Metformin Use During The First Trimester Of Pregnancy
Go to: First-trimester exposure The Motherisk Program recently conducted a retrospective cohort study on pregnancy outcome among women with PCOS15 and a meta-analysis of all published studies with data on pregnancy outcomes with respect to major malformations.16 In the retrospective cohort study, 72 PCOS patients exposed to metformin were compared with 48 PCOS patients who conceived without metformin in five different fertility clinics. The prevalence of major malformations was similar in the two groups. The metformin group had a higher prevalence of multiple pregnancies and prematurity. Prematurity is a substantial confounder of concomitant use of other fertility drugs.15 Results of the meta-analysis are encouraging. In the five studies included in the statistical analysis, there was no increase in the rate of major malformations, and in fact, metformin might actually have a protective effect in women with PCOS. In the treated group, there were three malformations among 172 babies (1.7%); in the control group, there were 17 malformations among 235 babies (7.2%). The odds ratio was 0.50 in favour of treatment.16 In summary, no evidence currently in the literature shows that use of metformin in women with PCOS is associated with increased risk of malformations. Most of the studies applicable to PCOS restricted exposure to the first trimester, ie, metformin was discontinued as soon as pregnancy was diagnosed. Evidence beyond the first trimester is anecdotal at this point. Large well-controlled studies of humans are needed. For women with non–insulin-dependent diabetes mellitus, insulin is still considered the treatment of choice during pregnancy, although glyburide has been shown not to cross the human placenta.17,18 Motherisk questions are prepared by the Motherisk Tea Continue reading >>
3 Things You Need To Know About Metformin
September 30, 2015 by Dr. Brooke in Be Better , Eat Better , pcos 3 Things You Need To Know About Metformin Metformin is recommended by doctors for women with PCOS that want to loose weight or otherwise manage their PCOS and insulin resistance. But there are 3 very important things that you need to know about it including the fact that it's not the only option! Let me first say, I dont hate Metformin for women with PCOS . For some women it really does help spur ovulation, control blood sugar and help with some weight management but.its not without its share of issues. And its definitely not the magic bullet for weight loss although its usually presented that way. How Metformin (or its generic form: Glucophage) Works Metformin is typically given with meals throughout the day, or more commonly now the extended release version is given once with dinner or at bedtime. While only having to pop a pill one time per day is always appealing, this once a day dosing (especially at bedtime) is where I see the most problems with my patients. It lowers both fasting and post meal glucose levels by decreasing the glucose absorption in your intestines after a meal; as well as decreasing the amount of glucose your liver makes for later use. It also does help improve insulin sensitivity by increasing glucose movement into a cell. All sounds good so far right? Not so fast, here are the most common issues I see in women using Metformin: Metformin is notorious for causing sometimes severe digestive issues including stomach pain or upset, nausea, vomiting, diarrhea and even a sense of body weakness or metallic taste in the mouth in some. And it is touted as not causing low blood sugar as many older blood sugar lowering drugs did, however I see it every day in my practice that Metformin can m Continue reading >>
About Metformin
Metformin is a medicine used to treat type 2 diabetes and sometimes polycystic ovary syndrome (PCOS). Type 2 diabetes is an illness where the body doesn't make enough insulin, or the insulin that it makes doesn't work properly. This can cause high blood sugar levels (hyperglycemia). PCOS is a condition that affects how the ovaries work. Metformin lowers your blood sugar levels by improving the way your body handles insulin. It's usually prescribed for diabetes when diet and exercise alone have not been enough to control your blood sugar levels. For women with PCOS, metformin stimulates ovulation even if they don't have diabetes. It does this by lowering insulin and blood sugar levels. Metformin is available on prescription as tablets and as a liquid that you drink. Key facts Metformin