Can Metformin Cause Migraines?
Question Originally asked by Community Member SKAM Can Metformin Cause Migraines? I have just been diagnosed with Type 2 Diabetes and put on 2000 mg of metformin. I began having “ice pick”-like migraine headaches. Could there be a connection? Answer Hi SKAM, “Ice pick” headaches can be alarming because they start and stop before we really know what’s going on. They often feel like an ice pick is being jammed into our head, hence the name Ice Pick Headace. We have more information for you HERE. Glucophage (Metformin) does have headache listed as one of its potential side effects. Some of these side effects may lessen as your body adjusts to the medication. MyDiabetesCentral.com is a wonderful site that may help you with education and support with your new diagosis. Good luck Nancy You should know Answers to your question are meant to provide general health information but should not replace medical advice you receive from a doctor. No answers should be viewed as a diagnosis or recommended treatment for a condition. Continue reading >>
Fda Says Sglt2-metformin Combo Can Be Used Right Away
FDA Says SGLT2-Metformin Combo Can Be Used Right Away A recent study showed patients with type 2 diabetes did better if given the combination therapy at the outset than if given 1 of the components as monotherapy. The combination diabetes therapy Invokamet, a fixed-dose of canagliflozin (Invokana) and metformin, now has FDA approval as a first-line therapy, according to statement from the drugs manufacturer, Janssen Pharmaceuticals. With this new approval, Invokamet may now be prescribed in adults with type 2 diabetes (T2D) who are not already being treated with canagliflozin or metformin and may benefit from dual therapy, the statement said. The drug, first approved in August 2014, is the first combination of an SGLT2 inhibitor and metformin available in the United States. Canagliflozin was the first of the class of sodium-glucose co-transporter-2 (SGLT2) inhibitors approved by FDA in 2013. Until now, Invokamet could be prescribed only for patients who were not achieving blood glucose targets on either canagliflozin or metformin, or for T2D adults who were already being treated on the drugs separately. Using combination therapy from the start allows patients to get the benefits of both medications while taking 1 pill, which may improve adherence. Metformin has long been the standard first-line therapy for T2D; however, new treatment guidelines from the American Diabetes Association call for using combination therapy from the start for patients with more elevated levels of glycated hemoglobin (A1C).1 A phase 3 study published in Diabetes Care in March found that among patients not taking any therapy to reduce A1C, those given the combination therapy at the outset had greater A1C reductions than those given either dose of canagliflozin (100 mg or 300 mg) or metformin se Continue reading >>
The Many Faces Of Metformin
In 2004, Clifford Bailey of the Diabetes Group from Aston University in Birmingham, United Kingdom described metformin, the most widely prescribed drug for treating diabetes, as ironic: In our high-tech era of drug discovery and development this first-line treatment for type 2 diabetes is little removed from an herbal remedy of the Middle Ages. Despite its chemical simplicity and detailed investigation, metformin continues to evade a complete exposé of its cellular activity (Pract Diab Int April 2004 Vol.21 No. 3) Now, almost a decade later, a team led by Morris Birnbaum, M.D., Ph.D. from the Institute for Diabetes, Obesity and Metabolism, is getting closer to a clear picture of how this drug works, which, in addition to its widespread use for diabetes, is being tested for treating dementia and cancer. The Birnbaum lab and colleagues found that metformin works in a different way than previously understood. They found that in mice it suppresses the liver hormone glucagon’s ability to generate an important signaling molecule, which points to new drug targets. For fifty years, one of the few classes of therapeutics effective in reducing the overactive glucose production associated with diabetes has been the biguanides, which includes metformin. The inability of insulin to keep liver glucose output in check is a major factor in the high blood sugar of type 2 diabetes and other diseases of insulin resistance. “Overall, metformin lowers blood glucose by decreasing liver production of glucose,” says Birnbaum. “But we didn’t really know how the drug accomplished that.” Birnbaum’s Nature study describes a novel mechanism by which metformin antagonizes the action of glucagon, thus reducing fasting glucose levels. The team showed that metformin leads to the accumula Continue reading >>
