Metformin Targets The Metabolic Achilles Heel Of Human Pancreatic Cancer Stem Cells
Metformin Targets the Metabolic Achilles Heel of Human Pancreatic Cancer Stem Cells Contributed equally to this work with: Enza Lonardo, Michele Cioffi Affiliation: Stem Cells & Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain Contributed equally to this work with: Enza Lonardo, Michele Cioffi Affiliation: Stem Cells & Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain Affiliation: Stem Cells & Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain Affiliation: Stem Cells & Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain Affiliation: Stem Cells & Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain Affiliation: Stem Cells & Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain Affiliation: Stem Cells & Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain Affiliation: Gastrointestinal Cancer Clinical Research Unit, Clinical Research Programme (CNIO), Spanish National Cancer Research Centre, Madrid, Spain Affiliation: Stem Cells & Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain Pancreatic ductal adenocarcinomas contain a subset of exclusively tumorigenic cancer stem cells (CSCs), which are capable of repopulating the entire heterogeneous cancer cell populations and are highly resistant to standard chemotherapy. Here we demonstrate that metformin selectively ablated pancreatic CSCs as evidenced by diminished expression of pluripotency- Continue reading >>
Metformina: Medlineplus Medicinas
Marcas comerciales de producto combinados La metformina raras veces puede ocasionar una condicin seria, mortal llamada acidosis lctica. Informe a su mdico si usted tiene enfermedad del rin. Su mdico podra indicarle que no tome metformina. Tambin, informe a su mdico si es mayor de 65 aos y si tiene o ha tenido un infarto, apopleja, cetoacidosis diabtica (azcar en sangre que sea suficientemente alta como para ocasionar sntomas graves y requiere tratamiento mdico de emergencia) o coma, o enfermedad cardaca o heptica. Tomar ciertos otros medicamentos con metformina puede aumentar el riesgo de acidosis lctica. Informe a su mdico si est tomando acetazolamida (Diamox), diclorfenamida (Keveyis), metazolamida, topiramato (Topamax, en Osymia), o zonisamida (Zonegran). Informe a su mdico si tuvo recientemente cualquiera de las siguientes condiciones o si las desarroll durante el tratamiento: infeccin grave, diarrea fuerte, vmitos o fiebre, o si bebe mucho menos lquidos de lo usual por cualquier motivo. Es posible que tenga que dejar de tomar metformina hasta que se recupere. Si va a someterse a una ciruga, incluso una ciruga dental, o cualquier procedimiento mdico mayor, informe a su mdico que est tomando metformina. Digale a su mdico tambin si usted tiene planificado de tener cualquier procedimiento radiolgico en el que se injyecta una sustancia de contraste, particularmente si usted bebe o alguna vez ha bebido grandes cantidades de alcohol, tiene o alguna vez ha tenido enfermedad del higado o insuficiencia cardaca. Es posible que tenga que dejar de tomar metformina antes del procedimiento y esperar 48 horas para reiniciar el tratamiento. Su mdico le dir exactamente cundo debe dejar de tomar la metformina y cundo deber empezar a tomarla de nuevo. Si experimenta cualquiera de los Continue reading >>
Metformin Hcl 500mg En Espanol
The Spanish name of Metformin is Metformina. La metformina es un medicamento antidiabiatico oral que se utiliza para ayudar a reducir y controlar los niveles de azcar en la sangre, junto con dieta y ejercicio. Se puede provocar efectos secundarios, tales como nuseas, mareos, dolor de estmago y flatulencia. la metformina solo pueden tomar personas con diabetis para bajar de peso o personas regular con sobrepeso what is teva metformin hcl tablets used for ## Hi mook, Metformin is an oral anti-diabetic drug in the biguanide class. ... 1reply You may use your first name, or for more privacy, make up a nickname. Optional. Always hidden. This allows us to notify you when a reply is posted here. Discussion Thread Guidelines:Any participation in the discussion threads signifies your agreement with the Terms of Use and Privacy Policy .(1) Act civilized and be respectful towards others. No profanity, vulgarity or lewd / suggestive content is allowed.(2) Posts encouraging, facilitating, or seeking advice about the abuse of medications or other substances are prohibited.(3) Personal contact information (such as telephone numbers, email addresses, etc) is not allowed to appear on our discussion threads.(4) We do not allow our forums to be used for buying, selling, trading, or for the promotion of a product or service.(5) Posting external links to other web sites is not allowed without our prior approval.(6) We reserve the right to edit or remove content which we find objectionable to the community at our sole discretion. Join over 75,000 subscribers and we'll send you a Continue reading >>
