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Metformin While Cutting

Should We All Take Metformin?

Should We All Take Metformin?

Metformin (Glucopage) is a wonderful drug that bodybuilders use for a very long time, nothing very spectacular just another drug in the bodybuilders toolbox. I wrote a few times before about this drug, in 2012 about its potential to burn fat and in general in 2014. But this drug is studied intensively and in 2015 this article in The Telegraph increased the interest in Metformins ability to increase life-span and improve quality of life. T he Food and Drug Administration (FDA) always maintained that aging is not a disease and most scientists have taken the same position. But because many studies confirmed that Metformin was able to slow down aging and prevent many conditions linked with aging, general consensus changed. Belgian researchers tested metformin on the tiny roundworm C.elegans the worms not only aged slower, but they also stayed healthier longer. They did not slow down or develop wrinkles. Mice treated with Metformin increased their lifespan by nearly 40 per cent and their bones were also stronger. Last year Cardiff University found that when patients with diabetes were given the drug metformin they in fact lived longer than others without the condition, even though they should have died eight years earlier on average. To analyze the advantage outside treatment of diabetes, the Food and Drug Administration has green-lighted a clinical trial in the U.S. for what has become known as the Targeting Aging with Metformin (TAME) study. The researchers will give Metformin to about 3.000 elderly people, who either suffer from or have a high risk of developing diseases like cancer, heart disease, or cognitive problems. They'll then track them over six years to see if the drug prevents aging-related diseases that were not pre-existing. They'll also be looking to see if i Continue reading >>

Experience Of Metformin Hcl (glucophage)

Experience Of Metformin Hcl (glucophage)

i have been using metformin on my refeed/cheat days while dieting with good results. i get an awesome pump. I also have started adding it to my medium day which is 2moro. theirs a few threads on it and loads over on promuscle.com so have a look around. Already done alot of research from a variety of sources including UKM.. I was after more personal opinions on the med TBH ive used it also and it does give you that fuller feel or pumped if you will.one thing though is that it makes me s**t bricks twice a day ?????????.i usually take 1000mg a day before meals gastrointestinal upset if you take it on empty stomach.. took it 3 times a day, after carb meals.. 500mg.. i've also used it to induce ketosis in 2 days.. fcuk the 1wk hell you'd have to go through otherwise.. I forgot to add i alsol used it to introduce ketosis in 2 days. worked well and much less dangerous than using slin. Really good for cutting. When I use it, I can not seem to gain fat no matter what I eat. Used it with GH before, and dropping body fat was extremely easy. I've used it many different ways. Daily use is the best for cutting. Used it with cheat meals only while cutting before, and it kept fat off, but not nearly as amazing results as when using it daily. Really like the stuff - cheap, keeps me full, nothing in the way of hypo obviously, seems to predetermine me to stay leaner as I gain wieght. Love the fullness it gives, and as someone above says, it gives really good pumps. Cant wait until I am very lean again, I think it will be the ideal chem for helping carbup, cant wait to experiment. On the negative sides I have noted stomach upset/heartburn if not taken with food, so I take it immediately after meals. I have also noticed when I jsut start taking it, I get a headache later that same day, but Continue reading >>

Cutting Back On Carbs - Metformin Reaction?

Cutting Back On Carbs - Metformin Reaction?