When The Best Cure Isn't
You hear the pitch in drug ads all the time: "Ask your doctor if this medication is right for you." Trouble is, in many cases the only way your doctor can answer the question is by having you try the drug. And, as the latest research reveals, what's "right" for the smiling folks in a TV commercial may be just plain wrong for you. One reason: Each of us responds uniquely to any given medication. "Your liver and kidney function, overall health, treatment for other conditions, and genetics all play a role in how a drug affects you," says Martha Gerrity, MD, PhD, clinical evidence specialist at the Center for Evidence-Based Policy at Oregon Health & Sciences University. Another reason: The chances of your having a good response are simply not in your favor. "To market a medication, all you have to do is prove that it's better, on average, than a sugar pill," says Mark Gibson, deputy director of the OHSU center. A drug that works 20% of the time, for instance, may be considered effective--even though it does nothing for 80% of patients. Those odds could improve soon, thanks to a national push to comb through studies and scientific reviews to determine who gets better most often on which drugs. Called comparative effectiveness research, the initiative aims to produce a reliable set of guidelines that will enable you and your doctor to choose treatments based on solid evidence, not guesswork. The Obama administration has made comparative effectiveness research a priority, funneling over $1 billion--"a huge increase," says Gibson--into the program as part of the government's stimulus package. Already, 28 research centers funded by the government's Agency for Healthcare Research and Quality (AHRQ) have produced a wealth of findings on treatments for many common, chronic conditio Continue reading >>
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Metformin And Migraine Headaches
If this is your first visit, be sure tocheck out the FAQ by clicking thelink above. You may have to register before you can post: click the register link above to proceed. To start viewing messages,select the forum that you want to visit from the selection below. Did anyone else start experiencing Migraines after starting Metformin? I have been on 2000 mg/day since 2007 and shortly after starting I started getting severe migraines that last for several days at a time. Prior to taking Metformin I had never experienced a headache like that nor did I have many headaches at all. Now it seems like I am getting them every couple of weeks. meds: metformin 2000 mg/day; synthroid 150 mcg M/W/F 175 Mcg T/TH/S/S; Alysse (Aviene), B12 and Iron injections monthly symptoms: overweight, irregular/no periods, unwanted hair, discolored skin, uncontrollable weight gain even w/diet and exercise. son born Jan. 23, 2004. dx with hypothyroidism at 2 months old. has high functional autism. I usually get a headache after taking Met. I load up on water and 1000mg tylenol and it seems to take care of it. Me (28), DH (41), DSS (18), DSD (14), DD (6), DS (5) TTC Cycle #1: 50mg Clomid, Novarel 10000iu (CD 15), 2 follies- BFN TTC Cycle #2: 100mg Clomid, Novarel 10000iu (CD16), 1 follie- BFN TTC Cycle #3: 2.5mg Femara, No dominant follies CD14, Dr. cancelled. i AM GETTinG VERY BAD HEADEAChES AND i hAVE BEEN WONDERinG if tHEY ARE ThE CAUSE OF METFORMin!! GOiNG TO SEE ThE DR. ON THURSDAY! iLL LET YOU KNOW. me-(24) bf && dh-(32) our miracle ds-(2) 7/4/09 @ 1lb, 7ozs TTC#2 SiNCE 3/2010 LOST 60 POUNDS!! GOT bfP11/3/11 I didn't put it together either until my mom started taking it for diabetes and she is a nurse and was smart and looked ALL the side effects up and read that it can cause headaches. I never Continue reading >>
Stop The Metformin Madness
I have never been a fan of Metformin. It seemed too good to be true. Many years ago I had a conversation with a researcher about all of its possible therapeutic indications. His lab was actively pursuing the anti-cancer angle. That should have been a clue that Metformin might be causing more damage than we recognized, but it wasn’t. At that point, I was still enamored with the wonders of pharmacology and hadn’t yet begun my path toward understanding medication adverse reactions. Indeed, it wasn’t until very recently, when a family member began suffering from one of these reactions, that I began my investigation in full. This is what I learned. Type 2 Diabetes is Big Business The global profits from Type 2 diabetes medications rested at a paltry $23 billion dollars in 2011 but are expected to grow to over $45 billion annually by 2020. The market growth is bolstered in large part by the ever-expanding demand for