Buying Metformin In Spain (metformin), Costco Pharmacy Metformin Inquiry - Diabetes
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Metformin
Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes,[4][5] particularly in people who are overweight.[6] It is also used in the treatment of polycystic ovary syndrome.[4] Limited evidence suggests metformin may prevent the cardiovascular disease and cancer complications of diabetes.[7][8] It is not associated with weight gain.[8] It is taken by mouth.[4] Metformin is generally well tolerated.[9] Common side effects include diarrhea, nausea and abdominal pain.[4] It has a low risk of causing low blood sugar.[4] High blood lactic acid level is a concern if the medication is prescribed inappropriately and in overly large doses.[10] It should not be used in those with significant liver disease or kidney problems.[4] While no clear harm comes from use during pregnancy, insulin is generally preferred for gestational diabetes.[4][11] Metformin is in the biguanide class.[4] It works by decreasing glucose production by the liver and increasing the insulin sensitivity of body tissues.[4] Metformin was discovered in 1922.[12] French physician Jean Sterne began study in humans in the 1950s.[12] It was introduced as a medication in France in 1957 and the United States in 1995.[4][13] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[14] Metformin is believed to be the most widely used medication for diabetes which is taken by mouth.[12] It is available as a generic medication.[4] The wholesale price in the developed world is between 0.21 and 5.55 USD per month as of 2014.[15] In the United States, it costs 5 to 25 USD per month.[4] Medical uses[edit] Metformin is primarily used for type 2 diabetes, but is increasingly be Continue reading >>
Metformina - Wikipedia, La Enciclopedia Libre
frmaco antidiabtico de aplicacin oral del tipo biguanida La metformina, o el preparado comercial clorhidrato de metformina, es un frmaco antidiabtico de aplicacin oral del tipo biguanida . Se utiliza comnmente en el tratamiento y la prevencin de la diabetes mellitus tipo 2 , antes conocida como diabetes no insulinodependiente, particularmente en pacientes con sobrepeso , as como en nios y personas que presentan una funcin renal normal. Se indica por s sola como adyuvante del ejercicio fsico y la dieta en pacientes cuya hiperglucemia no puede ser controlada slo con modificaciones en la dieta. [2] La metformina es tan efectiva reduciendo los niveles elevados de glucosa en sangre como las sulfonilureas , las tiazolidinedionas y la insulina . A diferencia de muchos otros antidiabticos, por s sola, la metformina no produce hipoglucemia . La metformina tambin reduce los niveles de LDL y triglicridos circulantes en la sangre y puede ayudar a perder peso. [3] Para el ao 2009, la metformina era uno de dos antiglicemiantes orales que pertenecen a la lista modelo de medicamentos esenciales de la Organizacin Mundial de la Salud , junto con la glibenclamida , [4] y es el nico medicamento conocido capaz de prevenir las enfermedades cardiovasculares asociadas a la diabetes. [5] No se recomienda sobrepasar los 2 g de metformina al da. Para evitar al mximo las reacciones adversas se indica la metformina a dosis bajas y consumirla durante las comidas. Algunos preparados comerciales combinan la metformina con clorpropamida o nateglinida . Las biguanidas , como la metformina, la fenformina y la buformina , estas dos ltimas ya retiradas del mercado, tienen su origen histrico en la planta Galega officinalis (ruda cabruna o galega) que se ocupaba en la poca medieval para reducir la miccin ex Continue reading >>
Mg Metformin - Translation Into Spanish - Examples English | Reverso Context
