Metformin, High Blood Pressure ,underactive Thyroid.
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community Metformin, High Blood Pressure ,Underactive thyroid. I take thyroxine for an underactive thyroid. I was diagnosed diabetes type 2 just over a year ago but just borderline as first test 50 second test 48. I was not given medication although metformin has been mentioned. I found this forum and have taken the advice to low carb and have lost just over 2 stone amazing given i had never managed before. I still have several more stones to lose but i have stalled for a little while now. Last check with DN blood pressure was up my main concern is if i am expected to take Metformin and or another tablet for blood pressure that i make a wise choice. Thanks to this forum i know to ask for Metformin SR. I did not see the GP when diagnosed have managed by seeing DN changed my diet. My thyroid is reasonable at the moment but obviously does not help me to lose weight my main concern is not to over mix any medication not totally sure what the GP will suggest just wondered if anyone had same problems and had found a way Continue reading >>
Fda-approved High Blood Pressure Drug Extends Life Span In Roundworms
An FDA-approved drug to treat high blood pressure seems to extend life span in worms via a cell signaling pathway that may mimic caloric restriction. UT Southwestern Medical Center researchers find that an FDA-approved drug to treat high blood pressure seems to extend life span in worms via a cell signaling pathway that may mimic caloric restriction. The drug, hydralazine, extended life span about 25 percent in two strains of C. elegans (roundworms), one a wild type and the other bred to generate high levels of a neurotoxic protein called tau that in humans is associated with Alzheimer's disease. "This is the first report of hydralazine treatment activating the NRF2/SKN-1 signaling pathway. We found the drug extends the life span of worms as well as or better than other potential anti-aging compounds such as curcumin and metformin. The treatment also appeared to maintain their health as measured by tests of flexibility and wiggling speed," said Dr. Hamid Mirzaei, Assistant Professor of Biochemistry at UT Southwestern and senior author of the study, published today in Nature Communications. The NRF2 pathway protects human cells from oxidative stress. The body's ability to protect itself against damaging oxygen free radicals diminishes with age, he said. One of the hallmarks of aging and neurodegenerative diseases such as Alzheimer's and Parkinson's is oxidative stress, which is believed to result cumulatively from inflammatory and infectious illnesses throughout life, Dr. Mirzaei explained. SKN-1, a C. elegans transcription factor, corresponds to NRF2 in humans. Both play a pivotal role in their respective species' responses to oxidative stress and life span, he said. The UT Southwestern researchers were searching for a chemical probe they could use in experiments to id Continue reading >>
Metformin And Blood Pressure Meds???
Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. So I was getting caught up on the threads this morning, and was reading in one (Metformin and stomach pain)that took place primarily in 2/2009 this post: I have been on Metformin for the last 7 years with no problem. During the last year I have experience severe stomach pain and bloating after eating. It was so bad at one point that I stopped eating for two weeks and lost 10 pounds during that time. They checked gallbladder, pancreas, stomach, etc. I've had an endoscopy, ct scans, etc. with no indications of an type of problem. I've seen several doctors and the last one suggested that I discontinue the Metformin for about two weeks to see if it subsides. I've been off the Metformin now for 6 days and pain is better. I'm hoping that this will be the answer to my problem. After reading many sites, I discovered that Metformin shouldn't be taken with certain kinds of blood-pressure medications. I am on Norvasc, Toprol, and Lisinopril. It is unusal to develop problems from Metformin after taking it for some time, but if this is what has been causing this horrible pain, I will be glad to have found the culprit. I am on Metformin and I also take 3 bp meds----one of which is the Toprol this poster specifically mentions. Is there some kind of bad interaction b/w the Metformin and certain blood pressure meds? Thanks for anyone who can shed any light on this. Well I got prescribed norvasc (=amlodipine) at the same time as Metformin. So I suppose doctor knew about the interaction? (rolling my eyes) Honestly, before the dx, I was on ramipril...well supposedly as I only took in occasionally. I know, that i Continue reading >>
Are There Any Interactions With Medications?
