Metformin + Viagra More Effective Treatment For Erectile Function
Insulin-resistant men had significant improvement in erectile function when metformin was added to sildenafil(Viagra), according to data from a small clinical study. Metformin increases the activity of sildenafil. Pablo Knoblovits, M.D., of Hospital Italiano de Buenos Aires in Argentina, reported at the Endocrine Society meeting that, sildenafil alone had failed to improve erectile function, and men who received a placebo in addition to the phosphodiesterase-5 (PDE5) inhibitor continued to have erectile problems, “We think metformin potentiates the activity of sildenafil by improving insulin resistance and nitric oxide activity in the vascular endothelium of the penis.” Dr. Knoblovits noted that, erectile function depends in large part on the release of nitric oxide by the vascular endothelium. Sildenafil and other PDE5 inhibitors improve erectile function by inhibiting the breakdown to nitric oxide. Obesity, metabolic syndrome, and Type 2 diabetes all interfere with nitric oxide-mediated endothelial function. The three conditions are characterized by insulin resistance, which can interfere with PDE5 inhibitors’ ability to prolong the effects of nitric oxide on penile vascular endothelium, Dr. Knoblovits continued. In animal models of erectile dysfunction, the diabetes drug metformin improved erectile function. To determine whether the drug has similar activity in humans, investigators studied 30 insulin-resistant men who had significant erectile dysfunction despite treatment with sildenafil. Dr. Knoblovits reported that 17 men used sildenafil on demand plus metformin 1,700 mg/day, and the remaining 13 used sildenafil and placebo. Evaluations at baseline and after two and four months of treatment included calculation of body mass index and waist circumference; mea Continue reading >>
Metformin Viagra Interaction
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Should I Take A Viagra Pill While I Am Using Metformin?
Home Q & A Questions Should I take a viagra pill... Should I take a viagra pill while I am using Metformin? viagra , diabetes, type 2 , erectile dysfunction , metformin , sexual dysfunction, ssri induced I am taking for last 8 months Metformin and I am taking it after meals, 2 times a day. But I also taking a vigra pills when ever I need sex. Is this ok for my health? No results found - however, this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist. Still looking for answers? Try searching for what you seek or ask your own question . What if viagra is taken and not nessarally needed for erectile dysfunction? What could happen to the The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Subscribe to receive email notifications whenever new articles are published. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated Feb 28th, 2018), Cerner Multum (updated Mar 1st, 2018), Wolters Kluwer (updated Mar 1st, 2018) and others. To view content sources and attributions, please refer to our editorial policy . Continue reading >>
Viagra For Type 2 Diabetes: 'little Blue Pill' Reduces Insulin Resistance Without Risk Of Heart And Kidney Disease
The “little blue pill” not only helps men “get it up” during sex, it may also up insulin sensitivity among diabetics. A recent study published in the Journal of Clinical Endocrinology and Metabolism found sildenafil — the drug that treats erectile dysfunction (ED) — can ward off type 2 diabetes in those with prediabetes, while reducing the risk of heart and kidney disease. In the U.S., 29 million Americans have diabetes and three in 10 adults have prediabetes, according to the Society’s Endocrine Facts and Figures report. Without intervention, 30 percent of people with prediabetes are likely to develop type 2 diabetes within five years. Dr. Nancy J. Brown, author of the study from Vanderbilt University School of Medicine in Nashville, Tenn., believes additional strategies, like sildenafil, are necessary to help slow the progression from prediabetes to diabetes. "Weight loss and exercise regimens can be difficult to maintain, and some current medications have been limited by concerns about adverse effects. Sildenafil and related drugs could offer a potential avenue for addressing the rising number of diabetes diagnoses," she said in the press release. Sildenafil, typically known for treating ED, works by inhibiting an enzyme that breaks down the natural blood vessel-relaxing chemical, cGMP. The drug has been proven to increase insulin sensitivity in mice, but the effect of the drug on humans with prediabetes has been unknown. Someone who is insulin sensitive requires smaller amounts of insulin to lower blood sugar levels than someone who has a low sensitivity, or is insulin resistant. Insulin resistance occurs when there are high blood sugar levels in the body and the individual cannot produce enough insulin, or insulin does not function properly to clear s Continue reading >>