Absolute bioavailability of a 500 mg metformin tablet is approximately 50-60% in healthy subjects. La biodisponibilidad absoluta de un comprimido de 500 mg de metformina es aproximadamente de 50-60% en sujetos sanos. Absolute bioavailability of a 500 mg or 850 mg metformin tablet is approximately 50-60% in healthy subjects. La biodisponibilidad absoluta de un comprimido de 500 u 850 mg de metformina es aproximadamente del 50 al 60% en sujetos sanos. Co-administration of multiple twice-daily doses of 1000 mg metformin with 50 mg sitagliptin did not meaningfully alter the pharmacokinetics of sitagliptin in patients with type 2 diabetes. La coadministracin de dosis repetidas de 1000 mg de metformina dos veces al da con 50 mg de sitagliptina no alter significativamente la farmacocintica de sitagliptina en pacientes con diabetes tipo 2. 1 mg rosiglitazone and 500 mg metformin; 2 mg rosiglitazone and 500 mg metformin; 2 mg rosiglitazone and 1000 mg metformin or 4 mg rosiglitazone and 1000 mg metformin. 1 mg de rosiglitazona y 500 mg de metformina ; 2 mg de rosiglitazona y 500 mg de metformina ; 2 mg de rosiglitazona y 1.000 mg de metformina 4 mg de rosiglitazona y 1.000 mg de metformina . The tablets contain 80 mg fenofibrate and 500 mg metformin, 80 mg fenofibrate and 850 mg metformin, or 54 mg fenofibrate and 850 mg metformin. Los comprimidos contienen 80 mg de fenofibrato y 500 mg de metformina , 80 mg de fenofibrato y 850 mg de metformina , o 54 mg de fenofibrato y 850 mg de metformina . 17 For the different doses on metformin, Efficib is available in strengths of 50 mg sitagliptin and 850 mg metformin hydrochloride or 1,000 mg metformin hydrochloride. Para las diferentes dosis de metformina, Efficib est disponible en concentraciones de 50 mg de sitagliptina junto con 85 Continue reading >>
Patient Resources | Invokamet (canagliflozin & Metformin Hcl)
INVOKANA (canagliflozin) is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. INVOKANA is not recommended in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. INVOKAMET and INVOKAMET XR are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both canagliflozin and metformin is appropriate. INVOKAMET and INVOKAMET XR are not recommended in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. IMPORTANT SAFETY INFORMATION for INVOKANA, INVOKAMET (canagliflozin/metformin HCl), and INVOKAMET XR WARNING: LACTIC ACIDOSIS AND LOWER-LIMB AMPUTATION Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. The onset of metformin-associated lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Metformin-associated lactic acidosis was characterized by elevated blood lactate levels (>5 mmol/L); anion gap acidosis (without evidence of ketonuria or ketonemia); an increased lactate:pyruvate ratio; and metformin plasma levels generally >5 mcg/mL. Risk factors for metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs (eg, carbonic anhydrase inhibitors such as topiramate), age 65 years old or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (eg, acute congestive heart failure), excessive alcohol intake, and hepatic impairment. Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high-risk group Continue reading >>
Metformin Hydrochloride Noun
[...] esperan que el protocolo de metformina podra tener efectos [...] sinergticos similares en otros tipos de cncer. After treatment with hot water, halofuginone is extracted as the free base into ethyl acetate and subsequently partitioned as the hydrochloride into an aqueous acid solution. Tras tratamiento con agua caliente, la halofuginona se extrae como base libre en acetato de etilo y posteriormente se somete a separacin como clorhidrato en una solucin cida acuosa. On its own, metformin, which was given in lower [...] doses than normal for diabetics, did not have such a striking effect, indicating [...] crecimiento, tiamina en forma de clorhidrato de tiamina, dentro de determinados lmites There is limited evidence to support the use of pilocarpine hydrochloride in the treatment of radiation-induced salivary gland dysfunction. Las pruebas a favor del uso de clorhidrato de pilocarpina para el tratamiento de la disfuncin de las glndulas salivales inducida por radiacin son limitadas. In some cases, your doctor may give you an injection of the drug naloxone hydrochloride. En algunos casos, su mdico le puede administrar una inyeccin del medicamento hidrocloruro de naloxeno. This campaign, called "secure water" is possible thanks to support from two organizations, the International Center in [...] which have donated hydrochloride and supported us with [...] Because metformin is traditionally used to treat [...] type 2 diabetes, its use in preventing diabetes may be considered somewhat atypical. Debido a que la metformina es usada tradicionalmente [...] para tratar la diabetes tipo 2, su uso en prevenir la diabetes puede considerarse un poco atpico. These two new products are used to treat type 2 diabetes [...] mellitus when the use of metformin is not enough. Estos dos n Continue reading >>
Medicine Information - Kaiser Permanente
