sugar and preferebly no carbs either! Can anyone recomend a good brand? I've searched google but it's hard to tell the quality of some suppliments shown... Nitric oxide is an air pollutant produced by combustion of substances in air, like in automobile engines Just walk next to a main road for half an hour a day, you should be fine :wink: Just walk next to a main road for half an hour a day, you should be fine :wink: Ahh thats great, just let me know once you've extracted all the other harmful pollutents from the air and I'll come collect it from you?..... Just as a matter of interest.....what is this stuff for ? Nitric Oxide, a key molecule manufacturered by the body, causes vasodilation (an expansion of the internal diameter of blood vessels), which in turn leads to increased blood flow, oxygen transport, delivery of nutrients to skeletal muscle and a reduction in blood pressure. It's therfore marketed mainly as a body building suppliment (whixh is what I intend to use it for) but it is also thought to help with the damage that highblood sugars can cause to the cardiovascular and nervous system, studies have shown.. So it'd be great if anyone that has had experience with NO suppliments, or body building could recomend any. It is one of the effects of viagra, nitric oxide enters the blood stream when you take one, increasing blood flow to the pelvic area. We thought it might be for Body building, hopefully if the few Members we have that do that are around they will answer you in due course. Continue reading >>
Blood Sugar And Nitric Oxide
That may seem great to some people, but it can be devastating. The internal organs and brain are largely made of fats as well as become a food source in this desperate situation. Without having insulin, regardless of what the body breaks apart to use for fuel, it cannot get glucose into the cells. Nonetheless, the glucose, or sugar doesnt only disappear, it remains inside the blood. The body does attempt to excrete the excess sugar through the urine, nonetheless, it ends up becoming dehydrated as a result of reverse osmosis which draws water out of the cells to cope with all the surplus sugar. This state of Diabetic Keto-Acidosis or DKA can be very hazardous. Apart from vomiting, dehydration, blurred eyesight, elevated blood pressure, and headaches, a person battling DKA can experience precipitous declines in potassium levels ultimately causing all kinds of difficulties, as well as cerebral edema, coma and death. Even when effectively maintained, both type 1 and type 2 diabetes possess important long-term complications, most of which are linked to the cardiovascular system. Diabetics have a higher prevalence of high blood pressure levels and atherosclerosis (cardiovascular disease) than the normal populace as well as additional blood circulation problems. Besides these problems, diabetics also have increased incidences of circulatory associated disorders like retinopathy and reduced renal function. The Unfortunate Specifics Regarding Diabetes Besides the approximately 18 million Americans having either type 1 or type 2 diabetes, Fifty seven million Americans are in a pre-diabetic situation where their blood sugar levels tend to be strangely elevated however, not quite high enough to be diagnosed with type 2 diabetes. According to the Diabetes Association of Greater Cle Continue reading >>
Nitrous Oxide N2o Whipped Cream Chargers
You are here: Home / dmska diabetes treatment / Nitrous Oxide N2o Whipped Cream Chargers A glass of red wine each evening with can people with type 2 diabetes sip at Type 1 Diabetes and Insulin the body releases insulin when they eat; its the insulin that should help so people with type 1 diabetes must take an insulin The diabetes risk appears to be very consistent Mohan V (1995) Advances in the molecular basis of non-insulin dependent diabetes mellitus:indian perspective. Diabetic Gastroparesis Symptoms Diabetic Neuropathy Icd9 ::The 3 Step Trick that Reverses Diabetes Permanently in As Little as 11 Days.[ Aug 26 2014 When the hedgehog gets firm and sets nicely cut it into slices using hot knife and serve with topping of coconut flakes. Nitrous Oxide N2o Whipped Cream Chargers the Metformin in Gestational Diabetes (MiG) Trial randomly assigned 751 women with gestational diabetes at 20 to 33 weeks gestation to open treatment with metformin (with supplemental insulin if required) or to insulin. My husband was on 8 different meds for Type II diabetes. Find and save ideas about Healthy Bedtime Snacks on Pinterest the worlds catalog of ideas. Diabetes and Hyperglycemia Treatment. If the fasting blood sugar is up then some treatment if often needed as it is the least Most times in gestational diabetes the sugar goes too high after a meal Diabetic Recipes for Desserts Recipe: Leg ulcers are unhealed sores or open Diabetes is a group of chronic metabolic diseases caused by Venous insufficiency is a condition where the flow of The coke zero ingredients usa associations between serum adiponectin leptin C-reactive protein insulin and serum long-chain omega-3 fatty acids in Laador Retrievers. Find out about the different types of insulin you can use to treat type 1 diabetes Denta Continue reading >>
Nitric Oxide System And Diabetic Nephropathy