When Viagra Doesn’t Work
Treating Erectile Dysfunction Erectile dysfunction is a common occurrence in men with diabetes. The incidence of erectile dysfunction increases progressively with age, from 5% in men age 20 to 75% in men over age 65. The cause of erectile dysfunction in men with diabetes is usually related to a decrease in the blood supply to the penis as well as to injury to the nerves that are responsible for the erection mechanism. A decrease in testosterone production has also been identified as the cause in some men with diabetes. Since 1998, when sildenafil (brand name Viagra) first came on the market, oral therapy has been successfully used to treat erectile dysfunction in many men with diabetes. (Sildenafil was followed in 2003 by the drugs tadalafil [Cialis], vardenafil [Levitra] and avanafil [Stendra], which work in much the same way.) Some 50% of men with Type 1 diabetes who try the drugs report improved erections, and some 60% men with Type 2 diabetes do, too. However, that leaves a large percentage of men with diabetes and erectile dysfunction who do not respond to therapy with one of these pills. This article takes a look at what can be done to treat those men who do not respond to oral therapy. Why therapy fails There are a number of reasons a man may not achieve the desired result from an oral erectile dysfunction drug. In some cases, a man may experience drug side effects severe enough to outweigh any potential benefit of taking the drug. Possible side effects of these drugs include headache, facial flushing, nasal congestion, and transient abnormal vision. (In October 2007, the FDA added a warning about sudden hearing loss to the package labels of oral erectile dysfunction drugs. While it’s not absolutely clear that the drugs can cause sudden hearing loss, a number o Continue reading >>
Diabetes Pills Costing Just 2p Each Could Give Men's Love Lives A Lift
Tablets costing just 2p each could be a new treatment for men with erection problems. New research suggests the medicine, called metformin, could boost a man's performance in the bedroom. The drug has been widely used on the NHS for many years to treat patients with type 2 diabetes. But now scientists think it may also work as an alternative to anti-impotence drugs such as Viagra or Cialis. Laboratory tests at the Georgia Health Sciences University in the U.S. show the diabetes drug boosts erectile function by relaxing blood vessels in the genital area, allowing blood to flow more freely into the penis. Although it has yet to be tested in humans, it could quickly emerge as a new treatment because it is readily available, extremely cheap and has an excellent safety record. One in ten men in the UK suffers erectile dysfunction at some point in their lives. Although drugs such as Viagra, Cialis and Levitra have revolutionised treatment in the last ten years, around 30 per cent of men who take them experience no improvement. For these men, the only other options are to inject drugs straight into the penis, or use a pump that manually increases blood supply to the organ. Neither is very popular. Metformin has been attracting a great deal of attention from researchers in recent years, mostly because it seems to hold promise as a potentially powerful new weapon against certain cancers, such as prostate, breast and ovarian tumours. The drug belongs to a class of medicines known as biguanides, which have been used for decades to treat type 2 diabetes - the form of the disease that normally affects obese people and those over 40. Taken twice a day, it works by reducing the amount of glucose produced by the liver and helping cells mop up sugar that is circulating in the bloodstrea Continue reading >>
Metformin And Viagra Drug Interactions - From Fda Reports - Ehealthme
