Metformin And Mood Swings Please Help
Hello and Blessings everyone. Can anyone offer me insight to this Metformin and mood swings. I swear since my first dose It gives me such a feeling of being on edge. I BECAME SO MOODY. I take 500mg 2x a day. Has anyone else had this happen? Please advise so I know I am not going crazy. It does not state mood changes or anything close to it in the caution information. Re: Metformin and MOOD SWINGS please help Lactic acidosis is the one dangerous side effects, with symptoms such as: weakness, aching muscles, trouble breathing, dizziness or unexplained stomach upset. Possible side effects are allergic reaction: breathing trouble, feeling that your throat is closing, swelling of lips or face, or hives. Other less serious side effects that are more usual are nausea, vomiting, diarrhea, bloating, excessive gas, and appetite changes. These symptoms usually go away after the first few weeks. There may be something else going on. Are you newly diagnosed? If you are, you may be depressed or anxious about having diabetes. If you're not newly diagnosed, maybe you are anxious or depressed about something else. If you are depressed or anxious for more than one week, you may want to consult your doctor. Re: Metformin and MOOD SWINGS please help It could be the diabetes itself causing the mood swings. Talk with the doctor about this possibility. Good luck. Re: Metformin and MOOD SWINGS please help I am also on Metformin 500mg 2x a day but i am also in menopause and I know that is causing my mood swings. Re: Metformin and MOOD SWINGS please help I take Metformin 500 mgs 2x a day and I don't get any mood swings. I would check for hormone problems like menopause or hormone deficiencies. I am taking progesterone now since January of this year as I wasn't making enough hormone to shed my u Continue reading >>
Personality And Behavior Changes
By Michael B. First, MD, Department of Psychiatry, Columbia University; Division of Clinical Phenomenology, New York State Psychiatric Institute Healthy people differ significantly in their overall personality, mood, and behavior. Each person also varies from day to day, depending on the circumstances. However, a sudden, major change in personality and/or behavior, particularly one that is not related to an obvious event (such as taking a drug or losing a loved one), often indicates a problem. Changes in personality and behavior can be roughly categorized as one of the following: These categories are not disorders. They are just one way doctors organize different types of abnormal thought, speech, and behavior. These changes in personality and behavior can be caused by physical or mental health problems. People may have more than one type of change. For example, people with confusion due to a drug interaction sometimes have hallucinations, and people with mood extremes may have delusions. Confusion and delirium refer to a disturbance of consciousness. That is, people are less aware of their environment and, depending on the cause, may be excessively agitated and belligerent or drowsy and sluggish. Some people alternate between being less alert and being overly alert. Their thinking appears cloudy and slow or inappropriate. They have trouble focusing on simple questions and are slow to respond. Speech may be slurred. Often, people do not know what day it is, and they may not be able to say where they are. Some cannot give their name. Delusions are fixed false beliefs that people hold despite evidence against those beliefs. Some delusions are based on a misinterpretation of actual perceptions and experiences. For example, people may feel persecuted, thinking that a perso Continue reading >>
The Many Faces Of Metformin
In 2004, Clifford Bailey of the Diabetes Group from Aston University in Birmingham, United Kingdom described metformin, the most widely prescribed drug for treating diabetes, as ironic: In our high-tech era of drug discovery and development this first-line treatment for type 2 diabetes is little removed from an herbal remedy of the Middle Ages. Despite its chemical simplicity and detailed investigation, metformin continues to evade a complete exposé of its cellular activity (Pract Diab Int April 2004 Vol.21 No. 3) Now, almost a decade later, a team led by Morris Birnbaum, M.D., Ph.D. from the Institute for Diabetes, Obesity and Metabolism, is getting closer to a clear picture of how this drug works, which, in addition to its widespread use for diabetes, is being tested for treating dementia and cancer. The Birnbaum lab and colleagues found that metformin works in a different way than previously understood. They found that in mice it suppresses the liver hormone glucagon’s ability to generate an important signaling molecule, which points to new drug targets. For fifty years, one of the few classes of therapeutics effective in reducing the overactive glucose production associated with diabetes has been the biguanides, which includes metformin. The inability of insulin to keep liver glucose output in check is a major factor in the high blood sugar of type 2 diabetes and other diseases of insulin resistance. “Overall, metformin lowers blood glucose by decreasing liver production of glucose,” says Birnbaum. “But we didn’t really know how the drug accomplished that.” Birnbaum’s Nature study describes a novel mechanism by which metformin antagonizes the action of glucagon, thus reducing fasting glucose levels. The team showed that metformin leads to the accumula Continue reading >>
Is Personality Change A Side Effect Of Metformin (meformin) ? ( Factmed.com )
