diabetestalk.net

Metformin Stomach

Upset Stomach With Metformin

Upset Stomach With Metformin

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community I'm newly diagnosed type 2 and think it likely I'll be prescribed metformin. I also suffer from IBS. I've read that it can cause stomach upset. I'm slightly worried that I might be wedded to the loo - again! Can anyone offer advice on how it may have affected them and how long any upset lasts? Every one of us is different where drugs are concerned. I never had any problems at all with Metformin as my GP increased the dosage gradually. Others have mega problems with it. Here is a link to a search for Metformin on this site. There are over 3000 mentions. If you have the time take a look. i was on metformin for a few mnths with insulin, i found i had a lot of trapped wind but never runs,i also have ibs Ouch....trapped wind is sore. That's reassuring that it didn't cause the runs - that's what I fear the most. Thanks for your reply totsy bernie.freeman Type 2 Well-Known Member I had tummy problems at first with Metformin, but I found a post on here that advised to take metformin in the middle of a meal, I did and guesss what ? no more tummy problems. Try it it may work for you too ! I have always had 'weird' bowl movements. The first time I took metformin, the night was horriffic, but then no real problems since. Hi I too am on Metformin and had few stomach problems in first few days of taking them, terrible cramps and feeling of sickness more than anything else - spoke to the nurse and she suggested taking them during or after meal rather than before and it seems to have worked for me. I too had a lot of problems with Metformin. I came off them and have tried the slow release version and I get on a lot better. Saw the Nurse today and I have to increase a Continue reading >>

Side Effects Of Metformin: What You Should Know

Side Effects Of Metformin: What You Should Know

Metformin is a prescription drug used to treat type 2 diabetes. It belongs to a class of medications called biguanides. People with type 2 diabetes have blood sugar (glucose) levels that rise higher than normal. Metformin doesn’t cure diabetes. Instead, it helps lower your blood sugar levels to a safe range. Metformin needs to be taken long-term. This may make you wonder what side effects it can cause. Metformin can cause mild and serious side effects, which are the same in men and women. Here’s what you need to know about these side effects and when you should call your doctor. Find out: Can metformin be used to treat type 1 diabetes? » Metformin causes some common side effects. These can occur when you first start taking metformin, but usually go away over time. Tell your doctor if any of these symptoms are severe or cause a problem for you. The more common side effects of metformin include: heartburn stomach pain nausea or vomiting bloating gas diarrhea constipation weight loss headache unpleasant metallic taste in mouth Lactic acidosis The most serious side effect metformin can cause is lactic acidosis. In fact, metformin has a boxed warning about this risk. A boxed warning is the most severe warning from the Food and Drug Administration (FDA). Lactic acidosis is a rare but serious problem that can occur due to a buildup of metformin in your body. It’s a medical emergency that must be treated right away in the hospital. See Precautions for factors that raise your risk of lactic acidosis. Call your doctor right away if you have any of the following symptoms of lactic acidosis. If you have trouble breathing, call 911 right away or go to the nearest emergency room. extreme tiredness weakness decreased appetite nausea vomiting trouble breathing dizziness lighthea Continue reading >>

Diabetes Drugs: Metformin

Diabetes Drugs: Metformin

Editor’s Note: This is the second post in our miniseries about diabetes drugs. Tune in on August 21 for the next installment. Metformin (brand names Glucophage, Glucophage XR, Riomet, Fortamet, Glumetza) is a member of a class of medicines known as biguanides. This type of medicine was first introduced into clinical practice in the 1950’s with a drug called phenformin. Unfortunately, phenformin was found to be associated with lactic acidosis, a serious and often fatal condition, and was removed from the U.S. market in 1977. This situation most likely slowed the approval of metformin, which was not used in the U.S. until 1995. (By comparison, metformin has been used in Europe since the 1960’s.) The U.S. Food and Drug Administration (FDA) required large safety studies of metformin, the results of which demonstrated that the development of lactic acidosis as a result of metformin therapy is very rare. (A finding that has been confirmed in many other clinical trials to date.) Of note, the FDA officer involved in removing phenformin from the market recently wrote an article highlighting the safety of metformin. Metformin works primarily by decreasing the amount of glucose made by the liver. It does this by activating a protein known as AMP-activated protein kinase, or AMPK. This protein acts much like an “energy sensor,” setting off cellular activities that result in glucose storage, enhanced entry of glucose into cells, and decreased creation of fatty acids and cholesterol. A secondary effect of the enhanced entry of glucose into cells is improved glucose uptake and increased storage of glycogen (a form of glucose) by the muscles. Additionally, the decrease in fatty acid levels brought about by metformin may indirectly improve insulin resistance and beta cell func Continue reading >>

Metformin - Oral, Glucophage

Metformin - Oral, Glucophage

are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>

Metformin Tearing Up My Husband's Stomach...