works by reducing the amount of sugar your liver releases into your blood. It also makes your body respond better to insulin. Insulin is the hormone that controls the level of sugar in your blood. It's best to take metformin with a meal to reduce the side effects. The most common side effects are feeling sick, vomiting, diarrhoea, stomach ache and going off your food. Metformin does not cause weight gain (unlike some other diabetes medicines). Metformin may also be called by the brand names Bolamyn, Diagemet, Glucient, Glucophage, and Metabet. Who can and can't take metformin Metformin can be taken by adults. It can also be taken by children from 10 years of age on the advice of a doctor. Metformin isn't suitable for some people. Tell your doctor before starting the medicine if you: have had an allergic reaction to metformin or other medicines in the past have uncontrolled diabetes have liver or kidney problems have a severe infection are being treated for heart failure or you have recentl Continue reading >>
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Metformin For Gestational Diabetes - What It Is And How It Works
In the UK it is common to use Metformin for gestational diabetes where dietary and lifestyle changes are not enough to lower and stabilise blood sugar levels. It is widely used to help lower fasting blood sugar levels as well as post meal levels. Metformin is an oral medication in tablet form. It is used in diabetics to help the body use insulin better by increasing how well the insulin works. In pregnancy it can be used in women who have diabetes before becoming pregnant (Type 2 diabetes) and in women who develop diabetes during pregnancy (gestational diabetes). Metformin is also used for other conditions too, commonly used in those that have PCOS (polycystic ovarian syndrome). Metformin is a slow release medication. Here are the most commonly asked Q&A on Metformin for gestational diabetes from our Facebook support group Why do I need to take Metformin? For many ladies with gestational or type 2 diabetes, if lower blood sugar levels cannot be reached through diet and exercise then medication will be required to assist. If blood sugar levels remain high, then the diabetes is not controlled and can cause major complications with the pregnancy and baby. Some consultants will prescribe Metformin on diagnosis of gestational diabetes on the basis of your GTT results. Others will let you try diet control first and when blood glucose levels rise out of target range, or close to the target range, they may prescribe Metformin as a way to help lower and control your levels. NICE guidelines regarding the timing and use of Metformin for gestational diabetes 1.2.19 Offer a trial of changes in diet and exercise to women with gestational diabetes who have a fasting plasma glucose level below 7 mmol/litre at diagnosis. [new 2015] 1.2.20 Offer metformin[4] to women with gestational dia Continue reading >>
- Women in India with Gestational Diabetes Mellitus Strategy (WINGS): Methodology and development of model of care for gestational diabetes mellitus (WINGS 4)
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Metformin Is Making Me Soooo Sick! - Fertility / Infertility / Ivf - Medhelp
Oh Lord - if anyone at all can help me, I would be forever greatful. I just started metformin (PCOS) about a week and a half ago. I was instructed to take 1 pill a day for 1 week, then 2 pills a day the second week, and finally 3 pills a day the third week and then 3 pills a day from then on out. I CAN'T TAKE THE SICKNESS. I am constantly nausous. I wake up nasous, go to bed nausous, don't eat - get nausous, eat - get nausous. I can't take this. Any ideas what to do? I am only on 1000mg right now and I still have to go up to 1500mg next week. I don't think I can take much more. HELP!!! I had the same symptoms when I started on metformin. I was told to cut down on carbs. The first 2 weeks were awful. Are you taking it with food? Because if I took it on an empty stomach, I get nauseous and then I CANT EAT! And I was drinking lots of water. I am now up to 4 pills a day (2 in the AM and 2 in the PM). When I told my doc about my nausea, he cut me back down to 1 pill a day. I think it takes a while for the body to get used to it... The way I take mine is AFTER each meal.And they're spread out during the day... I cut down on carbs, ate more veggies and lean meat/chicken, fish..pretty much a healthy diet with metformin... Continue reading >>
Is It Safe To Use Metformin During Pregnancy?
