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Natural Source Of Metformin

The Origins Of Metformin

The Origins Of Metformin

Goat's rue, French lilac, Italian fitch, and professor weed are all names for the same plant: Galega officinalis. This perennial herb, 3 feet tall and with purple, blue, or white flowers, was used in folk medicine to treat diabetes starting in the Middle Ages, maybe earlier. Though it gave rise to metformin, one of the most popular diabetes medications in the world, G. officinalis is now widely considered poisonous. In the early 20th century, researchers isolated a compound from G. officinalis called guanidine, which could lower blood glucose levels in animals but was also toxic. Chemists found that they could make the compound more tolerable by bonding two guanidines together, forming a biguanide. Metformin is one such biguanide, first synthesized in 1929 and then clinically developed in the late 1950s by the French physician Jean Sterne, who gave it its first trade name, Glucophage ("glucose eater"). Two other biguanides—phenformin and buformin—were also produced around this time but later withdrawn because they became associated with lactic acidosis. This condition results from a buildup of lactic acid in the blood, lowering its pH to unhealthy levels. It can be particularly dangerous for people with diabetes. Metformin seemed guilty by association, and the damage done to its reputation meant that metformin took time to catch on, even though it was later shown to trigger lactic acidosis only in rare cases. Over the next few decades, studies about metformin's safety and efficacy trickled in, but it wasn't until the landmark United Kingdom Prospective Diabetes Study (1977 to 1997) that metformin gained the renown that it enjoys today. In the study, overweight and obese people with type 2 diabetes on metformin lived longer and had fewer heart attacks than those wit Continue reading >>

Metformin For Pcos? At Least Four Natural Methods Are Equally Effective.

Metformin For Pcos? At Least Four Natural Methods Are Equally Effective.

Several medical research studies have shown that just changing your diet and lifestyle can be just as effective as taking metformin. For example, the Universidade de So Paulo in Brazil studied 40 women who had PCOS (polycystic ovary syndrome). Fifteen women took metformin for six months and 12 just improved their lifestyle. At the end of six months, the results were virtually the same for both groups. About 67% in each group had improvements in their menstrual cycle. Both groups had smaller waists and lost weight. Of course, taking drugs to manage your PCOS symptoms and improving yourlifestyle are not mutually exclusive! So you're into taking drugs, youcan do both! OK, so maybe you're wondering what a "lifestyle" consists of. For starters, it consists of a diet especially designed to rebalance your hormones , increased exercise, better management of chronic stress, and getting enough sleep. There are several compelling reasons why you should consider a more "holistic" approach using physical activity, healthy diet, stress management, and special nutrients. A healthy diet and lifestyle is just as effective as metformin (Glucophage). You may be able to reduce your dosage or eliminate it altogether. A healthy diet and lifestyle is ultimately less expensive. A holistic approach builds your health whereas drugs does not. A holistic approach does not have drug side effects and is safer than taking drugs. The role of healthy diet, exercise and stress management is extensively described in The Natural Diet Solution to PCOS and Infertility e-book. Studies have shown that these inexpensive measures are as effective as metformin -- and, they obviously have no side effects. If you improve your diet and increase your level of exercise, you may be able to reduce or even eliminate yo Continue reading >>