Black Seed Medications for diabetes (Antidiabetes drugs) Interaction Rating: Moderate Be cautious with this combination. Talk with your health provider. Black seed might lower blood sugar in some people. Diabetes medications are also used to lower blood sugar. Taking black seed along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed. br/> Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others. Medications that decrease the immune system (Immunosuppressants) Interaction Rating: Moderate Be cautious with this combination. Talk with your health provider. Black seed might increase the immune system. By increasing the immune system, black seed might decrease the effectiveness of medications that decrease the immune system. Some medications that decrease the immune system include include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others. Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) Interaction Rating: Moderate Be cautious with this combination. Talk with your health provider. Black seed might slow blood clotting. Taking black seed along with medications that also slow blood clotting might increase the chances of bruising and bleeding. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), nonsteroidal anti-inflammato Continue reading >>
When Blood Pressure Is Too Low
Talk around blood pressure typically centers on what to do if blood pressure is too high. We know that high blood pressure is more common in people with diabetes than people without diabetes. We also know that uncontrolled high blood pressure is a risk factor for stroke, heart disease, and kidney disease. The American Diabetes Association recommends a blood pressure goal of less than 140/80 for most people with diabetes. But what if your blood pressure is too low? Is it cause for concern? And what do you do about it? Low blood pressure defined Low blood pressure is also known as “hypotension.” You might be thinking that low blood pressure is a good thing, especially if yours tends to run on the high side. But the reality is that low blood pressure can be a serious condition for some people. For people without diabetes, the American Heart Association recommends a blood pressure of less than 120 over 80 (written as 120/80). Low blood pressure is generally defined as a blood pressure of less than 90/60. If your blood pressure tends to hover in that area without any symptoms, then there’s likely no cause for concern. But if symptoms occur, that’s a signal that something is amiss. Symptoms of low blood pressure Low blood pressure may be a sign that there’s an underlying medical condition, especially if your blood pressure drops suddenly or if you have the following symptoms: • Dizziness or lightheadedness • Fainting • Fast or irregular heartbeat • Feeling weak • Feeling confused • Lack of concentration • Blurred vision • Cold, clammy skin • Nausea • Rapid, shallow breathing • Depression • Dehydration That’s quite a list. Some of the above symptoms can occur if you have, say, the flu, a stomach bug, or have been outside for a long time in h Continue reading >>
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The Effect Of Metformin On Blood Pressure And Metabolism In Nondiabetic Hypertensive Patients.
Abstract OBJECTIVES: To study the effect of metformin on blood pressure and metabolism in nondiabetic hypertensives. DESIGN: A six-week single-blind placebo wash-out, followed by a double-blind placebo-controlled parallel group design with skew randomization (2:2:1) to metformin 850 mg b.i.d. (n = 10), metformin 500 mg b.i.d. (n = 10), or placebo b.i.d. (n = 5) for 12 weeks. Office blood pressure (oBP), ambulatory blood pressure (aBP), lipoproteins, and oral glucose tolerance (OGTT) were measured/performed before and during treatment. SUBJECTS: Sixteen male and nine female nondiabetic (OGTT) patients (median age 57 (39-74) years) with verified hypertension (White-coat excluded) for 4 (0-20) years. RESULTS: The possible effect of metformin treatment and dosage was tested with a two-factor analysis of variance. Treatment induced a significant decline in diastolic oBP, P < 0.05. This