Introduction This page is designed to help you determine the relationship, if any, between METFORMIN (MEFORMIN) and PERSONALITY CHANGE. In doing so, we compare METFORMIN (MEFORMIN) with other drugs that cause PERSONALITY CHANGE, to help you evaluate whether or not METFORMIN (MEFORMIN) causes PERSONALITY CHANGE. Likewise, this page shows the most highly-reported side effects of METFORMIN (MEFORMIN), so you can see if PERSONALITY CHANGE ranks among METFORMIN (MEFORMIN)'s most well-known side effects. Reports of METFORMIN (MEFORMIN) causing PERSONALITY CHANGE: 1 Reports of any side effect of METFORMIN (MEFORMIN) : 1 Percentage of METFORMIN (MEFORMIN) patients where PERSONALITY CHANGE is a reported side effect: 100.0000% FDA reports of any drug causing PERSONALITY CHANGE : 3932 Average percentage for all medicated patients where PERSONALITY CHANGE is reported as a complication: 0.0246% Physician opinion on METFORMIN (MEFORMIN) as adverse event culprit: Overall opinion for all reports of this drug: Most frequent diagnoses/indications for prescribing METFORMIN (MEFORMIN): My husband's personality has changed severely since he's had been taking metformin. He went from an introvert to a complete jerk. Loud, loss of control over eating, thought pattern is skewed, irresponsible, dies not want to be held accountable, excessive gambling. What other medicine can he take to replace metformin? My husband has had the same side effects!! Loud ,obnoxious, extremely mean person, Gamble's. Arrogant to everyone. He is very difficult to live with. My husband has had the same side effects!! Loud ,obnoxious, extremely mean person, Gamble's. Arrogant to everyone. He is very difficult to live with. My husband has been taking this medicine for years now and has developed multiple personalities a Continue reading >>
Has Anyone Had A Psychiatric Response To Metformin?
Has anyone had a psychiatric response to Metformin? New Member Diagnoses Metabolic Syndrom or Pre-Diabetes not sr Has anyone had a psychiatric response to Metformin? When I was taking Metformin for a bit over two weeks I was having this horrible aggresion, anger, hostility, just this horrible horrible mood. At the same time I had increased a beta blocker called Betaxolol. I was not sure if one of the other caused this awful mood in me so I stopped them both the same night and the next day Ifelt better that quick. I've since gone back on the beta blocker and the moods have not returned, so wondering how can Metformin cause me to react that way. I did check my BS during those times and for the most part it was in the 90's or slightly higher depending on what I had eaten. Idont know what happened to me, not sure if it didnt mix wiht the beta blocker or what. I should of stopped one at a time to see but I messed up. Now Iwant to go backon the metformin especially after today seeing my fasting back up to 99 and to 114 an hour after that without eating...and 3 hours after a mcdonalds egg mcmuffin it was still at 112, so was really bummed at that too....shows me that Met was really helping in just that short of time. I read alot of people say they felt better on it but I dont know what that means cause I didnt feel any better but my numbers were great! So just wondering if anyone felt crazy with Met..thanks! D.D. Family Getting much harder to control Some report anger just with higher bs numbers, having your bs out of sorts puts the whole body that way. When I was very high I was very angry and I do mean very angry but more at myself and sometimes at others. When I got my bs down to the 200 level it got better, my sugar for along time ran in the 300s and 400s so 200s seem pre Continue reading >>
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Metformin And Agression?
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community can I ask whether any one taking misinform have ever had any side effect relating to aggression? recently diagnosed as type 2 my GP has been upping my metformin until I am taking 4-5 per day, over the past couple of days however I have noticed that for no or very little reason I experience what I can only describe as pure rage...there is no 'build up' to this feeling and it seems to go the same way! I have an appointment in an hour or so and I know that he will up the dose from 3 to 4 today because the upset stomach is not as ofter now! ...I am worried in case it is the medication that is causing this and wanted to ask whether that could be the case? sorry Moonfruit but I have never had aggressive feelings that I can put down to the metformin. When I was first diagnosed I used to get feels of rage inexplicably but I felt it was caused by the underlying stress from the diabetes diagnosis. As I have come to grips with everything over the last year or so and reduced the metformin (less loo dashes) I don't have the same intensity of feelings and back to my normal self (character wise anyway!) Hi moonfruit, have you been given decent advice about your diet? I don't mean the usual 'eat starchy foods with every meal' crap. I mean reduce your carbs etc. As you are recently diagnosed Truffle is right about the anger you may feel about having diabetes, it does do that. Most GP's tend to think that only way to control diabetes is by medicating, to be honest it takes your control away, and this can be frustrating in itself. I take the maximum daily dose of Metformin and I am probably one of the most chilled people there is. What are you BG's like? If they are hig Continue reading >>
Interactions Between Glipizide-metformin Oral And Selected-antidiabetics-maois