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community Cutting back on carbs - Metformin reaction? I have been using Metformin for a while now (years) with minimal side effects. Currently on 2 * 500Mg (one morning, one evening). I had a bit of queasiness for about a week when first taking it but seemed to adjust O.K. After slowly drifting to the dark side I have recently sharply cut down on carbohydrates and although I haven't been carb counting I am relatively low carb. However this has coincided with increased queasiness and a feeling of discomfort in my lower gut. It has just occurred to me that this might be a reaction to a change in diet. I am considering skipping the pills for a couple of days to see if this brings about a change, and perhaps upping the carbs for a couple of days whilst taking the pills to see if this makes any difference. However I thought I would also ask on here (in the Discussion forum because this is T2, and medication and low carb) if anyone has seen a similar reaction when reducing carb intake. Also, do people generally manage O.K. on Metformin and low carb? I have been using Metformin for a while now (years) with minimal side effects. Currently on 2 * 500Mg (one morning, one evening). I had a bit of queasiness for about a week when first taking it but seemed to adjust O.K. After slowly drifting to the dark side I have recently sharply cut down on carbohydrates and although I haven't been carb counting I am relatively low carb. However this has coincided with increased queasiness and a feeling of discomfort in my lower gut. If it helps, last September I was put on 2 x 500g Metformin, morning and evening, like you, and suffered no side-effects whatsoever. That left me wonderin Continue reading >>

Metformin For Weight Loss

Metformin For Weight Loss

I've been reading reports that taking the diabetic drug Metformin, even if you don't have diabetes, can help you lose weight. Does anyone have any experience with this? I've been reading reports that taking the diabetic drug Metformin, even if you don't have diabetes, can help you lose weight. Does anyone have any experience with this? But what will the effect on your blood sugar levels be? But what will the effect on your blood sugar levels be? Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Its pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Unlike sulfonylureas, metformin does not produce hypoglycemia in either patients with type 2 diabetes or normal subjects (except in special circumstances, see PRECAUTIONS) and does not cause hyperinsulinemia. With metformin therapy, insulin secretion remains unchanged while fasting insulin levels and day-long plasma insulin response may actually decrease. So how come somebody hasn't resold glucophage as fatfade and made a million bucks yet? So how come somebody hasn't resold glucophage as fatfade and made a million bucks yet? I did not say it was significantly effective. From my recall, it is marginally effective and not all that consistent except in pre-diabetes. It might be of benefit as a step in obesity management. Some history of its use in bodybuilding community... Bodybuilders experimented with this back in the mid- to late-90s. Dan Duchaine wrote about it in Muscle Media 2000 Oct Continue reading >>

Metformin And Muscle Growth

Metformin And Muscle Growth

by Mike Arnold Over the last few years insulin sensitizers, and metformin in particular, have become quite popular among bodybuilders due to their many positive effects, one of which is the ability to combat growth hormone/exogenous insulin induced insulin resistance. While their physique and health enhancing benefits are undeniable, many have begun utilizing these compounds indiscriminately, adhering to a more is better philosophy in terms of dose, frequency of use, and the number of compounds employed. This may be advantageous with some drugs, but is it true in this instance? Insulin sensitizers are rather unique in that many of their positive and negative effects are mediated through a single pathway; an enzyme known as adenosine monophosphate-activated protein kinase, or AMPK for short. Acting as a cellular energy regulator, AMPK is responsible for maintaining cellular energy homeostasis via the regulation of ATP levels. When the body is exposed to stresses that deplete ATP, such as heat shock, or much more commonly, low blood glucose and hypoxia as a result of diet and exercise, this enzyme is activated. As a result, processes which involve ATP consumption (fatty acid and cholesterol synthesis) are turned off, while processes which involve ATP production (fatty acid and glucose oxidation) are turned on in an attempt to replenish cellular energy levels. This has a number of beneficial effects. It improves insulin sensitivity (via improved insulin receptor function and increased Glut-4 translocation), increases glucose uptake into muscle tissue, simulates fat loss, improves cholesterol values, and results in an overall improvement in metabolic health. With such a diverse number of benefits and with all of them directly applicable to the goals/circumstances of a bodyb Continue reading >>