Metformin

Metformin

Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes,[4][5] particularly in people who are overweight.[6] It is also used in the treatment of polycystic ovary syndrome.[4] Limited evidence suggests metformin may prevent the cardiovascular disease and cancer complications of diabetes.[7][8] It is not associated with weight gain.[8] It is taken by mouth.[4] Metformin is generally well tolerated.[9] Common side effects include diarrhea, nausea and abdominal pain.[4] It has a low risk of causing low blood sugar.[4] High blood lactic acid level is a concern if the medication is prescribed inappropriately and in overly large doses.[10] It should not be used in those with significant liver disease or kidney problems.[4] While no clear harm comes from use during pregnancy, insulin is generally preferred for gestational diabetes.[4][11] Metformin is in the biguanide class.[4] It works by decreasing glucose production by the liver and increasing the insulin sensitivity of body tissues.[4] Metformin was discovered in 1922.[12] French physician Jean Sterne began study in humans in the 1950s.[12] It was introduced as a medication in France in 1957 and the United States in 1995.[4][13] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[14] Metformin is believed to be the most widely used medication for diabetes which is taken by mouth.[12] It is available as a generic medication.[4] The wholesale price in the developed world is between 0.21 and 5.55 USD per month as of 2014.[15] In the United States, it costs 5 to 25 USD per month.[4] Medical uses[edit] Metformin is primarily used for type 2 diabetes, but is increasingly be Continue reading >>

Natural Alternatives To 10 Of The Most Common Drugs

Natural Alternatives To 10 Of The Most Common Drugs

Do you ever feel like you’re being held hostage by drug companies? All too often, people are made to believe that they have no options when it comes to taking a drug. If your doctor says you need a drug for a serious health problem, you might think it is the only thing you can do. You may feel frightened at the prospect of going against your doctor’s recommendations. You may be wary of seeking out natural alternatives. Drug safety is becoming a major concern among many health professionals. Reports to the FDA of serious adverse drug events, including deaths, have more than doubled in recent years. This is more than enough reason to do a little of your own research and explore natural alternatives before you get that prescription filled. Learn about the harmful side effects associated with the drug. Also, seek out some secondary advice. Research whether the risks outweigh the benefits. Consider what lifestyle changes you could make to improve your health. And investigate some natural alternatives, which may help you avoid taking prescription drugs. Here are some drugs with clinically proven natural alternatives worth trying: 1. Ibuprofen vs. Curcumin NSAIDs like Celebrex, aspirin and ibuprofen do reduce the pain and inflammation of osteoarthritis. However, they can irritate your stomach. There is concern that over time, they can make osteoarthritis worse. They can block the repair process. These drugs have been found to actually retard the growth of cartilage. On the other hand, curcumin is an all natural spice that has been found to curb inflammation. In one recent study, which explored natural alternatives, curcumin outperformed ibuprofen for knee pain after just six weeks. What to Take: 1,000-1,500 mg a day. 2. Ambien vs. Melatonin Ambien can be a great help for p Continue reading >>

Berberine For Diabetes – Is It A Natural Alternative To Metformin?

Berberine For Diabetes – Is It A Natural Alternative To Metformin?

Incidence of insulin resistance, obesity, and other metabolic diseases have reached massive proportions in our culture. The current popular glucose-lowering drug treatment, Metformin comes with some potential serious side effects. However, there is a natural Metformin alternative that can help the body efficiently process sugar, thereby being safer than pharmaceutical interventions. It’s known as Berberine. What is Berberine and Where Does it Come From? Berberine is a plant photochemical that’s found in several different plants, including goldenseal, European barberry, phellodendron, goldthread, Oregon grape, and tree turmeric. It possesses powerful anti-diabetic properties, as well as being anti-bacterial and immune system enhancing. As well as diabetes it can be used as a treatment for a number of other health problems including hyperlipidemia, heart disease, and cancer. It can regulate blood glucose, increase insulin sensitivity as well as metabolizing fats (burning fat). Berberine has been widely studied, with nearly 1000 studies published on it in the last 5 years alone. There is a body of evidence supporting it’s efficacy in lowering blood-glucose and increasing insulin sensitivity for both humans and animals. However, Berberine is not a new discovery. For thousands of years the Chinese and Ayurvedic communities has been aware of the amazing benefits of Berberine. The blood-sugar lowering effects have been documented in China and India for hundreds of years. Although it was primarily used for treating inflammation, infections, and diarrhea, as diabetes was not as common then as it is now (1). A Natural Substitute For Metformin? However, as the incidence of diabetes has grown, the recent studies have focused on it’s ability to treat the condition. The studi Continue reading >>