1.Cooper AJ, Keddie KMG. Hypotensive collapse and hypoglycaemia after mebanazine -- a monoamine-oxidase inhibitor. Lancet 1964 May 23;1:1133-5. 2.Cooper AJ, Ashcroft G. Potentiation of insulin hypoglycaemia by M.A.O.I. antidepressant drugs. Lancet 1966 Feb 19;1(7434):407-9. 3.Cooper AJ. The action of mebanazine, a mono amine oxidase inhibitor antidepressant drug in diabetes. II. Int J Neuropsychiatry 1966 Aug; 2(4):342-5. 4.Cooper AJ, Ashcroft G. Modification of insulin and sulfonylurea hypoglycemia by monoamine- oxidase inhibitor drugs. Diabetes 1967 Apr; 16(4):272-4. 5.Adnitt PI. Hypoglycemic action of monoamineoxidase inhibitors (MAOI'S). Diabetes 1968 Oct;17(10):628-33. 6.Absher JR, Black DW. Tranylcypromine withdrawal delirium. J Clin Psychopharmacol 1988 Oct;8(5):379-80. 7.Ramsay RR, Dunford C, Gillman PK. Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. Br J Pharmacol 2007 Nov;152(6):946-51. 8.Peter C, Hongwan D, Kupfer A, Lauterburg BH. Pharmacokinetics and organ distribution of intravenous and oral methylene blue. Eur J Clin Pharmacol 2000 Jun;56(3):247-50. 9.Aleyassine H, Gardiner RJ. Dual action of antidepressant drugs (MAO inhibitors) on insulin release. Endocrinology 1975 Mar;96(3):702-10. 10.Aleyassine H, Lee SH. Inhibition of insulin release by substrates and inhibitors of monoamine oxidase. Am J Physiol 1972 Mar;222(3):565-9. 11.Aleyassine H, Lee SH. Inhibition by hydrazine, phenelzine and pargyline of insulin release from rat pancreas. Endocrinology 1971 Jul;89(1):125-9. Continue reading >>
Will You Have Personality Change With Metformin - From Fda Reports - Ehealthme
A study for a 41 year old woman who takes Gabapentin NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk. You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088). If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Continue reading >>
Long-term Safety, Tolerability, And Weight Loss Associated With Metformin In The Diabetes Prevention Program Outcomes Study
Long-Term Safety, Tolerability, and Weight Loss Associated With Metformin in the Diabetes Prevention Program Outcomes Study The Diabetes Prevention Program Research Group* Corresponding author: Diabetes Prevention Program Coordinating Center, [email protected] . A slide set summarizing this article is available online. Received 2011 Jul 8; Accepted 2011 Dec 20. Copyright 2012 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See for details. This article has been cited by other articles in PMC. Metformin produced weight loss and delayed or prevented diabetes in the Diabetes Prevention Program (DPP). We examined its long-term safety and tolerability along with weight loss, and change in waist circumference during the DPP and its long-term follow-up. The randomized double-blind clinical trial of metformin or placebo followed by a 78-year open-label extension and analysis of adverse events, tolerability, and the effect of adherence on change in weight and waist circumference. No significant safety issues were identified. Gastrointestinal symptoms were more common in metformin than placebo participants and declined over time. During the DPP, average hemoglobin and hematocrit levels were slightly lower in the metformin group than in the placebo group. Decreases in hemoglobin and hematocrit in the metformin group occurred during the first year following randomization, with no further changes observed over time. During the DPP, metformin participants had reduced body weight and waist circumference compared with placebo (weight by 2.06 5.65% vs. 0.02 5.52%, P < 0.001, and waist circumference by 2.13 7.06 cm vs. 0.79 6.54 cm, P < 0.001 in metformin v Continue reading >>
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Metformin And Anger/aggression
If this is your first visit, be sure tocheck out the FAQ by clicking thelink above. You may have to register before you can post: click the register link above to proceed. To start viewing messages,select the forum that you want to visit from the selection below. Anybody had Metformin cause anger, aggression, or severe impatience? I used to take Metformin a year or 2 ago, stopped when I hit a plateau, and wanted to go "natural" . So I tried to start up again last week, and I have been so MEAN! Can't stand my coworkers or DH, can barely tolerate DS, and feel like hitting perfect strangers in the supermarket. Had to quit cuz that is no way to treat people, and am starting to come back down. Does met do this? BTW, doc appt. next week, with all new bloodwork, so maybe she will have something to help. Good vibes/prayers appreciated. PCOS, IBS, Clinical Depression, Lyme Disease, allergies trying to go natural, down to 1 script, 1 OTC(love u Zyrtec!) and lots of vitamins I think it may. I seem to have some similar symptoms. It seems to just be in the evenings for me. I am a little over sensative. Especially when I am hungry, or tired, or both. I have not seen it as a symptom anywhere. Maybe it is just the hormone changes it is causing and is not a direct symptom of met. ME~34~ Hidden Content ~husband Hidden Content 41~ I took some time for myself to get healthy. I lost 50lbs and cured most of my pcos symptoms! Only problem left high testosterone and irregular periods. Currently taking 1500mg metformin baby asprin Folbic and a prenatal with DHA. So far the Met has regulated my period and I'm O'ing!!!! Dh has low count 10 million and low morphology. He's taking vitamin E Folbic and a perscription multi vitamin. I've read somewhwere that mild hypoglycemia can be characterised by Continue reading >>
Can Metformin Cause Personality Changes?