Diabetes Drugs: Metformin

Diabetes Drugs: Metformin

Editor’s Note: This is the second post in our miniseries about diabetes drugs. Tune in on August 21 for the next installment. Metformin (brand names Glucophage, Glucophage XR, Riomet, Fortamet, Glumetza) is a member of a class of medicines known as biguanides. This type of medicine was first introduced into clinical practice in the 1950’s with a drug called phenformin. Unfortunately, phenformin was found to be associated with lactic acidosis, a serious and often fatal condition, and was removed from the U.S. market in 1977. This situation most likely slowed the approval of metformin, which was not used in the U.S. until 1995. (By comparison, metformin has been used in Europe since the 1960’s.) The U.S. Food and Drug Administration (FDA) required large safety studies of metformin, the results of which demonstrated that the development of lactic acidosis as a result of metformin therapy is very rare. (A finding that has been confirmed in many other clinical trials to date.) Of note, the FDA officer involved in removing phenformin from the market recently wrote an article highlighting the safety of metformin. Metformin works primarily by decreasing the amount of glucose made by the liver. It does this by activating a protein known as AMP-activated protein kinase, or AMPK. This protein acts much like an “energy sensor,” setting off cellular activities that result in glucose storage, enhanced entry of glucose into cells, and decreased creation of fatty acids and cholesterol. A secondary effect of the enhanced entry of glucose into cells is improved glucose uptake and increased storage of glycogen (a form of glucose) by the muscles. Additionally, the decrease in fatty acid levels brought about by metformin may indirectly improve insulin resistance and beta cell func Continue reading >>

Metformin Aka Glucophage For Cutting Cycle.

Metformin Aka Glucophage For Cutting Cycle.

Metformin aka Glucophage for cutting cycle. Instant Access Registration Takes Less Than 15 Seconds! You May Not Post Until Registered. IGF-1 lr3 Sale + Free SARM! **NEW PRICE** Endurobolic GW & Stenabolic SR Now Available! Metformin aka Glucophage for cutting cycle. A good study and a clear explanation about why add glucophage in your cutting cycles. Metformine activate the AMPK.This enzymatic switch is activated with fisical training and send the imput to burn more fats and more carbs to the muscle fibers to produce more energy. This is a lately discover of the professor Grahame Hardie,at Cellular Signalling next to Dundee univeristy. Also metformin is know as a good appetite suppressor. Metformin inhibits catecholamine-stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis study. AU: Flechtner-Mors-M; Ditschuneit-HH; Jenkinson-CP; Alt-A; Adler-G AD: Department of Internal Medicine, University of Ulm, Germany. [emailprotected] AIMS: Metformin has been reported to decrease the plasma concentrations of non-esterified fatty acids in Type 2 diabetic subjects. This study investigated the effects of metformin on basal and catecholamine-stimulated lipolysis in abdominal subcutaneous adipose tissue of obese, hyperinsulinaemic, hypertensive subjects. METHODS: Fourteen subjects with severe obesity (12 female, two male, age 35.4 +/- 4 years, body mass index 48.2 +/- 2 kg/m2, body fat mass 63.3 +/- 5 kg) were recruited. Glycerol and lactate concentrations were determined in the presence of metformin and after administration of catecholamines using microdialysis. Simultaneously, blood flow was assessed with the ethanol escape method. RESULTS: Glycerol release was lowered by metformin during the 3-h experiment Continue reading >>

My Personal Experience With Metformin (glucophage): A Great Cutting/anticatabolic Drug.

My Personal Experience With Metformin (glucophage): A Great Cutting/anticatabolic Drug.

My personal experience with Metformin (Glucophage): A great cutting/anticatabolic drug. My personal experience with Metformin (Glucophage): A great cutting/anticatabolic drug. Welcome to the EliteFitness.com Bodybuilding Site! Please join this discussion about My personal experience with Metformin (Glucophage): A great cutting/anticatabolic drug. within the Anabolic Steroids category. Excerpt: Tried Glucophage (Metformin) to cut a little. Metformin is an antidiabetic drug, it does several things: 1. Reduces carbohydrate absorption in your intestines by about one third, so you decrease total calories, and insulin release. 2. Reduces insulin resistance, so your body produces a little less insulin, which decreases fat storage. 3. It reduces gluconeogenesis, that is sugar formation from amino-acids, thus reducing muscle breakdown during fasting. Read more or register here to join the discussion below... My personal experience with Metformin (Glucophage): A great cutting/anticatabolic drug. Tried Glucophage (Metformin) to cut a little. Metformin is an antidiabetic drug, it does several things: 1. Reduces carbohydrate absorption in your intestines by about one third, so you decrease total calories, and insulin release. 2. Reduces insulin resistance, so your body produces a little less insulin, which decreases fat storage. 3. It reduces gluconeogenesis, that is sugar formation from amino-acids, thus reducing muscle breakdown during fasting. I started with a very low dose of 125mg (1/4 of a 500 mg tab), and went up to 850 mg (one 850 mg tab). Now I always take it at night, preferably before dinner, since it upsets your stomach a little bit, when you start taking it, or when you increase the dose. Have lost 12 pounds in less than 3 weeks, incredibly, most of them fat, have reta Continue reading >>