Cinnamon And Other Herbal Remedies

Cinnamon And Other Herbal Remedies

Can herbs and spices replace some or all diabetes medicines? For some people they can, but you have to be really careful with these and any other alternative treatments. Here are some herbal approaches to managing diabetes and some things to consider if you want to try them. Last fall, Amy Campbell wrote eight blog entries about different herbs and spices and their health benefits. Definitely check these pieces out. But there are many other herbs used around the world to treat and prevent diabetes. Almost all categories of diabetes drug have herbal analogs. Any discussion of herbs for diabetes has to start with cinnamon. Cinnamon is thought to possibly act as an insulin sensitizer, like metformin (brand name Glucophage and others) and the thiazolidinedione drugs (such as Actos). A Pakistani study of 60 adults with Type 2 in Diabetes Care showed an average glucose level drop of 18% to 29% in those who took cinnamon, and better cholesterol levels compared to placebo (inactive treatment). Even though there is generally no money to study herbs, people started to get excited and some small follow-up studies were done. One, also published in Diabetes Care, was done in Oklahoma City. Forty-three adults with Type 2 were split into two groups, and no significant differences were found between cinnamon and placebo groups. That’s why studies can be so confusing. A lot depends on who is being studied. Quite probably, the Pakistani subjects may have been more sensitive to cinnamon, or had different diets, or some other difference from the Americans. Over the next few years, other cinnamon studies were reported; some indicating significant benefits, some not. But if you look at the comments section of this Diabetes Self-Management blog entry, you can see that many readers have foun Continue reading >>

Natural Alternatives To Metformin

Natural Alternatives To Metformin

Around the globe there are thousands who are diagnosed with type 2 diabetes, and the number keeps growing with each passing day. The disease limits a persons food choices and has to take medicines to keep blood sugar levels from spiking, as diabetes will lead to fatal conditions when left untreated. Metformin is an antidiabetic medication for type 2 diabetes with an efficacy thats recorded since the 50s and now is among the most prescribed drug in the entire world. The side effects associated with its use are commonly gastrointestinal (diarrhea, nausea, vomiting), headaches, and rarely sleeplessness and lethargy. Unfortunately not all patients can take metformin because of other side effects that may exacerbate their existing medical conditions. The list below enumerates some natural alternatives to metformin for those, with prior consultation from experts, who need other ways of treating their type 2 diabetes: Do not substitute this for actual advice from an expert as many cases require treatment that CAN NOT be remediedwith natural options. These natural optionsmay only be helpful in addition to treatments, again consult with a medical professional before self treating or self diagnosing. The gel found in the inner part of the plants leaf has been discovered to possess anti-diabetic properties. Its fiber, glycoprotein, and polysaccharide contents help the body in efficiently using glucose and in removing excess ones. It also decreases blood lipids and swelling, improves wound healing, and bolsters the bodys defenses and vascular health, both known for being compromised by diabetes. Fresh aloe vera can be added into salad dishes or turned into juices and smoothies but its potency may be reduced if mixed with other fruits. Antioxidants are the bodys defenses against th Continue reading >>