therapeutics like Metformin or Glucophage. Metformin is the first line of treatment and standard of care for insulin resistance across all populations of Type 2 diabetics with over 49 million Americans on Metformin in 2011-2012. It is particularly popular in women’s health with an increasing reliance on Metformin for the metabolic dysfunction observed in women with PCOS, PCOS-related infertility and even gestational diabetes. Metformin is prescribed so frequently and considered so innocuous that it is sometimes euphemistically referred to as vitamin M. If we quickly scan the safety research for metformin, there is little immediate evidence suggesting any side effects whatsoever. In fact, in addition to controlling blood sugar by blocking the hepatic glucose dump, this drug is suggested to promote weight loss, increase ovulation in women, (thereby helping a Continue reading >>
Topomax: What You Should Know About This Common Migraine Medication
Heres the latest from the Migraine Relief Center Keep up with the doctors, patients, treatmentsand resultsfrom all our locations. Topomax: What You Should Know About This Common Migraine Medication Posted by Migraine Relief Center on Feb 3, 2016 12:00:00 PM Medication is typically the first-line of defense for teens and adults who suffer from migraines. Unfortunately, most medications are designed to provide migraine relief. The inherent problem with this being that the migraine has already started and, for many, it's too little, too late to benefit from more than a marginal decrease in pain or discomfort. Instead of migraine relief, patients suffering from chronic migraines seek migraine prevention - medications and/or treatments that prevent migraines from occurring in the first place. This is where Topamax comes into play. Topamax Is Preventative Migraine Treatment One of the things that sets Topamax apart from typical migraine treatments is that it's considered a prophylactic, meaning it prevents the condition before it even starts. It is important to note that while Topamax works to prevent a migraine attack, it does not treat a headache that has already begun. Originally created as a treatment for epilepsy, smaller doses can be used to control certain types of migraine headaches. This is due to the fact that epilepsy and migraines appear to have some shared biological markers. Topamax is taken daily, and it is important that you take each and every dose, without fail, in order for it to work as intended. While taking Topamax for migraines, it's recommended that you: Drink plenty of water throughout the day to prevent kidney stones and maintain your body's electrolytes in balance. Honor your doctor's requests for blood tests if necessary. Never skip doses if you a Continue reading >>
Metformin For The Prevention Of Episodic Migraine (mpem)
Metformin for the Prevention of Episodic Migraine (MPEM) Migraine is the third most prevalent disease in the world. Preventive treatment is indicated in about 40% of individuals with episodic migraine. Although 4 treatments are approved by the US Food and Drug Administration for prevention of episodic migraine, none were designed to prevent migraine, efficacy is modest, and all have significant adverse-event profiles. As a result, less than 1/3 of migraine sufferers with who are candidates for prevention receive drug treatment and of those who are treated, more than 85% have discontinued the preventive drug within one year. Migraine pain is associated with the activation and sensitization of specific receptors involved in pain-promoting pathways. Metformin, which is a widely available, well-tolerated anti-diabetic medication, can downregulate pain-promoting pathways. Metformin has demonstrated positive results in animal models of migraine in the laboratory. Given the longstanding use and established safety record of metformin, the investigators will evaluate the safety and efficacy of metformin for preventive treatment of migraine in a randomized, double-blind, placebo-controlled, crossover trial. quadruple (participant, care provider, investigator, outcomes assessor) The reduction in the number of migraine days per month during 12 weeks of treatment with metformin vs placebo (primary end point). The response rate (percentage of patients with a >50% reduction in migraine days per month) during 12 weeks of treatment with metformin vs placebo (secondary end point). Number of participants with treatment-related adverse events All participants from 18 years up to 65 years old. Inclusion Criteria: 1. age 18-65 years 2. a diagnosis of migraine with or without aura for >1 yea Continue reading >>
Metformin May Reduce Treatment-related Weight Gain In Autism