Insulin And Metformin

Insulin And Metformin

Now I am sure BBB can answer this question. Will it be beneficial to use Metformin with Slin? I have never run insulin but am starting to plan my GH/IGF/Slin protocol now for after my competitions in October. I am good on how to run GH/IGF as I am currently and have run them a few times now. I was reading conflicting arguments on taking metformin pre-workout and slin pwo. I would be starting with Slin very low maybe around the 4-5iu range unless someone can make me feel safer going any higher as I am intimidated by the though of Slin (hence why I am reseaching so early). I currently run Metformin at 1500mg once a week during my refeed meal as I am on the Palumbo Keto Diet. I definitely notice that when I take it during this carb loaded meal (400g+) I can get my body back into Ketosis within a 12 hr period. If you could help me with a safe starting protocol with the Metformin and Slin it would be appreciated. Yup your going to say that running 4iu's daily isn't nearly as affective as your protocol. I am cutting as of right now so your protocol is not needed. My goals are a slow bulk, when I come out of the contest I'll be adding in carbs very slowly first just pwo and 30g per meal with my 50g pro/20g fat per meal. I will continue to ramp it up as I dont want to suffer from edema the first few weeks. I will be on no AAS as after this contest I want to take a few months off. I plan on running the slin at low doses for a few months if I can keep the fat down during the bulk. I will be starting all this around 4%bf so I dont anticipate putting on a lot of fat. I will, again, preface this by saying I don't use these drugs, so my perspective might be inaccurate without anecdotal evidence, but, I will give you my science perspective on glucophage. I see ZERO reason to use gluc Continue reading >>

Metformin

Metformin

anyone have expierience with metformin and the best time and way to take it? new to this one? anyhelp would be gratefully helpful I'm using it for a month right now as an antiaging with 3 iu of gh and I notice btter response from the gh I take it on the morning 500mg somtimes after work out with at least 50g of carbo Anyone ever taken metformin with a Trenbolone and Winstrol cycle? If so, please elaborate on your experience. I plan to cycle trenbolone, stanozolol and metformin. Thanks! are you diabetic? are you hypoglycemic? are you just taking it to loose weight. has it been prescribed to you? I have not seen it in the bodybuilding seen yet but I can see where guys our age can benefit from it. I will keep an eye on this thread to see what else I can learn from it.try this link Anyone ever taken metformin with a Trenbolone and Winstrol cycle? If so, please elaborate on your experience. I plan to cycle trenbolone, stanozolol and metformin. Thanks! why? when everone told you your cycle was horrible in the q&a? Effect of metformin on insulin sensitivity and insulin secretion in female obese patients with normal glucose tolerance.Binnert C, Seematter G, Tappy L, Giusti V. Institute of Physiology, School of Medicine, University of Lausanne, Lausanne, Switzerland. OBJECTIVES: Metformin is recognized as the treatment of chronic obese, insulin-resistant type 2 diabetic patients. Whether it improves insulin sensitivity in obese patients with normal glucose tolerance remains unknown. METHODS: Eight obese female patients with normal glucose tolerance were studied during a double blinded, randomized cross-over study including a 2-week administration of metformin and a 2-week administration of placebo. Insulin secretion and insulin sensitivity were assessed after metformin and plac Continue reading >>

Metformin Lowers Total And Free Testosterone Levels???