Metformin and Viagra drug interactions - from FDA reports Drug interactions are reported among people who take Metformin and Viagra together. This review analyzes the effectiveness and drug interactions between Metformin and Viagra. It is created by eHealthMe based on reports of 1,265 people who take the same drugs from FDA , and is updated regularly. On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA since 1977. Our original studies have been referenced on 400+ peer-reviewed medical publications, including: The Lancet, and Mayo Clinic Proceedings. 1,265 people who take Metformin, Viagra are studied. Most common drug interactions over time *: Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle) Renal failure acute (rapid kidney dysfunction) Respiratory failure (inadequate gas exchange by the respiratory system) Sepsis (a severe blood infection that can lead to organ failure and death) Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart) Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung) Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased) Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves) Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis) Generalised oedema (swelling all over the body) Pulmonary embolism (blockage of the main artery of the lung) Arthritis (form of joint disorder that involves inflammation of o Continue reading >>
List Of 56 Drugs That Should Not Be Mixed With Viagra Contains Some Surprises
By Jim Edwards MoneyWatch January 6, 2009, 10:22 AM List of 56 Drugs That Should Not Be Mixed With Viagra Contains Some Surprises Last Updated Jan 6, 2009 10:22 AM EST Public Citizen has published a list of 56 drugs that interact badly with erectile dysfunction pills such as Pfizer's Viagra. Public Citizen's WorstPills.com site reports : In combination with ED drugs, these 56 drugs can cause dangerous falls in blood pressure that could lead to a heart attack or stroke; a potentially harmful "overdose," even when taking the recommended amount; and decrease the effectiveness of the ED drugs themselves. The drugs include the usual suspects, such as nitrates for blood pressure. Taken in combination with Viagra, Cialis ior Levitra nitrates can lead to potentially lethal drops in blood pressure. But the list also includes some surprises -- household name drugs that shouldn't be taken with ED pills -- including Flomax, Provigil and grapefruit juice. Some drugs increase plasma concentrations of ED drugs, potentially leading to toxicity, and others reduce those concentrations, making the drugs ineffective. Some examples: Continue reading >>
Metformin And Viagra Drug Interactions - Drugs.com
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A Combination Of Leucine, Metformin, And Sildenafil Treats Nonalcoholic Fatty Liver Disease And Steatohepatitis In Mice
A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice Antje Bruckbauer ,1 Jheelam Banerjee ,1 Lizhi Fu ,2 Fenfen Li ,2 Qiang Cao ,2 Xin Cui ,2 Rui Wu ,2 Hang Shi ,2 Bingzhong Xue ,2and Michael B. Zemel 1 1NuSirt Biopharma Inc., 11020 Solway School Rd, Knoxville, TN 37931, USA 2Center for Obesity Reversal, Department of Biology, Georgia State University, 33 Gilmer Street SE, Atlanta, GA 30302, USA Received 7 June 2016; Revised 7 October 2016; Accepted 19 October 2016 Copyright 2016 Antje Bruckbauer et al. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Sirt1, AMPK, and eNOS modulate hepatic energy metabolism and inflammation and are key players in the development of NASH. L-leucine, an allosteric Sirt1 activator, synergizes with low doses of metformin or sildenafil on the AMPK-eNOS-Sirt1 pathway to reverse mild NAFLD in preclinical mouse models. Here we tested a possible multicomponent synergy to yield greater therapeutic efficacy in NAFLD/NASH. Liver cells and macrophages or an atherogenic diet induced NASH mouse model was treated with two-way and three-way combinations. The three-way combination Sild-Met-Leu increased hepatic fatty acid oxidation and reduced lipogenic gene expression and inflammatory marker in vitro. In mice, Sild-Met-Leu reduced the diet induced increases of ALT, TGF, PAI-1, IL1, and TNF, hepatic collagen expression, and nearly completely reversed hepatocyte ballooning and triglyceride accumulation, while all two-way combinations had only modest effects. Therefore, these data provide preclinical evidence for therapeutic Continue reading >>
Sildenafil Does Not Enhance But Rather Attenuates Vasorelaxant Effects Of Antidiabetic Agents.
