Metformin Weight Loss – How It Works, Benefits, And Side Effects
Do you find it extremely difficult to refrain from eating all the time? Have you gained too much weight? Or did your doctor just tell you that you have polycystic ovaries? If you answered “yes” to any one of these questions, chances are your body is resistant to insulin. According to the National Institute of Diabetes and Digestive and Kidney Diseases, insulin resistance can lead to diabetes type 2, prediabetes, and infertility. This can take a toll on your physical and emotional health (1). To counteract these health problems, doctors often prescribe the drug Metformin. This drug has helped many to lose weight and improve insulin sensitivity, and it can definitely help you too. So, read on to find out how Metformin can help you lose weight, the dosage, side effects, and much more. What Is Metformin? Metformin is a drug that helps to control the blood glucose levels. It is a derivative of biguanide (a group of drugs that prevent the production of glucose by the liver) that helps to improve insulin sensitivity, thereby reducing the sugar levels in the blood and the risk of diabetes type 2. It also helps regulate the amount of sugar absorbed in the intestine. Metformin was first synthesized in the 1920s. But only in 1957, it was made available in the market as an effective antidiabetic drug. It is generally sold under the brand name Glucophage and is taken orally. It is taken by people who are obese and at the risk of developing diabetes type 2 and by women who have irregular periods and are at a risk of PCOs and infertility (2). So, how does Metformin aid weight loss? Find out next. Metformin And Weight Loss – How It Works ? In obese individuals, metformin acts by suppressing the production of sugar by the liver. It reduces the rate of gluconeogenesis and glycogeno Continue reading >>
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Must I Increase My Dose Of Metformin To Lose Weight?
Weight loss is an integral aspect of improving Polycystic Ovarian Syndrome, or PCOS, in women who are overweight. Carrying extra weight can cause the condition’s symptoms to become more severe, and can even increase the level of Insulin Resistance (IR) that a woman experiences.1 IR occurs when the body’s cells become desensitized to insulin, preventing the hormone from turning glucose into energy. This results in high blood sugar and, in some cases, diabetes. For this reason, Metformin, a popular diabetes medication, is also used to improve PCOS. Aside from regulating blood sugar levels, this pharmaceutical, also known as Glucophage, contributes to weight loss. How Metformin Encourages PCOS Weight Loss Insulin is a hormone that triggers both hunger and the production of fat cells. Therefore, by reducing insulin, women can reduce the amount of food they eat as well as the amount of fat cells that their bodies produce.2 Metformin’s primary function is to reduce insulin, so it is only natural that this medication contributes to weight loss. How Much Medication Is Necessary? Dosage is determined by several factors; healthcare professionals consider medical history, body type, and severity of symptoms when coming to the proper dosage. Metformin comes in three different sized pills: 500 mg, 850 mg, and 1,000 mg.2 Generally, individuals are prescribed between 850 and 1,000 mg two times per day, with 850 mg three times per day being the maximum amount of the medication safe to consume.2 Typically, doctors will prescribe a low dose to gauge the body’s reaction to the medication.2 If the body needs more, physicians will alter the dosage until the right amount is achieved. Because so many factors contribute to the proper dosage, many women who are prescribed different amou Continue reading >>
Pcos Strategies: Will I Lose Weight With Metformin?