Metformin Lowers Total And Free Testosterone Levels???

Metformin lowers total and free testosterone levels??? Metformin lowers total and free testosterone levels??? i want to use METFORMIN on my PCT,but i have heard that it lowers total and free testosterone .it is true?what you know about that?and about using it on PCT,what do you know?i am thinking of using it only on my working day/post-workout Research Methods and Procedures: Twenty obese men with type 2 diabetes (mean body mass index [BMI]: 35.5 1.1 kg/m2) and 20 nondiabetic obese men were enrolled in the study. We measured serum follicle-stimulating hormone, luteinizing hormone (LH), total testosterone (TT), free testosterone (FT), sex-hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), and plasma leptin levels before and 3 months after metformin treatment. Both groups were placed on a hypocaloric diet and 850 mg of metformin taken orally twice daily for 3 months. Results: Metformin and hypocaloric diets led to decreases in BMI and waist and hip circumferences in both groups. A significant decrease in TT levels in the diabetic group and FT levels in the control group was found, whereas follicle-stimulating hormone, LH, and DHEAS levels were not changed significantly. A significant increase in SHBG levels was observed in the control group but not in the patient group. Leptin levels also decreased after treatment in both groups. Decreased testosterone levels were not correlated to changes in waist and hip circumference, waist-to-hip ratio, BMI, and levels of fasting blood glucose, leptin, SHBG, or DHEAS in the diabetic group. However, a decrease in FT was correlated to changes in the levels of SHBG (r = -0.71, p = 0.001) and LH (r = 0.80, p = 0.001) but not to other parameters. Discussion: We conclude that metformin treatment combined with a hypoca Continue reading >>

Steroids Forum: General/general Talk/metformin (glucophage)

Steroids Forum: General/general Talk/metformin (glucophage)

j223 Sun, Jun 30th, '13 22:11 13 replies, 2537 views Metformin is an oral drug used by diabetics (and many other medical conditions such as PCOS). It is considered a biguanide. Metformin has many benefits. It reduces insulin resistance, helps lower LDL cholesterol and triglycerides. Metformin suppresses glucose production from inside the liver. Metformin is good for cutting, can induce ketosis in a quick manner as well. Many use it to maintain high glycogen levels in a carb depleted state. Which leaves the user fuller and more vascular and lowers the conversion of carbs to fat tissue after a massive cheat meal. Most common side effects are upset stomach and heartburn. If the drug is taken on a full stomach these sides should be minimal. It is said that the sides die down after you get used to it. Metformin is very safe and has millions of prescriptions out there. Well I just wanted to make this post in hopes to get more information from other members here who have used it successfully. How do you like it? What type of benefits have you noticed from metformin? I'm sure some people here have used it so lets hear it ! Continue reading >>

3 Things You Need To Know About Metformin

3 Things You Need To Know About Metformin

September 30, 2015 by Dr. Brooke in Be Better , Eat Better , pcos 3 Things You Need To Know About Metformin Metformin is recommended by doctors for women with PCOS that want to loose weight or otherwise manage their PCOS and insulin resistance. But there are 3 very important things that you need to know about it including the fact that it's not the only option! Let me first say, I dont hate Metformin for women with PCOS . For some women it really does help spur ovulation, control blood sugar and help with some weight management but.its not without its share of issues. And its definitely not the magic bullet for weight loss although its usually presented that way. How Metformin (or its generic form: Glucophage) Works Metformin is typically given with meals throughout the day, or more commonly now the extended release version is given once with dinner or at bedtime. While only having to pop a pill one time per day is always appealing, this once a day dosing (especially at bedtime) is where I see the most problems with my patients. It lowers both fasting and post meal glucose levels by decreasing the glucose absorption in your intestines after a meal; as well as decreasing the amount of glucose your liver makes for later use. It also does help improve insulin sensitivity by increasing glucose movement into a cell. All sounds good so far right? Not so fast, here are the most common issues I see in women using Metformin: Metformin is notorious for causing sometimes severe digestive issues including stomach pain or upset, nausea, vomiting, diarrhea and even a sense of body weakness or metallic taste in the mouth in some. And it is touted as not causing low blood sugar as many older blood sugar lowering drugs did, however I see it every day in my practice that Metformin can m Continue reading >>

Is It Safe To Reduce Metformin Usage By Half?