Berberine Is Superior To Metformin

Berberine Is Superior To Metformin

New findings show that berberine has antiobesity effects and that … Metformin is a widely used first-line antidiabetic drug prescribed by doctors for the treatment of type 2 diabetes, particularly in the overweight and obese. By Will Block A new review focuses on several studies showing that the plant alkaloid berberine can lower blood glucose as effectively as the drug metformin at similar doses (500 mg, taken 3 times/day), and perhaps even better in some ways.1 Berberine is found in Coptis chinensis (goldenthread), Berberis aquifolium (Oregon grape), Berberis vulgaris (barberry), Hydrastis canadensis (goldenseal), and Berberis aristata (tree turmeric). Traditionally, it has been used for more than 2500 years in both Ayurvedic and Chinese medicine, with growing interest in its effects in metabolic and cardiovascular disease in the Western world in the last decade. Berberine has a wide range of healthful uses that include cardiovascular, anti-inflammatory, and antimicrobial (it acts against bacterial diarrhea, intestinal parasites, fungal infections, Candida albicans, yeast, and possibly methicillin-resistant Staphylococcus aureus). Berberine for Diabetes Mellitus Type 2 As we have already reported (see “Take This Dye for Diabetes” in the November 2010 issue), two recent studies (also covered in the recent review) show the effectiveness of berberine compared to metformin for type 2 diabetes.2 In the first study, 36 adults with newly diagnosed type 2 diabetes were randomly assigned to treatment with berberine or metformin (500 mg 3 times/day) in a 3-month trial. The hypoglycemic effect of berberine was similar to that of metformin. Metformin is a widely used first-line antidiabetic drug prescribed by doctors for the treatment of type 2 diabetes, particularly in the Continue reading >>

Natural Alternative For Metformin

Natural Alternative For Metformin

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community I've been a type 2 Diabetic for some years now and I'm concerned about the damage to my Pancreas caused by hitting it with a maximum 2 gram dose of Metformin every day, to create more insulin? I wondered if anybody has any experience of replacing Metformin with a natural alternative, like water-soluble cinamon extract, and if so, any advice about dosages? Actually metformin is a safe enough drug to take. It doesnt stimulate the pancreas to go into overdrive. I am not sure about cinnamon, works for some not for others. Have to be careful not to take too much of it as it can irritate the stomach lining and large doses are said to be carcinogenic. Apparently cider vinegar helps blood sugar control but probably not enough to turf out the metformin. Personally for me it helped to reduce carbs but I stresz this was my choice and you need not feel a failure if you cant or wont try that. As far as I am aware Metformin doesn't stimulate the pancreas to produce insulin; rather it acts on the muscle cells to make them less resistant to glucose from the bloodstream. It also has some helpful effects. I don't mind taking it because it's supposed to facilitate weight loss. I wish it would hurry up! :wink: There is a thread on here somewhere devoted to the subject of metformin. I'm concerned about the damage to my Pancreas caused by hitting it with a maximum 2 gram dose of Metformin every day, to create more insulin? Metformin Helps you cope with insulin resistance ? Metformin works in several ways. The medicine reduces the amount of sugar made by the liver, limits the amount of sugar absorbed into the body from the diet, and makes insulin receptors more sensitive (h Continue reading >>

Can This Herb Completely Replace Drugs For Type-2 Diabetics?

Can This Herb Completely Replace Drugs For Type-2 Diabetics?

A few weeks ago, I received this email from a diabetic patient of mine. He's been working hard to control his blood sugar. He said, "Hi Frank, I have some very good news that I'm excited to tell you. I've been following your program closely and was a little discouraged. Although my A1c levels [average blood sugar levels] have been dropping, my fasting blood sugar has not. It was still at 123. About two to three weeks ago, I began taking berberine (500 mg, three times daily) and my fasting blood sugar dropped into the 90s. I'm stoked! Sincerely, Rich." So the question I had to answer for myself is, "Why did Rich fail to respond well to my usual program, and then do so well on berberine?" Berberine is a phytochemical (plant chemical) found in many different plants. When used in herbal medicine, the usual sources are barberry, goldenseal, or Oregon grape. It's the main alkaloid of Coptis chinensis, which Asian folk medicine uses to treat diabetes. You also may hear people refer to Coptis chinensis as Chinese Goldthread, Huang-Lian, and Huang-LienIt. Berberine has a lot of uses. It can treat heart disease, immune disorders, digestive problems, eye infections, and other infections. I had never heard of it being all that effective in diabetes. So as soon as Rich sent me that message, I looked into it. I found several well-written scientific articles describing an effect of berberine that I could hardly believe. It seems that you can use it as a substitute for insulin. One study, published just last year looked at the effect of berberine on how well muscle cells take in sugar. As you probably already know, except when we are actively exercising, sugar cannot get into muscle cells unless insulin is present to escort it in. That's why the blood sugar goes up when patients either Continue reading >>