Weight loss is important for women who are fighting Polycystic Ovarian Syndrome, or PCOS, because excess weight can cause complications that make this condition worse.1 This disorder is often accompanied by Insulin Resistance, which can lead to weight gain because it causes excess blood sugar and insulin to float through the bloodstream.1 Therefore, PCOS weight loss is an important part of improving this condition. Can Medication Contribute to Weight Loss? PCOS drugs are designed to address the core issues of the condition: Insulin Resistance and a hormonal imbalance. One of these drugs, Metformin, actually causes women to lose weight. Also known as Glucophage, this pharmaceutical promotes weight loss at a price; the side effects that are associated with this medication range from mild to severe. In an effort to lose weight, PCOS sufferers may take this drug anyway. The Risk Involved Metformin poses many risks, which commonly include:2 Increased sweating and thirst Muscle pain Fever Chills Weakness Heart palpitations Lightheadedness Dizziness Difficulty breathing Abnormal stools Nail problems Flushing (this occurs when the skin, particularly that of the face, turns red) Additional risks, such as allergic reactions, kidney and liver failure, and electrolyte disturbances, may also occur.2 While these side effects are dangerous, the benefits of the pharmaceutical sometimes outweigh the risks, depending upon individual circumstances. Losing Weight the Healthy Way Although taking Metformin can contribute to weight loss, it is not the only way in which women can shed excess pounds to improve their health. Achieving healthy, sustainable weight loss is the goal of many women who have PCOS, so losing weight in the proper manner is important. While this drug may contribute to wei Continue reading >>
Will Metformin Help Me Lose Weight?
Weight loss is an integral aspect of improving Polycystic Ovarian Syndrome, or PCOS, in women who are overweight. Carrying extra weight can cause the condition’s symptoms to become more severe, and can even increase the level of Insulin Resistance (IR) that a woman experiences.1 IR occurs when the body’s cells become desensitized to insulin, preventing the hormone from turning glucose into energy. This results in high blood sugar and, in some cases, diabetes. For this reason, Metformin, a popular diabetes medication, is often prescribed for PCOS. Aside from regulating blood sugar levels, this pharmaceutical, also known as Glucophage, is thought to contribute to weight loss. How Metformin Encourages PCOS Weight Loss Insulin is a hormone that triggers both hunger and the production of fat cells. Therefore, by reducing insulin, women can reduce the amount of food they eat as well as the amount of fat cells that their bodies produce.2 Metformin’s primary function is to reduce insulin, so it is only natural that this medication contributes to weight loss. How Much Medication Is Necessary? Dosage is determined by several factors; healthcare professionals consider medical history, body type, and severity of symptoms when coming to the proper dosage. Metformin comes in three different sized pills: 500 mg, 850 mg, and 1,000 mg.2 Generally, individuals are prescribed between 850 and 1,000 mg two times per day, with 850 mg three times per day being the maximum amount of the medication safe to consume.2 Typically, doctors will prescribe a low dose to gauge the body’s reaction to the medication.2 If the body needs more, physicians will alter the dosage until the right amount is achieved. Because so many factors contribute to the proper dosage, many women who are prescribed d Continue reading >>
Polycystic Ovary Syndrome: Is Metformin (glucophage) The Magic Pill For Losing Weight With Pcos?
Do you have Polycystic Ovary Syndrome and are you struggling with your weight? You'll no doubt have heard that Metformin (Glucophage) can help you out. It's positive effects stretch far beyond weight loss, but is Metformin right for you? Do you suffer from Polycystic Ovary Syndrome and are you obese, as around 44 percent of women with the condition are ? You can't have missed the multitude of reasons to try to lose weight, ranging from improved insulin and androgen levels, higher self-esteem, and improved fertility , to better odds of success during fertility treatments  and a lower risk of developing type 2 diabetes . While there is evidence to suggest that a low glycemic index diet, the best diet plan for PCOS sufferers, is your optimal dietary ticket to weight loss, you may still find that losing weight with PCOS is easier said than done. That is, for many women, where the medication Metformin (Glucophage) comes in — any woman looking for PCOS weight loss solutions online will quickly come across the suggestion to try Metformin to lose weight. Is Glucophage really the magic pill for losing weight with PCOS, and what else could the drug do for you? Metformin is, primarily, a medication prescribed to people suffering from non-insulin-dependent (type 2) diabetes that doesn't respond to dietary modifications. It decreases intestinal absorption of glucose and improves insulin sensitivity.  