Is It Safe To Reduce Metformin Usage By Half?

Is it safe to reduce Metformin usage by half? Is it safe to reduce Metformin usage by half? I am a 47 yo male and have been a type 2 diabetic for about 5 years due to really poor eating and exercise habits. My last blood work was in August and my A1C level was 8.7%, so the doc increased my Metformin from 500 mg once daily to 1000 mg twice daily. My glucose levels improved but it was only a slight improvement because my eating habits were still terrible. I was getting reading that were in the 160s in the mornings with post meals somewhere between 180 and 220. It wasn't until I changed my eating and exercise habits that my glucose levels normalized. Since making these changes, my glucose levels are in the high end of the normal range. Morning fasting: about 125, 2 hours after meals: 110, evening before bed: 110. I've even had random daily readings from 90 to 100. Since my glucose levels have normalized after making lifestyle changes, is it safe to cut back my usage by half? I can't get into see the doc for another 2 months to speak with him about this, and I don't want to wait that long to cut back my meds. We can't advise an Rx change, but just for reference... Optimal Super good Normal FBG is 85 or less I would call your doctor and ask First. I have been on the max of Metformin for almost 10 years. My Fastings are 90 and I am thin . I have always eaten healthy, lots of veggies. I am still on 2000 mg of Metformin and just added Januvia because my fastings were rising above 100. 115 pounds, Breast Cancer dx'd 6/16, 6 months of chemo and 6 weeks of radiation 2000 metformin ER, 100 mg Januvia,Glimperide, Prolia, Gabapentin, Meloxicam, Probiotic with a Prebiotic, , Lisinopril, B-12, B-6, Tumeric, Magnesium, Calcium, Vit D, and Occuvite mostly vegan diet, low fat and around Continue reading >>

Metformine...good For Fat Loss

Metformine...good For Fat Loss

View and discuss the latest research articles and FAQ's as well as numerous Detailed Drug Profiles Want More? We have a full site section dedicated to Anabolic Steroid Articles and Anabolic Books From a long time ago in a Galaxy far, far away A good study and a clear explanation about why add glucophage in your cutting cycles. Metformine activate the AMPK.This enzymatic switch is activated with fisical training and send the imput to burn more fats and more carbs to the muscle fibers to produce more energy. This is a lately discover of the professor Grahame Hardie,at Cellular Signalling next to Dundee univeristy. Also metformin is know as a good appetite suppressor. Metformin inhibits catecholamine-stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis study. AU: Flechtner-Mors-M; Ditschuneit-HH; Jenkinson-CP; Alt-A; Adler-G AD: Department of Internal Medicine, University of Ulm, Germany. [email protected] AIMS: Metformin has been reported to decrease the plasma concentrations of non-esterified fatty acids in Type 2 diabetic subjects. This study investigated the effects of metformin on basal and catecholamine-stimulated lipolysis in abdominal subcutaneous adipose tissue of obese, hyperinsulinaemic, hypertensive subjects. METHODS: Fourteen subjects with severe obesity (12 female, two male, age 35.4 +/- 4 years, body mass index 48.2 +/- 2 kg/m2, body fat mass 63.3 +/- 5 kg) were rec***ted. Glycerol and lactate concentrations were determined in the presence of metformin and after administration of catecholamines using microdialysis. Simultaneously, blood flow was assessed with the ethanol escape method. RESULTS: Glycerol release was lowered by metformin during the 3-h experiment (P<0.01). Continue reading >>

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