Metformin Tearing Up My Husband's Stomach...

Metformin tearing up my husband's stomach... Metformin tearing up my husband's stomach... My husband was diagnosed Type 2 about 2 years ago. He's always been very active (12 mile mountain bike rides, beach volleyball, etc). His A1C was at 8.1 when diagnosed. Both his parents are type 2, both a very overweight while he is not. We went vegan and it dropped for about 6 months but crept back up. His Dr started him on Metformin. He took 500 in am, 500 at night. It absolutely tore his stomach up, terrible heart burn, stomach cramps, diarrhea. He endured that for another 6 months, but it only brought his A1C down to 7.8... not enough to be worth the pain. He's cut sugar, no soda, no white carbs, 1 low carb beer a week, exercises daily, even no birthday cake (he used to love birthday cake). I'm looking for suggestions on a secondary medication to add to Metformin (which he now takes only at night). He's 6ft 1 and weighs 202... not a tiny guy, but not obese, age 48. This Nebraska farmer guy went VEGAN! What he's doing is not sustainable and not really working. I've got to find some other suggestions or he's going to burn out and give up. Any suggestions are appreciated. Is your husband on the ER (Extended Release) version of metformin? That stops the gastric distress for many Type 2. If he is already on the ER version, I suggest he talks to his doctor about trying one of the other oral diabetes meds instead of metformin, not as well as. There are quite a few, and he could find one or more of those that he can tolerate. Why is your husband eating a vegan diet? Most of us here eat a low carb high fat (LCHF) diet which allows us to eat fish, bacon, eggs, red meat, chicken etc. My husband was diagnosed Type 2 about 2 years ago. He's always been very active (12 mile mountain bike ri Continue reading >>

Relief For Diabetes Stomach Pain

Relief For Diabetes Stomach Pain

Managing diabetes often brings changes in what we eat and the medications we take. You may also notice some changes in how your gut, or gastrointestinal (GI) tract, feels, sounds, and responds. Changes in eating You are likely making changes in eating habits, including more foods rich in fiber, such as fruits, vegetables, and beans. Fiber can be filling without adding unwanted calories, and it can help improve abnormal cholesterol levels. But there may be a few uh-ohs if you rapidly increase the amount you eat. "Gas and bloating are a side effect of fiber," says Judith Wylie-Rosett, Ed.D., R.D., professor of health promotion and nutrition research at Albert Einstein College of Medicine in Bronx, New York. "Increasing your intake gradually may help." She suggests adding legumes, such as beans and lentils, to increase dietary fiber. "Throwing out the water you soak them in and giving them an extra rinse before cooking may also help decrease the gas and bloating," she says. Glucose-lowering meds Several prescription medications used to lower blood glucose levels in type 2 diabetes can stir up your gut. Experts tend to suggest that you start with a low dose and slowly increase it based on your provider's instructions. Metformin Metformin, the typical starting medication in type 2 diabetes to bring blood glucose levels in range, can lead to heartburn, nausea, or diarrhea. Ralph DeFronzo, M.D., professor of medicine and chief of the diabetes division at the University of Texas Health Science Center at San Antonio, says, "I try to use metformin in all of my patients who have type 2 diabetes. When there is a problem, it is diarrhea and abdominal discomfort. There are 5-10 percent of people who just can't tolerate it." Typically, metformin is started at a low dose and increased Continue reading >>