Metformin is a commonly used drug for managing type 2 diabetes. It is considered an effective treatment option for many people with diabetes, but is it safe for pregnant women? Metformin is a drug that helps to lower blood sugar. It is considered one of the best first line treatments for type 2 diabetes. A review posted to Diabetology & Metabolic Syndrome notes that metformin helps to lower blood sugar levels, strengthens the endocrine system, improves insulin resistance, and reduces fat distribution in the body. Before taking any drugs, including metformin, a pregnant woman has to be absolutely sure that the drugs will not affect her or her baby. Effects of metformin use during and after pregnancy Some people are concerned about using metformin during and after pregnancy because it crosses the placenta. This means that when a pregnant woman takes metformin, so does her baby. However, the results of the few studies that have been carried out so far into the effects of taking metformin during pregnancy have been positive. A 2014 review posted to Human Reproduction Update found that the drug did not cause birth defects, complications, or diseases. The researchers did note, however, that larger studies should be carried out to make this evidence more conclusive. Metformin and gestational diabetes A separate review posted to Human Reproduction Update noted that women who took metformin to treat gestational diabetes (diabetes during pregnancy) gained less weight than women who took insulin. A 2-year follow-up study found that babies born to the women treated with metformin had less fat around their organs, which could make them less prone to insulin resistance later in life. This could mean that children who are exposed to metformin at a young age could gain long-term benefi Continue reading >>
Metformin (oral Route)
Precautions Drug information provided by: Micromedex It is very important that your doctor check your progress at regular visits, especially during the first few weeks that you take this medicine. Blood and urine tests may be needed to check for unwanted effects. This medicine may interact with the dye used for an X-ray or CT scan. Your doctor should advise you to stop taking it before you have any medical exams or diagnostic tests that might cause less urine output than usual. You may be advised to start taking the medicine again 48 hours after the exams or tests if your kidney function is tested and found to be normal. Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests. It is very important to carefully follow any instructions from your health care team about: Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team. Other medicines—Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems. Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur with lifestyle changes, such as changes in exercise or diet. Counseling on birth control and pregnancy may be needed because of the problems that can occur in pregnancy for patients with diabetes. Travel—Keep a recent prescription and your medical history with you. Be prepared for an emergency as you would norm Continue reading >>
Gestational Diabetes - Should I Try Extra Hard To Avoid Metformin?8
I am 33+2 and am self monitoring. Failed GTT last pregnancy but managed with diet but was very strict. Basically have got to the point where I need to avoid bread to keep my post meal numbers below 7. They have told me not to starve myself and I don't feel particulary hungry and I reckon I could get through the next 2 weeks (can stop testing at 35 weeks) with vast majority of my numbers in range. If I don't I will need to go on Metformin, test until the end of pregnancy and possibly transfer my care to a different hospital. DS had no sugar problems at birth, was not big (although I think I have a poorly functioning placenta) so am assuming this baby will be fine and would like to avoid all the fuss if not necessary, but at the same time don't want to put the baby at risk. BTW, my hospital tests before and 2 hours after meals for 3 days a week. I have read guidelines are now 1 hr after meals with a 7.8 rather than 7 cut off? Is this a problem. Last time had a C-section at 39+2 as didn't want an induction and will do the same this time. My consultant was suggesting an induction this time but not sure inductions after a c-section are a good idea plus don't really mind having a section again. What do they do differently after 35 weeks if you are on Metformin and what changes pre and post birth? Don't think about it like that as in if I can just get through this and then I am home and dry. If you are struggling with your sugars, don't hide it or cut out foods without talking to your mw, if you need metformin so be it. I am currently on this and am 33+2. I had mild gdd before and it was a shock to find it hard this time, I was diet controlled before and this time it's worse. Infact my GDD in my last diet was so mild it was missed and ds was born very ill. So I have had it of Continue reading >>
Is Diabetes Causing My Nausea?