Metformin May Reduce Treatment-Related Weight Gain in Autism Metformin May Reduce Treatment-Related Weight Gain in Autism (HealthDay News) Metformin may be effective in decreasing weight gain associated with atypical antipsychotic use in autism spectrum disorder, according to a study published in JAMA Psychiatry. Michael Aman, PhD, a retired professor of psychology at The Ohio State University in Columbus, and colleagues enrolled 60 individuals with autism spectrum disorder aged 6 to 17. The patients were overweight due to the side effects of taking antipsychotic medications for irritability and agitation. For the study, participants were given either metformin or an inactive placebo for 16 weeks. The researchers found that patients given metformin had much greater reductions in BMI than those who took the placebo. Metformin was well tolerated overall. "Our results showed that gastrointestinal side effects occurred for more days in the metformin group compared to placebo group, but the large majority of children taking metformin were able to maintain their treatment," Dr Aman said in a university news release. Continue reading >>
Metformin And Migraine
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community I was diagnosed with T2 two months ago and take 500mg SR Metformin with breakfast (mainly porridge) each day but as a life-long migrainer, I am experiencing more frequent and severe migraines. My GP doesn't think there should be a link with the Metformin and that the reason for the increase is probably related to anxiety relating to my new condition. Just wondering if anyone else out there has experienced similar problems with headaches/migraines? Hi yes I have had several migraines since I started glucophage 6 weeks ago .Especially when increasing the dose above 1500mg.Previously I got a migraine about every 3 months .I am now on 2000mg a day and although the migraines have settled I am tired and bloated and queasy.Due to have bloods checked next week and a review so hoping it's settled down by then . I did wonder if the migraines were related to the falling of sugars but the metformin hasn't made that much diff e fence to them Dropping from 11 ish to 8/9 ish . Hi yes I have had several migraines since I started glucophage 6 weeks ago .Especially when increasing the dose above 1500mg.Previously I got a migraine about every 3 months .I am now on 2000mg a day and although the migraines have settled I am tired and bloated and queasy.Due to have bloods checked next week and a review so hoping it's settled down by then . Glad to hear your migraines have settled and hope you have much improved bloods as a result of your review. I also have a review next week so, fingers crossed! I've been a chronic migraine sufferer most of my adult life and am on medication for it. I was on 3x500g standard metformin initially after my diabetes diagnosis, and am now taking Continue reading >>
Can Metformin Cause Migraines?
Pepcid vs. Prilosec Vestura vs. Yaz Rephresh Pro B Side Effects Lacri Lube Alternative Primolut N Weight Gain Treato does not review third-party posts for accuracy of any kind, including for medical diagnosis or treatments, or events in general. Treato does not provide medical advice, diagnosis or treatment. Usage of the website does not substitute professional medical advice. The side effects featured here are based on those most frequently appearing in user posts on the Internet. The manufacturer's product labeling should always be consulted for a list of side effects most frequently appearing in patients during clinical studies. Talk to your doctor about which medications may be most appropriate for you. The information reflected here is dependent upon the correct functioning of our algorithm. From time-to-time, our system might experience bugs or glitches that affect the accuracy or correct application of mathematical algorithms. We will do our best to update the site if we are made aware of any malfunctioning or misapplication of these algorithms. We cannot guarantee results and occasional interruptions in updating may occur. Please continue to check the site for updated information. Continue reading >>
Comparative Evaluation Of The Therapeutic Effect Of Metformin Monotherapy With Metformin And Acupuncture Combined Therapy On Weight Loss And Insulin Sensitivity In Diabetic Patients