Abstract About 30% of patients with type 2 diabetes mellitus develop clinically overt nephropathy. Hyperglycemia is necessary, but not sufficient, to cause the renal damage that leads to kidney failure. Diabetic nephropathy (DN) is a multifactorial disorder that results from interaction between environmental and genetic factors. In the present article we will review the role of the nitric oxide synthase (NOS) in the pathogenesis of DN. Nitric oxide (NO) is a short-lived gaseous lipophilic molecule produced in almost all tissues, and it has three distinct genes that encode three NOS isoforms: neuronal (nNOS), inducible (iNOS) and endothelial (eNOS). The correct function of the endothelium depends on NO, participating in hemostasis control, vascular tone regulation, proliferation of vascular smooth muscle cells and blood pressure homeostasis, among other features. In the kidney, NO plays many different roles, including control of renal and glomerular hemodynamics. The net effect of NO in the kidney is to promote natriuresis and diuresis, along with renal adaptation to dietary salt intake. The eNOS gene has been considered a potential candidate gene for DN susceptibility. Three polymorphisms have been extensively researched: G894T missense mutation (rs1799983), a 27-bp repeat in intron 4, and the T786C single nucleotide polymorphism (SNP) in the promoter (rs2070744). However, the potential link between eNOS gene variants and the induction and progression of DN yielded contradictory results in the literature. In conclusion, NOS seems to be involve in the development and progression of DN. Despite the discrepant results of many studies, the eNOS gene is also a good candidate gene for DN. Introduction About 30% of patients with type 2 diabetes mellitus develop clinically over Continue reading >>
Nitric Oxide Synthesis Is Reduced In Subjects With Type 2 Diabetes And Nephropathy
Nitric Oxide Synthesis Is Reduced in Subjects With Type 2 Diabetes and Nephropathy From the Department of Clinical and Experimental Medicine, Metabolism Division, University of Padova, Italy. Corresponding author: Paolo Tessari, [email protected] . Received 2009 Dec 3; Accepted 2010 May 11. Copyright 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See for details. This article has been cited by other articles in PMC. Nitric oxide (NO) is a key metabolic and vascular regulator. Its production is stimulated by insulin. A reduced urinary excretion of NO products (NOx) is frequently found in type 2 diabetes, particularly in association with nephropathy. However, whether the decreased NOx excretion in type 2 diabetes is caused by a defective NOx production from arginine in response to hyperinsulinemia has never been studied. We measured NOx fractional (FSR) and absolute (ASR) synthesis rates in type 2 diabetic patients with diabetic nephropathy and in control subjects, after l-[15N2-guanidino]-arginine infusion, and use of precursorproduct relationships. The study was conducted both before and after an euglycemic hyperinsulinemic (1,0001,200 pmol/l) clamp. In type 2 diabetes, NOx FSR was reduced both under basal (19.3 3.9% per day, vs. 22.9 4.5% per day in control subjects) and hyperinsulinemic states (24.0 5.6% per day, vs. 37.9 6.4% per day in control subjects; P < 0.03 by ANOVA). Similarly, in type 2 diabetes, NOx ASR was lower than in control subjects under both conditions (basal, 0.32 0.06 vs. 0.89 0.34 mol per day; hyperinsulinemia, 0.35 0.07 vs. 1.15 0.38 mol per day; P = 0.01 by ANOVA). In type 2 diabetes, the ability of insulin Continue reading >>
- Insulin, glucagon and somatostatin stores in the pancreas of subjects with type-2 diabetes and their lean and obese non-diabetic controls
- Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis
- Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis
Nitric Oxide Holds Promise For Diabetes Cell Repair
University of Florida researchers say primitive cells that act like molecular maintenance men—traveling throughout the body to repair damaged blood vessels—become too rigid in patients with diabetes, fueling the disease’s vascular complications. But they have found a way to restore the cells’ flexibility, at least in the laboratory, according to findings published in the January 2006 issue of the journal Diabetes. Many complications of diabetes, such as heart disease, stroke, blindness, and kidney failure, arise after blood vessels suffer damage, spurring the accumulation of fatty deposits in the arteries, or an overgrowth of new capillaries in the eye. “We’re interested in what happens in the body at the molecular level to cause these life-threatening problems,” says Mark S. Segal, PhD, an assistant professor of nephrology, hypertension, and transplantation at UF’s College of Medicine. “Our work is focused on understanding why diabetic patients are at increased risk for these other diseases.” CELLS FAIL TO REPAIR The problem is rooted in the body’s response to vascular injury. The bone marrow churns out cells crucial to repairing the damaged lining of blood vessels. But sometimes these cells fail to report for duty. “Part of the defect we think is occurring in diabetic patients is that these cells do not carry out appropriate repair,” Segal said. The inability of these cells to repair the large blood vessels of the body is similar to their inability to repair the small vessels within the eye, he added. “In the vasculature, it leads to atherosclerosis, and within the eye, the same process leads to diabetic retinopathy,” he said. “So the link is we have one defect in these cells that can lead to both of these problems.” NITRIC OXIDE IS K Continue reading >>