decline was, however, not significantly different comparing metformin and placebo. Systolic oBP, diastolic aBP, and systolic aBP showed no significant change by treatment. The decline in diastolic oBP was 5 mmHg in the pooled group of metformin-treated patients, P < 0.005. Different gender and the presence of obesity had no impact on the decline in diastolic oBP within this group. Changes in fasting C-peptide and fasting insulin during treatment were unrelated to blood pressure changes. High fasting insulin (> 60 pmol L[-1]) or high fasting C-peptide (> 1000 pmol L[-1]) at baseline did not favour an effect of metformin on diastolic oBP. Glucose metabolism and lipoproteins were unchanged in all groups. CONCLUSIONS: Although metformin treatment induced a decline in diastolic office blood pressure in nondiabetic hypertensives, the decline was not different from that during placebo treatment. Metf Continue reading >>
Metformin And Blood Pressure Increased - From Fda Reports
Blood pressure increased is found among people who take Metformin, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Aspirin, and have High blood cholesterol. This review analyzes which people have Blood pressure increased with Metformin. It is created by eHealthMe based on reports of 199,020 people who have side effects when taking Metformin from FDA , and is updated regularly. What to expect? If you take Metformin and have Blood pressure increased, find out what symptoms you could have in 1 year or longer. You are not alone! Join a support group for people who take Metformin and have Blood pressure increased Personalized health information On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA since 1977. Our tools are simple to use, anonymous and free. Start now >>> Number of reports submitted per year: < 1 month: 27.87 % 1 - 6 months: 14.21 % 6 - 12 months: 10.93 % 1 - 2 years: 7.65 % 2 - 5 years: 19.67 % 5 - 10 years: 15.3 % 10+ years: 4.37 % Gender of people who have Blood pressure increased when taking Metformin *: female: 60.77 % male: 39.23 % Age of people who have Blood pressure increased when taking Metformin *: 0-1: 0.06 % 2-9: 0.06 % 10-19: 0.47 % 20-29: 1.28 % 30-39: 5.24 % 40-49: 11.78 % 50-59: 25.58 % 60+: 55.53 % Top conditions involved for these people *: High Blood Cholesterol (753 people, 12.13%) Depression (378 people, 6.09%) Rheumatoid Arthritis (327 people, 5.27%) Pain (289 people, 4.66%) Gastroesophageal Reflux Disease (223 people, 3.59%) Top co-used drugs for these people *: Aspirin (734 people, 11.82%) Lisinopril (720 people, 11.60%) Simvastatin (558 people, 8.99%) Lipitor (551 people, 8.88%) Lantus (450 people, 7.25%) Top othe Continue reading >>
Canagliflozin And Metformin (oral Route)
Precautions Drug information provided by: Micromedex It is very important that your doctor check your progress at regular visits, especially during the first few weeks that you take this medicine. Blood and urine tests may be needed to check for unwanted effects. It is very important to follow carefully any instructions from your doctor about: Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your doctor. Other medicines—Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems. Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur because of lifestyle changes, such as changes in exercise and diet. Furthermore, counseling on contraception and pregnancy may be needed because of the problems that can occur in patients with diabetes during pregnancy. Travel—Keep a recent prescription and your medical history with you. Be prepared for an emergency as you would normally. Make allowances for changing time zones and keep your meal times as close as possible to your usual meal times. In case of emergency—There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. It is a good idea to wear a medical identification (ID) bracelet or neck chain at all times. Also, carry an ID card in your wallet or purse that says that you have diabetes and a list of all of your medicines. Under certain conditions, too much metformin can cause a Continue reading >>
Metformin, Can It Raise Your Blood Presure?