Nausea comes in many forms. Sometimes it can be mild and short-lived. Other times, it can be severe and last for a long time. For people with diabetes, nausea is a common complaint. It can even be a sign of a life-threatening condition that requires swift medical attention. 5 common causes of nausea Factors related to your diabetes may cause you to feel nausea. Medication Metformin (Glucophage) is one of the more common medications used to treat diabetes. Nausea is a potential side effect for people taking this medication. Taking metformin on an empty stomach may make nausea worse. Injectable medications used to treat diabetes, such as exenatide (Byetta), liraglutide (Victoza), and pramlintide (Symlin), may also cause nausea. The nausea may go away after extended use. Your doctor may also start you on a lower dosage to try to reduce or eliminate nausea. Hypo- and hyperglycemia Hyperglycemia (elevated blood sugar levels) or hypoglycemia (blood sugar levels that are too low) may cause nausea. Check your blood sugar and respond appropriately if you suspect abnormal blood sugar levels. To avoid hypo- and hyperglycemia, stick to your diabetes meal plan, monitor your blood sugar, and take your medication as prescribed. You should also avoid exercising in extreme temperatures and keep cool by drinking cold liquids during outside activities, advises Sheri Colberg, PhD, author, exercise physiologist, and expert on diabetes management. Diabetic ketoacidosis Severe nausea may be a sign of diabetic ketoacidosis. This is a dangerous medical condition that must be treated to avoid coma or even death. Symptoms include: nausea excessive thirst frequent urination abdominal pain weakness or fatigue shortness of breath confusion fruity-scented breath If you suspect diabetic ketoacidosis, Continue reading >>
Metformin - Oral, Glucophage
are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>
Diabetes Drugs: Metformin
Editor’s Note: This is the second post in our miniseries about diabetes drugs. Tune in on August 21 for the next installment. Metformin (brand names Glucophage, Glucophage XR, Riomet, Fortamet, Glumetza) is a member of a class of medicines known as biguanides. This type of medicine was first introduced into clinical practice in the 1950’s with a drug called phenformin. Unfortunately, phenformin was found to be associated with lactic acidosis, a serious and often fatal condition, and was removed from the U.S. market in 1977. This situation most likely slowed the approval of metformin, which was not used in the U.S. until 1995. (By comparison, metformin has been used in Europe since the 1960’s.) The U.S. Food and Drug Administration (FDA) required large safety studies of metformin, the results of which demonstrated that the development of lactic acidosis as a result of metformin therapy is very rare. (A finding that has been confirmed in many other clinical trials to date.) Of note, the FDA officer involved in removing phenformin from the market recently wrote an article highlighting the safety of metformin. Metformin works primarily by decreasing the amount of glucose made by the liver. It does this by activating a protein known as AMP-activated protein kinase, or AMPK. This protein acts much like an “energy sensor,” setting off cellular activities that result in glucose storage, enhanced entry of glucose into cells, and decreased creation of fatty acids and cholesterol. A secondary effect of the enhanced entry of glucose into cells is improved glucose uptake and increased storage of glycogen (a form of glucose) by the muscles. Additionally, the decrease in fatty acid levels brought about by metformin may indirectly improve insulin resistance and beta cell func Continue reading >>
Metformin First Trimester
I'm not really sure why some people are on it their entire pregnancy and some are told to stop after a certain amount of time. When I brought it up to my doctor, she just told me to continue taking it... Hi everyone! This my first post. I am 35 and have PCOS with insulin resistance so I am on metformin. I went off BC for first time since 2006 in November just to see what my body would do (I could easily go 3-4 months between periods before BC). In December, I saw a reproductive endocrinologist and although I started my period the next day they did an ultrasound and then followed up with blood work that said I wasn't ovulating. I got a bit frisky with my BF and found out 1/30/15 that I was pregnant. Shocked and pretty excited! I was kind of sadly ready to not be able to have kids due to PCOS. I am almost 8 weeks and don't go into my doctor for first appointment until 