Marca de fbrica comn name(s): Glucophage En raras ocasiones, un exceso de metformina puede acumularse en el organismo y causar una afeccin grave (en ocasiones mortal) conocida como acidosis lctica. Es ms probable que se produzca acidosis lctica si es una persona de edad avanzada, si tiene enfermedad renal o heptica, deshidratacin, o insuficiencia cardaca, si consume mucho alcohol, si se somete a una ciruga, a una radiografa o a algn procedimiento exploratorio con contraste yodado, o si usa determinados medicamentos. Para algunas afecciones es posible que su mdico le indique que deje de tomar este medicamento durante un perodo corto de tiempo. Consulte a su mdico o farmacutico para obtener ms informacin.Deje de tomar este medicamento y busque atencin mdica de urgencia si presenta cualquiera de los siguientes sntomas de acidosis lctica, como cansancio inusual, mareos, somnolencia intensa, escalofros, piel azulada/fra, dolor muscular, dificultad para respirar/respiracin acelerada, ritmo cardaco lento/irregular, dolor estomacal con nuseas, vmitos o diarrea. La metformina se utiliza junto con un programa de alimentacin y ejercicio adecuado y posiblemente con otros medicamentos para controlar los niveles elevados de azcar en la sangre. Se usa en pacientes con diabetes tipo 2. El control de los niveles altos de azcar en la sangre ayuda a prevenir el dao renal, la ceguera, los problemas neurolgicos, la prdida de extremidades y los problemas de funcin sexual. El control apropiado de la diabetes tambin puede reducir su riesgo de sufrir un ataque cardaco o un derrame cerebral. La metformina acta ayudando a restablecer la respuesta apropiada de su organismo a la insulina que usted produce naturalmente. Tambin reduce la cantidad de azcar que el hgado produce y que se absorbe en el Continue reading >>
Medicine Information - Kaiser Permanente
Al hacer clic en "Continuar", el sitio web se traducir al ingls hasta que usted cierre esta sesin. Si desea que el ingls sea su preferencia permanente de idioma en este sitio, vaya a su informacin personal de perfil. Al hacer clic en "Continuar", el sitio web se traducir al espaol hasta que usted cierre esta sesin. Si desea que el espaol sea su preferencia permanente de idioma en este sitio, vaya a su informacin personal de perfil. Al hacer clic en "Continuar", usted regresar al principio de este formulario, y toda la informacin que haya ingresado en el formulario se perder. Adems, el sitio web se traducir al ingls hasta que usted cierre sesin. Al hacer clic en "Continuar", usted regresar al principio de este formulario, y toda la informacin que haya ingresado en el formulario se perder. Adems, el sitio web se traducir al espaol hasta que usted cierre sesin. No se puede cambiar el idioma en este proceso. No se puede cambiar el idioma en este proceso. This page is not available. Please make sure you entered the correct Web address, or try again later. use the "Back" button in your browser window Continue reading >>
Qu Es Metformin Hcl 500 Mg?
Escrito por Abigail Adams | Fecha actualizada July 18, 2017 El clorhidrato de metformina, o HCL, es una medicacin oral que se compra con receta. La medicacin trabaja con una dieta apropiada y ejercicios para bajar el nivel de glucosa en sangre en lo pacientes diabticos y para otros propsitos determinados por los mdicos. Debido a las posibles complicaciones y efectos secundarios, un monitoreo de la funcin renal y de los niveles de azcar en sangre ayudarn a determinar si la medicacin es segura para los pacientes. Los pacientes usan esta medicacin para tratar la diabetes mellitus tipo 2. Esta forma de diabetes no es dependiente de la insulina y le permite al cuerpo aumentar el azcar no usada en el flujo sanguneo. La metformina trabaja para bajar el nivel de azcar, pero no afecta la produccin de insulina. Las mujeres tambin pueden tomar el medicamento para tratar el sndrome ovrico poliqustico, porque estimula a los ovarios a liberar un huevo. La metformina HCL est disponible en tabletas orales de liberacin regular y extendida. Los mdicos prescriben las regulares de 500 mg para que se tomen divididas en dosis pequeas a lo largo del da, mientras que las de liberacin extendida son prescritas para tomar por la noche con la cena, de acuerdo a RxList.com. Un mdico puede cambiar la cantidad de la dosis dependiendo de los niveles del azcar en sangre. Para comenzar, generalmente se prescriben 500 mg dos veces por da, de acuerdo a la MayoClinic.com. Para reducir las posibilidades de los efectos secundarios, la metformina debe ser tomada con las comidas. Tragar la tableta de liberacin extentida, sin aplastarla y morderla, es importante para que el medicamento se reparta por el cuerpo. Guarda el medicamento a temperatura ambiente y lejos del alcance de los nios. La metformina causa ef Continue reading >>
Metformin