Question Originally asked by Community Member William Metformin, Can It Raise Your Blood Presure? I have used Metformin for 5 days. Didn’t feel well yesterday, Myblood pressure was up to 180X 115. Could Metofrmin be the cause? Answer Hi William, Thanks for your question. Metformin is not known to cause an increase in blood pressure, but medications can affect people differently. If you are concerned about the increase, or if it persists, you may want to discuss this with your doctor. You can read more about metformin and its side effects here. Best of luck, Casey You should know Answers to your question are meant to provide general health information but should not replace medical advice you receive from a doctor. No answers should be viewed as a diagnosis or recommended treatment for a condition. Answered By: Casey McNulty Continue reading >>
FORTAMET® (metformin hydrochloride) Extended-Release Tablets DESCRIPTION FORTAMET® (metformin hydrochloride) Extended-Release Tablets contain an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N, Ndimethylimidodicarbonimidic diamide hydrochloride) is a member of the biguanide class of oral antihyperglycemics and is not chemically or pharmacologically related to any other class of oral antihyperglycemic agents. The empirical formula of metformin hydrochloride is C4H11N5•HCl and its molecular weight is 165.63. Its structural formula is: Metformin hydrochloride is a white to off-white crystalline powder that is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. FORTAMET® Extended-Release Tablets are designed for once-a-day oral administration and deliver 500 mg or 1000 mg of metformin hydrochloride. In addition to the active ingredient metformin hydrochloride, each tablet contains the following inactive ingredients: candellila wax, cellulose acetate, hypromellose, magnesium stearate, polyethylene glycols (PEG 400, PEG 8000), polysorbate 80, povidone, sodium lauryl sulfate, synthetic black iron oxides, titanium dioxide, and triacetin. FORTAMET® meets USP Dissolution Test 5. System Components And Performance FORTAMET® was developed as an extended-release formulation of metformin hydrochloride and designed for once-a-day oral administration using the patented single-composition osmotic technology (SCOT™). The tablet is similar in appearance to other film-coated oral administered tablets but it consists of an osmotically active core formulation that is surrounded by a semipermeable membra Continue reading >>
Diabetes Drugs: Metformin
Editor’s Note: This is the second post in our miniseries about diabetes drugs. Tune in on August 21 for the next installment. Metformin (brand names Glucophage, Glucophage XR, Riomet, Fortamet, Glumetza) is a member of a class of medicines known as biguanides. This type of medicine was first introduced into clinical practice in the 1950’s with a drug called phenformin. Unfortunately, phenformin was found to be associated with lactic acidosis, a serious and often fatal condition, and was removed from the U.S. market in 1977. This situation most likely slowed the approval of metformin, which was not used in the U.S. until 1995. (By comparison, metformin has been used in Europe since the 1960’s.) The U.S. Food and Drug Administration (FDA) required large safety studies of metformin, the results of which demonstrated that the development of lactic acidosis as a result of metformin therapy is very rare. (A finding that has been confirmed in many other clinical trials to date.) Of note, the FDA officer involved in removing phenformin from the market recently wrote an article highlighting the safety of metformin. Metformin works primarily by decreasing the amount of glucose made by the liver. It does this by activating a protein known as AMP-activated protein kinase, or AMPK. This protein acts much like an “energy sensor,” setting off cellular activities that result in glucose storage, enhanced entry of glucose into cells, and decreased creation of fatty acids and cholesterol. A secondary effect of the enhanced entry of glucose into cells is improved glucose uptake and increased storage of glycogen (a form of glucose) by the muscles. Additionally, the decrease in fatty acid levels brought about by metformin may indirectly improve insulin resistance and beta cell func Continue reading >>
A1c Change Vs. Sitagliptin + Metformin | Invokamet Xr (canagliflozin/metformin Hcl Extended-release)
Dual therapy vs placebo + metformin at 26 weeks and vs sitagliptin + metformin at 52 weeks (Lavalle-Gonzlez et al) Adouble-blind, placebo- and active-controlled study of 1284 patients who were inadequately controlled on metformin alone. Study consisted of a 2-week, single-blind, placebo run-in period, a 26-week, placebo- and active-controlled treatment period (period 1) followed by a 26-week, active-controlled treatment period (period 2). Patients were randomized to the addition of canagliflozin 100 mg, canagliflozin 300 mg, sitagliptin 100 mg, or placebo. The primary endpoint was the change in A1C from baseline through week 26; change in A1C from baseline through week 52 was a prespecified secondary endpoint.1 Reference: 1. Lavalle-Gonzlez FJ, Januszewicz A, Davidson J, et al. Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trial. Diabetologia. 2013;56:2582-2592. Supplemental tables available at: Accessed May 16, 2018. INVOKANA (canagliflozin) is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. INVOKANA is not recommended in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. INVOKAMET and INVOKAMET XR are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both canagliflozin and metformin is appropriate. INVOKAMET and INVOKAMET XR are not recommended in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. IMPORTANT SAFETY INFORMATION for INVOKANA, INVOKAMET (canagliflozin/metformin HCl), and INVOKAMET XR WARNING: LACTIC ACIDOSIS AND LOWER-LIMB AMPUTATION Postmarketing Continue reading >>