Glucophage was first used on PCOS patients in order to discover what role insulin resistance played in the development of Polycystic Ovary Syndrome . Subsequent studies found that the drug had potent positive effects on women with PCOS. Not only was Metformin found to be an effective weight loss medication in women suffering from Polycystic Ovary Syndrome, it was add Continue reading >>
Metformin And Weight Loss In Obese Women With Polycystic Ovary Syndrome: Comparison Of Doses
Context: Metformin treatment of women with polycystic ovary syndrome (PCOS) is widespread, as determined by studies with diverse patient populations. No comparative examination of weight changes or metabolite responses to different doses has been reported. Objective: The aim of this study was to determine whether different doses of metformin (1500 or 2550 mg/ d) would have different effects on body weight, circulating hormones, markers of inflammation, and lipid profiles. Design: The study included prospective cohorts randomized to two doses of metformin. Setting: The study was performed at a university teaching hospital with patients from gynecology/endocrinology clinics. Patients: The patients studied were obese (body mass index, 30 to <37 kg/m2; n = 42) and morbidly obese (body mass index, ≥37 kg/m2; n = 41) women with PCOS. Intervention: Patients were randomized to two doses of metformin, and parameters were assessed after 4 and 8 months. Main Outcome Measures: The main outcome measures were changes in body mass, circulating hormones, markers of inflammation, and lipid profiles. Results: Intention to treat analyses showed significant weight loss in both dose groups. Only the obese subgroup showed a dose relationship (1.5 and 3.6 kg in 1500- and 2550-mg groups, respectively; P = 0.04). The morbidly obese group showed similar reductions (3.9 and 3.8 kg) in both groups. Suppression of androstenedione was significant with both metformin doses, but there was no clear dose relationship. Generally, beneficial changes in lipid profiles were not related to dose. Conclusion: Weight loss is a feature of protracted metformin therapy in obese women with PCOS, with greater weight reduction potentially achievable with higher doses. Additional studies are required to determine wh Continue reading >>
Metformin Weight Loss – Does It Work?
Metformin weight loss claims are something that are often talked about by health professionals to be one of the benefits of commencing metformin therapy, but are they true? At myheart.net we’ve helped millions of people through our articles and answers. Now our authors are keeping readers up to date with cutting edge heart disease information through twitter. Follow Dr Ahmed on Twitter @MustafaAhmedMD Metformin is possibly one of the most important treatments in Type II Diabetes, so the question of metformin weight loss is of the utmost importance, as if true it could provide a means to lose weight as well as control high sugar levels found in diabetes. What is Metformin? Metformin is an oral hypoglycemic medication – meaning it reduces levels of sugar, or more specifically glucose in the blood. It is so effective that the American Diabetes Association says that unless there is a strong reason not to, metformin should be commenced at the onset of Type II Diabetes. Metformin comes in tablet form and the dose is gradually increased until the maximum dose required is achieved. How Does Metformin Work & Why Would it Cause Weight Loss? Metformin works by three major mechanisms – each of which could explain the “metformin weight loss” claims. These are: Decrease sugar production by the liver – the liver can actually make sugars from other substances, but metformin inhibits an enzyme in the pathway resulting in less sugar being released into the blood. Increase in the amount of sugar utilization in the muscles and the liver – Given that the muscles are a major “sink” for excess sugar, by driving sugar into them metformin is able to reduce the amount of sugar in the blood. Preventing the breakdown of fats (lipolysis) – this in turn reduces the amount of fatt Continue reading >>
Metformin As An Initial Adjunct To Low-dose Liraglutide Enhances The Weight-decreasing Potential Of Liraglutide In Obese Polycystic Ovary Syndrome: Randomized Control Study