Metformin~ Stomach Upset - 3 Fat Chicks On A Diet Weight Loss Community

Metformin~ Stomach Upset - 3 Fat Chicks On A Diet Weight Loss Community

3 Fat Chicks on a Diet Weight Loss Community Can someone please give me a little help with this problem? I am suppose to take 1000mg twice a day. When I take it this way I get terrible stomach upset. I try and break it down but then never get in all the dosage(i have 500mg tablets). I was thinking about taking something like pepto bismol before taking metformin. I do take it after eating but still feel ill when I take it. Hi CIRCLES . . . Sorry to hear you are having problems . . . Stomach problems are quite common with Metformin, especially at the beginning, but they usually tend to subside after the first month or so on the mediction. How long have you been taking Metformin? Many doctors start patients at a relatively low dosage and then have them increase it after the system becomes used to the lower amount. I would suggest that you call your doctor, or your pharmacist, to discuss the situation rather than attempting to take any kind of OTC medication with it. Thanks for the reply. I have been on Met for a little over a year now started on 500mg twice a day(1000mg). It was recently increased to 1000mg twice a day(2000mg). I did try and increase slowly, I even try to break it down to three times a day(missing a dose actually, the afternoon). It's when I try and take 1000mg at one time that I get sick from it. Maybe I can try and split a pill and take 750mg twice a day, but then again that's not 2000mg is it How about trying 750 for breakfast; 500 for lunch; and another 750 at dinner -- or even 500 mg, 4 times a day. I also take 2000 mg daily but have really not had any particular problems with doing the 1000 twice a day. If it were me, I'd be tempted to try the 500 four times (just to avoid having to split the pills). Be sure to eat something (even a glass of milk) w Continue reading >>

Stomach Pain Effect Of Metformin

Stomach Pain Effect Of Metformin

I occasionally had calf cramps that I did not associate with metformin. Yesterday, the muscles hardened in calves and thighs, the pain lasted 2 days. A muscle group in the left calf is still hard and cramps for a few minutes when getting up. My neck muscles are still hurting. I puked in pain and I was so dizzy that I fell over. I could barely breathe I also had unbearable stomach ache and my kidney area hurt a lot, also laterally in the back I was in pain and hardly got any air. I also did not see properly and had difficulty swallowing. I was so exhausted that I did not want to live anymore My endocrinologist prescribed metformin for insulin resistance. The first 2 days I had about 2 hours after taking to fight with latent nausea. The first 4 weeks when creeping in and then another 2 weeks after a dose increase, I had a bloating stomach. So far I did not know that, reminded me very much of a symptom of pancreatitis. I felt limp, had a sore stomach and was exhausted after the slightest stress (climbing stairs, shopping). After about 5-6 weeks my liver values (g-GT), which are already increased from 193 (norm 6-42) to 232, after 6 more weeks the g-GT was at 497! That was when my doctor and I unanimously decided to drop off Metformin again. As a side effect, we hoped that I would lose some weight, but unfortunately this has not been confirmed, on the contrary, I got after about 8 weeks more bingeing (I have an eating disorder) than before, so that 7 kg, which I had painstakingly removed had again been very fast on it. Nevertheless, I would recommend it to try, because there are many who have made good experiences with it. Metformin for Cholesterol value increase ; High blood pressure ; Diabetes mellitus type i Before taking without diagnosis of diabetes: tiredness, consta Continue reading >>

Does Metformin Cause Weight Loss? What To Know Before You Take It

Does Metformin Cause Weight Loss? What To Know Before You Take It

If you’re managing type 2 diabetes with metformin (Glucophage), you might be well acquainted with unwanted side effects of this drug — namely, upset stomach, diarrhea, muscle aches, and sleepiness. These can be a figurative and literal pain, but you might welcome one side effect of metformin with open arms, particularly if you’ve struggled to lose weight. Metformin isn’t a weight loss drug, but researchers have found a link between the drug and weight loss. In fact, a long-term study published in April 2012 in the journal Diabetes Care that was conducted by the Diabetes Prevention Program (DPP) concluded that the drug could serve as a treatment for excess body weight, although more studies are needed. What Is Metformin and How Does It Work? “[Metformin] has been considered a first-line medication in the treatment of type 2 diabetes, and it mainly acts by lowering the amount of glucose released by the liver,” says Minisha Sood, MD, an endocrinologist at Lenox Hill Hospital in New York City. “It also helps a hormone called insulin to work better by helping muscles use glucose in a more efficient manner. When insulin works better (and insulin sensitivity improves), a person’s insulin levels are lower than they would be otherwise.” There’s no cure for type 2 diabetes, but the right combination of medication and healthy lifestyle can stabilize blood sugar levels, which, of course, is the end goal of any diabetes treatment. As the medication helps your body properly metabolize food and restores your ability to respond to insulin, you’ll not only feel better, you can potentially avoid complications of high blood sugar, such as heart disease, kidney damage, nerve damage (diabetic neuropathy), and eye damage (retinopathy). Why Does Metformin Cause Weight Lo Continue reading >>

Metformin (oral Route)

Metformin (oral Route)