Metformin may rarely cause a serious, life-threatening condition called lactic acidosis. Tell your doctor if you have kidney disease. Your doctor will probably tell you not to take metformin. Also, tell your doctor if you are over 65 years old and if you have ever had a heart attack; stroke; diabetic ketoacidosis (blood sugar that is high enough to cause severe symptoms and requires emergency medical treatment); a coma; or heart or liver disease. Taking certain other medications with metformin may increase the risk of lactic acidosis. Tell your doctor if you are taking acetazolamide (Diamox), dichlorphenamide (Keveyis), methazolamide, topiramate (Topamax, in Qsymia), or zonisamide (Zonegran). Tell your doctor if you have recently had any of the following conditions, or if you develop them during treatment: serious infection; severe diarrhea, vomiting, or fever; or if you drink much less fluid than usual for any reason. You may have to stop taking metformin until you recover. If you are having surgery, including dental surgery, or any major medical procedure, tell the doctor that you are taking metformin. Also, tell your doctor if you plan to have any x-ray procedure in which dye is injected, especially if you drink or have ever drunk large amounts of alcohol or have or have had liver disease or heart failure. You may need to stop taking metformin before the procedure and wait 48 hours to restart treatment. Your doctor will tell you exactly when you should stop taking metformin and when you should start taking it again. If you experience any of the following symptoms, stop taking metformin and call your doctor immediately: extreme tiredness, weakness, or discomfort; nausea; vomiting; stomach pain; decreased appetite; deep and rapid breathing or shortness of breath; dizzi Continue reading >>
Metformin - Spanish Translation Linguee
Being a smoker, overweight or obese, or having glycemic control issues did [...] relationship between metformin and pancreatic [...] Ser fumador, tener exceso de peso o ser obeso, o tener problemas de control de la diabetes [...] protectora entre la metformina y el riesgo de [...] cncer de pncreas, observaron Li y su equipo. Some received a placebo, while others got a daily dose of Algunos recibieron un placebo, y otros una dosis diaria de 2,000 Because metformin is traditionally used to treat [...] type 2 diabetes, its use in preventing diabetes may be considered somewhat atypical. Debido a que la metformina es usada tradicionalmente [...] para tratar la diabetes tipo 2, su uso en prevenir la diabetes puede considerarse un poco atpico. These two new products are used to treat type 2 diabetes [...] mellitus when the use of metformin is not enough. Estos dos nuevos productos estn indicados para el tratamiento de la diabetes mellitus tipo 2 [...] cuando el uso de metformina es insuficiente. Metformin (Glucophage) has been shown to [...] lower the risk of developing type 2 diabetes by 31%. Se ha demostrado que la metformina (Glucophage) disminuye [...] el riesgo de padecer diabetes tipo 2 en un 31%. Limited data demonstrated no evidence of difference [...] in effect between metformin and the OCP on hirsutism [...] Continue reading >>
Metformin And Its Clinical Use: New Insights For An Old Drug In Clinical Practice
Metformin and its clinical use: new insights for an old drug in clinical practice 1Medical and Surgical Sciences Department, Bologna University, Italy 2Department of Endocrinology and Metabolic Diseases, Ufuk University, Ankara, Turkey Corresponding author: Arrigo F.G. Cicero MD, PhD, Medical and Surgical Sciences, Department S. Orsola-Malpighi University, Hospital Pad. 2, Via Albertoni 15, 40138, Bologna, Italy. Phone: +39 3498558017. Fax: +39 0516826125. E-mail: [email protected] Received 2012 Sep 5; Revised 2012 Oct 19; Accepted 2012 Oct 28. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC. Metformin is generally recommended as first-line treatment in type 2 diabetes, especially in overweight patients, but in recent years new indications for its use have emerged. Metformin has been found to be safe and efficacious both as monotherapy and in combination with all oral antidiabetic agents and insulins. If metformin use during pregnancy and the lactation period is supported by few data, it could be indicated for women with polycystic ovary syndrome, since it could diminish circulating androgens and insulin resistance, thus ameliorating the ovulation rate. Metformin seems to reduce cancer risk, which appears to be increased in diabetics, and is a promising agent for oncoprevention and chemotherapy combinations. Moreover, metformin could find a place in the treatment of non-alcoholic fatty liver disease. Lactic acidosis could be decreased by avoiding metformin use in patients with hypovolemia, sepsis, renal im Continue reading >>