Go to: Introduction Obesity is not intrinsically associated with PCOS, yet the risk of obesity is ≥2.8-fold higher in women with PCOS, compared with women without PCOS, with an estimated prevalence of 49% (1). The quantity and distribution of fat is a major contributor to the severity of PCOS (2,3). Weight reduction in the individuals with the highest weight should be an important treatment target when PCOS is associated with obesity (4–6). However, weight-independent treatment targets that are intrinsically associated with the syndrome should also be involved in initial treatment of obese patients with PCOS. Recent clinical practice guidelines recommend lifestyle modification as the first line of intervention (7) in obese patients with PCOS, although the treatment goals with lifestyle intervention are usually challenging to achieve, and non-sustainable in everyday life. The glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide (LIRA) at a dose of 3 mg daily was recently approved as an anti-obesity drug. Randomized placebo-controlled and active-comparator studies have demonstrated that LIRA is able to increase weight loss among overweight and obese patients in a dose-dependent manner with once-daily doses of 1.2–3.0 mg (8,9). The proportion of patients experiencing 5–10% weight loss was higher following treatment with LIRA compared with placebo and orlistat treatment (9). Higher doses of ≥3 mg daily are more effective compared with lower doses, although this increase in efficacy occurs with decreased tolerability, a higher frequency of side effects and higher costs (10). These data support the potential benefit of LIRA among overweight and obese patients with prediabetes. The efficacy of LIRA in obese women with PCOS has yet to be elucidated. A small ra Continue reading >>
Pcos Treatment: Metformin
We've been discussing Polycystic Ovarian Syndrome (PCOS) and its impact on the health of women of size. Today, let's discuss the use of metformin in the treatment of PCOS. So far we've talked about the definition and symptoms of PCOS, how it presents, its testing and diagnosis, and its possible causes. Now we are discussing common treatment protocols for the metabolic issues of PCOS, and the pros and cons of each treatment option. (Fertility treatment will be covered in a different set of posts.) Today, we discuss metformin (Glucophage). Disclaimer: While the following information is based on my best understanding of the research, I am not a medical health-care professional and no medical advice should be inferred. Always do your own research and consult your healthcare provider. Trigger Warning: Remember that the purpose of these posts is to provide a basic introduction to PCOS with a size acceptance approach that is rare on PCOS websites. However, there will be some occasional mention of weight loss in some posts because this is part of the traditional approach to treating PCOS and fair coverage demands exploring the pros and cons of all treatments. This approach has been approved by the fatosphere monitors. In this post, there is a brief mention of the weight loss properties associated with metformin in some people. Insulin-Sensitizing Agent Overview Because insulin resistance (IR) is a strong part of the PCOS profile, because IR may be an integral part of its mechanism, and because decompensation of glucose tolerance due to IR is a big part of the long-term health impact of PCOS, treatment with insulin-sensitizing agents is considered a vitally important part of PCOS treatment by most clinicians. Insulin-sensitizing agents help the body to use its own insulin more e Continue reading >>
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6 Reasons Why Metformin Might Not Be Safe For Pcos
Have you been prescribed metformin for PCOS and are wondering what the side affects are? Metformin is often described as a ‘safe’ drug, but read on to find out why this might not be the case. When I was diagnosed with PCOS, the first thing I asked my GP was what I could take to ‘fix’ it. She gently explained that there was no pill or surgery that could cure my condition. However, there was a drug that could help with the elevated insulin levels caused by it. Metformin, she claimed, was a safe drug with no major side effects that would help with insulin resistance and weight loss. Sign me up. At first, I thought metformin was the wonder drug. I lost about 5kg in 4 months, more than I had ever been able to lose previously. I was ecstatic. I had a quick look online to see whether there were any side effects and initially found that diarrhea, loose stools, fatigue, and muscle