Metformin - The Source Natural Foods

Metformin - The Source Natural Foods

Brand Names: U.S.: Fortamet;Glucophage;Glucophage XR;Glumetza;Riomet Brand Names: Canada: Apo-Metformin;Ava-Metformin;CO Metformin;Dom-Metformin;Glucophage;Glumetza;Glycon;JAMP-Metformin;JAMP-Metformin Blackberry;Med-Metformin;Mylan-Metformin;Novo-Metformin;Nu-Metformin;PHL-Metformin;PMS-Metformin;PRO-Metformin;Q-Metformin;RANT-Metformin;ratio-Metformin;Riva-Metformin;Sandoz-Metformin FC It is used to lower blood sugar in patients with high blood sugar (diabetes). It may take 1 month to see the full effect. It is used to stop high blood sugar (diabetes). Metformin lowers sugar and helps insulin work better. This drug may be used alone or with other high blood sugar (diabetes) drugs. Take as you have been told, even if you are feeling better. Take with or without food. Take with food if it causes an upset stomach. Long-acting products: Swallow whole. Do not chew, break, or crush. Fortamet: Take with a full glass of water. Follow the diet and workout plan that your doctor told you about. Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor. A small number of people may have more acid in their blood. Metformin may cause this. It may happen in people whose liver or kidneys do not work the right way. Do not give the extended release product to a child younger than 17 years of age. If you have an allergy to metformin or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lip Continue reading >>

Herbal Alternatives To Metformin

Herbal Alternatives To Metformin

Metformin (Glucophage, Glumetza, Fortamet) is typically prescribed to counteract the effects of insulin resistance -- the body's sluggish response to the blood-sugar-lowering hormone insulin. Insulin resistance can lead to high blood sugars and may eventually progress to prediabetes or type 2 diabetes (T2DM). Metformin improves insulin sensitivity of the body tissues and reduces liver glucose production, both of which help lower blood sugar levels. The American Diabetes Association recommends metformin as a first-choice medicine to treat T2DM. It is also sometimes used in combination with exercise and weight loss in people with prediabetes. Some evidence suggests that a few herbs might mimic some of the effects of metformin. However, no herb is a proven alternative to metformin. Video of the Day Goat’s rue, or Galega officinalis, is an age-old remedy. In times past, it was used for assorted ailments, including diabetes. Metformin is a man-made chemical that's closely related to a substance found in goat’s rue. Animal studies from the 1970s and 1980s established that substances in goat's rue have blood-sugar-lowering effects. Some of these chemicals can be toxic, however, so human studies are lacking. A recent animal study was published in April 2008 in the "British Journal of Pharmacology." Researchers found that mice fed galegine -- a chemical found in goat's rue -- ate less, lost weight and had reduced blood sugar levels, compared to mice that weren't fed the chemical. Goat's rue is not approved for diabetes treatment by the U.S. Food and Drug Administration or Germany's Commission E, a scientific advisory board that reviews and approves herbal medicines. Commission E noted significant health risks with goat's rue and the availability of more effective diabetes tr Continue reading >>