Original Article | Open Comparative evaluation of the therapeutic effect of metformin monotherapy with metformin and acupuncture combined therapy on weight loss and insulin sensitivity in diabetic patients Nutrition & Diabetes volume 6, page e209 (2016) Obesity induces insulin resistance (IR), the key etiologic defect of type 2 diabetes mellitus (T2DM). Therefore, an incidence of obesity-induced diabetes is expected to decrease if obesity is controlled. Although Metformin is currently one of the main treatment options for T2DM in obese patients, resulting in an average of 5% weight loss, adequate weight control in all patients cannot be achieved with Metformin alone. Thus, additional therapies with a weight loss effect, such as acupuncture, may improve the effectiveness of Metformin. We designed this randomized clinical trial (RCT) to compare the effects of Metformin monotherapy with that of Metformin and acupuncture combined therapy on weight loss and insulin sensitivity among overweight/obese T2DM patients, to understand whether acupuncture plus Metformin is a better approach than Metformin only on treating diabetes. To understand whether acupuncture can be an insulin sensitizer and, if so, its therapeutic mechanism. Our results show that Metformin and acupuncture combined therapy significantly improves body weight, body mass index (BMI), fasting blood sugar (FBS), fasting insulin (FINS), homeostasis model assessment (HOMA) index, interleukin-6 (IL-6), tumor necrosis factor- (TNF-), leptin, adiponectin, glucagon-like peptide-1 (GLP-1), resistin, serotonin, free fatty acids (FFAs), triglyceride (TG), low-density lipoprotein cholesterol (LDLc), high-density lipoprotein cholesterol (HDLc) and ceramides. Consequently, Metformin and acupuncture combined therapy is more ef Continue reading >>
Metformin Still Best As First Type 2 Diabetes Treatment
home / diabetes center / diabetes a-z list / metformin best as first type 2 diabetes treatment article Metformin Still Best as First Type 2 Diabetes Treatment Want More News? Sign Up for MedicineNet Newsletters! MONDAY, Jan. 2, 2017 (HealthDay News) -- Newly updated guidelines reaffirm that metformin is the first-line drug for people with type 2 diabetes , and that several other medications -- including newer ones -- can be added if needed. The recommendations come from the American College of Physicians (ACP). The American Academy of Family Physicians endorsed the new guidelines. The ACP updated the guidelines because of new research into diabetes drugs , and the U.S. Food and Drug Administration approval of new diabetes drugs . "Metformin, unless contraindicated, is an effective treatment strategy because it has better effectiveness, is associated with fewer adverse effects, and is cheaper than most other oral medications," ACP president Dr. Nitin Damle said in a college news release. "The escalating rates of obesity in the U.S. are increasing the incidence and prevalence of diabetes substantially. Metformin has the added benefit of being associated with weight loss ," Damle said. The ACP recommends that if a patient needs to take a second drug by mouth to lower blood sugar levels, physicians should look at adding a sulfonylurea, thiazolidinedione, SGLT-2 inhibitor, or a DPP-4 inhibitor. SGLT-2 inhibitors include canagliflozin ( Invokana ), empagliflozin (Jardiance) and dapagliflozin ( Farxiga ). DPP-4 inhibitors include sitagliptin ( Janumet , Januvia ) or linagliptin (Jentadueto, Tradjenta ). Brand names for metformin include Glumetza , Glucophage , and Fortamet . "Adding a second medication to metformin may provide additional benefits," Damle said. "However, the i Continue reading >>
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Metformin - Oral, Glucophage
are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>
Metformin (oral Route)
Precautions Drug information provided by: Micromedex It is very important that your doctor check your progress at regular visits, especially during the first few weeks that you take this medicine. Blood and urine tests may be needed to check for unwanted effects. This medicine may interact with the dye used for an X-ray or CT scan. Your doctor should advise you to stop taking it before you have any medical exams or diagnostic tests that might cause less urine output than usual. You may be advised to start taking the medicine again 48 hours after the exams or tests if your kidney function is tested and found to be normal. Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests. It is very important to carefully follow any instructions from your health care team about: Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team. Other medicines—Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems. Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur with lifestyle changes, such as changes in exercise or diet. Counseling on birth control and pregnancy may be needed because of the problems that can occur in pregnancy for patients with diabetes. Travel—Keep a recent prescription and your medical history with you. Be prepared for an emergency as you would norm Continue reading >>