soreness were commonly experienced. But I thought that it was small price to pay for finally being able to lose some weight. However, when I investigated further I found that that there are some much more sinister side effects of metformin that aren’t so widely publicised. These include: – Depleting our bodies of essential nutrients. – Increasing the risk of having a baby with a neural tube defect by up to 9 times. – Reducing energy levels by almost 50%. – Killing beneficial gut bacteria. This article is not intended to be a case against metformin for PCOS. There is no doubt that metformin helps to reduce weight, lowers blood glucose levels, and promotes ovulation. My concern is the lack of studies about the safety of long-term use of metformin for PCOS, especially in utero. Drugs can help with the associated symptoms of a disease, but they cannot fix the root cause of it. Metformin i Continue reading >>
Can You Take Metformin For Weight Loss? A Look At The Numbers
Metformin is a medication said to cause weight loss, but is it true? Should you be worried if you are underweight, or should you use it if you want a slimmer waistline? This article takes a looks at the current evidence and if you can take metformin for weight loss. What is Metformin? Metformin belongs to the class of medications called “oral hypoglycemics.” This means it’s taken by mouth to help reduce blood sugar (glucose) levels. For this reason, metformin is commonly used for the management of type 2 diabetes. How Does Metformin Work? The way metformin works isn’t fully understood yet. However, what is known is that it reduces the production of sugar by liver cells (1). Metformin also improves insulin sensitivity and influences the bacterial community in the gut. It may have anti-inflammatory effects that could be beneficial for metabolic health too (2, 3). Metformin may also cause weight loss by reducing food intake and blocking gastrointestinal absorption of glucose, at least in theory (4). Summary: Commonly prescribed for type 2 diabetes, metformin is a medication that influences the metabolism and absorption of sugar. What is Metformin Used For? Metformin has been approved for treating type 2 diabetes. This medication is also sometimes prescribed for the following: Research continues on other uses for metformin including: Anti-aging or anti-cancer effects (8) Helping manage type 1 diabetes (9) Reducing the risk of heart disease (10). Summary: Metformin has been approved for the management of type 2 diabetes. It is sometimes prescribed for other conditions that involve abnormal blood sugar, such as diabetes during pregnancy. Can You Take Metformin For Weight Loss? Metformin helps manage type 2 diabetes, a health condition associated with being overweight. Continue reading >>
Pcos Weight Gain Causes And Treatments
Many of these conditions can lead to heart disease . In fact, women with PCOS are four to seven times more likely to have a heart attack than women of the same age without the condition. Experts think weight gain also helps trigger PCOS symptoms, such as menstrual abnormalities and acne . What can I do to lose weight if I have polycystic ovary syndrome? Losing weight not only cuts your risk for many diseases, it can also make you feel better.When you have PCOS, shedding just 10% of your body weight can bring your periods back to normal. It can also help relieve some of the symptoms of polycystic ovary syndrome. Weight loss can improve insulin sensitivity. That will reduce your risk of diabetes , heart disease, and other PCOS complications. To lose weight, start with a visit to your doctor. The doctor will weigh you and check your waist size and body mass index. Body mass index is also called BMI, and it is the ratio of your height to your weight. Your doctor may also prescribe medication. Several medications are approved for PCOS, including birth control pills and anti-androgen medications. The anti-androgen medications block the effects of male hormones. A few medications are used specifically to promote weight loss in women with PCOS. These include: Metformin ( Glucophage ). Metformin is a diabetes drug that helps the body use insulin more efficiently. It also reduces testosterone production. Some research has found that it can help obese women with PCOS lose weight. Thiazolidinediones. These should be used with contraception . The drugs pioglitazone ( Actos ) and rosiglitazone ( Avandia ) also help the body use insulin. In studies, these drugs improved insulin resistance. But their effect on body weight is unclear. All patients using Avandia must review and fully un Continue reading >>
Pcos And Metformin:how Long Before You Started Losing Weight?