8 Natural Alternatives To Actos And Metformin

8 Natural Alternatives To Actos And Metformin

If you suffer from Type 2 diabetes, there is a good chance that you’ve had a discussion with your doctor about the prescription drug Metformin. It is often initiated at the diagnosis of diabetes and helps to reduce blood sugars in an effective way. The problem however with this solution is its inability to work for everyone. Additionally, many users of Metformin may find the side effects of this drug extremely bothersome. The first thing to remember is that the development of Type 1 diabetes is not your fault, no matter what your medical providers might have you believe. Diabetes is caused by your body’s inability to process, driving up your blood sugars. However, Type 2 diabetes (adult onset) can be avoided many times and even reversed with the right diet, exercise program and proper natural herbs and vitamins. Dealing with High Blood Sugar Levels Maintaining your blood sugar levels into acceptable ranges is critically necessary to maintain your quality of life, which means your routines are going to be changing no matter what you do. High blood sugars can cause nerve and kidney damage, so it is important to act now. Whether you want to avoid prescription medication, or suffer with current side effects, many natural alternatives exist for Metformin. These options may be able to effectively treat your diabetes and help you feel back in control again 8 Natural Alternatives to Metformin 1. Lifestyle Changes: For many that suffer with Type 2 diabetes, basic lifestyle changes are often the primary thing that is necessary for treatment of their disease. For many people, this means an increased level of exercise and an improvement in their overall nutrition. The goal of these lifestyle changes is to get on an effective weight loss plan that is combined with higher levels Continue reading >>

Berberine Compared To Metformin In Women With Pcos

Berberine Compared To Metformin In Women With Pcos

Wei W, Zhao H, Wang A, et al. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. Eur J Endocrinol. 2012;166:99-105. Participants One hundred Chinese women of reproductive age who met diagnostic criteria for polycystic ovarian syndrome (PCOS) and insulin resistance were randomized to the study; 89 completed the study. All subjects received advice from a nutritionist and were instructed to limit dietary fat and carbohydrates without restricting calories. Thirty minutes of moderate to intense exercise per day was recommended but not monitored. All subjects also received the antiandrogen compound cyproterone acetate (2.0 mg/day) in a combined oral contraceptive pill with 35 mcg ethinyl estradiol, taken in a cyclic fashion. Berberine hydrochloride, 500 mg 3 times/day (n=31) Metformin, 500 mg 2 times/day for the first week, then 3 times/day for the remainder of the study (n=30) Placebo tablet 2 times/day (n=28) Study parameters assessed Clinical, hormonal and metabolic assessments were made at baseline and repeated after 3 months of treatment. Clinical assessment included height, weight, body mass index (BMI), waist circumference, and waist-to-hip ratio. Reproductive hormone parameters assessed were total testosterone, sex hormone–binding globulin, and free androgen index. Carbohydrate metabolic parameters included fasting plasma glucose, fasting insulin, and 2-hour oral glucose tolerance test. The degree of insulin resistance was then estimated using various methods, including fasting glucose/insulin ratio, homeostasis model assessment for insulin resistance, and area under the curve for insulin. Lipid profile parameters included triglycerides, total cholesterol, low-de Continue reading >>

The Surprising Truth About Metformin

The Surprising Truth About Metformin

The “natural” blood-sugar remedy that had been sidelined for far too long What I’m about to tell you may be shocking. And it’s sure to ruffle the feathers of many of the “natural know-it-alls.” But the science is clear, so I’m not afraid to say it: If you have unmanaged Type II diabetes, you should consider the drug metformin as a first line of treatment. And you won’t get the full story anywhere else, since the natural health industry wouldn’t be caught dead recommending a drug. So, please allow me to do the honors here… Think of it as your emergency “get out of jail free card” Diabetes is deadly. High blood sugar coursing through your body destroys your eyes, kidneys, heart, brain, and more. So the sooner you bring it down the better. (Just like high blood pressure, for which I also recommend tried and true medications as a first-line treatment for unmanaged hypertension.) And in this case, the science is clear—the drug metformin has been proven safe and effective for most people. And since it’s now a generic drug, it’s highly cost effective, too. Now don’t get me wrong…I’m not saying diet and exercise isn’t important. In fact, they’re the best means for preventing and even reversing Type II diabetes entirely. Something metformin can’t do. And there are certainly dietary supplements that can help with maintaining healthy blood sugar (like berberine). But Type II diabetes doesn’t develop overnight. And let’s face it, changing the habits and consequences that got us there in the first place isn’t an overnight task either. So if you need additional help, this is one rare instance where you shouldn’t be afraid to look at a mainstream therapy. And when an option this effective comes along to help kick-start your efforts saf Continue reading >>

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