Sildenafil does not enhance but rather attenuates vasorelaxant effects of antidiabetic agents. Department of Pharmacology, Midwestern University, Downers Grove, IL, USA. Type 2 diabetic men commonly experience erectile dysfunction for which phosphodiesterase-5 (PDE5) inhibitors like sildenafil (Viagra) are often recommended. By preventing degradation of cyclic guanosine monophosphate (cGMP) in vascular smooth muscle, these inhibitors also enhance arterial vasorelaxant effects of nitric oxide donors (which stimulate cGMP synthesis). In the present work, we confirmed this enhancing effect after co-administration of sildenafil with nitroprusside to freshly-isolated rat tail arterial tissues. However, in the same tissues we also observed that sildenafil does not enhance but rather attenuates vasorelaxant effects of three commonly-used antidiabetic drugs, i.e. the biguanide metformin and the thiazolidinediones pioglitazone and rosiglitazone. Indeed, sildenafil completely blocked vasorelaxant effects of low concentrations of these drugs. In addition, we found that this same novel anti-vasorelaxant interaction of sildenafil with these agents was abolished by either 1) omitting extracellular glucose or 2) inhibiting specific smooth muscle glycolytic pathways; pathways known to preferentially utilize extracellular glucose to fuel certain adenosine triphosphate (ATP)-dependent ion transporters: e.g. ATP-sensitive K channels, sarcoplasmic reticulum Ca-ATPase, plasma membrane Ca-ATPase and Na/K-ATPase. Accordingly, we suspect that altered activity of one or more of these ion transporters mediates the observed attenuating (anti-vasorelaxant) interaction of sildenafil with the antidiabetic drugs. The present results are relevant because hypertension is so common and difficult to con Continue reading >>
Metformin Medication May Help Treat Erectile Dysfunction
New research suggests that the widely used type 2 diabetes drug metformin could double as a treatment for men with erection problems. In addition to helping people with type 2 diabetes keep control of their blood sugar levels, scientists at Georgia Health Sciences University in the US believe metformin may also provide an alternative option to anti-impotence drugs such as Viagra. Results from laboratory tests at the University, published online in the Journal of Sexual Medicine, showed the diabetes medication may improve erectile function by increasing levels of the naturally occurring chemical nitric oxide in the body. This makes blood vessels in the genital area more flexible and dilated, thus increasing the flow of blood into the penis. However, the tests were only conducted on laboratory rats so it is unclear whether the drug would have the same effect in humans. "Metformin is an old, cheap, well-tried and tested drug which is usually well tolerated," commented Dr David Edwards, a GP who runs the male sexual health clinic at the Oxfordshire-based White House Surgery. "But it was only used for 28 days, which is a short time, and just in rats. Many diabetics are already on metformin and yet erectile dysfunction is very common in this group. It may be that their problems might be worse if they were not on the drug." 10% of men in the UK experience erectile dysfunction at some point in their lives. Among people diagnosed with diabetes, it is even more common with up to 75% of diabetic men experiencing erection problems during their lifetime. Tweet Type 2 diabetes mellitus is a metabolic disorder that results in hyperglycemia (high blood glucose levels) due to the body: Being ineffective at using the insulin it has produced; also known as insulin resistance and/or Being Continue reading >>
Metformin Viagra Interaction
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Metformin Viagra Interaction But Just Like Her 1, 607 Reward For The Return
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Can I Take Ramipril, Viagra And Metformin Togther?
Can I take Ramipril, Viagra and Metformin togther? Can I take Ramipril, Viagra and Metformin togther? Good Afternoon, and thank you for your question. ACE inhibitors, such as Ramipril, may potentiate the hypoglycemic effects of oral antidiabetic drugs, including metformin. The mechanism is unknown. Symptomatic and sometimes severe hypoglycemia has occurred (per drugs.com). This means that you should not take these together, without your doctor's approval. So it is possible to take them together, but you would need to carefully monitor your blood sugar levels, and if it was found that the Ramipril potentiated (increased) the effect of your metformin, you might need a decreased dose of metformin, or another drug may be substituted for Ramipril. It is also recommended that Patients receiving the combination of Ramipril and Metformin be advised to avoid rising abruptly from a sitting or recumbent position, especially following treatment initiation or a dosage increase, and to contact their doctor if they experience symptoms of hypotension such as dizziness, lightheadedness, fainting, or tachycardia. There are no other interactions listed for this combination of drugs (Ramipril, Viagra, and Metformin). I hope this is helpful. Please reply if you have any questions or need clarification. Susan Ivy and 87 other Health Specialists are ready to help you A new question is answered every 9 seconds Ask an ExpertExperts are full of valuable knowledge and are ready to help with any question. Credentials confirmed by a Fortune 500 verification firm. Get a Professional AnswerVia email, text message, or notification as you wait on our site. Ask follow up questions if you need to. 100% Satisfaction GuaranteeRate the answer you receive. Ask-a-doc Web sites: If you've got a quick question Continue reading >>