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Drug information provided by: Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Abdominal or stomach discomfort cough or hoarseness decreased appetite diarrhea fast or shallow breathing fever or chills general feeling of discomfort lower back or side pain muscle pain or cramping painful or difficult urination sleepiness Less common Anxiety blurred vision chest discomfort cold sweats coma confusion cool, pale skin depression difficult or labored breathing dizziness fast, irregular, pounding, or racing heartbeat or pulse feeling of warmth headache increased hunger increased sweating nausea nervousness nightmares redness of the face, neck, arms, and occasionally, upper chest seizures shakiness shortness of breath slurred speech tightness in the chest unusual tiredness or weakness wheezing Rare Behavior change similar to being drunk difficulty with concentrating drowsiness lack or loss of strength restless sleep unusual sleepiness Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Acid or sour stomach belching bloated excess air or gas in the stomach or intestines full feeling heartburn indigestion loss of appetite metallic taste in the mouth passing of gas stomachache stom Continue reading >>
Interactions Between Glipizide-metformin Oral And Antidiabetics-oral-aspirin-81-mg-salicylates
Can Diabetes Affect Your Mood?
My husband has type 2 diabetes, which is now being controlled by medicine. I find that he is sometimes particularly irritable or even mean, which is very out of character for him. Is this common with type 2 diabetes, or with high or low readings? — Sally, Florida It is great that you are seeking a better understanding of your husband’s illness. Diabetes is a disease that not only affects individuals but also those close to them. As a result, those who have good family support in the care of their diabetes do much better in managing their illness. There are a few reasons for behavioral changes like those you see in your husband among people with diabetes. One is the effect of abnormally low glucose levels in the bloodstream. The other reason is depression, which can be triggered by the diagnosis of diabetes, the burden of daily management, and fear of complications. Low glucose levels can cause symptoms including impaired judgment, anxiety, moodiness, belligerence, fatigue, apathy, confusion, dizziness, blurred vision, and a lack of coordination. I would advise your husband to check his sugar levels at the times when he is irritable. If his mood is indeed due to low glucose levels, the symptoms will improve if he raises his blood sugar, for example, by drinking orange juice or taking glucose tablets. It is also important to consult with his doctor to adjust his medicines or dietary intake. On the other hand, your husband’s irritability can be a manifestation of depression. Many people with depression are undiagnosed and thus do not receive the necessary counseling and treatment. Also, depression symptoms vary from person to person, which can make it difficult to diagnose. Signs such as lack of sleep, overeating or lack of appetite, poor concentration, and other sym Continue reading >>
Stroke Survivor: Metformin Warning.
When I was first hospitalised with a stroke, some of the tests they did were for diabetes. Stroke and heart problems are often associated with uncontrolled diabetes. In my case, it seems that I had been an undiagnosed 'skinny type 2' diabetic for some years. How that is diagnosed, and the differences between type 1 and type 2 diabetes and how that can lead to stroke is for another post. For the purposes of this post, I'd like to post a little warning about the treatment of diabetes, and how it can negatively impact stroke care. To control the diabetes, I was prescribed Metformin, a very effective treatment. Getting the dosage right takes some time. Lots of self testing and blood average blood sugar level tests (Hba1c), liver and kidney function tests. I take 500 mg tablets three times a day. There is, however, a little known side effect with Metformin. B12 deficiency. It's by no means inevitable, or common, but effectively, the longer you take it, and the higher the dosage of Metformin,, (Or Metfartin, as users call it) the more likely B12 deficiency. The problem is that B12 deficiency mimics many of the problems with uncontrolled diabetes and stroke, in particular, pain in fingers and toes (and yup, even if you have weakness, lack of feeling or paralysis through stroke, you can get pain) Lack of feeling or pins and needles in extremities, confusion, certain forms of psychosis and personality changes - for instance feeling a need for isolation or being unusually bad tempered.... I've had no extreme symptoms, but my recent blood tests have thrown up large, badly formed blood cells, so I'm being investigated for various B12 deficiency problems. I'm fairly confident that the Metformin is the culprit. I've deliberately avoided going into depth here because of time constrai Continue reading >>