Precautions Drug information provided by: Micromedex It is very important that your doctor check your progress at regular visits, especially during the first few weeks that you take this medicine. Blood and urine tests may be needed to check for unwanted effects. This medicine may interact with the dye used for an X-ray or CT scan. Your doctor should advise you to stop taking it before you have any medical exams or diagnostic tests that might cause less urine output than usual. You may be advised to start taking the medicine again 48 hours after the exams or tests if your kidney function is tested and found to be normal. Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests. It is very important to carefully follow any instructions from your health care team about: Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team. Other medicines—Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems. Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur with lifestyle changes, such as changes in exercise or diet. Counseling on birth control and pregnancy may be needed because of the problems that can occur in pregnancy for patients with diabetes. Travel—Keep a recent prescription and your medical history with you. Be prepared for an emergency as you would norm Continue reading >>

Metformin (glucophage) Side Effects & Complications

Metformin (glucophage) Side Effects & Complications

The fascinating compound called metformin was discovered nearly a century ago. Scientists realized that it could lower blood sugar in an animal model (rabbits) as early as 1929, but it wasn’t until the late 1950s that a French researcher came up with the name Glucophage (roughly translated as glucose eater). The FDA gave metformin (Glucophage) the green light for the treatment of type 2 diabetes in 1994, 36 years after it had been approved for this use in Britain. Uses of Generic Metformin: Glucophage lost its patent protection in the U.S. in 2002 and now most prescriptions are filled with generic metformin. This drug is recognized as a first line treatment to control blood sugar by improving the cells’ response to insulin and reducing the amount of sugar that the liver makes. Unlike some other oral diabetes drugs, it doesn’t lead to weight gain and may even help people get their weight under control. Starting early in 2000, sales of metformin (Glucophage) were challenged by a new class of diabetes drugs. First Avandia and then Actos challenged metformin for leadership in diabetes treatment. Avandia later lost its luster because it was linked to heart attacks and strokes. Sales of this drug are now miniscule because of tight FDA regulations. Actos is coming under increasing scrutiny as well. The drug has been banned in France and Germany because of a link to bladder cancer. The FDA has also required Actos to carry its strictest black box warning about an increased risk of congestive heart failure brought on by the drug. Newer diabetes drugs like liraglutide (Victoza), saxagliptin (Onglyza) and sitagliptin (Januvia) have become very successful. But metformin remains a mainstay of diabetes treatment. It is prescribed on its own or sometimes combined with the newer d Continue reading >>

Surviving Metformin

Surviving Metformin

What was your first week on Metformin like? Horrendous? Terrible? Filled with waves of nausea? The sickest you’ve felt in your life? Let’s reminisce for a minute: About a dozen years ago, on December 24, I went to the doctor for a routine physical. Are you envious of my holiday plans? This was in the years before Pinterest, so I was carrying on with regular life activities on Christmas Eve morn rather than bedazzling the cap of an Elf on the Shelf. Anyway, at the Christmas Eve check-up, my physician mentioned that he had read promising things about Metformin being used in women with PCOS. We chatted about Metformin for a bit, talked about other PCOS things, finished up the tests, and then I headed to the pharmacy to pick up the prescription. We had our traditional Christmas Eve dinner of ham, funeral potatoes, salad with asparagus and strawberries; rolls, and other delicious items. Breaking with tradition, this year’s Christmas Eve dinner was followed by Metformin for me. After dinner, we read the Christmas story from the Bible, watched a short film depicting the events in Luke 2, read a new Christmas book, and headed off to bed. That’s when the fun began. In sum: Worst Christmas Ever. Pros: Family, friends, gifts, good music, good food. Cons: Visiting the loo every 15 minutes, constant nausea, wanting to curl up in bed and not wake up for days. Public Service Announcement: Do not start Metformin for the first time on the day prior to a major holiday. My first year on Metformin was pretty rough. I felt like I had morning sickness every single day. I had diarrhea and nausea every morning. When I skipped a few doses hoping for relief, my symptoms would be twice as bad when I re-started. Looking back, I’m actually amazed that I kept taking the medication. If I st Continue reading >>