The Multiple Benefits Of Metformin
Metformin (brand name "Glucophage") has been used in the treatment of type II diabetes for the past 40 years.1 This drug counteracts many of the underlying factors that result in the manifestation of this insidious disease. Metformin also produces helpful side benefits that can protect against the lethal complications of type II diabetes. Frequently prescribed anti-diabetic drugs fail to address the fundamental causes of type II diabetes and can induce serious side effects. Type II diabetes affects between 16 to 19 million Americans. About 75% of type II diabetics will die from a cardiovascular-related disease. Conventional doctors often prescribe drugs for the purpose of lowering blood sugar levels. These drugs do not adequately address the multiple underlying pathologies associated with the type II diabetic state. Type II diabetes is characterized by cellular insulin resistence. The result is excess accumulation of glucose in the bloodstream as cells become resistant to the effects of insulin. Type II diabetes is characterized by cellular insulin resistence. The result is excess accumulation of glucose in the bloodstream because cells become resistant to the effects of insulin and fail to take up glucose As the type II diabetic condition progresses, many people gain weight and develop more fat cells.2 Treating type II diabetes with insulin-enhancing therapy increases the risk of cardiovascular complications, induces weight gain, and fails to correct the underlying cause of the disease. Many type II diabetics produce too much insulin in a futile attempt to drive glucose into insulin-resistant cells. When doctors prescribe insulin-enhancing drugs to these type II diabetics, a temporarily reduction of serum glucose may occur, but the long-term effects of this excess insu Continue reading >>
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Metformin, Oral Tablet
Metformin oral tablet is available as both a generic and brand-name drug. Brand names: Glucophage, Glucophage XR, Fortamet, and Glumetza. Metformin is also available as an oral solution but only in the brand-name drug Riomet. Metformin is used to treat high blood sugar levels caused by type 2 diabetes. FDA warning: Lactic acidosis warning This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects. Lactic acidosis is a rare but serious side effect of this drug. In this condition, lactic acid builds up in your blood. This is a medical emergency that requires treatment in the hospital. Lactic acidosis is fatal in about half of people who develop it. You should stop taking this drug and call your doctor right away or go to the emergency room if you have signs of lactic acidosis. Symptoms include tiredness, weakness, unusual muscle pain, trouble breathing, unusual sleepiness, stomach pains, nausea (or vomiting), dizziness (or lightheadedness), and slow or irregular heart rate. Alcohol use warning: You shouldn’t drink alcohol while taking this drug. Alcohol can affect your blood sugar levels unpredictably and increase your risk of lactic acidosis. Kidney problems warning: If you have moderate to severe kidney problems, you have a higher risk of lactic acidosis. You shouldn’t take this drug. Liver problems warning: Liver disease is a risk factor for lactic acidosis. You shouldn’t take this drug if you have liver problems. Metformin oral tablet is a prescription drug that’s available as the brand name drugs Glucophage, Glucophage XR, Fortamet, and Glumetza. Glucophage is an immediate-release tablet. All of the other brands are extended-r Continue reading >>
Glipizide And Metformin
Glipizide-Metformin 2.5 mg-250 mg-MYL round, white, imprinted with G31, M What is the most important information I should know about glipizide and metformin? Do not use glipizide and metformin if you have congestive heart failure or kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking glipizide and metformin. Take care not to let your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency. Some people develop lactic acidosis while taking metformin. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. What is glipizide and metformin? Glipizide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels. Glipizide and metformin is for people with type 2 diabetes who do not use daily insulin injections. This medication is not for treating type 1 diabetes. Glipizide and metformin may also be used for purposes not listed in this medication guide. What should I discuss with my healthca Continue reading >>