PCOS and Metformin:How long before you started losing weight? If this is your first visit, be sure tocheck out the FAQ by clicking thelink above. You may have to register before you can post: click the register link above to proceed. To start viewing messages,select the forum that you want to visit from the selection below. PCOS and Metformin:How long before you started losing weight? For the rest of you girls who are as blessed as me to have PCOS, =( and went on MetFormin, how long did it take you to start losing weight, how much did you lose, and what dosage did they start you on, how much overweight were you? Sorry for all the questions but I got diagnosed a couple weeks ago and got my prescription for MetFormin today... I just wanted to know how all of you guys benefited from the medicine!! Lost about 4 pounds right away. Cycle started about a week or so into taking met. Continuoulsy loosing I am about 260, 262 5'3 but lots of muscles, and major problem belly fat. Cycles are 32 days right on time past two months. I am in indy as well. Currently not ttc but I haven't ovulated yet. If you don't stand for something...you will fall for anything. good to see you here. I answered your question on that other board [I'm medicmamm over there] I never lost any weight on metformin and I have been taking it for a year or so. I have lost 15 pounds but that was by excercising and changing my eating habits. I guess I was not one of the lucky ones! Darn! I guess I weighed about 168 to 172 when I was first put on met. and that is how much I still weighed up until 2 months ago when I got sick of being curvy and changed my lifestyle. Met. did not make me O on my own, but it did help regulate my cycles a bit. I've been taking metformin for about 2-3 weeks now...and even though my mood Continue reading >>
Metformin, Weight Loss & Pcos – Does It Actually Work?
Did you know that one of the main reasons you can't lose weight with PCOS is because of your hormones? It's true, and that's why many women (and physicians) turn to using Metformin to try and help with weight loss. But just because it works for some people doesn't mean it will necessarily work for YOU. Find out why metformin helps with weight loss, but more important what works better and how to finally lose weight if you have PCOS. Insulin & PCOS: Why It's so Important One of the most common medications prescribed for PCOS is metformin. But, PCOS is a hormonal condition which results in weight gain, hair growth on the face, infertility, acne and estrogen/progesterone imbalances. So why is metformin, a medication used to lower blood sugar and treat insulin resistance, used to treat estrogen/progesterone imbalances in women? The logic is quite simple: Most of the symptoms of PCOS (all those listed above) stem from insulin resistanc e! In fact many physicians recommend that ALL women with PCOS should be treated for insulin resistance regardless of what their fasting insulin and fasting blood sugar levels are. This means that the root cause of PCOS (at least the majority of it) is insulin resistance, and this is why metformin is so commonly used to treat. Insulin resistance causes a block of glucose uptake in your skeletal muscles which results in a lower metabolism (and weight gain), insulin also directly acts on your ovaries and adrenals increasing androgens like testosterone and DHEA. It's also the action of insulin on your pituitary that results in increased LH production which over stimulates your ovaries resulting in the characteristic "cysts" of PCOS. High levels of DHEA and testosterone lead to acne and hair growth (hirsutism). But one simple question r Continue reading >>
Polycystic Ovary Syndrome (pcos) And Weight Gain
Most women at some point have to contend with weight gain. But for women with polycystic ovary syndrome (PCOS), losing weight can become a constant struggle. PCOS is the most common hormonal disorder in women of childbearing age and can lead to issues with fertility. Women who have PCOS have higher levels of male hormones and are also less sensitive to insulin or are "insulin-resistant." Many are overweight or obese. As a result, these women can be at a higher risk of diabetes, heart disease, sleep apnea, and uterine cancer. If you have PCOS, certain lifestyle changes can help you shed pounds and reduce the disease's severity. Why does polycystic ovary syndrome cause weight gain? PCOS makes it more difficult for the body to use the hormone insulin, which normally helps convert sugars and starches from foods into energy. This condition -- called insulin resistance -- can cause insulin and sugar -- glucose -- to build up in the bloodstream. High insulin levels increase the production of male hormones called androgens. High androgen levels lead to symptoms such as body hair growth, acne, irregular periods -- and weight gain. Because the weight gain is triggered by male hormones, it is typically in the abdomen. That is where men tend to carry weight. So, instead of having a pear shape, women with PCOS have more of an apple shape. Abdominal fat is the most dangerous kind of fat. That’s because it is associated with an increased risk of heart disease and other health conditions. What are the risks associated with PCOS-related weight gain? No matter what the cause, weight gain can be detrimental to your health. Women with PCOS are more likely to develop many of the problems associated with weight gain and insulin resistance, including: Endometrial cancer Many of these condit Continue reading >>