3/9/15. I am really concerned about gestational diabetes. Has anyone had that? I know the insulin resistance test that I failed was the pregnancy sugar drink test. Those of you that have stopped taking metformin - how has your blood sugar and A1C been? Thanks for replies this is new, exciting, and scary at the same time! : ) I have PCOS and my doctor took me off of metformin at 7 weeks. Once we were able to see the baby's heartbeat they said that it was safe for me to stop taking metformin. The reason that some doctors do not want you to stay on metformin throughout your entire pregnancy is because there has not been enough studies to know for sure if it is safe to take during pregnancy. It has been shown to cross the placenta and get to your baby. It hasn't been found to be dangerous to your baby when this happens, but there also is not enough research to prove that it is safe. I was taking 1500mg of metfo Continue reading >>
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Gd: Horrific Metformin Side Effects
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community Newbie here. Had a browse, thought I'd post. I'm 19w4d and was diagnosed with GD at 17w5d after glycosuria at 16w1d. Midwives and doctors are very concerned as I'm so early on. I haven't been able to control my bloods by diet and exercise at all, and started metformin this past Tuesday at 18w6d. They are expecting to see me again this coming Tuesday at 19w6d to discuss insulin. The problem is, I am utterly miserable on metformin. I started on 500mg in the morning and 500mg at night and was told to gradually increase the dose, going up to 1000mg at night after two days. The first time I took it, I went to bed feeling sick and then got up to use the bathroom and had very loose stools. With every dose I have taken the side effects have got worse. I now can't keep any food down, have true diarrhoea (sorry) to the extent that I've even had an episode of incontinence. I'm utterly miserable and scared to take it. Today I skipped my breakfast dose and of course I feel much better. I'm petrified of taking it, fed up of being so violently sick. Now I know that lots of people experience digestive issues in the beginning and it then settles, so the best thing is to keep on taking it. But my issues are just getting worse. Should I keep taking it anyway? It makes me vomit and I can't eat, and I also won't be able to leave my house if I do. My appointment is in two days on Tuesday, but I'll be able to call them tomorrow. Nobody is there over the weekend. Has this happened to anyone else? What did you do? Metformin caused me the same problems including the incontinence. However I am not pregnant so can only advise you to phone first thing tomorrow and take advice fro Continue reading >>
Metformin Making Me Sick During Pregnancy
Metformin making me sick during pregnancy Metformin making me sick during pregnancy # Diabetes Test During Pregnancy - Uti And Diabetes It has allowed me to use less insulin during my current pregnancy,.During pregnancy, this medication should be used only when clearly needed.I believe it is making me pee. and while it did help me ovulate, it made me so sick that I.Treatment with Metformin for PCOS and Infertility. Treatment with Metformin for PCOS and. # Snacks For Gestational Diabetes - Metformin Diabetes Metformin - eMedTV: Health Information Brought To Life It is one of the most dangerous complications that can occur during pregnancy and is a major cause of both. Does Metformin make you more fertile? - HowStuffWorks My general dr. diagnosed me with PCOS and put me on 1000mg of metformin a.Join our mailing list and get the information you need to make confident. 2 doctor put me on metformin which brings me to my 1st. The metformin pKa values make metformin a stronger base than most other basic drugs with. Metformin made me very, very sick when I first started taking it.There may be times during pregnancy when using medicine is a choice. (metformin) for diabetes. I started having stomach aches and felt sick. Is. Pharmacokinetic studies suggest that clearance of metformin may be increased during pregnancy and dosing may need. Women with PCOS are at higher risk for certain problems or complications during pregnancy. Effects of metformin on early pregnancy loss in the polycystic ovary.If I use metformin throughout pregnancy will it affect the baby. Metformin (Glucophage) Side Effects & Complications - The Infertility Metformin for PCOS: How much do. makes me very sick I have to.March 3, 2013. particularly if this health metabolic condition is well controlled during preg Continue reading >>