Metformin And The Gastrointestinal Tract

Metformin And The Gastrointestinal Tract

Go to: Introduction Metformin—dimethylbiguanide—is an oral glucose-lowering agent. Its origins can be traced to Galega officinalis, also known as French lilac or goat’s rue [1]. In the early 20th century it was noted to lower blood glucose concentrations in animals, but it was not until the 1950s that Jean Sterne studied dimethylbiguanide and subsequently developed ‘Glucophage’ [2]. Over the last 15 years, metformin has become the first-line agent for the treatment of type 2 diabetes, as noted in several international guidelines, including the ADA-EASD guidelines [3]. Metformin has had a chequered history—it was initially eclipsed by phenformin, which was withdrawn in the late 1970s after it was discovered to be associated with lactic acidosis [4]. The lower propensity of metformin for hyperlactataemia [5] and success in several large randomised controlled clinical trials, such as the UK Prospective Diabetes Study (UKPDS) [6], confirmed its clinical benefit. It is widely recognised that metformin improves glycaemic control with a good safety profile, weight neutrality or weight loss, lack of associated hypoglycaemia, reduced cardiovascular mortality and low cost [3]. However, a large proportion of patients cannot tolerate the medication in adequate amounts because of its associated side effects. Up to 25% of patients suffer metformin-associated gastrointestinal (GI) side-effects, with approximately 5% unable to tolerate metformin at all [7]. In addition to this interindividual variation in side effects, there is variability in the efficacy of metformin. There are likely to be a number of factors to account for this variability in efficacy, for example, our group (Zhou et al) recently established that the glycaemic response to metformin is moderately heritabl Continue reading >>

Metformin And The Stomach Issues That Go Along W... | Diabetic Connect

Metformin And The Stomach Issues That Go Along W... | Diabetic Connect

A friend told me something that was really helpful: Metformin needs LARGE amounts of water and HATES anything buttery or greasy. That's helped me out a LOT when dealing with the fun side-effects of Met. However, I will say that I ended up having to a slow-step-up on my Met dosage (I cut the pills in half and took basically a half-dose for about 2 weeks before going to a 3/4 dose for another week then finally going to a full dose/day [2 pills]). I still have some problems, but not nearly what I was having and only when I eat certain foods. That list you're on is kind of insane, but I hope it works for your BGs. I'm starting Junuvia on Sunday with the Met. Will let ya know how it goes. They made a wholesale change in my meds yesterday. They took me off of the Invokamet and put me on Invokana and Metformin plus a once a week shot called Trulicity. And added Crestor and something for triglycerides. I find that getting adequate FIBER at least 20 grams a daymore if you candoes a great deal to mitigate the GI effects of Metfartin. I still get the fart attacks now and then, but not the explosive problem you are probably having at the moment. I am with these guys, I believe your stomach trouble will eventually calm down. I had that trouble to at first, I think most people do when they start metformin . It can frequently take a couple of weeks to adjust. If you find that it is to difficult to continue, maybe you can have your doctor temporarily lower your dose. Depends on what dosage you were started at. Stomach issues were immediate for me when I started taking it. After maybe 2 months I somewhat adjusted and switched over to the XR version. Took myself off of it in August because of the massive, massive hair loss it cursed me with. I went through the same thing you are going t Continue reading >>

Metformin Side Effects And How To Deal With Them

Metformin Side Effects And How To Deal With Them

Metformin side effects include diabetic neuropathy, brain fog, and digestive issues. You can address them through diet, Vitamin B12, CoQ10, and exercise. Let us understand the drug Metformin in detail and study different forms of metformin, its uses and common metformin side effects along with how to deal with them. Metformin: What Is It Used For? Metformin is an old warhorse in the pharma battle against diabetes. It has been the mainstay in the treatment of Type 2 Diabetes for more than fifty years, often matching or outperforming newer drugs. In fact, many new combination drugs are often created with metformin as one of the main ingredients. Thanks to its long run in the pharmaceutical world, the side effects of Metformin are also well known. The Metformin-PCOS connection has been studied extensively since a majority of health complications associated with PCOS (polycystic ovarian syndrome) are due to hyperinsulinemia (high amounts of insulin in the blood stream). Metformin is known to reduce circulating insulin levels. The use of this drug in women with PCOS has shown highly encouraging results. RELATED: 10 Easy Breakfast Ideas For Diabetics Most Prescribed Names in Metformin Category Include: Fortamet: It is an extended-release formulation that contains metformin hydrochloride. The tablets are designed for once-a-day administration. They deliver either 500 mg or 1000 mg of metformin. The tablet is made using a patented technology called SCOTTM that delivers the active compound slowly and at a constant rate. Glucophage: Glucophage tablets contain metformin hydrochoride. They contain either 500 mg, 850 mg or 1000 mg of the active compound. Glucophage tablets do not contain any special covering and need to be taken multiple times a day until the prescribed dosage is me Continue reading >>

More in diabetes